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The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 2009]
BCL2L14 (BCL2 Like 14) is a Protein Coding gene. Among its related pathways are TP53 Regulates Transcription of Cell Death Genes and Regulation of Apoptosis by Parathyroid Hormone-related Protein. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is BCL2L12.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 11054413 |
GO:0019901 | protein kinase binding | IPI | 17280616 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0012505 | endomembrane system | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0043229 | intracellular organelle | IDA | 11054413 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gene Expression |
.48
|
|
2 | TP53 Regulates Transcription of Cell Death Genes | ||
3 | Regulation of TP53 Activity | ||
4 | Direct p53 effectors | ||
5 | Regulation of Apoptosis by Parathyroid Hormone-related Protein |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006915 | apoptotic process | IEA,IDA | 17280616 |
GO:0042981 | regulation of apoptotic process | TAS | -- |
GO:2001236 | regulation of extrinsic apoptotic signaling pathway | IBA | 21873635 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||
SP6: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | BCL2L14 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | BCL2L14 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | BCL2L14 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Bcl2l14 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Bcl2l14 30 |
|
||
Chicken (Gallus gallus) |
Aves | BCL2L14 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101732952 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | CABZ01020840.1 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
775306 | Benign: not provided | 12,079,512(+) | G/A | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2676351 | CNV | deletion | 23128226 |
esv3628598 | CNV | loss | 21293372 |
esv7410 | CNV | loss | 19470904 |
nsv1046355 | CNV | loss | 25217958 |
nsv557583 | CNV | gain | 21841781 |
No disorders were found for BCL2L14 Gene.