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Aliases for BCL2L2 Gene

Aliases for BCL2L2 Gene

  • BCL2 Like 2 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 51 2 3
  • Bcl2-L-2 3 4
  • BCLW 3 4
  • Apoptosis Regulator Bcl-W 4
  • Apoptosis Regulator BCL-W 3
  • Bcl-2-Like Protein 2 3
  • KIAA0271 4
  • PPP1R51 3
  • BCL-W 3

External Ids for BCL2L2 Gene

Previous GeneCards Identifiers for BCL2L2 Gene

  • GC14P021148
  • GC14P017563
  • GC14P021766
  • GC14P022845
  • GC14P023776
  • GC14P003892
  • GC14P023791
  • GC14P023464
  • GC14P023564
  • GC14P023677
  • GC14P023800
  • GC14P023889
  • GC14P023948
  • GC14P024061

Summaries for BCL2L2 Gene

Entrez Gene Summary for BCL2L2 Gene

  • This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for BCL2L2 Gene

BCL2L2 (BCL2 Like 2) is a Protein Coding gene. Diseases associated with BCL2L2 include Small Intestinal Adenocarcinoma. Among its related pathways are Apoptosis Modulation and Signaling and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and BH domain binding. An important paralog of this gene is BCL2L1.

UniProtKB/Swiss-Prot for BCL2L2 Gene

  • Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

Gene Wiki entry for BCL2L2 Gene

Additional gene information for BCL2L2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L2 Gene

Genomics for BCL2L2 Gene

GeneHancer (GH) Regulatory Elements for BCL2L2 Gene

Promoters and enhancers for BCL2L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I023297 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.9 1910 5.5 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 BCL2L2 HOMEZ PPP1R3E PIR57322 ACIN1 RNA5SP383 RNF31 LOC102724814 ENSG00000259321 RBM23
GH14I023305 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.4 +8.5 8493 4.4 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 BCL2L2-PABPN1 BCL2L2 SLC22A17 EFS MYH6 HOMEZ RNA5SP383 PIR33428
GH14I022927 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.8 -369.2 -369183 3.2 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF548 SP3 PRMT5 LOC101926933 TRR-ACG1-3 HAUS4 NGDN ACIN1 RBM23 LOC102724814 PABPN1 SLC7A8
GH14I022976 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 -318.9 -318884 7.6 MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 E2F8 ZNF143 AJUBA ACIN1 NGDN PRMT5 C14orf93 HAUS4 RBM23 LOC102724814 PABPN1 MMP14
GH14I024194 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10 +897.1 897087 3.5 HDGF PKNOX1 CLOCK MLX ZFP64 ARID4B SIN3A DMAP1 IRF4 YY1 TM9SF1 PIR45873 RNF31 TINF2 MDP1 SLC22A17 PSME2 KHNYN RNA5SP383 JPH4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BCL2L2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BCL2L2 gene promoter:

Genomic Locations for BCL2L2 Gene

Genomic Locations for BCL2L2 Gene
12,970 bases
Plus strand

Genomic View for BCL2L2 Gene

Genes around BCL2L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL2L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL2L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL2L2 Gene

Proteins for BCL2L2 Gene

  • Protein details for BCL2L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bcl-2-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K0F4
    • Q2M3U0
    • Q5U0H4

    Protein attributes for BCL2L2 Gene

    193 amino acids
    Molecular mass:
    20746 Da
    Quaternary structure:
    • Interacts with HIF3A (via C-terminus domain). Interacts with BOP.
    • Interacts with HIF3A (via C-terminus domain). Interacts with BOP.
    • Sequence=BAA19666.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BCL2L2 Gene

    Alternative splice isoforms for BCL2L2 Gene


neXtProt entry for BCL2L2 Gene

Post-translational modifications for BCL2L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL2L2 Gene

Antibody Products

  • Abcam antibodies for BCL2L2
  • Santa Cruz Biotechnology (SCBT) Antibodies for BCL2L2

No data available for DME Specific Peptides for BCL2L2 Gene

Domains & Families for BCL2L2 Gene

Gene Families for BCL2L2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for BCL2L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The BH4 motif seems to be involved in the anti-apoptotic function.
  • Belongs to the Bcl-2 family.
  • The BH4 motif seems to be involved in the anti-apoptotic function.
  • The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2.
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BCL2L2: view

Function for BCL2L2 Gene

Molecular function for BCL2L2 Gene

GENATLAS Biochemistry:
BCL2-like 2,antiapoptotic,expressed in lymphoid and myeloid cells
UniProtKB/Swiss-Prot Function:
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

Gene Ontology (GO) - Molecular Function for BCL2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15694340
GO:0042802 identical protein binding IPI 22000515
GO:0042803 protein homodimerization activity IBA --
GO:0046982 protein heterodimerization activity IMP,IEA 16645638
GO:0051400 BH domain binding IEA --
genes like me logo Genes that share ontologies with BCL2L2: view
genes like me logo Genes that share phenotypes with BCL2L2: view

Animal Models for BCL2L2 Gene

MGI Knock Outs for BCL2L2:

Animal Model Products

CRISPR Products

miRNA for BCL2L2 Gene

miRTarBase miRNAs that target BCL2L2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCL2L2 Gene

Localization for BCL2L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL2L2 Gene

Mitochondrion membrane; Peripheral membrane protein. Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCL2L2 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 4
plasma membrane 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for BCL2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IBA --
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with BCL2L2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BCL2L2 Gene

Pathways & Interactions for BCL2L2 Gene

genes like me logo Genes that share pathways with BCL2L2: view

Pathways by source for BCL2L2 Gene

SIGNOR curated interactions for BCL2L2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for BCL2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007283 spermatogenesis TAS 8761287
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA --
GO:0042981 regulation of apoptotic process IEA --
GO:0043066 negative regulation of apoptotic process IMP,TAS 17289999
genes like me logo Genes that share ontologies with BCL2L2: view

Drugs & Compounds for BCL2L2 Gene

(10) Drugs for BCL2L2 Gene - From: DrugBank, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Navitoclax Investigational Pharma Target BCL-2 inhibitors 28
Gossypol Investigational Pharma PAF inhibitor;anti-fertility and anti-cancer 24
ABT-263 (Navitoclax) Pharma Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w 0
ABT-737 Pharma Bcl-2 inhibitor 0
AT-101 Pharma BH3-mimetic,gossypol enantiomer, BCL-2 inhibitors 0

(7) ApexBio Compounds for BCL2L2 Gene

Compound Action Cas Number
ABT-263 (Navitoclax) Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w 923564-51-6
ABT-737 Bcl-2 inhibitor 852808-04-9
AT-101 BH3-mimetic,gossypol enantiomer 90141-22-3
Bax inhibitor peptide P5 Bax inhibitor 579492-83-4
Bax inhibitor peptide V5 Bax inhibitor 579492-81-2
Gossypol PAF inhibitor;anti-fertility and anti-cancer 303-45-7
Sabutoclax pan-Bcl-2 inhibitor 1228108-65-3
genes like me logo Genes that share compounds with BCL2L2: view

Drug Products

Transcripts for BCL2L2 Gene

Unigene Clusters for BCL2L2 Gene

BCL2-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3: -

Relevant External Links for BCL2L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BCL2L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BCL2L2 Gene

Protein differential expression in normal tissues from HIPED for BCL2L2 Gene

This gene is overexpressed in Bone (13.8) and Frontal cortex (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BCL2L2 Gene

Protein tissue co-expression partners for BCL2L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of BCL2L2 Gene:


SOURCE GeneReport for Unigene cluster for BCL2L2 Gene:


mRNA Expression by UniProt/SwissProt for BCL2L2 Gene:

Tissue specificity: Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.

Evidence on tissue expression from TISSUES for BCL2L2 Gene

  • Nervous system(4.6)
  • Lung(4.4)
  • Liver(4.3)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with BCL2L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL2L2 Gene

Orthologs for BCL2L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL2L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BCL2L2 33 34
  • 99.83 (n)
(Bos Taurus)
Mammalia BCL2L2 33 34
  • 95.85 (n)
(Monodelphis domestica)
Mammalia BCL2L2 34
  • 95 (a)
(Canis familiaris)
Mammalia BCL2L2 33 34
  • 94.82 (n)
(Rattus norvegicus)
Mammalia Bcl2l2 33
  • 94.3 (n)
(Mus musculus)
Mammalia Bcl2l2 33 16 34
  • 93.78 (n)
(Ornithorhynchus anatinus)
Mammalia BCL2L2 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bcl2l2 33
  • 67.03 (n)
African clawed frog
(Xenopus laevis)
Amphibia xR1 33
Species where no ortholog for BCL2L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BCL2L2 Gene

Gene Tree for BCL2L2 (if available)
Gene Tree for BCL2L2 (if available)

Paralogs for BCL2L2 Gene

Paralogs for BCL2L2 Gene

(5) SIMAP similar genes for BCL2L2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with BCL2L2: view

Variants for BCL2L2 Gene

Sequence variations from dbSNP and Humsavar for BCL2L2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000038650 -- 23,309,658(+) T/C 3_prime_UTR_variant
rs1000946613 -- 23,310,177(+) C/T 3_prime_UTR_variant
rs1001383421 -- 23,309,267(+) C/T 3_prime_UTR_variant
rs1001866831 -- 23,304,779(+) C/T upstream_transcript_variant
rs1002085630 -- 23,304,872(+) T/G upstream_transcript_variant

Variation tolerance for BCL2L2 Gene

Residual Variation Intolerance Score: 40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BCL2L2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BCL2L2 Gene

Disorders for BCL2L2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BCL2L2 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
small intestinal adenocarcinoma
  • adenocarcinoma of small bowel
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for BCL2L2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with BCL2L2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCL2L2 Gene

Publications for BCL2L2 Gene

  1. bcl-w, a novel member of the bcl-2 family, promotes cell survival. (PMID: 8761287) Gibson L … Cory S (Oncogene 1996) 2 3 4 22 58
  2. Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix. (PMID: 12651847) Denisov AY … Gehring K (The Journal of biological chemistry 2003) 3 4 22 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 44 58
  5. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PMID: 20855536) Kelly JL … Cerhan JR (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58

Products for BCL2L2 Gene

Sources for BCL2L2 Gene

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