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The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepres... See more...
Aliases for BCL6 Gene
Aliases for BCL6 Gene
External Ids for BCL6 Gene
- HGNC: 1001
- Entrez Gene: 604
- Ensembl: ENSG00000113916
- OMIM: 109565
- UniProtKB: P41182
Previous HGNC Symbols for BCL6 Gene
- ZNF51
Previous GeneCards Identifiers for BCL6 Gene
- GC03M184254
- GC03M188700
- GC03M188841
- GC03M188760
- GC03M188921
- GC03M187439
- GC03M184843
Summaries for BCL6 Gene
-
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
GeneCards Summary for BCL6 Gene
BCL6 (BCL6 Transcription Repressor) is a Protein Coding gene. Diseases associated with BCL6 include Primary Mediastinal Large B-Cell Lymphoma and Intravascular Large B-Cell Lymphoma. Among its related pathways are Transcriptional misregulation in cancer and Notch Signaling Pathway (WikiPathways). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is BCL6B.
UniProtKB/Swiss-Prot Summary for BCL6 Gene
-
Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.
Additional gene information for BCL6 Gene
- HGNC(1001)
- Entrez Gene(604)
- Ensembl(ENSG00000113916)
- OMIM(109565)
- UniProtKB(P41182)
- Open Targets Platform(ENSG00000113916)
- Monarch Initiative
- Search for BCL6 at DataMed
- Search for BCL6 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BCL6 Gene
Genomics for BCL6 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BCL6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BCL6 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BCL6
- Top Transcription factor binding sites by QIAGEN in the BCL6 gene promoter:
-
- AP-1
- STAT5A
Genomic Locations for BCL6 Gene
Genomic Locations for BCL6 Gene
- chr3:187,721,377-187,745,725
- (GRCh38/hg38)
- Size:
- 24,349 bases
- Orientation:
- Minus strand
- chr3:187,439,165-187,463,515
- (GRCh37/hg19)
- Size:
- 24,351 bases
- Orientation:
- Minus strand
Genomic View for BCL6 Gene
Genes around BCL6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q27.3 by HGNC
- 3q27.3 by Entrez Gene
- 3q27.3 by Ensembl
BCL6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BCL6 Gene
Proteins for BCL6 Gene
-
Protein details for BCL6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P41182-BCL6_HUMAN
- Recommended name:
- B-cell lymphoma 6 protein
- Protein Accession:
- P41182
- A7E241
- B8PSA7
- D3DNV5
Protein attributes for BCL6 Gene
- Size:
- 706 amino acids
- Molecular mass:
- 78846 Da
- Quaternary structure:
-
- Homodimer. Interacts (via BTB domain) with the corepressors BCOR, NCOR1 and SMRT/NCOR2; the interactions are direct. Forms preferably ternary complexes with BCOR and SMRT/NCOR2 on target gene promoters but, on enhancer elements, interacts with SMRT/NCOR2 and HDAC3 to repress proximal gene expression. Interacts with histone deacetylases HDAC2, HDAC5 and HDAC9 (via the catalytic domain). Interacts with ZBTB7 and BCL6B. Interacts with SCF(FBXO11) complex; the interaction is independent of phosphorylation and promotes ubiquitination. Interacts (when phosphorylated) with PIN1; the interaction is required for BCL6 degradation upon genotoxic stress. Interacts with ZBTB17; inhibits ZBTB17 transcriptional activity. Interacts with CTBP1, autoinhibits its transcriptional expression. Interacts with NOTCH1 NCID and SIRT1; leads to a epigenetic repression of selective NOTCH1-target genes. Interacts (nor via BTB domain neither acetylated) with the NuRD complex components CHD4, HDAC1, MBD3 and MTA3; the interaction with MTA3 inhibits BCL6 acetylation and is required for BCL6 transpriptional repression.
Three dimensional structures from OCA and Proteopedia for BCL6 Gene
Post-translational modifications for BCL6 Gene
- Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-333 and Ser-343. Phosphorylated by ATM in response to genotoxic stress. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.
- Polyubiquitinated (PubMed:9649500, PubMed:22113614, PubMed:30190310). Polyubiquitinated by SCF(FBXO11), leading to its degradation by the proteasome (PubMed:22113614). Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteaseome: ubiquitination by the SCF(FBXL17) complex takes place when aberrant BTB domain dimers are formed (PubMed:30190310).
- Acetylated at Lys-379 by EP300 which inhibits the interaction with NuRD complex and the transcriptional repressor function. Deacetylated by HDAC- and SIR2-dependent pathways.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for BCL6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ Bcl6 Antibody
- NSJ Bioreagents BCL6 Antibody
-
BioLegend
- Bcl-6 Antibody (648302)
- Bcl-6 Antibody (648301)
- Bcl-6 Antibody (358503)
- Bcl-6 Antibody (358504)
- Bcl-6 Antibody (358505)
- Bcl-6 Antibody (358506)
- Bcl-6 Antibody (358512)
- Bcl-6 Antibody (358510)
- Bcl-6 Antibody (358509)
- PerCP/Cyanine5.5 Bcl-6 Antibody (358508)
- PerCP/Cyanine5.5 Bcl-6 Antibody (358507)
- Bcl-6 Antibody (358511)
-
Custom Antibody ServicesOriGene Antibodies for BCL6
- Novus Biologicals Antibodies for BCL6
- Invitrogen Antibodies for BCL6 (AFLGC-BCL6)
- antibodies-online: Show 39 available BCL6 Antibodies ranked by validation data
- Compare Top BCL6 Antibodies
-
Recommended
- 62 WB Antibodies (anti-mouse)
- 21 IHC (f) Antibodies (anti-mouse)
- 13 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 9 IHC Antibodies (anti-mouse)
- 8 FACS Antibodies (anti-mouse)
- 187 WB Antibodies (anti-human)
- 61 IHC Antibodies (anti-human)
- 39 IHC (p) Antibodies (anti-human)
- 21 IHC (f) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 11 FACS Antibodies (anti-human)
- 3 IF Antibodies (anti-human)
- 52 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
-
Boster Bio Antibodies for BCL6
-
Custom Antibody ServicesProSci Antibodies for BCL6
-
Santa Cruz Biotechnology (SCBT) Antibodies for BCL6
- Sino Biological Antibodies for BCL6
Protein Products
-
OriGene Purified Proteins for BCL6
- Search Origene for MassSpec and Protein Over-expression Lysates for BCL6
- Origene Custom Protein Services for BCL6
- Sino Biological Recombinant Proteins for BCL6
- Browse Sino Biological Cell Lysates
-
Signalway Proteins for BCL6
-
Abcam proteins for BCL6
Assay Products
- antibodies-online: Show 4 available BCL6 Elisa Kits ranked by validation data
- Compare Top BCL6 Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for BCL6
-
Signalway ELISA kits for BCL6
No data available for DME Specific Peptides for BCL6 Gene
Domains & Families for BCL6 Gene
Gene Families for BCL6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for BCL6 Gene
- InterPro:
- Blocks:
-
- C2H2-type zinc finger signature
- BTB/POZ domain
- ProtoNet:
Suggested Antigen Peptide Sequences for BCL6 Gene
- GenScript: Design optimal peptide antigens:
-
- BCL6 protein (A0N7C6_HUMAN)
- BCL6 protein (A0N7C7_HUMAN)
- B-cell CLL/lymphoma 6 (A5PL18_HUMAN)
- Zinc finger transcription factor BCL6S (B5B0A5_HUMAN)
- Zinc finger protein 51 (BCL6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P41182UniProtKB/Swiss-Prot:
BCL6_HUMAN :- The BTB domain mediates homodimerization. Its dimer interface mediates peptide binding such as to corepressors BCOR and NCOR2 (PubMed:18212045). Interaction with corepressors through the BTB domain is needed to facilitate the rapid proliferation and survival of GC B-cells but is not involved in the T(FH) formation and BCL6-mediated suppression of T(H)2 and T(H)17 differentiationrequired for GC formation (By similarity).
- Domain:
-
- The BTB domain mediates homodimerization. Its dimer interface mediates peptide binding such as to corepressors BCOR and NCOR2 (PubMed:18212045). Interaction with corepressors through the BTB domain is needed to facilitate the rapid proliferation and survival of GC B-cells but is not involved in the T(FH) formation and BCL6-mediated suppression of T(H)2 and T(H)17 differentiationrequired for GC formation (By similarity).
Function for BCL6 Gene
Molecular function for BCL6 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated during maturation of dendritic cells by selective stimuli such as bacterial lipopolysaccharides (LPS), CD40LG and zymosan. Protein levels decreases upon genotoxic stress in a dose- and time-dependent way.
- GENATLAS Biochemistry:
- zinc finger transcriptional repressor,expressed in B cells and CD4+ T cells,within the germinal center,recruiting a SMRT/SIN3A/histone deacetylase complex to mediate transcriptional repression,involved in B cell lymphomas with translocations t(3;14),t(3;13),t(2;3),t(3;22),t(3;4),t(3;11),t(3;6) and others,sequence specific transcriptional repression
- GENATLAS Biochemistry:
- breakpoint in B cell non Hodgkin lymphoma,in translocations t(3;14),t(2;3),t(3;22),t(3;4),t(3;11) and others,same as LAZ3
Phenotypes From GWAS Catalog for BCL6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | -- |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA,IBA | 21873635 |
| GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding | IEA | -- |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IBA | 21873635 |
| GO:0003676 | nucleic acid binding | IEA | -- |
Phenotypes for BCL6 Gene
- MGI mutant phenotypes for BCL6:
-
inferred from 11 alleles
- immune system phenotype
- respiratory system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- hematopoietic system phenotype
- integument phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for BCL6:
-
- no effect
- Increased cell death HMECs cells
- Reduced mammosphere formation
- Increased homologous recombination repair frequency
- Synthetic lethal with vaccinia virus (VACV) infection
- Two nuclei (binuclear)
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased viability in non-small-cell lung cancer (NSCLC) lineage; decreased viability in pancreas lineage
Animal Models for BCL6 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BCL6 - Select products 50% OFF >
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-
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCL6
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCL6
miRNA for BCL6 Gene
- miRTarBase miRNAs that target BCL6
-
- hsa-miR-9-5p (MIRT000640)
- hsa-miR-127-3p (MIRT004463)
- rno-miR-127-3p (MIRT004901)
- hsa-miR-339-5p (MIRT005929)
- hsa-miR-30b-5p (MIRT006324)
- hsa-miR-155-5p (MIRT006927)
- mmu-miR-26a-5p (MIRT011267)
- mmu-miR-9-5p (MIRT015404)
- hsa-miR-335-5p (MIRT017492)
- hsa-miR-124-3p (MIRT022507)
- hsa-miR-21-5p (MIRT035524)
- mmu-miR-34a-5p (MIRT054305)
- mmu-miR-34b-5p (MIRT054306)
- mmu-miR-34c-5p (MIRT054307)
- hsa-miR-205-5p (MIRT054375)
- mmu-miR-3084-3p (MIRT584586)
- mmu-miR-712-5p (MIRT584587)
- mmu-miR-205-5p (MIRT584588)
- hsa-miR-187-3p (MIRT731339)
- hsa-miR-544a (MIRT732380)
- mmu-miR-127-3p (MIRT732504)
- hsa-miR-346 (MIRT734752)
- hsa-miR-10a-5p (MIRT734916)
Targeted motifs for BCL6 Gene
HOMER Transcription Factor Regulatory Elements motif BCL6
- Consensus sequence: NNNCTTTCCAGGAAA Submotif: canonical Cell Type: Liver GEO ID: GSE31578
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for BCL6 - Select products 50% OFF >
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-
- MG210168
- MR210168
- MR210168L3
- MR210168L4
- RC219007
- RC219007L1
- RC219007L2
- RC219007L3
- RC219007L4
- RC226063
- RC226063L3
- RC226063L4
- RC226102
- RC226102L3
- RC226102L4
- RG219007
- RG226063
- RG226102
- RR207059
- RR207059L3
- RR207059L4
- MR210168L3V
- MR210168L4V
- RC219007L1V
- RC219007L2V
- RC219007L3V
- RC219007L4V
- RC226063L3V
- RC226063L4V
- RC226102L3V
- RC226102L4V
- RR207059L3V
- RR207059L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BCL6
- Addgene plasmids for BCL6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCL6
Cell Line Products
-
Horizon Cell Lines for BCL6
No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for BCL6 Gene
Localization for BCL6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BCL6 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| golgi apparatus | 4 |
| plasma membrane | 3 |
| extracellular | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| peroxisome | 1 |
- Nucleoplasm (4)
- Golgi apparatus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IDA | 7795255 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005657 | colocalizes_with replication fork | IDA | 10490843 |
| GO:0005794 | Golgi apparatus | IDA | -- |
Pathways & Interactions for BCL6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytokine Signaling in Immune system | ||
| 2 | Gene Expression |
.48
|
|
| 3 | TP53 Regulates Transcription of Cell Death Genes | ||
| 4 | NF-kappaB Signaling | ||
| 5 | FoxO signaling pathway | ||
Pathways by source for BCL6 Gene
1 Sino Biological pathway for BCL6 Gene
7 BioSystems pathways for BCL6 Gene
9 Reactome pathways for BCL6 Gene
2 KEGG pathways for BCL6 Gene
1 GeneGo (Thomson Reuters) pathway for BCL6 Gene
- Immune response BCR pathway
1 R&D Systems pathway for BCL6 Gene
1 Cell Signaling Technology pathway for BCL6 Gene
Interacting Proteins for BCL6 Gene
Selected Interacting proteins:
P41182-BCL6_HUMAN
ENSP00000384371
for BCL6 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for BCL6
SIGNOR curated interactions for BCL6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 11929873 |
| GO:0000902 | cell morphogenesis | IEA | -- |
| GO:0001817 | regulation of cytokine production | IBA | 21873635 |
| GO:0001953 | negative regulation of cell-matrix adhesion | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
Transcripts for BCL6 Gene
mRNA/cDNA for BCL6 Gene
- 4 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000406870 3306 nts (view in UCSC)
- ENST00000419510 4178 nts (view in UCSC)
- ENST00000232014 2710 nts (view in UCSC)
- ENST00000450123 2003 nts (view in UCSC)
- ENST00000479110 635 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BCL6 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BCL6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCL6
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCL6
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCL6
- Browse OriGene Inhibitory RNA Products For BCL6
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Clone Products
- Applied Biological Materials (abm): Clones for BCL6 - Select products 50% OFF >
- * BCL6 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210168
- MR210168
- MR210168L3
- MR210168L4
- RC219007
- RC219007L1
- RC219007L2
- RC219007L3
- RC219007L4
- RC226063
- RC226063L3
- RC226063L4
- RC226102
- RC226102L3
- RC226102L4
- RG219007
- RG226063
- RG226102
- RR207059
- RR207059L3
- RR207059L4
- MR210168L3V
- MR210168L4V
- RC219007L1V
- RC219007L2V
- RC219007L3V
- RC219007L4V
- RC226063L3V
- RC226063L4V
- RC226102L3V
- RC226102L4V
- RR207059L3V
- RR207059L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BCL6
- Addgene plasmids for BCL6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCL6
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||
| SP4: |
Relevant External Links for BCL6 Gene
- GeneLoc Exon Structure for
- BCL6
Expression for BCL6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Granulocytes Peripheral Blood
- Double Positive Thymocytes Thymus
- Hematopoietic Bone Marrow
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Bone Marrow
- Inner Cell Mass (Early Embryonic Tissues)
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
-
Skeletal Muscle (Muscoskeletal System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for BCL6 Gene
This gene is overexpressed in Whole Blood (x10.0) and Muscle - Skeletal (x6.2).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BCL6
SOURCE GeneReport for Unigene cluster for BCL6 Gene:
Hs.478588mRNA Expression by UniProt/SwissProt for BCL6 Gene:
P41182-BCL6_HUMAN
Tissue specificity:
Expressed in germinal center T- and B-cells and in primary immature dendritic cells.
Evidence on tissue expression from TISSUES for BCL6 Gene
- Muscle(4.7)
- Liver(4.7)
- Nervous system(4.5)
- Lymph node(3.9)
- Blood(3.8)
- Bone marrow(3.8)
- Spleen(3.5)
- Intestine(3.2)
- Skin(3.2)
- Heart(3)
- Lung(3)
- Kidney(2.9)
- Thyroid gland(2.6)
- Stomach(2.5)
- Pancreas(2.4)
- Adrenal gland(2.4)
- Gall bladder(2.4)
- Eye(2.1)
- Bone(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL6 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- immune
- integumentary
- lymphatic
- nervous
Regions:
Head and neck:
- brain
- head
Abdomen:
- spleen
General:
- blood
- lymph node
- skin
- sweat gland
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for BCL6
-
OriGene qPCR primer pairs and template standards for BCL6
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for BCL6 Gene
Orthologs for BCL6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BCL6 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | BCL6 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | BCL6 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Bcl6 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Bcl6 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | BCL6 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | BCL6 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | BCL6 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | bcl6 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | bcl6a 30 31 |
|
OneToMany | |
| bcl6ab 31 |
|
OneToMany | |||
| zgc73162 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7076 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Kr 32 |
|
|
|
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for BCL6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for BCL6 Gene
- ENSEMBL:
- Gene Tree for BCL6 (if available)
- TreeFam:
- Gene Tree for BCL6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BCL6: view image
Paralogs for BCL6 Gene
Paralogs for BCL6 Gene
(100) SIMAP similar genes for BCL6 Gene using alignment to 8 proteins:
- BCL6_HUMAN
- A0N7C6_HUMAN
- A0N7C7_HUMAN
- A5PL18_HUMAN
- B5B0A5_HUMAN
- C9JCS5_HUMAN
- C9JL16_HUMAN
- Q16413_HUMAN
- BACH2
- ZNF
- ZNF818P
- Bach2
- BACH1
- KLHL3
- ZNF883
- ZNF78L1
- ZBTB21
- DKFZp434J0650
- KLHL2
- ZNF55
- ZNF410
- kr-znf3
- ZBTB3
- HIC1
- ZNF770
- ZFS-6
- ZBTB7C
- KLHL32
- ZBTB49
- ZBTB17
- ZNF131
- NACC1
- ZNF833P
- HZF30
- HZF16
- ZBTB44
- ZNF740
- ZKSCAN1
- KLHL18
- DKFZp686N0199
- zf30
- ZNF468
- ZBTB38
- KLHL36
- smap-7
- ZNF331
- ZFP1
- PLZF
- KEAP1
- KLHL24
- DKFZp686M04222
- ZNF808
- ZNF282
- HZF36
- CTCFL
- KLHL26
- KLF1
- ZFS-2
- ZNF702P
- ZNF72
- ZNF500
- ZNF260
- KBTBD8
- ZBTB22
- ZNF22
- MYNN
- ZNF697
- ZNF323
- ZNF32
- ZSCAN21
- ZNF600
- ZNF578
- ZNF146
- ZNF138
- ZFS-1
- DKFZp686O1631
- DKFZp666C237
- ZBTB16
- ZBTB1
- KLHL10
- BCL6B
- ZBTB14
- ZNF234
- ZNF826P
- ZNF705A
- ZNF664
- Nbla00121
- HZF40
- A-328A3.4
- ZNF83
- ZNF80
- ZNF204
- ZNF141
- ZFS-5
- MST154
- HZF17
- ZNF844
- DKFZp570I0164
- ZNF75A
- ZFP64
- DKFZp313M0722
- ZBTB47
- ZNF589
- ZNF710
- ZNF660
- ZNF585B
- ZNF124
- DKFZp434G1930
Variants for BCL6 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BCL6 Gene
| SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 717149 | Benign: not provided | 187,729,778(-) | G/A | SYNONYMOUS_VARIANT | |
| 725713 | Benign: not provided | 187,733,525(-) | T/A | INTRON_VARIANT | |
| 729093 | Benign: not provided | 187,722,497(-) | T/C | SYNONYMOUS_VARIANT | |
| 729094 | Likely Benign: not provided | 187,729,200(-) | C/T | MISSENSE_VARIANT | |
| 734312 | Likely Benign: not provided | 187,725,085(-) | G/A | INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2664940 | CNV | deletion | 23128226 |
| nsv1073701 | CNV | deletion | 25765185 |
Residual Variation Intolerance Score:
44.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.62;
78.21% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BCL6 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL6 Gene
Disorders for BCL6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| primary mediastinal large b-cell lymphoma |
|
|
| intravascular large b-cell lymphoma |
|
|
| high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement |
|
|
| follicular lymphoma 1 |
|
|
| lymphoma |
|
Search BCL6 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
BCL6_HUMAN- Note=Chromosomal aberrations involving BCL6 are a cause of B-cell non-Hodgkin lymphomas (B-cell NHL), including diffuse large B-cell lymphoma and follicular lymphoma. Approximately 40% of diffuse large B-cell lymphomas and 5 to 10% of follicular lymphomas are associated with chromosomal translocations that deregulate expression of BCL6 by juxtaposing heterologous promoters to the BCL6 coding domain (PubMed:10469447, PubMed:10753856, PubMed:12414651, PubMed:11821949). Translocation t(3;14)(q27;q32). Translocation t(3;22)(q27;q11) with immunoglobulin gene regions (PubMed:11821949). Translocation t(3;7)(q27;p12) with IKZF1 gene 5'non-coding region (PubMed:10753856). Translocation t(3;6)(q27;p21) with Histone H4 (PubMed:12414651). Translocation t(3;16)(q27;p11) with IL21R. Translocation t(3;13)(q27;q14) with LCP1 (PubMed:10469447). {ECO:0000269 PubMed:10469447, ECO:0000269 PubMed:10753856, ECO:0000269 PubMed:11821949, ECO:0000269 PubMed:12414651}.
- Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.
- Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
Genatlas disease for BCL6 Gene
B-cell,diffuse large-cell lymphoma,follicular lymphoma and mantel cell lymphoma,mucosa-associated lymphoid tissue non Hodgkin lymphoma with translocations t(3;14)(q27;q32),t(3;13)(q27;q14),t(2;3)(p12;q27),t(3;22)(q27;q11),t(3;4)(q27;p11),t(3;11)(q27;q23),t(3;6)(q27;p21.3),also rearranged in some marginal zone B-cell lymphoma,mutated in human herpes-8 positive primary effusion lymphoma (PEL)
Additional Disease Information for BCL6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
Publications for BCL6 Gene
- BCL6: somatic mutations and expression in early-stage chronic lymphocytic leukemia. (PMID: 19367498) Jantus Lewintre E … García-Conde J (Leukemia & lymphoma 2009) 3 23 41
- Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development. (PMID: 19336552) Morton LM … Hartge P (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 23 41
- CtBP is an essential corepressor for BCL6 autoregulation. (PMID: 18212045) Mendez LM … Ye BH (Molecular and cellular biology 2008) 3 4 23
- The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. (PMID: 15577913) Phan RT … Dalla-Favera R (Nature 2004) 3 4 23
- The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma. (PMID: 11821949) Ueda C … Ohno H (Oncogene 2002) 3 4 23
ExternalLinks
Products for BCL6 Gene
- Custom Antibody ServicesOriGene Antibodies for BCL6
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- Custom Assay Services
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- OriGene qPCR primer pairs for BCL6
- OriGene qPCR primer pairs and template standards for BCL6
- OriGene CRISPR knockouts for BCL6
- MG210168
- MR210168
- MR210168L3
- MR210168L4
- RC219007
- RC219007L1
- RC219007L2
- RC219007L3
- RC219007L4
- RC226063
- RC226063L3
- RC226063L4
- RC226102
- RC226102L3
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- RG219007
- RG226063
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- RR207059
- RR207059L3
- RR207059L4
- MR210168L3V
- MR210168L4V
- RC219007L1V
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- RC226063L3V
- RC226063L4V
- RC226102L3V
- RC226102L4V
- RR207059L3V
- RR207059L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for BCL6
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- Novus Biologicals proteins and lysates for BCL6
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- VectorBuilder Virus packaging for BCL6 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for BCL6
- Addgene plasmids for BCL6
- antibodies-online: Show 39 available BCL6 Antibodies ranked by validation data
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- 62 WB Antibodies (anti-mouse)
- 21 IHC (f) Antibodies (anti-mouse)
- 13 IHC (p) Antibodies (anti-mouse)
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- 9 IHC Antibodies (anti-mouse)
- 8 FACS Antibodies (anti-mouse)
- 187 WB Antibodies (anti-human)
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- 12 IF (p) Antibodies (anti-human)
- 11 FACS Antibodies (anti-human)
- 3 IF Antibodies (anti-human)
- 52 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- antibodies-online: Show 4 available BCL6 Elisa Kits ranked by validation data
- Compare Top BCL6 Elisa Kits
- Quality Products:
- antibodies-online: Show 8 available BCL6 Proteins ranked by validation data
- Compare Top BCL6 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for BCL6
- Search Santa Cruz Biotechnology (SCBT) for BCL6 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BCL6
- Custom Antibody ServicesProSci Antibodies for BCL6
- Search for BCL6 Proteins at ProSci
- Horizon Cell Lines for BCL6
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCL6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCL6
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- Boster Bio Antibodies for BCL6
- Boster Bio ELISA Kits for BCL6
Sources for BCL6 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
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- (83) Illumina
- (84) COMPARTMENTS
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- (89) antibodies-online
- (90) CYP
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