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This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. M... See more...
Aliases for BCL2L2 Gene
Aliases for BCL2L2 Gene
External Ids for BCL2L2 Gene
- HGNC: 995
- NCBI Entrez Gene: 599
- Ensembl: ENSG00000129473
- OMIM®: 601931
- UniProtKB/Swiss-Prot: Q92843
Previous GeneCards Identifiers for BCL2L2 Gene
- GC14P021148
- GC14P017563
- GC14P021766
- GC14P022845
- GC14P023776
- GC14P003892
- GC14P023791
- GC14P023464
- GC14P023564
- GC14P024507
- GC14P024635
- GC14P024748
- GC14P025033
- GC14P023677
- GC14P023800
- GC14P023889
- GC14P023948
- GC14P024061
- GC14P024179
- GC14P024290
- GC14P024390
- GC14P025306
- GC14P025609
Summaries for BCL2L2 Gene
-
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for BCL2L2 Gene
BCL2L2 (BCL2 Like 2) is a Protein Coding gene. Diseases associated with BCL2L2 include Burkitt Lymphoma and Alzheimer Disease. Among its related pathways are Regulation of Apoptosis by Parathyroid Hormone-related Protein and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and BH domain binding. An important paralog of this gene is BCL2L1.
UniProtKB/Swiss-Prot Summary for BCL2L2 Gene
-
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
Additional gene information for BCL2L2 Gene
- HGNC (995)
- NCBI Entrez Gene (599)
- Ensembl (ENSG00000129473)
- OMIM® (601931)
- UniProtKB/Swiss-Prot (Q92843)
- Open Targets Platform(ENSG00000129473)
- Alliance of Genome Resources
- Search for BCL2L2 at DataMed
- Search for BCL2L2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BCL2L2 Gene
Genomics for BCL2L2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BCL2L2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BCL2L2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BCL2L2
- Top Transcription factor binding sites by QIAGEN in the BCL2L2 gene promoter:
-
- c-Ets-1
- E2F
- E2F-1
- E2F-2
- Sp1
- STAT1
Genomic Locations for BCL2L2 Gene
Latest Assembly
- chr14:23,298,790-23,311,751
- (GRCh38/hg38)
- Size:
- 12,962 bases
- Orientation:
- Plus strand
Previous Assembly
- chr14:23,776,042-23,780,960
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 4,919 bases
- Orientation:
- Plus strand
Genomic View for BCL2L2 Gene
Genes around BCL2L2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q11.2 by HGNC
- 14q11.2 by Entrez Gene
- 14q11.2 by Ensembl
BCL2L2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BCL2L2 Gene
Proteins for BCL2L2 Gene
-
Protein details for BCL2L2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92843-B2CL2_HUMAN
- Recommended name:
- Bcl-2-like protein 2
- Protein Accession:
- Q92843
- A8K0F4
- Q2M3U0
- Q5U0H4
Protein attributes for BCL2L2 Gene
- Size:
- 193 amino acids
- Molecular mass:
- 20746 Da
- Quaternary structure:
-
- Interacts with HIF3A (via C-terminus domain). Interacts with BOP.
- SequenceCaution:
-
- Sequence=BAA19666.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 3]: Based on a readthrough transcript which may produce a BCL2L2-PABPN1 fusion protein.
Three dimensional structures from OCA and Proteopedia for BCL2L2 Gene
Protein Expression for BCL2L2 Gene
Post-translational modifications for BCL2L2 Gene
Other Protein References for BCL2L2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences BCL2L2 / Bcl-w Monoclonal Antibody and BCL2L2 / Bcl-w Antibody
- G Biosciences Immunotag™ BCL2L2 Antibody and Immunotag™ BCLW Antibody
- NSJ Bioreagents Bcl2L2 Antibody
- Novus Biologicals Antibodies for BCL2L2
-
Abcam antibodies for BCL2L2
- Invitrogen Antibodies for BCL2L2 (AFLGC-BCL2L2)
-
Custom Antibody ServicesProSci Antibodies for BCL2L2
-
Santa Cruz Biotechnology (SCBT) Antibodies for BCL2L2
- Sino Biological Antibodies for BCL2L2
Protein products for research
- G Biosciences Human Bcl-w/Bcl-2-like protein 2, Liquid
-
OriGene Purified Proteins for BCL2L2
- Search Origene for MassSpec and Protein Over-expression Lysates for BCL2L2
- Origene Custom Protein Services for BCL2L2
- Sino Biological Recombinant Proteins for BCL2L2
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for BCL2L2
-
ProSci Proteins for BCL2L2
-
Abcam proteins for BCL2L2
Assay products for research
- RayBiotech Human BCL-W ELISA
- antibodies-online: Show 14 available BCL2L2 Elisa Kits ranked by validation data
- Compare Top BCL2L2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for BCL2L2 Gene
Domains & Families for BCL2L2 Gene
Gene Families for BCL2L2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Predicted membrane proteins
- Transporters
Protein Domains for BCL2L2 Gene
- InterPro:
- Blocks:
-
- Apoptosis regulator Bcl-2 protein, BH
- Apoptosis regulator Bcl-2 protein, BH4
Suggested Antigen Peptide Sequences for BCL2L2 Gene
- GenScript: Design optimal peptide antigens:
-
- Apoptosis regulator Bcl-W (B2CL2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q92843UniProtKB/Swiss-Prot:
B2CL2_HUMAN :- The BH4 motif seems to be involved in the anti-apoptotic function.
- Belongs to the Bcl-2 family.
- Domain:
-
- The BH4 motif seems to be involved in the anti-apoptotic function.
- The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2.
- Family:
-
- Belongs to the Bcl-2 family.
Function for BCL2L2 Gene
Molecular function for BCL2L2 Gene
- UniProtKB/Swiss-Prot Function:
- Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
- GENATLAS Biochemistry:
- BCL2-like 2,antiapoptotic,expressed in lymphoid and myeloid cells
Phenotypes From GWAS Catalog for BCL2L2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15694340 |
| GO:0042802 | identical protein binding | IPI | 22000515 |
| GO:0042803 | protein homodimerization activity | IBA | 21873635 |
| GO:0044877 | protein-containing complex binding | IPI | -- |
| GO:0046982 | protein heterodimerization activity | IBA | 21873635 |
Phenotypes for BCL2L2 Gene
- MGI mutant phenotypes for BCL2L2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for BCL2L2:
-
- Decreased viability
- no effect
- Decreased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Increased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Increased viability with MLN4924 (a NAE inhibitor)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased vesicular stomatitis virus (VSV) infection
Animal Models for BCL2L2 Gene
- MGI Knock Outs for BCL2L2:
-
- Bcl2l2 Bcl2l2<tm1Sco>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for BCL2L2 - Starting at $85 >
- * BCL2L2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for BCL2L2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCL2L2
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCL2L2
miRNA for BCL2L2 Gene
- miRTarBase miRNAs that target BCL2L2
-
- hsa-miR-133b (MIRT001076)
- mmu-miR-497a-5p (MIRT003282)
- hsa-miR-122-5p (MIRT004364)
- hsa-miR-203a-3p (MIRT005453)
- hsa-miR-630 (MIRT005579)
- hsa-miR-204-5p (MIRT005819)
- hsa-miR-335-5p (MIRT006109)
- hsa-miR-214-3p (MIRT007294)
- hsa-miR-195-5p (MIRT007370)
- hsa-miR-24-3p (MIRT030447)
- hsa-miR-1296-5p (MIRT036076)
- hsa-miR-125b-5p (MIRT053019)
- hsa-miR-512-5p (MIRT053425)
- rno-miR-29a-3p (MIRT054511)
- hsa-miR-17-5p (MIRT368881)
- hsa-miR-20a-5p (MIRT368882)
- hsa-miR-93-5p (MIRT368883)
- hsa-miR-106a-5p (MIRT368884)
- hsa-miR-106b-5p (MIRT368885)
- hsa-miR-20b-5p (MIRT368886)
- hsa-miR-526b-3p (MIRT368888)
- hsa-miR-519d-3p (MIRT368890)
- mmu-miR-15b-5p (MIRT438297)
- mmu-miR-16-5p (MIRT438298)
- mmu-miR-195a-5p (MIRT438299)
- hsa-miR-5089-5p (MIRT510174)
- hsa-miR-6807-5p (MIRT510175)
- hsa-miR-6866-5p (MIRT510176)
- hsa-miR-877-5p (MIRT510177)
- hsa-miR-5589-5p (MIRT510178)
- hsa-miR-4731-5p (MIRT510179)
- hsa-miR-6506-5p (MIRT510180)
- hsa-miR-619-5p (MIRT510181)
- hsa-miR-186-3p (MIRT524754)
- hsa-miR-520h (MIRT524755)
- hsa-miR-520g-3p (MIRT524756)
- hsa-miR-512-3p (MIRT524757)
- hsa-miR-520e (MIRT524758)
- hsa-miR-520d-3p (MIRT524759)
- hsa-miR-520c-3p (MIRT524760)
- hsa-miR-520b (MIRT524761)
- hsa-miR-520a-3p (MIRT524762)
- hsa-miR-373-3p (MIRT524763)
- hsa-miR-302e (MIRT524764)
- hsa-miR-372-3p (MIRT524765)
- hsa-miR-302d-3p (MIRT524766)
- hsa-miR-302c-3p (MIRT524767)
- hsa-miR-302b-3p (MIRT524768)
- hsa-miR-302a-3p (MIRT524769)
- hsa-miR-6777-3p (MIRT538976)
- hsa-miR-874-5p (MIRT538977)
- hsa-miR-6845-3p (MIRT538978)
- hsa-miR-1976 (MIRT538979)
- hsa-miR-3653-5p (MIRT538980)
- hsa-miR-8073 (MIRT538981)
- hsa-miR-221-5p (MIRT538982)
- hsa-miR-361-3p (MIRT538983)
- hsa-miR-4691-3p (MIRT538984)
- hsa-miR-1228-3p (MIRT538985)
- hsa-miR-6769a-3p (MIRT538986)
- hsa-miR-4323 (MIRT538987)
- hsa-miR-3943 (MIRT538988)
- hsa-miR-449b-3p (MIRT538989)
- mmu-miR-3971 (MIRT601133)
- hsa-miR-129-2-3p (MIRT733550)
- rno-miR-676 (MIRT734840)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCL2L2
- Browse OriGene Inhibitory RNA Products For BCL2L2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL2L2
Clone products for research
- Applied Biological Materials (abm): Clones for BCL2L2 - Starting at $45 >
- * BCL2L2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG201573
- MG220491
- MR201573
- MR201573L3
- MR201573L4
- MR220491
- MR220491L3
- MR220491L4
- RC211152
- RC211152L1
- RC211152L2
- RC211152L3
- RC211152L4
- RC233402
- RG211152
- RG233402
- RR214220
- RR214220L3
- RR214220L4
- MR201573L3V
- MR201573L4V
- MR220491L3V
- MR220491L4V
- RC211152L1V
- RC211152L2V
- RC211152L3V
- RC211152L4V
- RR214220L3V
- RR214220L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BCL2L2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCL2L2
Cell Lines for research
-
Horizon Cell Lines for BCL2L2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCL2L2 Gene
Localization for BCL2L2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BCL2L2 Gene
- Mitochondrion membrane. Peripheral membrane protein. Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.
| Compartment | Confidence |
|---|---|
| mitochondrion | 4 |
| cytosol | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005741 | mitochondrial outer membrane | IBA | 21873635 |
| GO:0005829 | cytosol | IDA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for BCL2L2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis Modulation and Signaling |
.41
|
|
| 2 | Apoptosis and Autophagy | ||
| 3 | MicroRNAs in cancer | ||
| 4 | Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins |
Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins
-
|
|
| 5 | Direct p53 effectors | ||
Pathways by source for BCL2L2 Gene
5 BioSystems pathways for BCL2L2 Gene
1 KEGG pathway for BCL2L2 Gene
1 GeneGo (Thomson Reuters) pathway for BCL2L2 Gene
- Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins
1 Cell Signaling Technology pathway for BCL2L2 Gene
Interacting Proteins for BCL2L2 Gene
Selected Interacting proteins:
Q92843-B2CL2_HUMAN
ENSP00000250405
for BCL2L2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for BCL2L2
SIGNOR curated interactions for BCL2L2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002931 | response to ischemia | IEP | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007283 | spermatogenesis | TAS | 8761287 |
| GO:0007420 | brain development | IEP | -- |
| GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | IBA | 21873635 |
Drugs & Compounds for BCL2L2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| AT-101 | Approved, Investigational | Pharma | BH3-mimetic,gossypol enantiomer, BCL-2 inhibitors | 92 | ||
| Navitoclax | Investigational | Pharma | Target | BCL-2 inhibitors | 34 | |
| Gossypol | Investigational | Pharma | PAF inhibitor;anti-fertility and anti-cancer | 25 | ||
| ABT-263 (Navitoclax) | Pharma | Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w | 0 | |||
| ABT-737 | Pharma | Bcl-2 inhibitor | 0 |
(7) ApexBio Compounds for BCL2L2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| ABT-263 (Navitoclax) | Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w | 923564-51-6 |
| ABT-737 | Bcl-2 inhibitor | 852808-04-9 |
| AT-101 | BH3-mimetic,gossypol enantiomer | 90141-22-3 |
| Bax inhibitor peptide P5 | Bax inhibitor | 579492-83-4 |
| Bax inhibitor peptide V5 | Bax inhibitor | 579492-81-2 |
| Gossypol | PAF inhibitor;anti-fertility and anti-cancer | 303-45-7 |
| Sabutoclax | pan-Bcl-2 inhibitor | 1228108-65-3 |
Drug products for research
- G Biosciences Human Bcl-w/Bcl-2-like protein 2, Liquid
- ApexBio compounds for BCL2L2
Transcripts for BCL2L2 Gene
mRNA/cDNA for BCL2L2 Gene
- 2 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000250405 3526 nts (view in UCSC)
- ENST00000553824 548 nts (view in UCSC)
- ENST00000554635 545 nts (view in UCSC)
- ENST00000556100 1368 nts (view in UCSC)
- ENST00000556599 548 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for BCL2L2 - Starting at $85 >
- * BCL2L2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for BCL2L2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCL2L2
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCL2L2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCL2L2
- Browse OriGene Inhibitory RNA Products For BCL2L2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL2L2
Clone products for research
- Applied Biological Materials (abm): Clones for BCL2L2 - Starting at $45 >
- * BCL2L2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG201573
- MG220491
- MR201573
- MR201573L3
- MR201573L4
- MR220491
- MR220491L3
- MR220491L4
- RC211152
- RC211152L1
- RC211152L2
- RC211152L3
- RC211152L4
- RC233402
- RG211152
- RG233402
- RR214220
- RR214220L3
- RR214220L4
- MR201573L3V
- MR201573L4V
- MR220491L3V
- MR220491L4V
- RC211152L1V
- RC211152L2V
- RC211152L3V
- RC211152L4V
- RR214220L3V
- RR214220L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BCL2L2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCL2L2
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4 | ^ | 5a | · | 5b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||
| SP5: |
Relevant External Links for BCL2L2 Gene
- GeneLoc Exon Structure for
- BCL2L2
Expression for BCL2L2 Gene
This gene is overexpressed in Bone (13.8) and Frontal cortex (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BCL2L2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BCL2L2
SOURCE GeneReport for Unigene cluster for BCL2L2 Gene:
Hs.410026mRNA Expression by UniProt/SwissProt for BCL2L2 Gene:
Q92843-B2CL2_HUMAN
Tissue specificity:
Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.
Evidence on tissue expression from TISSUES for BCL2L2 Gene
- Nervous system(4.6)
- Lung(4.5)
- Liver(4.5)
- Intestine(2.8)
- Kidney(2.8)
- Heart(2.7)
- Skin(2.6)
- Muscle(2.4)
- Spleen(2.4)
- Pancreas(2.3)
- Stomach(2.2)
- Bone marrow(2.2)
- Lymph node(2.2)
- Blood(2.2)
- Adrenal gland(2.1)
- Thyroid gland(2.1)
Primer products for research
-
OriGene qPCR primer pairs for BCL2L2
-
OriGene qPCR primer pairs and template standards for BCL2L2
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL2L2 Gene
Orthologs for BCL2L2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BCL2L2 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | BCL2L2 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | BCL2L2 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | BCL2L2 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Bcl2l2 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Bcl2l2 29 16 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | BCL2L2 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | bcl2l2 29 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | xR1 29 |
|
- Species where no ortholog for BCL2L2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for BCL2L2 Gene
- ENSEMBL:
- Gene Tree for BCL2L2 (if available)
- TreeFam:
- Gene Tree for BCL2L2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BCL2L2: view image
- Alliance of Genome Resources:
- Additional Orthologs for BCL2L2
Paralogs for BCL2L2 Gene
(5) SIMAP similar genes for BCL2L2 Gene using alignment to 6 proteins:
- B2CL2_HUMAN
- G3V3B7_HUMAN
- G3V3G8_HUMAN
- G3V4B7_HUMAN
- G3V5A9_HUMAN
- H0YJC7_HUMAN
Variants for BCL2L2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BCL2L2 Gene
| SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs910332 | -- |
p.Gln133Arg |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.48;
10.39% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BCL2L2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BCL2L2 Gene
Disorders for BCL2L2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| burkitt lymphoma |
|
|
| alzheimer disease |
|
|
| leukemia, chronic lymphocytic |
|
|
| leukemia, acute myeloid |
|
|
Search BCL2L2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BCL2L2
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for BCL2L2 Gene
Publications for BCL2L2 Gene
- bcl-w, a novel member of the bcl-2 family, promotes cell survival. (PMID: 8761287) Gibson L … Cory S (Oncogene 1996) 2 3 4 22
- Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix. (PMID: 12651847) Denisov AY … Gehring K (The Journal of biological chemistry 2003) 3 4 22
- Co-inhibition of BCL-W and BCL2 restores antiestrogen sensitivity through BECN1 and promotes an autophagy-associated necrosis. (PMID: 20062536) Crawford AC … Clarke R (PloS one 2010) 3 22
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
- The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia. (PMID: 20959405) Kim DH … Lipton JH (Clinical cancer research : an official journal of the American Association for Cancer Research 2010) 3 40
ExternalLinks
Products for BCL2L2 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for BCL2L2
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- Origene Custom Protein Services for BCL2L2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCL2L2
- Browse OriGene Inhibitory RNA Products For BCL2L2
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- OriGene CRISPR knockouts for BCL2L2
- MG201573
- MG220491
- MR201573
- MR201573L3
- MR201573L4
- MR220491
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- RC211152
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- RC211152L3
- RC211152L4
- RC233402
- RG211152
- RG233402
- RR214220
- RR214220L3
- RR214220L4
- MR201573L3V
- MR201573L4V
- MR220491L3V
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- RC211152L1V
- RC211152L2V
- RC211152L3V
- RC211152L4V
- RR214220L3V
- RR214220L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BCL2L2
- Sino Biological Human cDNA Clone for BCL2L2
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- Browse Sino Biological Cell Lysates
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- Browse Sino Biological Assays
- Browse Recombinant Proteins
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals proteins and lysates for BCL2L2
- Browse Antibodies
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- ApexBio compounds for BCL2L2
- VectorBuilder Custom and pre-made DNA vectors for BCL2L2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for BCL2L2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for BCL2L2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for BCL2L2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for BCL2L2
- antibodies-online: Show 39 available BCL2L2 Antibodies ranked by validation data
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- Quality Products:
- antibodies-online: Show 17 available BCL2L2 Proteins ranked by validation data
- Compare Top BCL2L2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for BCL2L2
- Search Santa Cruz Biotechnology (SCBT) for BCL2L2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BCL2L2
- Custom Antibody ServicesProSci Antibodies for BCL2L2
- ProSci Proteins for BCL2L2
- Horizon Cell Lines for BCL2L2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCL2L2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCL2L2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for BCL2L2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL2L2
Sources for BCL2L2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources