The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepres... See more...

Aliases for BCL6 Gene

Aliases for BCL6 Gene

  • BCL6 Transcription Repressor 2 3 5
  • Zinc Finger Protein 51 2 3 4
  • Zinc Finger And BTB Domain-Containing Protein 27 3 4
  • B-Cell Lymphoma 6 Protein 3 4
  • B-Cell Lymphoma 5 Protein 3 4
  • B Cell CLL/Lymphoma 6 2 3
  • Protein LAZ-3 3 4
  • ZBTB27 3 4
  • ZNF51 3 4
  • BCL-5 3 4
  • BCL-6 3 4
  • BCL5 3 4
  • LAZ3 3 4
  • Lymphoma-Associated Zinc Finger Gene On Chromosome 3 3
  • Cys-His2 Zinc Finger Transcription Factor 3
  • Zinc Finger Transcription Factor BCL6S 3
  • B-Cell Lymphoma 6 Protein Transcript 3
  • BCL6, Transcription Repressor 2
  • BCL6A 3

External Ids for BCL6 Gene

Previous HGNC Symbols for BCL6 Gene

  • ZNF51

Previous GeneCards Identifiers for BCL6 Gene

  • GC03M184254
  • GC03M188700
  • GC03M188841
  • GC03M188760
  • GC03M188921
  • GC03M187439
  • GC03M184843

Summaries for BCL6 Gene

Entrez Gene Summary for BCL6 Gene

  • The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

GeneCards Summary for BCL6 Gene

BCL6 (BCL6 Transcription Repressor) is a Protein Coding gene. Diseases associated with BCL6 include Primary Mediastinal Large B-Cell Lymphoma and Intravascular Large B-Cell Lymphoma. Among its related pathways are Direct p53 effectors and FoxO family signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is BCL6B.

UniProtKB/Swiss-Prot Summary for BCL6 Gene

  • Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.

Gene Wiki entry for BCL6 Gene

Additional gene information for BCL6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BCL6 Gene

Genomics for BCL6 Gene

GeneHancer (GH) Regulatory Elements for BCL6 Gene

Promoters and enhancers for BCL6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J187735 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 515 +3.9 3915 13 EP300 FOXK2 HNRNPK ZBTB40 ZNF217 CTCF ZSCAN5C NRF1 TCF12 MYC BCL6 ENSG00000285938 ENSG00000228804 RFC4 SNORA4 SNORA63B SNORA81 LPP ST6GAL1 RTP4
GH03J187773 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 500.3 -28.4 -28354 1.5 SP1 EP300 RELA MEF2C TRIM22 BCL11A TCF12 CBFB TARDBP ARNT BCL6 ENSG00000224049 HSALNG0031438 lnc-RTP4-6
GH03J187985 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 30.1 -241.4 -241375 3 JUND FOS REST EP300 DEK CTCF ZNF316 GABPA FOSL2 CEBPB LINC01991 BCL6 LPP lnc-LPP-5
GH03J187967 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 16.8 -223.2 -223171 1.9 EP300 NCOR1 JUND FOS TCF7 CUX1 ZBTB25 SMARCC2 SKI TEAD1 BCL6 lnc-BCL6-7 LINC01991 ENSG00000236864
GH03J187849 Enhancer 1.1 FANTOM5 Ensembl ENCODE 19.3 -108.2 -108175 10.6 EP300 ATF2 MAFF FOS MAFK CEBPB RCOR1 NFE2 MAX FOSL2 BCL6 RTP4 piR-47086-196 lnc-LPP-9 LOC105374264 lnc-BCL6-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BCL6 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BCL6

Top Transcription factor binding sites by QIAGEN in the BCL6 gene promoter:
  • AP-1
  • STAT5A

Genomic Locations for BCL6 Gene

Genomic Locations for BCL6 Gene
chr3:187,721,377-187,745,725
(GRCh38/hg38)
Size:
24,349 bases
Orientation:
Minus strand
chr3:187,439,165-187,463,515
(GRCh37/hg19)
Size:
24,351 bases
Orientation:
Minus strand

Genomic View for BCL6 Gene

Genes around BCL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL6 Gene

Proteins for BCL6 Gene

  • Protein details for BCL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41182-BCL6_HUMAN
    Recommended name:
    B-cell lymphoma 6 protein
    Protein Accession:
    P41182
    Secondary Accessions:
    • A7E241
    • B8PSA7
    • D3DNV5

    Protein attributes for BCL6 Gene

    Size:
    706 amino acids
    Molecular mass:
    78846 Da
    Quaternary structure:
    • Homodimer. Interacts (via BTB domain) with the corepressors BCOR, NCOR1 and SMRT/NCOR2; the interactions are direct. Forms preferably ternary complexes with BCOR and SMRT/NCOR2 on target gene promoters but, on enhancer elements, interacts with SMRT/NCOR2 and HDAC3 to repress proximal gene expression. Interacts with histone deacetylases HDAC2, HDAC5 and HDAC9 (via the catalytic domain). Interacts with ZBTB7 and BCL6B. Interacts with SCF(FBXO11) complex; the interaction is independent of phosphorylation and promotes ubiquitination. Interacts (when phosphorylated) with PIN1; the interaction is required for BCL6 degradation upon genotoxic stress. Interacts with ZBTB17; inhibits ZBTB17 transcriptional activity. Interacts with CTBP1, autoinhibits its transcriptional expression. Interacts with NOTCH1 NCID and SIRT1; leads to a epigenetic repression of selective NOTCH1-target genes. Interacts (nor via BTB domain neither acetylated) with the NuRD complex components CHD4, HDAC1, MBD3 and MTA3; the interaction with MTA3 inhibits BCL6 acetylation and is required for BCL6 transpriptional repression.

    Three dimensional structures from OCA and Proteopedia for BCL6 Gene

    Alternative splice isoforms for BCL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCL6 Gene

Post-translational modifications for BCL6 Gene

  • Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-333 and Ser-343. Phosphorylated by ATM in response to genotoxic stress. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.
  • Polyubiquitinated (PubMed:9649500, PubMed:22113614, PubMed:30190310). Polyubiquitinated by SCF(FBXO11), leading to its degradation by the proteasome (PubMed:22113614). Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteaseome: ubiquitination by the SCF(FBXL17) complex takes place when aberrant BTB domain dimers are formed (PubMed:30190310).
  • Acetylated at Lys-379 by EP300 which inhibits the interaction with NuRD complex and the transcriptional repressor function. Deacetylated by HDAC- and SIR2-dependent pathways.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

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