Aliases for BCL3 Gene
External Ids for BCL3 Gene
Previous HGNC Symbols for BCL3 Gene
Previous GeneCards Identifiers for BCL3 Gene
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]
GeneCards Summary for BCL3 Gene
BCL3 (B Cell CLL/Lymphoma 3) is a Protein Coding gene. Diseases associated with BCL3 include Lymphoma and B-Cell Lymphomas. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and C-type lectin receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein binding, bridging. An important paralog of this gene is NFKBIE.
UniProtKB/Swiss-Prot for BCL3 Gene
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).