Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs. Overexpression of the encoded protein results in apoptosis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012] See more...
Aliases for BCL2L13 Gene
Aliases for BCL2L13 Gene
External Ids for BCL2L13 Gene
- HGNC: 17164
- Entrez Gene: 23786
- Ensembl: ENSG00000099968
- UniProtKB: Q9BXK5
Previous GeneCards Identifiers for BCL2L13 Gene
- GC22P015052
- GC22P016486
- GC22P016496
- GC22P018111
- GC22P001936
Summaries for BCL2L13 Gene
-
This gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs. Overexpression of the encoded protein results in apoptosis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for BCL2L13 Gene
BCL2L13 (BCL2 Like 13) is a Protein Coding gene. Diseases associated with BCL2L13 include Legionellosis and Cat Eye Syndrome. Among its related pathways are Regulation of Apoptosis by Parathyroid Hormone-related Protein and Mitophagy - animal. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activator activity involved in apoptotic process.
UniProtKB/Swiss-Prot Summary for BCL2L13 Gene
-
May promote the activation of caspase-3 and apoptosis.
Additional gene information for BCL2L13 Gene
- HGNC(17164)
- Entrez Gene(23786)
- Ensembl(ENSG00000099968)
- UniProtKB(Q9BXK5)
- Open Targets Platform(ENSG00000099968)
- Search for BCL2L13 at DataMed
- Search for BCL2L13 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BCL2L13 Gene
Genomics for BCL2L13 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BCL2L13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BCL2L13 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BCL2L13
- Top Transcription factor binding sites by QIAGEN in the BCL2L13 gene promoter:
-
- AhR
- Arnt
- CBF(2)
- CBF-A
- CBF-B
- CP1A
- Egr-1
- NF-Y
- NF-YA
- NF-YB
Genomic Locations for BCL2L13 Gene
Genomic Locations for BCL2L13 Gene
- chr22:17,628,855-17,730,855
- (GRCh38/hg38)
- Size:
- 102,001 bases
- Orientation:
- Plus strand
- chr22:18,111,621-18,213,388
- (GRCh37/hg19)
- Size:
- 101,768 bases
- Orientation:
- Plus strand
Genomic View for BCL2L13 Gene
Genes around BCL2L13 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.21 by HGNC
- 22q11.21 by Entrez Gene
- 22q11.21 by Ensembl
BCL2L13 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BCL2L13 Gene
Proteins for BCL2L13 Gene
-
Protein details for BCL2L13 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BXK5-B2L13_HUMAN
- Recommended name:
- Bcl-2-like protein 13
- Protein Accession:
- Q9BXK5
- B3KPE7
- Q96B37
- Q96IB7
- Q9BY01
- Q9HC05
- Q9UFE0
- Q9UKN3
Protein attributes for BCL2L13 Gene
- Size:
- 485 amino acids
- Molecular mass:
- 52723 Da
- Quaternary structure:
-
- Monomer.
- SequenceCaution:
-
- Sequence=AAF03602.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAG09680.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for BCL2L13 Gene
Post-translational modifications for BCL2L13 Gene
Other Protein References for BCL2L13 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_011544421.1
- XP_011544422.1
- XP_011544423.1
- XP_011544425.1
- XP_016884214.1
- XP_016884215.1
- XP_016884216.1
- XP_016884217.1
- XP_016884218.1
- XP_016884219.1
- XP_016884220.1
- XP_016884221.1
- XP_016884223.1
- NP_001257655.1
- NP_001257656.1
- NP_001257657.1
- NP_001257658.1
- NP_001257659.1
- NP_001257660.1
- NP_001257661.1
- NP_001257662.1
- NP_001257663.1
- NP_001257664.1
- NP_001350753.1
- NP_056182.2
Antibody Products
- LifeSpan BioSciences BCL2L13 / Bcl Rambo Antibody
-
Custom Antibody ServicesOriGene Antibodies for BCL2L13
- Novus Biologicals Antibodies for BCL2L13
- Invitrogen Antibodies for BCL2L13 (AFLGC-BCL2L13)
-
Biorbyt antibodies for BCL2L13
-
Custom Antibody ServicesProSci Antibodies for BCL2L13
-
Santa Cruz Biotechnology (SCBT) Antibodies for BCL2L13
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for BCL2L13
- Origene Custom Protein Services for BCL2L13
-
Abcam proteins for BCL2L13
No data available for DME Specific Peptides for BCL2L13 Gene
Domains & Families for BCL2L13 Gene
Gene Families for BCL2L13 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for BCL2L13 Gene
- InterPro:
- Blocks:
-
- Apoptosis regulator Bcl-2 protein, BH
- Apoptosis regulator Bcl-2 protein, BH4
- ProtoNet:
Suggested Antigen Peptide Sequences for BCL2L13 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein Mil1 (B2L13_HUMAN)
- cDNA, FLJ95299, highly similar to Homo sapiens BCL2-like 13 (apoptosis facilitator) (BCL2L13),nuclear gene encoding mitochondrial protein, mRNA (B2RB43_HUMAN)
- cDNA FLJ31686 fis, clone NT2RI2005382, highly similar to Bcl-2-like 13 protein (B3KPE7_HUMAN)
- cDNA FLJ55839, highly similar to Bcl-2-like 13 protein (B7Z238_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9BXK5- Family:
-
- Belongs to the Bcl-2 family.
Function for BCL2L13 Gene
Molecular function for BCL2L13 Gene
- UniProtKB/Swiss-Prot Function:
- May promote the activation of caspase-3 and apoptosis.
Phenotypes From GWAS Catalog for BCL2L13 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process | NAS | 11262395 |
Phenotypes for BCL2L13 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BCL2L13 - Select products 50% OFF >
- * BCL2L13 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BCL2L13
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCL2L13
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCL2L13
miRNA for BCL2L13 Gene
- miRTarBase miRNAs that target BCL2L13
-
- mmu-miR-541-5p (MIRT008269)
- hsa-miR-215-5p (MIRT024899)
- hsa-miR-34a-5p (MIRT025555)
- hsa-miR-10a-5p (MIRT025589)
- hsa-miR-192-5p (MIRT026746)
- hsa-miR-1301-3p (MIRT036025)
- hsa-miR-125b-5p (MIRT046068)
- hsa-miR-580-3p (MIRT449841)
- hsa-miR-6780b-5p (MIRT449842)
- hsa-miR-4725-3p (MIRT449843)
- hsa-miR-4271 (MIRT449844)
- hsa-miR-539-5p (MIRT449845)
- hsa-miR-6783-5p (MIRT449846)
- hsa-miR-6891-5p (MIRT449847)
- hsa-miR-4779 (MIRT449848)
- hsa-miR-3173-3p (MIRT449849)
- hsa-miR-100-3p (MIRT449850)
- hsa-miR-6808-5p (MIRT507970)
- hsa-miR-6833-5p (MIRT507971)
- hsa-miR-6079 (MIRT507972)
- hsa-miR-3190-3p (MIRT507973)
- hsa-miR-3689f (MIRT507974)
- hsa-miR-3689e (MIRT507975)
- hsa-miR-3689b-5p (MIRT507976)
- hsa-miR-3689a-5p (MIRT507977)
- hsa-miR-6799-5p (MIRT507978)
- hsa-miR-548au-3p (MIRT507979)
- hsa-miR-6851-5p (MIRT507980)
- hsa-miR-3689d (MIRT507981)
- hsa-miR-671-5p (MIRT507982)
- hsa-miR-6828-5p (MIRT507983)
- hsa-miR-190b (MIRT507984)
- hsa-miR-190a-5p (MIRT507985)
- hsa-miR-6134 (MIRT507986)
- hsa-miR-4530 (MIRT507987)
- hsa-miR-6754-5p (MIRT507988)
- hsa-miR-4270 (MIRT507989)
- hsa-miR-4441 (MIRT507990)
- hsa-miR-761 (MIRT507991)
- hsa-miR-3619-5p (MIRT507992)
- hsa-miR-214-3p (MIRT507993)
- hsa-miR-299-3p (MIRT507994)
- hsa-miR-4657 (MIRT507995)
- hsa-miR-4491 (MIRT507996)
- hsa-miR-6865-5p (MIRT507997)
- hsa-miR-6815-5p (MIRT507998)
- hsa-miR-4756-5p (MIRT507999)
- hsa-miR-4739 (MIRT508000)
- hsa-miR-1321 (MIRT508001)
- hsa-miR-6510-5p (MIRT508002)
- hsa-miR-34c-5p (MIRT508003)
- hsa-miR-449a (MIRT508004)
- hsa-miR-449b-5p (MIRT508005)
- hsa-miR-6878-3p (MIRT713955)
- hsa-miR-629-3p (MIRT713956)
- hsa-miR-4290 (MIRT713957)
- hsa-miR-7112-5p (MIRT713958)
- hsa-miR-877-3p (MIRT713959)
- hsa-miR-6872-3p (MIRT713960)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCL2L13
- Browse OriGene Inhibitory RNA Products For BCL2L13
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL2L13
Clone Products
- Applied Biological Materials (abm): Clones for BCL2L13 - Select products 50% OFF >
- * BCL2L13 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206921
- MR206921
- MR206921L3
- MR206921L4
- RC200042
- RC200042L1
- RC200042L2
- RC200042L3
- RC200042L4
- RC231566
- RC231606
- RC231741
- RC231955
- RC233218
- RC233219
- RC233220
- RC233221
- RC233223
- RC233224
- RG200042
- RG231566
- RG231606
- RG231741
- RG231955
- RG233218
- RG233219
- RG233220
- RG233221
- RG233223
- RG233224
- RR209036
- RR209036L3
- RR209036L4
- MR206921L3V
- MR206921L4V
- RC200042L1V
- RC200042L2V
- RC200042L3V
- RC200042L4V
- RR209036L3V
- RR209036L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BCL2L13
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCL2L13
Cell Line Products
-
Horizon Cell Lines for BCL2L13
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BCL2L13 Gene
Localization for BCL2L13 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BCL2L13 Gene
- [Isoform 2]: Mitochondrion membrane. Single-pass membrane protein. Nucleus.
- [Isoform 1]: Nucleus.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 4 |
| cytosol | 3 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Mitochondria (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005739 | mitochondrion | IDA,NAS | 11262395 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA,IDA | 11262395 |
| GO:0031966 | mitochondrial membrane | IEA | -- |
Pathways & Interactions for BCL2L13 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Legionellosis | ||
| 2 | Mitophagy - animal | ||
| 3 | Regulation of Apoptosis by Parathyroid Hormone-related Protein | ||
Pathways by source for BCL2L13 Gene
1 BioSystems pathway for BCL2L13 Gene
2 KEGG pathways for BCL2L13 Gene
Interacting Proteins for BCL2L13 Gene
Selected Interacting proteins:
Q9BXK5-B2L13_HUMAN
ENSP00000480836
for BCL2L13 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for BCL2L13
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | IEA,NAS | 11262395 |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | NAS | 11262395 |
| GO:0042981 | regulation of apoptotic process | IEA | -- |
No data available for SIGNOR curated interactions for BCL2L13 Gene
Transcripts for BCL2L13 Gene
mRNA/cDNA for BCL2L13 Gene
- 12 REFSEQ mRNAs :
- 29 NCBI additional mRNA sequence :
- 17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000399781 999 nts (view in UCSC)
- ENST00000399782 1381 nts (view in UCSC)
- ENST00000317582 4959 nts (view in UCSC)
- ENST00000498133 2662 nts (view in UCSC)
- ENST00000464649 435 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BCL2L13 - Select products 50% OFF >
- * BCL2L13 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BCL2L13
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCL2L13
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCL2L13
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCL2L13
- Browse OriGene Inhibitory RNA Products For BCL2L13
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL2L13
Clone Products
- Applied Biological Materials (abm): Clones for BCL2L13 - Select products 50% OFF >
- * BCL2L13 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206921
- MR206921
- MR206921L3
- MR206921L4
- RC200042
- RC200042L1
- RC200042L2
- RC200042L3
- RC200042L4
- RC231566
- RC231606
- RC231741
- RC231955
- RC233218
- RC233219
- RC233220
- RC233221
- RC233223
- RC233224
- RG200042
- RG231566
- RG231606
- RG231741
- RG231955
- RG233218
- RG233219
- RG233220
- RG233221
- RG233223
- RG233224
- RR209036
- RR209036L3
- RR209036L4
- MR206921L3V
- MR206921L4V
- RC200042L1V
- RC200042L2V
- RC200042L3V
- RC200042L4V
- RR209036L3V
- RR209036L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BCL2L13
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCL2L13
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | · | 14c | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: |
| ExUns: | 14d | · | 14e | · | 14f | · | 14g | · | 14h | · | 14i |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | |||||||||||
| SP7: | |||||||||||
| SP8: | |||||||||||
| SP9: | |||||||||||
| SP10: | |||||||||||
| SP11: | |||||||||||
| SP12: | |||||||||||
| SP13: | |||||||||||
| SP14: | |||||||||||
| SP15: | |||||||||||
| SP16: | |||||||||||
| SP17: |
Relevant External Links for BCL2L13 Gene
- GeneLoc Exon Structure for
- BCL2L13
Expression for BCL2L13 Gene
mRNA differential expression in normal tissues according to GTEx for BCL2L13 Gene
This gene is overexpressed in Muscle - Skeletal (x5.2).
This gene is overexpressed in Retina (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BCL2L13 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BCL2L13
SOURCE GeneReport for Unigene cluster for BCL2L13 Gene:
Hs.631672mRNA Expression by UniProt/SwissProt for BCL2L13 Gene:
Q9BXK5-B2L13_HUMAN
Tissue specificity:
Ubiquitous, with the highest levels of expression in heart, placenta and pancreas.
Evidence on tissue expression from TISSUES for BCL2L13 Gene
- Skin(4.6)
- Eye(4.6)
- Liver(4.5)
- Nervous system(4.1)
- Muscle(2.7)
- Heart(2.6)
- Lung(2.5)
- Kidney(2.4)
- Spleen(2.2)
- Blood(2.1)
Primer Products
-
OriGene qPCR primer pairs for BCL2L13
-
OriGene qPCR primer pairs and template standards for BCL2L13
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL2L13 Gene
Orthologs for BCL2L13 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BCL2L13 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | BCL2L13 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | BCL2L13 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Bcl2l13 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | BCL2L13 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | LOC689660 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | BCL2L13 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | BCL2L13 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | BCL2L13 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | bcl2l13 30 |
|
||
| Str.949 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | bcl2l13 30 31 |
|
OneToOne |
- Species where no ortholog for BCL2L13 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for BCL2L13 Gene
- ENSEMBL:
- Gene Tree for BCL2L13 (if available)
- TreeFam:
- Gene Tree for BCL2L13 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BCL2L13: view image
Paralogs for BCL2L13 Gene
(8) SIMAP similar genes for BCL2L13 Gene using alignment to 7 proteins:
- B2L13_HUMAN
- B2RB43_HUMAN
- B7Z238_HUMAN
- E9PDD6_HUMAN
- F2Z2C3_HUMAN
- H0Y3R5_HUMAN
- Q8IZP5_HUMAN
No data available for Paralogs for BCL2L13 Gene
Variants for BCL2L13 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BCL2L13 Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 777662 | Benign: not provided | 17,702,357(+) | G/T | MISSENSE_VARIANT,INTRON_VARIANT | |
| 788925 | Benign: not provided | 17,683,229(+) | T/C | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT | |
| rs2587070 | -. - | p.Ile46Argp.Ile46Thr | |||
| rs16981016 | - | p.Ile55Val | |||
| rs9306198 | - | p.Pro360Ser |
Residual Variation Intolerance Score:
65.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.00;
49.88% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BCL2L13 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BCL2L13
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL2L13 Gene
Disorders for BCL2L13 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| legionellosis |
|
|
| cat eye syndrome |
|
|
| mitochondrial complex i deficiency, nuclear type 1 |
|
|
Search BCL2L13 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BCL2L13
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for BCL2L13 Gene
Publications for BCL2L13 Gene
- Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere. (PMID: 11381032) Footz TK … McDermid HE (Genome research 2001) 2 3 4
- Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension. (PMID: 11262395) Kataoka T … Tschopp J (The Journal of biological chemistry 2001) 2 3 4
- Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation. (PMID: 26146385) Murakawa T … Otsu K (Nature communications 2015) 2 3
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
ExternalLinks
Products for BCL2L13 Gene
- Custom Antibody ServicesOriGene Antibodies for BCL2L13
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for BCL2L13
- Origene Custom Protein Services for BCL2L13
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCL2L13
- Browse OriGene Inhibitory RNA Products For BCL2L13
- OriGene qPCR primer pairs for BCL2L13
- OriGene qPCR primer pairs and template standards for BCL2L13
- OriGene CRISPR knockouts for BCL2L13
- MG206921
- MR206921
- MR206921L3
- MR206921L4
- RC200042
- RC200042L1
- RC200042L2
- RC200042L3
- RC200042L4
- RC231566
- RC231606
- RC231741
- RC231955
- RC233218
- RC233219
- RC233220
- RC233221
- RC233223
- RC233224
- RG200042
- RG231566
- RG231606
- RG231741
- RG231955
- RG233218
- RG233219
- RG233220
- RG233221
- RG233223
- RG233224
- RR209036
- RR209036L3
- RR209036L4
- MR206921L3V
- MR206921L4V
- RC200042L1V
- RC200042L2V
- RC200042L3V
- RC200042L4V
- RR209036L3V
- RR209036L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BCL2L13
- Sino Biological Human cDNA Clone for BCL2L13
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for BCL2L13
- Novus Biologicals proteins and lysates for BCL2L13
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for BCL2L13
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for BCL2L13 (AFLGC-BCL2L13)
- VectorBuilder Custom and pre-made DNA vectors for BCL2L13 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for BCL2L13 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for BCL2L13 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for BCL2L13 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for BCL2L13
- antibodies-online: Show 17 available BCL2L13 Antibodies ranked by validation data
- Compare Top BCL2L13 Antibodies
- antibodies-online: Search results for available BCL2L13 related products ranked by validation data
- antibodies-online: Show 4 available BCL2L13 Proteins ranked by validation data
- Compare Top BCL2L13 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for BCL2L13
- Search Santa Cruz Biotechnology (SCBT) for BCL2L13 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BCL2L13
- Custom Antibody ServicesProSci Antibodies for BCL2L13
- Search for BCL2L13 Proteins at ProSci
- Horizon Cell Lines for BCL2L13
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCL2L13
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCL2L13
- Search GeneCopoeia for miRNA 3'UTR Target clone products for BCL2L13
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL2L13
- Biorbyt antibodies for BCL2L13
Sources for BCL2L13 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB