BCL6 Gene (Protein Coding)

BCL6 Transcription Repressor

GC03M187721
GIFtS:
45
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepres... See more...

Aliases for BCL6 Gene

Aliases for BCL6 Gene

  • BCL6 Transcription Repressor 2 3 5
  • Zinc Finger Protein 51 2 3 4
  • ZBTB27 2 3 4
  • BCL5 2 3 4
  • LAZ3 2 3 4
  • Zinc Finger And BTB Domain-Containing Protein 27 3 4
  • B-Cell Lymphoma 6 Protein 3 4
  • B-Cell Lymphoma 5 Protein 3 4
  • B Cell CLL/Lymphoma 6 2 3
  • Protein LAZ-3 3 4
  • BCL6A 2 3
  • ZNF51 3 4
  • BCL-5 3 4
  • BCL-6 3 4
  • Lymphoma-Associated Zinc Finger Gene On Chromosome 3 3
  • Cys-His2 Zinc Finger Transcription Factor 3
  • Zinc Finger Transcription Factor BCL6S 3
  • B-Cell Lymphoma 6 Protein Transcript 3
  • BCL6, Transcription Repressor 2
  • BCL6 5

External Ids for BCL6 Gene

Previous HGNC Symbols for BCL6 Gene

  • ZNF51

Previous GeneCards Identifiers for BCL6 Gene

  • GC03M184254
  • GC03M188700
  • GC03M188841
  • GC03M188760
  • GC03M188921
  • GC03M187439
  • GC03M184843

Summaries for BCL6 Gene

Entrez Gene Summary for BCL6 Gene

  • The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

GeneCards Summary for BCL6 Gene

BCL6 (BCL6 Transcription Repressor) is a Protein Coding gene. Diseases associated with BCL6 include Primary Mediastinal Large B-Cell Lymphoma and Intravascular Large B-Cell Lymphoma. Among its related pathways are IL4-mediated signaling events and Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is BCL6B.

UniProtKB/Swiss-Prot Summary for BCL6 Gene

  • Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.

Gene Wiki entry for BCL6 Gene

Additional gene information for BCL6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BCL6 Gene

Genomics for BCL6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for BCL6 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH03J187735 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 265 +3.8 3775 13.3 BCLAF1 SP1 ZNF207 ZNF654 IKZF1 MYC NCOR1 ZNF600 SIX5 SSRP1 BCL6 ENSG00000285938 LOC100131635 SNORA4 SNORA63B RFC4 SNORA81 LPP ST6GAL1 RTP4
GH03J187773 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 250.3 -28.4 -28354 1.5 BCLAF1 SP1 BCL11A ZNF592 TARDBP TRIM22 IRF4 EBF1 CBFB SMARCA5 HSALNG0031435 BCL6 ENSG00000224049 lnc-RTP4-6 LPP
GH03J187985 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 30.1 -241.4 -241375 3 JUND CEBPB DEK CTCF MAX EP300 RAD21 RFX5 SMC3 ZNF316 BCL6 LPP HSALNG0031452 lnc-LPP-5 HSALNG0031449 LINC01991
GH03J187967 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 16.8 -223.2 -223171 1.9 ZNF600 JUND CEBPA ATF3 YY1 CEBPB DEK HOMEZ MAX KMT2B BCL6 HSALNG0031449 lnc-BCL6-7 ENSG00000236864 LINC01991 LPP
GH03J187954 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 14.9 -209.5 -209530 2.3 CEBPA BRCA1 YY1 CEBPB HOMEZ MAX EP300 RXRA RAD21 RFX5 BCL6 LPP RTP2 ENSG00000236864 HSALNG0031449 HSALNG0031446 lnc-BCL6-7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BCL6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BCL6

Top Transcription factor binding sites by QIAGEN in the BCL6 gene promoter:
  • AP-1
  • STAT5A

Genomic Locations for BCL6 Gene

Latest Assembly
chr3:187,721,377-187,745,725
(GRCh38/hg38)
Size:
24,349 bases
Orientation:
Minus strand

Previous Assembly
chr3:187,439,165-187,463,256
(GRCh37/hg19 by Entrez Gene)
Size:
24,092 bases
Orientation:
Minus strand

chr3:187,439,165-187,463,515
(GRCh37/hg19 by Ensembl)
Size:
24,351 bases
Orientation:
Minus strand

Genomic View for BCL6 Gene

Genes around BCL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for BCL6 Gene

Proteins for BCL6 Gene

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  • Protein details for BCL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41182-BCL6_HUMAN
    Recommended name:
    B-cell lymphoma 6 protein
    Protein Accession:
    P41182
    Secondary Accessions:
    • A7E241
    • B8PSA7
    • D3DNV5

    Protein attributes for BCL6 Gene

    Size:
    706 amino acids
    Molecular mass:
    78846 Da
    Quaternary structure:
    • Homodimer. Interacts (via BTB domain) with the corepressors BCOR, NCOR1 and SMRT/NCOR2; the interactions are direct. Forms preferably ternary complexes with BCOR and SMRT/NCOR2 on target gene promoters but, on enhancer elements, interacts with SMRT/NCOR2 and HDAC3 to repress proximal gene expression. Interacts with histone deacetylases HDAC2, HDAC5 and HDAC9 (via the catalytic domain). Interacts with ZBTB7 and BCL6B. Interacts with SCF(FBXO11) complex; the interaction is independent of phosphorylation and promotes ubiquitination. Interacts (when phosphorylated) with PIN1; the interaction is required for BCL6 degradation upon genotoxic stress. Interacts with ZBTB17; inhibits ZBTB17 transcriptional activity. Interacts with CTBP1, autoinhibits its transcriptional expression. Interacts with NOTCH1 NCID and SIRT1; leads to a epigenetic repression of selective NOTCH1-target genes. Interacts (nor via BTB domain neither acetylated) with the NuRD complex components CHD4, HDAC1, MBD3 and MTA3; the interaction with MTA3 inhibits BCL6 acetylation and is required for BCL6 transpriptional repression.

    Three dimensional structures from OCA and Proteopedia for BCL6 Gene

    Alternative splice isoforms for BCL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCL6 Gene

Post-translational modifications for BCL6 Gene

  • Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-333 and Ser-343. Phosphorylated by ATM in response to genotoxic stress. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.
  • Polyubiquitinated (PubMed:9649500, PubMed:22113614, PubMed:30190310). Polyubiquitinated by SCF(FBXO11), leading to its degradation by the proteasome (PubMed:22113614). Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteaseome: ubiquitination by the SCF(FBXL17) complex takes place when aberrant BTB domain dimers are formed (PubMed:30190310).
  • Acetylated at Lys-379 by EP300 which inhibits the interaction with NuRD complex and the transcriptional repressor function. Deacetylated by HDAC- and SIR2-dependent pathways.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for BCL6 Gene

Domains & Families for BCL6 Gene

Gene Families for BCL6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for BCL6 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • BTB/POZ domain

Suggested Antigen Peptide Sequences for BCL6 Gene

GenScript: Design optimal peptide antigens:
  • BCL6 protein (A0N7C6_HUMAN)
  • BCL6 protein (A0N7C7_HUMAN)
  • B-cell CLL/lymphoma 6 (A5PL18_HUMAN)
  • Zinc finger transcription factor BCL6S (B5B0A5_HUMAN)
  • Zinc finger protein 51 (BCL6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P41182

UniProtKB/Swiss-Prot:

BCL6_HUMAN :
  • The BTB domain mediates homodimerization. Its dimer interface mediates peptide binding such as to corepressors BCOR and NCOR2 (PubMed:18212045). Interaction with corepressors through the BTB domain is needed to facilitate the rapid proliferation and survival of GC B-cells but is not involved in the T(FH) formation and BCL6-mediated suppression of T(H)2 and T(H)17 differentiationrequired for GC formation (By similarity).
Domain:
  • The BTB domain mediates homodimerization. Its dimer interface mediates peptide binding such as to corepressors BCOR and NCOR2 (PubMed:18212045). Interaction with corepressors through the BTB domain is needed to facilitate the rapid proliferation and survival of GC B-cells but is not involved in the T(FH) formation and BCL6-mediated suppression of T(H)2 and T(H)17 differentiationrequired for GC formation (By similarity).
genes like me logo Genes that share domains with BCL6: view

Function for BCL6 Gene

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Molecular function for BCL6 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.
UniProtKB/Swiss-Prot Induction:
Down-regulated during maturation of dendritic cells by selective stimuli such as bacterial lipopolysaccharides (LPS), CD40LG and zymosan. Protein levels decreases upon genotoxic stress in a dose- and time-dependent way.
GENATLAS Biochemistry:
zinc finger transcriptional repressor,expressed in B cells and CD4+ T cells,within the germinal center,recruiting a SMRT/SIN3A/histone deacetylase complex to mediate transcriptional repression,involved in B cell lymphomas with translocations t(3;14),t(3;13),t(2;3),t(3;22),t(3;4),t(3;11),t(3;6) and others,sequence specific transcriptional repression
GENATLAS Biochemistry:
breakpoint in B cell non Hodgkin lymphoma,in translocations t(3;14),t(2;3),t(3;22),t(3;4),t(3;11) and others,same as LAZ3

Phenotypes From GWAS Catalog for BCL6 Gene

Gene Ontology (GO) - Molecular Function for BCL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0001161 intronic transcription regulatory region sequence-specific DNA binding IEA --
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IBA 21873635
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with BCL6: view
genes like me logo Genes that share phenotypes with BCL6: view

Human Phenotype Ontology for BCL6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for BCL6 Gene

MGI Knock Outs for BCL6:

Animal Models for research

Targeted motifs for BCL6 Gene
HOMER Transcription Factor Regulatory Elements motif BCL6
  • Consensus sequence: NNNCTTTCCAGGAAA Submotif: canonical Cell Type: Liver GEO ID: GSE31578

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL6

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for BCL6 Gene

Localization for BCL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL6 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCL6 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
plasma membrane 3
extracellular 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
cytosol 2
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BCL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 7795255
GO:0005654 nucleoplasm TAS --
GO:0005657 colocalizes_with replication fork IDA 10490843
GO:0005730 nucleolus IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with BCL6: view

Pathways & Interactions for BCL6 Gene

genes like me logo Genes that share pathways with BCL6: view

Pathways by source for BCL6 Gene

1 Sino Biological pathway for BCL6 Gene
1 GeneGo (Thomson Reuters) pathway for BCL6 Gene
  • Immune response BCR pathway
1 Cell Signaling Technology pathway for BCL6 Gene

SIGNOR curated interactions for BCL6 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BCL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 11929873
GO:0000902 cell morphogenesis IEA --
GO:0001817 regulation of cytokine production IBA 21873635
GO:0001953 negative regulation of cell-matrix adhesion IEA --
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with BCL6: view

Drugs & Compounds for BCL6 Gene

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(11) Drugs for BCL6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for BCL6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BCL6: view

Transcripts for BCL6 Gene

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mRNA/cDNA for BCL6 Gene

4 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL6

Alternative Splicing Database (ASD) splice patterns (SP) for BCL6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for BCL6 Gene

GeneLoc Exon Structure for
BCL6

Expression for BCL6 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BCL6 Gene

mRNA expression in normal human tissues for BCL6 Gene
mRNA expression by GTEx for BCL6 GenemRNA expression by BioGPS for BCL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL6 Gene

This gene is overexpressed in Whole Blood (x10.0) and Muscle - Skeletal (x6.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BCL6

SOURCE GeneReport for Unigene cluster for BCL6 Gene:

Hs.478588

mRNA Expression by UniProt/SwissProt for BCL6 Gene:

P41182-BCL6_HUMAN
Tissue specificity: Expressed in germinal center T- and B-cells and in primary immature dendritic cells.

Evidence on tissue expression from TISSUES for BCL6 Gene

  • Muscle(4.7)
  • Liver(4.6)
  • Nervous system(4.5)
  • Lymph node(3.6)
  • Bone marrow(3.5)
  • Blood(3.5)
  • Spleen(3.3)
  • Intestine(3)
  • Skin(3)
  • Heart(2.9)
  • Lung(2.8)
  • Kidney(2.7)
  • Thyroid gland(2.5)
  • Stomach(2.3)
  • Gall bladder(2.3)
  • Adrenal gland(2.3)
  • Pancreas(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL6 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • immune
  • integumentary
  • lymphatic
  • nervous
Regions:
Head and neck:
  • brain
  • head
Abdomen:
  • spleen
General:
  • blood
  • lymph node
  • skin
  • sweat gland
  • white blood cell
genes like me logo Genes that share expression patterns with BCL6: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for BCL6 Gene

Orthologs for BCL6 Gene

This gene was present in the common ancestor of animals.

Orthologs for BCL6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia BCL6 29 30
  • 99.48 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia BCL6 29
  • 92.45 (n)
Cow
(Bos Taurus)
 Mammalia BCL6 29 30
  • 91.41 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Bcl6 29
  • 89.33 (n)
Mouse
(Mus musculus)
 Mammalia Bcl6 29 16 30
  • 89.19 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia BCL6 30
  • 84 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia -- 30
  • 15 (a)
 ManyToMany
Chicken
(Gallus gallus)
 Aves BCL6 29 30
  • 77.05 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia BCL6 30
  • 76 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia bcl6 29
  • 68.21 (n)
Zebrafish
(Danio rerio)
 Actinopterygii bcl6a 29 30
  • 64.15 (n)
 OneToMany
bcl6ab 30
  • 48 (a)
 OneToMany
zgc73162 29
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.7076 29
Fruit Fly
(Drosophila melanogaster)
 Insecta Kr 31
  • 51 (a)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 30
  • 25 (a)
 OneToMany
Species where no ortholog for BCL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for BCL6 Gene

ENSEMBL:
Gene Tree for BCL6 (if available)
TreeFam:
Gene Tree for BCL6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BCL6: view image
Alliance of Genome Resources:
Additional Orthologs for BCL6

Paralogs for BCL6 Gene

Paralogs for BCL6 Gene

(100) SIMAP similar genes for BCL6 Gene using alignment to 8 proteins:

  • BCL6_HUMAN
  • A0N7C6_HUMAN
  • A0N7C7_HUMAN
  • A5PL18_HUMAN
  • B5B0A5_HUMAN
  • C9JCS5_HUMAN
  • C9JL16_HUMAN
  • Q16413_HUMAN
genes like me logo Genes that share paralogs with BCL6: view

Variants for BCL6 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BCL6 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs113668878 Likely Benign: not provided 187,728,547(-) A/G
NM_001706.5(BCL6):c.1356-3T>C 		INTRON
rs137878288 Not Provided: not specified 187,728,525(-) G/A
NM_001706.5(BCL6):c.1375C>T (p.Arg459Cys) 		MISSENSE
rs139744042 Likely Benign: not provided 187,729,200(-) C/T
NM_001706.5(BCL6):c.1205G>A (p.Arg402His) 		MISSENSE
rs140944763 Benign: not provided 187,733,525(-) T/A
NM_001706.5(BCL6):c.161+8A>T 		INTRON
rs146998695 Benign: not provided 187,722,497(-) T/C
NM_001706.5(BCL6):c.2082A>G (p.Ser694=) 		SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for BCL6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for BCL6 Gene

Variant ID Type Subtype PubMed ID
esv2664940 CNV deletion 23128226
nsv1073701 CNV deletion 25765185

Variation tolerance for BCL6 Gene

Residual Variation Intolerance Score: 44.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.62; 78.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BCL6 Gene

Human Gene Mutation Database (HGMD)
BCL6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCL6
Leiden Open Variation Database (LOVD)
BCL6

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL6 Gene

Disorders for BCL6 Gene

MalaCards: The human disease database

(96) MalaCards diseases for BCL6 Gene - From: ORP, COP, and GCD

Disorder Aliases PubMed IDs
primary mediastinal large b-cell lymphoma
  • large cell lymphoma of the mediastinum
intravascular large b-cell lymphoma
  • angioendotheliomatosis proliferans systemisata
follicular lymphoma 1
  • follicular lymphoma, susceptibility to, 1
high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement
lymphoma
  • lymphoid cancer
- elite association - COSMIC cancer census association via MalaCards
Search BCL6 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

BCL6_HUMAN
  • Note=Chromosomal aberrations involving BCL6 are a cause of B-cell non-Hodgkin lymphomas (B-cell NHL), including diffuse large B-cell lymphoma and follicular lymphoma. Approximately 40% of diffuse large B-cell lymphomas and 5 to 10% of follicular lymphomas are associated with chromosomal translocations that deregulate expression of BCL6 by juxtaposing heterologous promoters to the BCL6 coding domain (PubMed:10469447, PubMed:10753856, PubMed:12414651, PubMed:11821949). Translocation t(3;14)(q27;q32). Translocation t(3;22)(q27;q11) with immunoglobulin gene regions (PubMed:11821949). Translocation t(3;7)(q27;p12) with IKZF1 gene 5'non-coding region (PubMed:10753856). Translocation t(3;6)(q27;p21) with Histone H4 (PubMed:12414651). Translocation t(3;16)(q27;p11) with IL21R. Translocation t(3;13)(q27;q14) with LCP1 (PubMed:10469447). {ECO:0000269 PubMed:10469447, ECO:0000269 PubMed:10753856, ECO:0000269 PubMed:11821949, ECO:0000269 PubMed:12414651}.
  • Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.
  • Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.

Genatlas disease for BCL6 Gene

B-cell,diffuse large-cell lymphoma,follicular lymphoma and mantel cell lymphoma,mucosa-associated lymphoid tissue non Hodgkin lymphoma with translocations t(3;14)(q27;q32),t(3;13)(q27;q14),t(2;3)(p12;q27),t(3;22)(q27;q11),t(3;4)(q27;p11),t(3;11)(q27;q23),t(3;6)(q27;p21.3),also rearranged in some marginal zone B-cell lymphoma,mutated in human herpes-8 positive primary effusion lymphoma (PEL)

Additional Disease Information for BCL6

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with BCL6: view

Publications for BCL6 Gene

  1. BCL6: somatic mutations and expression in early-stage chronic lymphocytic leukemia. (PMID: 19367498) Jantus Lewintre E … García-Conde J (Leukemia & lymphoma 2009) 3 22 40
  2. Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development. (PMID: 19336552) Morton LM … Hartge P (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 22 40
  3. CtBP is an essential corepressor for BCL6 autoregulation. (PMID: 18212045) Mendez LM … Ye BH (Molecular and cellular biology 2008) 3 4 22
  4. The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. (PMID: 15577913) Phan RT … Dalla-Favera R (Nature 2004) 3 4 22
  5. The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma. (PMID: 11821949) Ueda C … Ohno H (Oncogene 2002) 3 4 22

ExternalLinks

View latest publications for BCL6 gene in Mastermind

Products for BCL6 Gene

  • Addgene plasmids for BCL6

Sources for BCL6 Gene