Aliases for BCL2L14 Gene
Aliases for BCL2L14 Gene
External Ids for BCL2L14 Gene
- HGNC: 16657
- Entrez Gene: 79370
- Ensembl: ENSG00000121380
- OMIM: 606126
- UniProtKB: Q9BZR8
Previous GeneCards Identifiers for BCL2L14 Gene
- GC12P012115
- GC12P011989
- GC12P012202
Summaries for BCL2L14 Gene
-
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 2009]
GeneCards Summary for BCL2L14 Gene
BCL2L14 (BCL2 Like 14) is a Protein Coding gene. Among its related pathways are Gene Expression and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include protein kinase binding.
UniProtKB/Swiss-Prot for BCL2L14 Gene
-
Plays a role in apoptosis.
Additional gene information for BCL2L14 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L14 Gene
Genomics for BCL2L14 Gene
GeneHancer (GH) Regulatory Elements for BCL2L14 Gene
Promoters and enhancers for BCL2L14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around BCL2L14 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the BCL2L14 gene promoter:
Regulatory Element Products
Genomic Locations for BCL2L14 Gene
Genomic Locations for BCL2L14 Gene
- chr12:12,049,844-12,211,084
- (GRCh38/hg38)
- Size:
- 161,241 bases
- Orientation:
- Plus strand
- chr12:12,202,778-12,364,018
- (GRCh37/hg19)
Genomic View for BCL2L14 Gene
Genes around BCL2L14 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.2 by Ensembl
- 12p13.2 by Entrez Gene
- 12p13.2 by HGNC
BCL2L14 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BCL2L14 Gene
Proteins for BCL2L14 Gene
-
Protein details for BCL2L14 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BZR8-B2L14_HUMAN
- Recommended name:
- Apoptosis facilitator Bcl-2-like protein 14
- Protein Accession:
- Q9BZR8
- A8KAD0
- Q96QR5
- Q9BZR7
Protein attributes for BCL2L14 Gene
- Size:
- 327 amino acids
- Molecular mass:
- 36598 Da
- Quaternary structure:
- No Data Available
Protein Expression for BCL2L14 Gene
Post-translational modifications for BCL2L14 Gene
- Phosphorylated by MELK, leading to inhibit its pro-apoptotic function.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for BCL2L14 Gene
Antibody Products
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-
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-
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-
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Protein Products
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-
Abcam proteins for BCL2L14
Assay Products
No data available for DME Specific Peptides for BCL2L14 Gene
Domains & Families for BCL2L14 Gene
Gene Families for BCL2L14 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for BCL2L14 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for BCL2L14 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BZR8- Family:
-
- Belongs to the Bcl-2 family.
Function for BCL2L14 Gene
Molecular function for BCL2L14 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in apoptosis.
Phenotypes From GWAS Catalog for BCL2L14 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 11054413 |
| GO:0019901 | protein kinase binding | IPI | 17280616 |
Phenotypes for BCL2L14 Gene
- GenomeRNAi human phenotypes for BCL2L14:
Animal Model Products
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-
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miRNA for BCL2L14 Gene
- miRTarBase miRNAs that target BCL2L14
Inhibitory RNA Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available BCL2L14 gene related products
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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Horizon Cell Lines for BCL2L14
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ViGene Biosciences adenoviral particle packaged cDNA for BCL2L14 gene
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ViGene Biosciences lentiviral particle packaged cDNA for BCL2L14 gene
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BCL2L14 Gene
Localization for BCL2L14 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BCL2L14 Gene
- Cytoplasm.
- Isoform 1: Cytoplasm, cytosol. Note=Diffusely distributed throughout the cytosol.
- Isoform 2: Endomembrane system. Note=Predominantly localized to cytosolic organelles.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 2 |
- Cytosol (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0012505 | endomembrane system | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0043229 | intracellular organelle | IDA | 11054413 |
Pathways & Interactions for BCL2L14 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
| 2 | TP53 Regulates Transcription of Cell Death Genes | ||
| 3 | Regulation of TP53 Activity | ||
| 4 | Direct p53 effectors | ||
| 5 | Regulation of Apoptosis by Parathyroid Hormone-related Protein | ||
Pathways by source for BCL2L14 Gene
2 BioSystems pathways for BCL2L14 Gene
Interacting Proteins for BCL2L14 Gene
Selected Interacting proteins:
ENSP00000309132
Q9BZR8-B2L14_HUMAN
for BCL2L14 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | IDA,IEA | 17280616 |
| GO:0042981 | regulation of apoptotic process | TAS | -- |
No data available for SIGNOR curated interactions for BCL2L14 Gene
Transcripts for BCL2L14 Gene
mRNA/cDNA for BCL2L14 Gene
- (8) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (46) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for BCL2L14 Gene
CRISPR Products
-
OriGene CRISPR knockouts for BCL2L14
- genomics-online: gRNA clones - Search results for available BCL2L14 gene related products
- Applied Biological Materials CRISPR for BCL2L14
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCL2L14
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Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for available BCL2L14 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for BCL2L14 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for BCL2L14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BCL2L14
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available BCL2L14 gene related products
- orf clones - Search results for available BCL2L14 gene related products
- Applied Biological Materials Clones for BCL2L14
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||
| SP6: | - |
Expression for BCL2L14 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
- Intestine (Gastrointestinal Tract)
-
Colon (Gastrointestinal Tract)
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for BCL2L14 Gene
This gene is overexpressed in Testis (x19.7), Colon - Transverse (x10.8), Small Intestine - Terminal Ileum (x5.2), and Stomach (x5.0).
This gene is overexpressed in Platelet (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BCL2L14 Gene
NURSA nuclear receptor signaling pathways regulating expression of BCL2L14 Gene:
BCL2L14SOURCE GeneReport for Unigene cluster for BCL2L14 Gene:
Hs.210343mRNA Expression by UniProt/SwissProt for BCL2L14 Gene:
Q9BZR8-B2L14_HUMAN
Tissue specificity:
Isoform 1 is widely expressed. Isoform 2 is testis-specific.
Evidence on tissue expression from TISSUES for BCL2L14 Gene
- Pancreas(4.1)
Primer Products
-
OriGene qPCR primer pairs for BCL2L14
-
OriGene qPCR primer pairs and template standards for BCL2L14
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Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL2L14 Gene
Orthologs for BCL2L14 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BCL2L14 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | BCL2L14 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | BCL2L14 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Bcl2l14 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Bcl2l14 33 |
|
||
| chicken (Gallus gallus) |
Aves | BCL2L14 33 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC101732952 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | CABZ01020840.1 34 |
|
OneToOne |
- Species where no ortholog for BCL2L14 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for BCL2L14 Gene
(1) SIMAP similar genes for BCL2L14 Gene using alignment to 5 proteins:
No data available for Paralogs for BCL2L14 Gene
Variants for BCL2L14 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000004613 | -- | 12,073,953(+) | G/C | intron_variant | |
| rs1000030616 | -- | 12,082,674(+) | T/G | intron_variant | |
| rs1000042838 | -- | 12,088,702(+) | C/T | intron_variant | |
| rs1000054810 | -- | 12,050,240(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000121685 | -- | 12,085,194(+) | G/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2676351 | CNV | deletion | 23128226 |
| esv3628598 | CNV | loss | 21293372 |
| esv7410 | CNV | loss | 19470904 |
| nsv1046355 | CNV | loss | 25217958 |
| nsv557583 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.19;
69.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BCL2L14 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BCL2L14
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL2L14 Gene
Disorders for BCL2L14 Gene
Additional Disease Information for BCL2L14
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for BCL2L14 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BCL2L14 Gene
Publications for BCL2L14 Gene
- Bcl-G, a novel pro-apoptotic member of the Bcl-2 family. (PMID: 11054413) Guo B … Reed JC (The Journal of biological chemistry 2001) 2 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
- Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PMID: 20855536) Kelly JL … Cerhan JR (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 39 available BCL2L14 Antibodies ranked by validation data
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Sources for BCL2L14 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
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