Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
BCL6 (BCL6 Transcription Repressor) is a Protein Coding gene. Diseases associated with BCL6 include Primary Mediastinal Large B-Cell Lymphoma and Intravascular Large B-Cell Lymphoma. Among its related pathways are Transcriptional misregulation in cancer and Notch Signaling Pathway (WikiPathways). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is BCL6B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | -- |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA,IBA | 21873635 |
GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding | IEA | -- |
GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IBA | 21873635 |
GO:0003676 | nucleic acid binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA,IDA | 7795255 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005657 | colocalizes_with replication fork | IDA | 10490843 |
GO:0005794 | Golgi apparatus | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytokine Signaling in Immune system | ||
2 | Gene Expression |
.48
|
|
3 | TP53 Regulates Transcription of Cell Death Genes | ||
4 | NF-kappaB Signaling | ||
5 | FoxO signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 11929873 |
GO:0000902 | cell morphogenesis | IEA | -- |
GO:0001817 | regulation of cytokine production | IBA | 21873635 |
GO:0001953 | negative regulation of cell-matrix adhesion | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | BCL6 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | BCL6 30 |
|
||
Cow (Bos Taurus) |
Mammalia | BCL6 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Bcl6 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Bcl6 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | BCL6 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | BCL6 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | BCL6 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | bcl6 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | bcl6a 30 31 |
|
OneToMany | |
bcl6ab 31 |
|
OneToMany | |||
zgc73162 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7076 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Kr 32 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
717149 | Benign: not provided | 187,729,778(-) | G/A | SYNONYMOUS_VARIANT | |
725713 | Benign: not provided | 187,733,525(-) | T/A | INTRON_VARIANT | |
729093 | Benign: not provided | 187,722,497(-) | T/C | SYNONYMOUS_VARIANT | |
729094 | Likely Benign: not provided | 187,729,200(-) | C/T | MISSENSE_VARIANT | |
734312 | Likely Benign: not provided | 187,725,085(-) | G/A | INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2664940 | CNV | deletion | 23128226 |
nsv1073701 | CNV | deletion | 25765185 |
Disorder | Aliases | PubMed IDs |
---|---|---|
primary mediastinal large b-cell lymphoma |
|
|
intravascular large b-cell lymphoma |
|
|
high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement |
|
|
follicular lymphoma 1 |
|
|
lymphoma |
|