This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association w... See more...

Aliases for BCL3 Gene

Aliases for BCL3 Gene

  • BCL3 Transcription Coactivator 2 3 5
  • Chronic Lymphatic Leukemia Protein 2 3
  • B-Cell Lymphoma 3-Encoded Protein 2 3
  • B-Cell Leukemia/Lymphoma 3 2 3
  • B-Cell Lymphoma 3 Protein 3 4
  • B Cell CLL/Lymphoma 3 2 3
  • Proto-Oncogene BCL3 3 4
  • D19S37 3 4
  • BCL-3 3 4
  • BCL4 3 4
  • BCL3, Transcription Coactivator 2
  • BCL3 5

External Ids for BCL3 Gene

Previous HGNC Symbols for BCL3 Gene

  • D19S37
  • BCL4

Previous GeneCards Identifiers for BCL3 Gene

  • GC19P045896
  • GC19P045642
  • GC19P049927
  • GC19P049943
  • GC19P045250
  • GC19P041684
  • GC19P044742

Summaries for BCL3 Gene

Entrez Gene Summary for BCL3 Gene

  • This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]

GeneCards Summary for BCL3 Gene

BCL3 (BCL3 Transcription Coactivator) is a Protein Coding gene. Diseases associated with BCL3 include B-Cell Lymphoma and Lymphoma. Among its related pathways are NF-KappaB Family Pathway and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein binding, bridging. An important paralog of this gene is NFKBIE.

UniProtKB/Swiss-Prot Summary for BCL3 Gene

  • Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).

Gene Wiki entry for BCL3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BCL3 Gene

Genomics for BCL3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BCL3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BCL3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BCL3

Top Transcription factor binding sites by QIAGEN in the BCL3 gene promoter:
  • AP-2gamma
  • C/EBPalpha
  • GATA-2
  • Lmo2
  • NF-kappaB
  • NF-kappaB1
  • Olf-1
  • STAT1
  • STAT3
  • STAT5B

Genomic Locations for BCL3 Gene

Genomic Locations for BCL3 Gene
chr19:44,742,620-44,760,044
(GRCh38/hg38)
Size:
17,425 bases
Orientation:
Plus strand
chr19:45,250,962-45,263,301
(GRCh37/hg19)
Size:
12,340 bases
Orientation:
Plus strand

Genomic View for BCL3 Gene

Genes around BCL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL3 Gene

Proteins for BCL3 Gene

  • Protein details for BCL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20749-BCL3_HUMAN
    Recommended name:
    B-cell lymphoma 3 protein
    Protein Accession:
    P20749

    Protein attributes for BCL3 Gene

    Size:
    454 amino acids
    Molecular mass:
    47584 Da
    Quaternary structure:
    • Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2, COPS5 and PIR. Interacts with CYLD (By similarity).
    SequenceCaution:
    • Sequence=AAA51815.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAA51816.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH64993.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BCL3 Gene

neXtProt entry for BCL3 Gene

Post-translational modifications for BCL3 Gene

  • Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation (By similarity).
  • Activated by phosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL3 Gene

No data available for DME Specific Peptides for BCL3 Gene

Domains & Families for BCL3 Gene

Gene Families for BCL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for BCL3 Gene

InterPro:
Blocks:
  • Ankyrin repeat signature
ProtoNet:

Suggested Antigen Peptide Sequences for BCL3 Gene

GenScript: Design optimal peptide antigens:
  • Proto-oncogene BCL3 (BCL3_HUMAN)
genes like me logo Genes that share domains with BCL3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BCL3 Gene

Function for BCL3 Gene

Molecular function for BCL3 Gene

UniProtKB/Swiss-Prot Function:
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).
GENATLAS Biochemistry:
inhibitor of REL/NFKB transcription factors,IKB (NFKBI) family

Phenotypes From GWAS Catalog for BCL3 Gene

Gene Ontology (GO) - Molecular Function for BCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IEA,IPI 10362352
GO:0008134 transcription factor binding IPI 8196632
GO:0030674 protein binding, bridging TAS 16306601
genes like me logo Genes that share ontologies with BCL3: view
genes like me logo Genes that share phenotypes with BCL3: view

Animal Models for BCL3 Gene

MGI Knock Outs for BCL3:
  • Bcl3 Bcl3<tm1b(EUCOMM)Wtsi>
  • Bcl3 Bcl3<tm1Rie>
  • Bcl3 Bcl3<tm1Rsch>
  • Bcl3 Bcl3<tm1Sbn>
  • Bcl3 Bcl3<tm1Ver>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCL3 Gene

Localization for BCL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL3 Gene

Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCL3 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Midbody (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 8196632
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 11387332
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with BCL3: view

Pathways & Interactions for BCL3 Gene

genes like me logo Genes that share pathways with BCL3: view

Pathways by source for BCL3 Gene

1 GeneGo (Thomson Reuters) pathway for BCL3 Gene
  • Immune response IL-9 signaling pathway
2 Qiagen pathways for BCL3 Gene
  • IL-9 Pathway
  • NF-KappaB Family Pathway

SIGNOR curated interactions for BCL3 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002268 follicular dendritic cell differentiation IEA --
GO:0002315 marginal zone B cell differentiation IEA --
GO:0002455 humoral immune response mediated by circulating immunoglobulin IEA --
GO:0002467 germinal center formation IEA --
GO:0006351 transcription, DNA-templated IDA 16306601
genes like me logo Genes that share ontologies with BCL3: view

Drugs & Compounds for BCL3 Gene

(2) Drugs for BCL3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for BCL3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BCL3: view

Transcripts for BCL3 Gene

mRNA/cDNA for BCL3 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL3

Alternative Splicing Database (ASD) splice patterns (SP) for BCL3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for BCL3 Gene

GeneLoc Exon Structure for
BCL3

Expression for BCL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BCL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL3 Gene

This gene is overexpressed in Whole Blood (x6.9) and Liver (x5.6).

Protein differential expression in normal tissues from HIPED for BCL3 Gene

This gene is overexpressed in Heart (53.9) and Adipocyte (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BCL3 Gene



Protein tissue co-expression partners for BCL3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BCL3

SOURCE GeneReport for Unigene cluster for BCL3 Gene:

Hs.31210

Evidence on tissue expression from TISSUES for BCL3 Gene

  • Lung(4.5)
  • Blood(3)
  • Bone marrow(2.8)
  • Liver(2.7)
  • Spleen(2.7)
  • Intestine(2.7)
  • Lymph node(2.7)
  • Skin(2.6)
  • Nervous system(2.4)
  • Kidney(2.2)
  • Muscle(2.2)
  • Stomach(2.1)
  • Heart(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL3 Gene

Germ Layers:
  • mesoderm
Systems:
  • immune
  • lymphatic
Regions:
General:
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with BCL3: view

No data available for mRNA Expression by UniProt/SwissProt for BCL3 Gene

Orthologs for BCL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia BCL3 30 31
  • 99.63 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia BCL3 30 31
  • 89.35 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Bcl3 30
  • 82.51 (n)
Mouse
(Mus musculus)
Mammalia Bcl3 30 17 31
  • 82.44 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia BCL3 31
  • 76 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia BCL3 31
  • 73 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia BCL3 31
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 13 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia BCL3 31
  • 53 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100489600 30
  • 59.5 (n)
Zebrafish
(Danio rerio)
Actinopterygii bcl3 31
  • 32 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6482 31
  • 13 (a)
OneToOne
Species where no ortholog for BCL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for BCL3 Gene

ENSEMBL:
Gene Tree for BCL3 (if available)
TreeFam:
Gene Tree for BCL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BCL3: view image

Paralogs for BCL3 Gene

(2) SIMAP similar genes for BCL3 Gene using alignment to 2 proteins:

  • BCL3_HUMAN
  • H7C0A2_HUMAN
genes like me logo Genes that share paralogs with BCL3: view

Variants for BCL3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BCL3 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
757967 Likely Benign: not provided 44,758,851(+) C/T INTRON_VARIANT
769458 Benign: not provided 44,757,714(+) G/T SYNONYMOUS_VARIANT
777532 Benign: not provided 44,757,093(+) T/C MISSENSE_VARIANT
rs369753256 Uncertain Significance: not specified 44,757,374(+) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for BCL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for BCL3 Gene

Variant ID Type Subtype PubMed ID
nsv1071935 CNV deletion 25765185
nsv2506 CNV deletion 18451855
nsv833841 CNV loss 17160897

Variation tolerance for BCL3 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BCL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCL3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL3 Gene

Disorders for BCL3 Gene

MalaCards: The human disease database

(15) MalaCards diseases for BCL3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
b-cell lymphoma
  • b-cell lymphocytic neoplasm
lymphoma
  • lymphoid cancer
leukemia
  • leukemias
anaplastic large cell lymphoma
  • alcl
leukemia, chronic lymphocytic 2
  • leukemia, chronic lymphocytic, susceptibility to, 2
- elite association - COSMIC cancer census association via MalaCards
Search BCL3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

BCL3_HUMAN
  • Note=A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions. {ECO:0000269 PubMed:2180580, ECO:0000269 PubMed:7896265}.

Genatlas disease for BCL3 Gene

B cell lymphoma with translocation t(14;19)(q32;q13.1)

Additional Disease Information for BCL3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with BCL3: view

Publications for BCL3 Gene

  1. The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. (PMID: 2180580) Ohno H … McKeithan TW (Cell 1990) 2 3 4 23
  2. GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity. (PMID: 15469820) Viatour P … Chariot A (Molecular cell 2004) 3 4 23
  3. Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family. (PMID: 11707390) Michel F … Müller CW (The EMBO journal 2001) 3 4 23
  4. Genomic structure of the candidate proto-oncogene BCL3. (PMID: 7896265) McKeithan TW … Hume E (Genomics 1994) 3 4 23
  5. The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. (PMID: 8453667) Bours V … Siebenlist U (Cell 1993) 3 4 23

Products for BCL3 Gene

  • Signalway ELISA kits for BCL3
  • Signalway Proteins for BCL3

Sources for BCL3 Gene