Aliases for BCL2L2 Gene
Aliases for BCL2L2 Gene
External Ids for BCL2L2 Gene
- HGNC: 995
- Entrez Gene: 599
- Ensembl: ENSG00000129473
- OMIM: 601931
- UniProtKB: Q92843
Previous GeneCards Identifiers for BCL2L2 Gene
- GC14P021148
- GC14P017563
- GC14P021766
- GC14P022845
- GC14P023776
- GC14P003892
- GC14P023791
- GC14P023464
- GC14P023564
- GC14P023677
- GC14P023800
- GC14P023889
- GC14P023948
- GC14P024061
Summaries for BCL2L2 Gene
-
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for BCL2L2 Gene
BCL2L2 (BCL2 Like 2) is a Protein Coding gene. Diseases associated with BCL2L2 include Small Intestinal Adenocarcinoma. Among its related pathways are Apoptosis Modulation and Signaling and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and BH domain binding. An important paralog of this gene is BCL2L1.
UniProtKB/Swiss-Prot for BCL2L2 Gene
-
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
Additional gene information for BCL2L2 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L2 Gene
Genomics for BCL2L2 Gene
GeneHancer (GH) Regulatory Elements for BCL2L2 Gene
Promoters and enhancers for BCL2L2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around BCL2L2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for BCL2L2 Gene
Genomic Locations for BCL2L2 Gene
- chr14:23,298,790-23,311,759
- (GRCh38/hg38)
- Size:
- 12,970 bases
- Orientation:
- Plus strand
- chr14:23,767,999-23,780,968
- (GRCh37/hg19)
Genomic View for BCL2L2 Gene
Genes around BCL2L2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q11.2 by Ensembl
- 14q11.2 by Entrez Gene
- 14q11.2 by HGNC
BCL2L2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BCL2L2 Gene
Proteins for BCL2L2 Gene
-
Protein details for BCL2L2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92843-B2CL2_HUMAN
- Recommended name:
- Bcl-2-like protein 2
- Protein Accession:
- Q92843
- A8K0F4
- Q2M3U0
- Q5U0H4
Protein attributes for BCL2L2 Gene
- Size:
- 193 amino acids
- Molecular mass:
- 20746 Da
- Quaternary structure:
-
- Interacts with HIF3A (via C-terminus domain). Interacts with BOP.
- Interacts with HIF3A (via C-terminus domain). Interacts with BOP.
- SequenceCaution:
-
- Sequence=BAA19666.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for BCL2L2 Gene
Protein Expression for BCL2L2 Gene
Post-translational modifications for BCL2L2 Gene
Other Protein References for BCL2L2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for BCL2L2 (Bcl-w)
-
Custom Antibody ServicesOriGene Antibodies for BCL2L2
- Novus Biologicals Antibodies for BCL2L2
-
Abcam antibodies for BCL2L2
-
Cloud-Clone Corp. Antibodies for BCL2L2
- Invitrogen Antibodies for BCL2L2
- GeneTex BCL2L2 antibody for BCL2L2
-
Santa Cruz Biotechnology (SCBT) Antibodies for BCL2L2
- Sino Biological Antibodies for BCL2L2
Protein Products
- R&D Systems Proteins and Enzymes for BCL2L2 (Bcl-w)
-
OriGene Purified Proteins for BCL2L2
- Search Origene for MassSpec and Protein Over-expression Lysates for BCL2L2
- Origene Custom Protein Services for BCL2L2
- Sino Biological Recombinant Proteins for BCL2L2
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for BCL2L2
-
Cloud-Clone Corp. Proteins for BCL2L2
- Search GeneTex for Proteins for BCL2L2
-
ProSci Proteins for BCL2L2
-
Abcam proteins for BCL2L2
Assay Products
- antibodies-online: Search results for 11 available BCL2L2 Elisa Kits ranked by validation data
- Compare Top BCL2L2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for BCL2L2 Gene
Domains & Families for BCL2L2 Gene
Gene Families for BCL2L2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Predicted membrane proteins
- Transporters
Protein Domains for BCL2L2 Gene
Suggested Antigen Peptide Sequences for BCL2L2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q92843UniProtKB/Swiss-Prot:
B2CL2_HUMAN :- The BH4 motif seems to be involved in the anti-apoptotic function.
- Belongs to the Bcl-2 family.
- Domain:
-
- The BH4 motif seems to be involved in the anti-apoptotic function.
- The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2.
- Family:
-
- Belongs to the Bcl-2 family.
Function for BCL2L2 Gene
Molecular function for BCL2L2 Gene
- GENATLAS Biochemistry:
- BCL2-like 2,antiapoptotic,expressed in lymphoid and myeloid cells
- UniProtKB/Swiss-Prot Function:
- Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15694340 |
| GO:0042802 | identical protein binding | IPI | 22000515 |
| GO:0042803 | protein homodimerization activity | IBA | -- |
| GO:0046982 | protein heterodimerization activity | IMP,IEA | 16645638 |
| GO:0051400 | BH domain binding | IEA | -- |
Phenotypes for BCL2L2 Gene
- MGI mutant phenotypes for BCL2L2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for BCL2L2:
-
- Increased vaccinia virus (VACV) infection
- Increased shRNA abundance (Z-score > 2)
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased transferrin (TF) endocytosis
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance (Z-score < -2)
- Decreased vesicular stomatitis virus (VSV) infection
Animal Models for BCL2L2 Gene
- MGI Knock Outs for BCL2L2:
-
- Bcl2l2 tm1Sco
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for BCL2L2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for BCL2L2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for BCL2L2 gene
- Search ViGene Biosciences for BCL2L2
CRISPR Products
-
OriGene CRISPR knockouts for BCL2L2
- genomics-online: gRNA clones - Search results for available BCL2L2 gene related products
- Applied Biological Materials CRISPR for BCL2L2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCL2L2
- GenScript: Design CRISPR guide RNA sequences for BCL2L2
miRNA for BCL2L2 Gene
- miRTarBase miRNAs that target BCL2L2
-
- hsa-mir-133b (MIRT001076)
- hsa-mir-122-5p (MIRT004364)
- hsa-mir-203a-3p (MIRT005453)
- hsa-mir-630 (MIRT005579)
- hsa-mir-204-5p (MIRT005819)
- hsa-mir-335-5p (MIRT006109)
- hsa-mir-214-3p (MIRT007294)
- hsa-mir-195-5p (MIRT007370)
- hsa-mir-24-3p (MIRT030447)
- hsa-mir-1296-5p (MIRT036076)
- hsa-mir-125b-5p (MIRT053019)
- hsa-mir-512-5p (MIRT053425)
- hsa-mir-17-5p (MIRT368881)
- hsa-mir-20a-5p (MIRT368882)
- hsa-mir-93-5p (MIRT368883)
- hsa-mir-106a-5p (MIRT368884)
- hsa-mir-106b-5p (MIRT368885)
- hsa-mir-20b-5p (MIRT368886)
- hsa-mir-526b-3p (MIRT368888)
- hsa-mir-519d-3p (MIRT368890)
- hsa-mir-5089-5p (MIRT510174)
- hsa-mir-6807-5p (MIRT510175)
- hsa-mir-6866-5p (MIRT510176)
- hsa-mir-877-5p (MIRT510177)
- hsa-mir-5589-5p (MIRT510178)
- hsa-mir-4731-5p (MIRT510179)
- hsa-mir-6506-5p (MIRT510180)
- hsa-mir-619-5p (MIRT510181)
- hsa-mir-186-3p (MIRT524754)
- hsa-mir-520h (MIRT524755)
- hsa-mir-520g-3p (MIRT524756)
- hsa-mir-512-3p (MIRT524757)
- hsa-mir-520e (MIRT524758)
- hsa-mir-520d-3p (MIRT524759)
- hsa-mir-520c-3p (MIRT524760)
- hsa-mir-520b (MIRT524761)
- hsa-mir-520a-3p (MIRT524762)
- hsa-mir-373-3p (MIRT524763)
- hsa-mir-302e (MIRT524764)
- hsa-mir-372-3p (MIRT524765)
- hsa-mir-302d-3p (MIRT524766)
- hsa-mir-302c-3p (MIRT524767)
- hsa-mir-302b-3p (MIRT524768)
- hsa-mir-302a-3p (MIRT524769)
- hsa-mir-6777-3p (MIRT538976)
- hsa-mir-874-5p (MIRT538977)
- hsa-mir-6845-3p (MIRT538978)
- hsa-mir-1976 (MIRT538979)
- hsa-mir-3653-5p (MIRT538980)
- hsa-mir-8073 (MIRT538981)
- hsa-mir-221-5p (MIRT538982)
- hsa-mir-361-3p (MIRT538983)
- hsa-mir-4691-3p (MIRT538984)
- hsa-mir-1228-3p (MIRT538985)
- hsa-mir-6769a-3p (MIRT538986)
- hsa-mir-4323 (MIRT538987)
- hsa-mir-3943 (MIRT538988)
- hsa-mir-449b-3p (MIRT538989)
- hsa-mir-129-2-3p (MIRT733550)
miRNA Products
- Search ViGene Biosciences for BCL2L2
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for BCL2L2
- Browse OriGene Inhibitory RNA Products For BCL2L2
- genomics-online: shRNA clones - Search results for available BCL2L2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for BCL2L2 gene
Clone Products
- Sino Biological Human cDNA Clone for BCL2L2
- VectorBuilder custom plasmid, inducible vectors for BCL2L2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BCL2L2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available BCL2L2 gene related products
- orf clones - Search results for available BCL2L2 gene related products
- Applied Biological Materials Clones for BCL2L2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for BCL2L2
-
ViGene Biosciences adenoviral particle packaged cDNA for BCL2L2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for BCL2L2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for BCL2L2 gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCL2L2 Gene
Localization for BCL2L2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BCL2L2 Gene
- Mitochondrion membrane; Peripheral membrane protein. Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| mitochondrion | 4 |
| plasma membrane | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005741 | mitochondrial outer membrane | IBA | -- |
| GO:0005829 | cytosol | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for BCL2L2 Gene
Pathways & Interactions for BCL2L2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis Modulation and Signaling |
.41
|
|
| 2 | MicroRNAs in cancer | ||
| 3 | Apoptosis and Autophagy | ||
| 4 | Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins | ||
| 5 | Direct p53 effectors | ||
Pathways by source for BCL2L2 Gene
5 BioSystems pathways for BCL2L2 Gene
1 KEGG pathway for BCL2L2 Gene
1 GeneGo (Thomson Reuters) pathway for BCL2L2 Gene
1 Cell Signaling Technology pathway for BCL2L2 Gene
Interacting Proteins for BCL2L2 Gene
Selected Interacting proteins:
Q92843-B2CL2_HUMAN
ENSP00000250405
for BCL2L2 Gene via
IID
STRING
UniProtKB
MINT
SIGNOR curated interactions for BCL2L2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007283 | spermatogenesis | TAS | 8761287 |
| GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | IBA | -- |
| GO:0042981 | regulation of apoptotic process | IEA | -- |
| GO:0043066 | negative regulation of apoptotic process | IMP,TAS | 17289999 |
Drugs & Compounds for BCL2L2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Navitoclax | Investigational | Pharma | Target | BCL-2 inhibitors | 28 | |
| Gossypol | Investigational | Pharma | PAF inhibitor;anti-fertility and anti-cancer | 24 | ||
| ABT-263 (Navitoclax) | Pharma | Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w | 0 | |||
| ABT-737 | Pharma | Bcl-2 inhibitor | 0 | |||
| AT-101 | Pharma | BH3-mimetic,gossypol enantiomer, BCL-2 inhibitors | 0 |
(7) ApexBio Compounds for BCL2L2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| ABT-263 (Navitoclax) | Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w | 923564-51-6 |
| ABT-737 | Bcl-2 inhibitor | 852808-04-9 |
| AT-101 | BH3-mimetic,gossypol enantiomer | 90141-22-3 |
| Bax inhibitor peptide P5 | Bax inhibitor | 579492-83-4 |
| Bax inhibitor peptide V5 | Bax inhibitor | 579492-81-2 |
| Gossypol | PAF inhibitor;anti-fertility and anti-cancer | 303-45-7 |
| Sabutoclax | pan-Bcl-2 inhibitor | 1228108-65-3 |
Transcripts for BCL2L2 Gene
mRNA/cDNA for BCL2L2 Gene
- (2) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (631) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for BCL2L2
- genomics-online: gRNA clones - Search results for available BCL2L2 gene related products
- Applied Biological Materials CRISPR for BCL2L2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCL2L2
- GenScript: Design CRISPR guide RNA sequences for BCL2L2
miRNA Products
- Search ViGene Biosciences for BCL2L2
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for BCL2L2
- Browse OriGene Inhibitory RNA Products For BCL2L2
- genomics-online: shRNA clones - Search results for available BCL2L2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for BCL2L2 gene
Clone Products
- Sino Biological Human cDNA Clone for BCL2L2
- VectorBuilder custom plasmid, inducible vectors for BCL2L2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BCL2L2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available BCL2L2 gene related products
- orf clones - Search results for available BCL2L2 gene related products
- Applied Biological Materials Clones for BCL2L2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4 | ^ | 5a | · | 5b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||
| SP5: |
Expression for BCL2L2 Gene
This gene is overexpressed in Bone (13.8) and Frontal cortex (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BCL2L2 Gene
NURSA nuclear receptor signaling pathways regulating expression of BCL2L2 Gene:
BCL2L2SOURCE GeneReport for Unigene cluster for BCL2L2 Gene:
Hs.410026mRNA Expression by UniProt/SwissProt for BCL2L2 Gene:
Q92843-B2CL2_HUMAN
Tissue specificity:
Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.
Evidence on tissue expression from TISSUES for BCL2L2 Gene
- Nervous system(4.6)
- Lung(4.4)
- Liver(4.3)
- Intestine(2.3)
Primer Products
-
OriGene qPCR primer pairs for BCL2L2
-
OriGene qPCR primer pairs and template standards for BCL2L2
- genomics-online: primer clones - Search results for available BCL2L2 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL2L2 Gene
Orthologs for BCL2L2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BCL2L2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | BCL2L2 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | BCL2L2 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | BCL2L2 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Bcl2l2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Bcl2l2 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | BCL2L2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | bcl2l2 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | xR1 33 |
|
- Species where no ortholog for BCL2L2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for BCL2L2 Gene
(5) SIMAP similar genes for BCL2L2 Gene using alignment to 6 proteins:
Variants for BCL2L2 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000038650 | -- | 23,309,658(+) | T/C | 3_prime_UTR_variant | |
| rs1000946613 | -- | 23,310,177(+) | C/T | 3_prime_UTR_variant | |
| rs1001383421 | -- | 23,309,267(+) | C/T | 3_prime_UTR_variant | |
| rs1001866831 | -- | 23,304,779(+) | C/T | upstream_transcript_variant | |
| rs1002085630 | -- | 23,304,872(+) | T/G | upstream_transcript_variant |
Residual Variation Intolerance Score:
40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.48;
10.39% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BCL2L2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BCL2L2 Gene
Disorders for BCL2L2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| small intestinal adenocarcinoma |
|
|
Search BCL2L2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BCL2L2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for BCL2L2 Gene
Publications for BCL2L2 Gene
- bcl-w, a novel member of the bcl-2 family, promotes cell survival. (PMID: 8761287) Gibson L … Cory S (Oncogene 1996) 2 3 4 22 58
- Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix. (PMID: 12651847) Denisov AY … Gehring K (The Journal of biological chemistry 2003) 3 4 22 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 44 58
- Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PMID: 20855536) Kelly JL … Cerhan JR (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
Products for BCL2L2 Gene
- R&D Systems Antibodies for BCL2L2 (Bcl-w)
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- Custom Antibody ServicesOriGene Antibodies for BCL2L2
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- ProSpec Recombinant Proteins for BCL2L2
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- ApexBio compounds for BCL2L2
- Cyagen custom Knockout/knockin (KOKI) mouse models for BCL2L2
- VectorBuilder custom plasmid, inducible vectors for BCL2L2
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 122 available BCL2L2 Antibodies ranked by validation data
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- antibodies-online: Search results for 20 available BCL2L2 Proteins ranked by validation data
- Compare Top BCL2L2 Proteins
- GeneTex BCL2L2 antibody for BCL2L2
- Search GeneTex for Proteins for BCL2L2
- ViGene Biosciences adenoviral particle packaged cDNA for BCL2L2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for BCL2L2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for BCL2L2 gene
- Search ViGene Biosciences for BCL2L2
- Santa Cruz Biotechnology (SCBT) Antibodies for BCL2L2
- Search Santa Cruz Biotechnology (SCBT) for BCL2L2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BCL2L2
- Search for BCL2L2 Antibodies at ProSci
- Custom Antibody Services
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- Horizon Cell Lines for BCL2L2
- genomics-online: cdna clones - Search results for available BCL2L2 gene related products
- orf clones - Search results for available BCL2L2 gene related products
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- genomics-online: primer clones - Search results for available BCL2L2 gene related products
- genomics-online: shRNA clones - Search results for available BCL2L2 gene related products
Sources for BCL2L2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
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- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems