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Aliases for BCL2L12 Gene

Aliases for BCL2L12 Gene

  • BCL2 Like 12 2 3 5
  • BCL2-Like 12 (Proline Rich) 2 3
  • Bcl-2 Related Proline-Rich Protein 3
  • Bcl-2-Related Proline-Rich Protein 4
  • Bcl-2-Like Protein 12 3
  • Bcl2-L-12 4
  • BPR 4

External Ids for BCL2L12 Gene

Previous GeneCards Identifiers for BCL2L12 Gene

  • GC19P050826
  • GC19P050536
  • GC19P054844
  • GC19P054860
  • GC19P050168
  • GC19P046545

Summaries for BCL2L12 Gene

Entrez Gene Summary for BCL2L12 Gene

  • This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for BCL2L12 Gene

BCL2L12 (BCL2 Like 12) is a Protein Coding gene. Among its related pathways are Regulation of Apoptosis by Parathyroid Hormone-related Protein. Gene Ontology (GO) annotations related to this gene include p53 binding.

Gene Wiki entry for BCL2L12 Gene

Additional gene information for BCL2L12 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L12 Gene

Genomics for BCL2L12 Gene

GeneHancer (GH) Regulatory Elements for BCL2L12 Gene

Promoters and enhancers for BCL2L12 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049662 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 -0.2 -183 5.4 PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF143 KLF13 IRF3 BCL2L12 SNORD35A ALDH16A1 PRR12 SNORD35B PTOV1-AS2 POLD1 NUP62 PNKP
GH19J049675 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.2 +13.1 13135 6.3 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 PRMT1 NUP62 POLD1 PRR12 IRF3 SNORD35A PTOV1-AS2 ALDH16A1 SNORD35B PNKP
GH19J049849 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.9 +186.0 186013 3.7 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 GC19M049851 PIR43463 PIR35655 PTOV1 PTOV1-AS1 PRR12 IRF3 SNRNP70 PIH1D1 SNORD35A
GH19J050649 Enhancer 1.2 Ensembl ENCODE 23.9 +984.7 984695 0.9 HDGF ATF1 ARNT YBX1 GLI4 ETS1 ZNF766 ARID2 ZNF416 ZNF143 POLD1 IRF3 NUP62 PRMT1 ENSG00000268047 SIGLEC17P BCL2L12 PTOV1 ENSG00000267808 CPT1C
GH19J049589 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -73.1 -73099 5.8 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 PRR12 NOSIP PIR34329 NUP62 POLD1 IRF3 ENSG00000268047 ALDH16A1 SNORD35A SNORD35B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BCL2L12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BCL2L12 gene promoter:
  • STAT1
  • p300
  • NF-kappaB
  • NF-kappaB1
  • p53

Genomic Locations for BCL2L12 Gene

Genomic Locations for BCL2L12 Gene
8,775 bases
Plus strand
8,775 bases
Plus strand

Genomic View for BCL2L12 Gene

Genes around BCL2L12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL2L12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL2L12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL2L12 Gene

Proteins for BCL2L12 Gene

  • Protein details for BCL2L12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bcl-2-like protein 12
    Protein Accession:
    Secondary Accessions:
    • Q3SY11
    • Q3SY13
    • Q96I96
    • Q9HB08

    Protein attributes for BCL2L12 Gene

    334 amino acids
    Molecular mass:
    36821 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BCL2L12 Gene


neXtProt entry for BCL2L12 Gene

Post-translational modifications for BCL2L12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BCL2L12 Gene

Domains & Families for BCL2L12 Gene

Gene Families for BCL2L12 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BCL2L12 Gene

Suggested Antigen Peptide Sequences for BCL2L12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Bcl-2 family.
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BCL2L12: view

Function for BCL2L12 Gene

Phenotypes From GWAS Catalog for BCL2L12 Gene

Gene Ontology (GO) - Molecular Function for BCL2L12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IEA --
genes like me logo Genes that share ontologies with BCL2L12: view
genes like me logo Genes that share phenotypes with BCL2L12: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BCL2L12 Gene

Localization for BCL2L12 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCL2L12 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BCL2L12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20837658
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with BCL2L12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BCL2L12 Gene

Pathways & Interactions for BCL2L12 Gene

genes like me logo Genes that share pathways with BCL2L12: view

Pathways by source for BCL2L12 Gene

SIGNOR curated interactions for BCL2L12 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for BCL2L12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0042981 regulation of apoptotic process IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 22262180
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA --
GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process IDA 22262180
genes like me logo Genes that share ontologies with BCL2L12: view

Drugs & Compounds for BCL2L12 Gene

No Compound Related Data Available

Transcripts for BCL2L12 Gene

Unigene Clusters for BCL2L12 Gene

BCL2-like 12 (proline rich):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L12 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP3: -
SP4: - -
SP5: - -

Relevant External Links for BCL2L12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BCL2L12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BCL2L12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BCL2L12 Gene

This gene is overexpressed in Bone (49.8) and Breast (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BCL2L12 Gene

Protein tissue co-expression partners for BCL2L12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BCL2L12 Gene:


SOURCE GeneReport for Unigene cluster for BCL2L12 Gene:


mRNA Expression by UniProt/SwissProt for BCL2L12 Gene:

Tissue specificity: Expressed mainly in breast, thymus, prostate, fetal liver, colon, placenta, pancreas, small intestine, spinal cord, kidney, and bone marrow and to a lesser extent in many other tissues. Isoform 2 is primarily expressed in skeletal muscle.

Evidence on tissue expression from TISSUES for BCL2L12 Gene

  • Liver(4.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with BCL2L12: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL2L12 Gene

Orthologs for BCL2L12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL2L12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BCL2L12 34 33
  • 98.9 (n)
(Canis familiaris)
Mammalia BCL2L12 34 33
  • 88.15 (n)
(Bos Taurus)
Mammalia BCL2L12 34 33
  • 87.2 (n)
(Rattus norvegicus)
Mammalia Bcl2l12 33
  • 82.67 (n)
(Mus musculus)
Mammalia Bcl2l12 16 34 33
  • 80.53 (n)
(Anolis carolinensis)
Reptilia BCL2L12 34
  • 31 (a)
(Danio rerio)
Actinopterygii BCL2L12 34
  • 24 (a)
Species where no ortholog for BCL2L12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCL2L12 Gene

Gene Tree for BCL2L12 (if available)
Gene Tree for BCL2L12 (if available)
Evolutionary constrained regions (ECRs) for BCL2L12: view image

Paralogs for BCL2L12 Gene Pseudogenes for BCL2L12 Gene

genes like me logo Genes that share paralogs with BCL2L12: view

No data available for Paralogs for BCL2L12 Gene

Variants for BCL2L12 Gene

Sequence variations from dbSNP and Humsavar for BCL2L12 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1057519880 likely-pathogenic, Malignant melanoma of skin, Squamous cell carcinoma of the skin 49,665,875(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000060931 -- 49,665,657(+) G/A 5_prime_UTR_variant, non_coding_transcript_variant
rs1000090313 -- 49,665,715(+) C/G 5_prime_UTR_variant, non_coding_transcript_variant
rs1000505753 -- 49,663,635(+) A/G upstream_transcript_variant
rs1001002761 -- 49,671,561(+) C/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BCL2L12 Gene

Variant ID Type Subtype PubMed ID
nsv1160655 CNV deletion 26073780
nsv469715 CNV gain+loss 16826518
nsv470150 CNV gain 18288195
nsv817854 CNV gain 17921354
nsv828578 CNV loss 20364138
nsv833864 CNV gain 17160897
nsv833865 CNV gain+loss 17160897
nsv953600 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for BCL2L12 Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.82; 58.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BCL2L12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL2L12 Gene

Disorders for BCL2L12 Gene

Additional Disease Information for BCL2L12

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for BCL2L12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BCL2L12 Gene

Publications for BCL2L12 Gene

  1. Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family. (PMID: 11401436) Scorilas A … Diamandis EP (Genomics 2001) 3 4 22 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PMID: 20855536) Kelly JL … Cerhan JR (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
  4. Molecular analysis and prognostic impact of the novel apoptotic gene BCL2L12 in gastric cancer. (PMID: 19903463) Florou D … Scorilas A (Biochemical and biophysical research communications 2010) 3 22 58
  5. What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator. (PMID: 18769159) Stegh AH … DePinho RA (Cell cycle (Georgetown, Tex.) 2008) 3 22 58

Products for BCL2L12 Gene

Sources for BCL2L12 Gene

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