The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepres... See more...

Aliases for BCL6 Gene

Aliases for BCL6 Gene

  • BCL6 Transcription Repressor 2 3 5
  • Zinc Finger Protein 51 2 3 4
  • Zinc Finger And BTB Domain-Containing Protein 27 3 4
  • B-Cell Lymphoma 6 Protein 3 4
  • B-Cell Lymphoma 5 Protein 3 4
  • B Cell CLL/Lymphoma 6 2 3
  • Protein LAZ-3 3 4
  • ZBTB27 3 4
  • ZNF51 3 4
  • BCL-5 3 4
  • BCL-6 3 4
  • BCL5 3 4
  • LAZ3 3 4
  • Lymphoma-Associated Zinc Finger Gene On Chromosome 3 3
  • Cys-His2 Zinc Finger Transcription Factor 3
  • Zinc Finger Transcription Factor BCL6S 3
  • B-Cell Lymphoma 6 Protein Transcript 3
  • BCL6, Transcription Repressor 2
  • BCL6A 3

External Ids for BCL6 Gene

Previous HGNC Symbols for BCL6 Gene

  • ZNF51

Previous GeneCards Identifiers for BCL6 Gene

  • GC03M184254
  • GC03M188700
  • GC03M188841
  • GC03M188760
  • GC03M188921
  • GC03M187439
  • GC03M184843

Summaries for BCL6 Gene

Entrez Gene Summary for BCL6 Gene

  • The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

GeneCards Summary for BCL6 Gene

BCL6 (BCL6 Transcription Repressor) is a Protein Coding gene. Diseases associated with BCL6 include Primary Mediastinal Large B-Cell Lymphoma and Intravascular Large B-Cell Lymphoma. Among its related pathways are Direct p53 effectors and FoxO family signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is BCL6B.

UniProtKB/Swiss-Prot Summary for BCL6 Gene

  • Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.

Gene Wiki entry for BCL6 Gene

Additional gene information for BCL6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BCL6 Gene

Genomics for BCL6 Gene

GeneHancer (GH) Regulatory Elements for BCL6 Gene

Promoters and enhancers for BCL6 Gene