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This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
BCL2L2 (BCL2 Like 2) is a Protein Coding gene. Diseases associated with BCL2L2 include Glioblastoma Multiforme and Lymphoma, Non-Hodgkin, Familial. Among its related pathways are Apoptosis Modulation and Signaling and Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and BH domain binding. An important paralog of this gene is BCL2L1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 15694340 |
GO:0042802 | identical protein binding | IPI | 22000515 |
GO:0042803 | protein homodimerization activity | IBA | 21873635 |
GO:0044877 | protein-containing complex binding | IEA | -- |
GO:0046982 | protein heterodimerization activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005739 | mitochondrion | IEA | -- |
GO:0005741 | mitochondrial outer membrane | IBA | 21873635 |
GO:0005829 | cytosol | IEA | -- |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptosis Modulation and Signaling |
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2 | Apoptosis and Autophagy | ||
3 | MicroRNAs in cancer | ||
4 | Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins |
Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins
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5 | Direct p53 effectors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002931 | response to ischemia | IEA | -- |
GO:0006915 | apoptotic process | IEA | -- |
GO:0007283 | spermatogenesis | TAS | 8761287 |
GO:0007420 | brain development | IEA | -- |
GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
AT-101 | Approved, Investigational | Pharma | BH3-mimetic,gossypol enantiomer, BCL-2 inhibitors | 86 | ||
Navitoclax | Investigational | Pharma | Target | BCL-2 inhibitors | 30 | |
Gossypol | Investigational | Pharma | PAF inhibitor;anti-fertility and anti-cancer | 24 | ||
ABT-263 (Navitoclax) | Pharma | Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w | 0 | |||
ABT-737 | Pharma | Bcl-2 inhibitor | 0 |
Compound | Action | Cas Number |
---|---|---|
ABT-263 (Navitoclax) | Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w | 923564-51-6 |
ABT-737 | Bcl-2 inhibitor | 852808-04-9 |
AT-101 | BH3-mimetic,gossypol enantiomer | 90141-22-3 |
Bax inhibitor peptide P5 | Bax inhibitor | 579492-83-4 |
Bax inhibitor peptide V5 | Bax inhibitor | 579492-81-2 |
Gossypol | PAF inhibitor;anti-fertility and anti-cancer | 303-45-7 |
Sabutoclax | pan-Bcl-2 inhibitor | 1228108-65-3 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4 | ^ | 5a | · | 5b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | BCL2L2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | BCL2L2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | BCL2L2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | BCL2L2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Bcl2l2 30 |
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||
Mouse (Mus musculus) |
Mammalia | Bcl2l2 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | BCL2L2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | bcl2l2 30 |
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||
African clawed frog (Xenopus laevis) |
Amphibia | xR1 30 |
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SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs910332 | - | p.Gln133Arg |
Disorder | Aliases | PubMed IDs |
---|---|---|
glioblastoma multiforme |
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lymphoma, non-hodgkin, familial |
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leukemia, chronic lymphocytic |
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myeloma, multiple |
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leukemia, acute myeloid |
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