Aliases for BCL2L2 Gene
External Ids for BCL2L2 Gene
Previous GeneCards Identifiers for BCL2L2 Gene
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for BCL2L2 Gene
BCL2L2 (BCL2 Like 2) is a Protein Coding gene. Diseases associated with BCL2L2 include Burkitt Lymphoma and Alzheimer Disease. Among its related pathways are Regulation of Apoptosis by Parathyroid Hormone-related Protein and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and BH domain binding. An important paralog of this gene is BCL2L1.
UniProtKB/Swiss-Prot Summary for BCL2L2 Gene
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.