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Aliases for BCL2L14 Gene

Aliases for BCL2L14 Gene

  • BCL2 Like 14 2 3 5
  • BCL2-Like 14 (Apoptosis Facilitator) 2 3
  • Bcl2-L-14 3 4
  • BCLG 3 4
  • Apoptosis Facilitator Bcl-2-Like Protein 14 3
  • Testicular Tissue Protein Li 26 3
  • Apoptosis Regulator BCL-G 3
  • Apoptosis Regulator Bcl-G 4

External Ids for BCL2L14 Gene

Previous GeneCards Identifiers for BCL2L14 Gene

  • GC12P012115
  • GC12P011989
  • GC12P012202

Summaries for BCL2L14 Gene

Entrez Gene Summary for BCL2L14 Gene

  • The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 2009]

GeneCards Summary for BCL2L14 Gene

BCL2L14 (BCL2 Like 14) is a Protein Coding gene. Among its related pathways are Gene Expression and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for BCL2L14 Gene

  • Plays a role in apoptosis.

Gene Wiki entry for BCL2L14 Gene

Additional gene information for BCL2L14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L14 Gene

Genomics for BCL2L14 Gene

GeneHancer (GH) Regulatory Elements for BCL2L14 Gene

Promoters and enhancers for BCL2L14 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J012070 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 657.5 +22.0 21973 3.2 BCOR CTCF PKNOX1 FOXA2 MAX ZMYM3 RAD21 TEAD3 POLR2A SCRT2 BCL2L14 GC12M012305
GH12J012049 Promoter 0.5 EPDnew 650.7 0.0 -2 0.1 BCL2L14 GC12P012010
GH12J011743 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 25.5 -297.8 -297776 18.1 HDGF PKNOX1 ATF1 SMAD1 IRF4 ZNF207 ATF7 ZNF548 RUNX3 RXRA ETV6 BCL2L14 TAS2R43 TAS2R20 TAS2R50 ENSG00000256682 ENSG00000256981 TAS2R14 DDX55P1 LINC01252
GH12J011808 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 21.5 -237.6 -237639 6.9 CTCF SOX13 JUN STAT5A DMAP1 BATF RELA NFATC1 EED ZSCAN29 BCL2L14 ETV6 GC12M012306 PIR45971
GH12J011828 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 19.4 -214.8 -214820 12.2 PKNOX1 FOXA2 SMAD1 IRF4 YY1 ATF7 FOS RUNX3 RXRA JUNB ETV6 BCL2L14 PIR45971 GC12M012306
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BCL2L14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BCL2L14 gene promoter:
  • IRF-1

Genomic Locations for BCL2L14 Gene

Genomic Locations for BCL2L14 Gene
161,241 bases
Plus strand
161,241 bases
Plus strand

Genomic View for BCL2L14 Gene

Genes around BCL2L14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL2L14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL2L14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL2L14 Gene

Proteins for BCL2L14 Gene

  • Protein details for BCL2L14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Apoptosis facilitator Bcl-2-like protein 14
    Protein Accession:
    Secondary Accessions:
    • A8KAD0
    • Q96QR5
    • Q9BZR7

    Protein attributes for BCL2L14 Gene

    327 amino acids
    Molecular mass:
    36598 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BCL2L14 Gene


neXtProt entry for BCL2L14 Gene

Post-translational modifications for BCL2L14 Gene

  • Phosphorylated by MELK, leading to inhibit its pro-apoptotic function.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BCL2L14 Gene

Domains & Families for BCL2L14 Gene

Gene Families for BCL2L14 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BCL2L14 Gene

Suggested Antigen Peptide Sequences for BCL2L14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Bcl-2 family.
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BCL2L14: view

Function for BCL2L14 Gene

Molecular function for BCL2L14 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in apoptosis.

Phenotypes From GWAS Catalog for BCL2L14 Gene

Gene Ontology (GO) - Molecular Function for BCL2L14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11054413
GO:0019901 protein kinase binding IPI 17280616
genes like me logo Genes that share ontologies with BCL2L14: view
genes like me logo Genes that share phenotypes with BCL2L14: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL2L14

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BCL2L14 Gene

Localization for BCL2L14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL2L14 Gene

Isoform 1: Cytoplasm, cytosol. Note=Diffusely distributed throughout the cytosol.
Isoform 2: Endomembrane system. Note=Predominantly localized to cytosolic organelles.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCL2L14 gene
Compartment Confidence
cytosol 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BCL2L14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
GO:0043229 intracellular organelle IDA 11054413
genes like me logo Genes that share ontologies with BCL2L14: view

Pathways & Interactions for BCL2L14 Gene

genes like me logo Genes that share pathways with BCL2L14: view

Gene Ontology (GO) - Biological Process for BCL2L14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IDA,IEA 17280616
GO:0042981 regulation of apoptotic process TAS --
genes like me logo Genes that share ontologies with BCL2L14: view

No data available for SIGNOR curated interactions for BCL2L14 Gene

Drugs & Compounds for BCL2L14 Gene

No Compound Related Data Available

Transcripts for BCL2L14 Gene

Unigene Clusters for BCL2L14 Gene

BCL2-like 14 (apoptosis facilitator):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL2L14

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: -

Relevant External Links for BCL2L14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BCL2L14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BCL2L14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL2L14 Gene

This gene is overexpressed in Testis (x19.7), Colon - Transverse (x10.8), Small Intestine - Terminal Ileum (x5.2), and Stomach (x5.0).

Protein differential expression in normal tissues from HIPED for BCL2L14 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BCL2L14 Gene

Protein tissue co-expression partners for BCL2L14 Gene

NURSA nuclear receptor signaling pathways regulating expression of BCL2L14 Gene:


SOURCE GeneReport for Unigene cluster for BCL2L14 Gene:


mRNA Expression by UniProt/SwissProt for BCL2L14 Gene:

Tissue specificity: Isoform 1 is widely expressed. Isoform 2 is testis-specific.

Evidence on tissue expression from TISSUES for BCL2L14 Gene

  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with BCL2L14: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL2L14 Gene

Orthologs for BCL2L14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL2L14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BCL2L14 34 33
  • 98.88 (n)
(Canis familiaris)
Mammalia BCL2L14 34 33
  • 79.14 (n)
(Bos Taurus)
Mammalia BCL2L14 34 33
  • 78.05 (n)
(Mus musculus)
Mammalia Bcl2l14 16 34 33
  • 77.43 (n)
(Rattus norvegicus)
Mammalia Bcl2l14 33
  • 77.16 (n)
(Gallus gallus)
Aves BCL2L14 34 33
  • 50.22 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732952 33
  • 55.19 (n)
(Danio rerio)
Actinopterygii CABZ01020840.1 34
  • 22 (a)
Species where no ortholog for BCL2L14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCL2L14 Gene

Gene Tree for BCL2L14 (if available)
Gene Tree for BCL2L14 (if available)
Evolutionary constrained regions (ECRs) for BCL2L14: view image

Paralogs for BCL2L14 Gene

(1) SIMAP similar genes for BCL2L14 Gene using alignment to 5 proteins:

  • B2L14_HUMAN
  • C9J3S1_HUMAN
  • C9K0Q9_HUMAN
genes like me logo Genes that share paralogs with BCL2L14: view

No data available for Paralogs for BCL2L14 Gene

Variants for BCL2L14 Gene

Sequence variations from dbSNP and Humsavar for BCL2L14 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000004613 -- 12,073,953(+) G/C intron_variant
rs1000030616 -- 12,082,674(+) T/G intron_variant
rs1000042838 -- 12,088,702(+) C/T intron_variant
rs1000054810 -- 12,050,240(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000121685 -- 12,085,194(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BCL2L14 Gene

Variant ID Type Subtype PubMed ID
esv2676351 CNV deletion 23128226
esv3628598 CNV loss 21293372
esv7410 CNV loss 19470904
nsv1046355 CNV loss 25217958
nsv557583 CNV gain 21841781

Variation tolerance for BCL2L14 Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.19; 69.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BCL2L14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL2L14 Gene

Disorders for BCL2L14 Gene

Additional Disease Information for BCL2L14

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for BCL2L14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BCL2L14 Gene

Publications for BCL2L14 Gene

  1. Bcl-G, a novel pro-apoptotic member of the Bcl-2 family. (PMID: 11054413) Guo B … Reed JC (The Journal of biological chemistry 2001) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
  5. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PMID: 20855536) Kelly JL … Cerhan JR (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58

Products for BCL2L14 Gene

Sources for BCL2L14 Gene

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