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Aliases for BCL2L11 Gene

Aliases for BCL2L11 Gene

  • BCL2 Like 11 2 3 5
  • BCL2-Like 11 (Apoptosis Facilitator) 2 3
  • BIM 3 4
  • Bcl-2 Interacting Mediator Of Cell Death 3
  • Bcl2-Interacting Mediator Of Cell Death 4
  • Bcl-2-Related Ovarian Death Agonist 3
  • Bcl-2 Interacting Protein Bim 3
  • Bcl-2-Like Protein 11 3
  • Bcl2-L-11 4
  • BAM 3
  • BOD 3

External Ids for BCL2L11 Gene

Previous GeneCards Identifiers for BCL2L11 Gene

  • GC02P109111
  • GC02P109802
  • GC02P111785
  • GC02P111976
  • GC02P111597
  • GC02P111876
  • GC02P104757

Summaries for BCL2L11 Gene

Entrez Gene Summary for BCL2L11 Gene

  • The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]

CIViC summary for BCL2L11 Gene

GeneCards Summary for BCL2L11 Gene

BCL2L11 (BCL2 Like 11) is a Protein Coding gene. Diseases associated with BCL2L11 include Ocular Hyperemia and Spastic Hemiplegia. Among its related pathways are Apoptosis Modulation and Signaling and Oncogenic MAPK signaling. Gene Ontology (GO) annotations related to this gene include microtubule binding.

UniProtKB/Swiss-Prot for BCL2L11 Gene

  • Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.

Tocris Summary for BCL2L11 Gene

  • Bcl-2 family proteins contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four Bcl-2 homology domains. Certain members (Bcl-2, Bcl-XL and Mcl-1) are antiapoptotic, whilst others (Bax, Bak, Bok) are proapoptotic.

Gene Wiki entry for BCL2L11 Gene

Additional gene information for BCL2L11 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L11 Gene

Genomics for BCL2L11 Gene

GeneHancer (GH) Regulatory Elements for BCL2L11 Gene

Promoters and enhancers for BCL2L11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I111120 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 556.8 +2.6 2618 4.3 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 BCL2L11 PIR45517 ANAPC1 RGPD6 GC02M111153 ACOXL
GH02I111117 Promoter/Enhancer 1.4 Ensembl ENCODE 550.8 -1.5 -1521 2 MLX ARID4B SIN3A ZNF48 ZNF143 SP5 MXD4 MIER2 REST KAT8 GC02M111122 PIR57884 BCL2L11 ACOXL-AS1 ACOXL
GH02I111119 Enhancer 0.4 ENCODE 556.9 +0.2 246 0.4 ZBTB33 EZH2 BCL2L11 GC02M111122 PIR57884 ACOXL-AS1 ACOXL
GH02I111121 Enhancer 0.4 ENCODE 550.8 -0.2 -219 0.2 SUZ12 ZBTB33 EZH2 GC02M111122 PIR57884 BCL2L11 ACOXL-AS1 ACOXL
GH02I111697 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +579.7 579701 2.4 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 E2F8 GC02M111609 ANAPC1 RPS20P11 TMEM87B ACOXL-AS1 BCL2L11 PIR34777 GC02P113656
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BCL2L11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BCL2L11 gene promoter:

Genomic Locations for BCL2L11 Gene

Genomic Locations for BCL2L11 Gene
49,070 bases
Plus strand

Genomic View for BCL2L11 Gene

Genes around BCL2L11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL2L11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL2L11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL2L11 Gene

Proteins for BCL2L11 Gene

  • Protein details for BCL2L11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bcl-2-like protein 11
    Protein Accession:
    Secondary Accessions:
    • A8K2W2
    • O43522
    • Q0MSE7
    • Q0MSE8
    • Q0MSE9
    • Q53R28
    • Q6JTU6
    • Q6T851
    • Q6TE14
    • Q6TE15
    • Q6TE16
    • Q6V402
    • Q8WYL6
    • Q8WYL7
    • Q8WYL8
    • Q8WYL9
    • Q8WYM0
    • Q8WYM1

    Protein attributes for BCL2L11 Gene

    198 amino acids
    Molecular mass:
    22171 Da
    Quaternary structure:
    • Forms heterodimers with a number of antiapoptotic Bcl-2 proteins, including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1, BHRF1, and BCL2L2/BCLW (PubMed:11997495, PubMed:27013495, PubMed:18812174). Isoform BimS and isoform Bim-alpha3 interact with BAX; this interaction may lead to BAX activation through conformational change (PubMed:11997495). Does not heterodimerize with proapoptotic proteins such as BAD, BOK or BAK. Identified in a complex containing BCL2L11, DYNLL1 and BCL2L1 isoform Bcl-X(L); BH3 integrity is required for BCL2L1-binding. Interacts with YWHAZ. When phosphorylated, interacts with TRIM2; this interaction is associated with ubiquitination and degradation (PubMed:21478148). Interacts with MCL1; may sequester BCL2L11 to prevent its pro-apoptotic activity (PubMed:27013495, PubMed:17389404). When phosphorylated, isoform BimEL interacts with USP27X; this interaction leads to BCL2L11 deubiquitination and stabilization (PubMed:27013495).

    Three dimensional structures from OCA and Proteopedia for BCL2L11 Gene

neXtProt entry for BCL2L11 Gene

Post-translational modifications for BCL2L11 Gene

  • Phosphorylation at Ser-69 by MAPK1/MAPK3 leads to interaction with TRIM2 and polyubiquitination, followed by proteasomal degradation (PubMed:15486195, PubMed:21478148). Deubiquitination catalyzed by USP27X stabilizes the protein (By similarity).
  • Ubiquitination by TRIM2 following phosphorylation by MAPK1/MAPK3 leads to proteasomal degradation. Conversely, deubiquitination catalyzed by USP27X stabilizes the protein.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for BCL2L11 (BIM Long (BIM L))
  • Abcam antibodies for BCL2L11
  • Santa Cruz Biotechnology (SCBT) Antibodies for BCL2L11

Protein Products

  • Cloud-Clone Corp. Proteins for BCL2L11
  • Abcam proteins for BCL2L11

No data available for DME Specific Peptides for BCL2L11 Gene

Domains & Families for BCL2L11 Gene

Gene Families for BCL2L11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for BCL2L11 Gene

Suggested Antigen Peptide Sequences for BCL2L11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The BH3 motif is required for interaction with Bcl-2 proteins and cytotoxicity.
  • Belongs to the Bcl-2 family.
  • The BH3 motif is required for interaction with Bcl-2 proteins and cytotoxicity.
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BCL2L11: view

Function for BCL2L11 Gene

Molecular function for BCL2L11 Gene

UniProtKB/Swiss-Prot Function:
Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
UniProtKB/Swiss-Prot Induction:
By ER stress in a DDIT3/CHOP-dependent manner.

Phenotypes From GWAS Catalog for BCL2L11 Gene

Gene Ontology (GO) - Molecular Function for BCL2L11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14596824
GO:0008017 microtubule binding IBA --
GO:0019901 protein kinase binding IEA --
GO:0046982 protein heterodimerization activity IEA --
GO:0070840 dynein complex binding IEA --
genes like me logo Genes that share ontologies with BCL2L11: view
genes like me logo Genes that share phenotypes with BCL2L11: view

Animal Models for BCL2L11 Gene

MGI Knock Outs for BCL2L11:

Animal Model Products

miRNA for BCL2L11 Gene

miRTarBase miRNAs that target BCL2L11

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCL2L11 Gene

Localization for BCL2L11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL2L11 Gene

Endomembrane system; Peripheral membrane protein. Note=Associated with intracytoplasmic membranes. {ECO:0000250}.
Isoform BimEL: Mitochondrion. Note=Translocates from microtubules to mitochondria on loss of cell adherence.
Isoform BimL: Mitochondrion.
Isoform BimS: Mitochondrion.
Isoform Bim-alpha1: Mitochondrion.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCL2L11 gene
Compartment Confidence
mitochondrion 5
cytosol 5
nucleus 4
cytoskeleton 3
plasma membrane 2
extracellular 2
endoplasmic reticulum 2
lysosome 1

Gene Ontology (GO) - Cellular Components for BCL2L11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IBA --
GO:0005741 mitochondrial outer membrane TAS --
GO:0005829 cytosol TAS --
GO:0005868 cytoplasmic dynein complex IEA --
genes like me logo Genes that share ontologies with BCL2L11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BCL2L11 Gene

Pathways & Interactions for BCL2L11 Gene

genes like me logo Genes that share pathways with BCL2L11: view

SIGNOR curated interactions for BCL2L11 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BCL2L11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001776 leukocyte homeostasis IEA --
GO:0001782 B cell homeostasis IEA --
GO:0001783 B cell apoptotic process IEA --
GO:0001822 kidney development IEA --
genes like me logo Genes that share ontologies with BCL2L11: view

Drugs & Compounds for BCL2L11 Gene

(25) Drugs for BCL2L11 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
imatinib Approved Pharma Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 0

(12) Additional Compounds for BCL2L11 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) Tocris Compounds for BCL2L11 Gene

Compound Action Cas Number
AT 101 Downregulates Bcl-2 and Mcl-1; pro-apoptotic 90141-22-3
BAM 7 Selective Bax activator; induces Bax-mediated apoptosis 331244-89-4
SMBA 1 High affinity and selective activator of Bax 906440-37-7
TW 37 Bcl-2 inhibitor; induces apoptosis 877877-35-5
genes like me logo Genes that share compounds with BCL2L11: view

Transcripts for BCL2L11 Gene

Unigene Clusters for BCL2L11 Gene

BCL2-like 11 (apoptosis facilitator):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - -
SP7: - - - - -
SP8: - - - - - -

Relevant External Links for BCL2L11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BCL2L11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BCL2L11 Gene

Protein differential expression in normal tissues from HIPED for BCL2L11 Gene

This gene is overexpressed in Blymphocyte (30.1), Placenta (26.3), and Ovary (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BCL2L11 Gene

Protein tissue co-expression partners for BCL2L11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BCL2L11 Gene:


SOURCE GeneReport for Unigene cluster for BCL2L11 Gene:


mRNA Expression by UniProt/SwissProt for BCL2L11 Gene:

Tissue specificity: Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.

Evidence on tissue expression from TISSUES for BCL2L11 Gene

  • Blood(4.6)
  • Spleen(4.4)
  • Liver(2.6)
  • Bone marrow(2.5)
  • Intestine(2.4)
  • Lung(2.4)
  • Nervous system(2.4)
  • Lymph node(2.2)
  • Kidney(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with BCL2L11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL2L11 Gene

Orthologs for BCL2L11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL2L11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BCL2L11 34
  • 100 (a)
(Canis familiaris)
Mammalia LOC612867 33
  • 93.64 (n)
BCL2L11 34
  • 92 (a)
(Mus musculus)
Mammalia Bcl2l11 33 16 34
  • 89.35 (n)
(Rattus norvegicus)
Mammalia Bcl2l11 33
  • 88.83 (n)
(Bos Taurus)
Mammalia BCL2L11 34
  • 88 (a)
(Monodelphis domestica)
Mammalia BCL2L11 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia BCL2L11 34
  • 68 (a)
(Anolis carolinensis)
Reptilia BCL2L11 34
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bcl2l11 33
  • 60.49 (n)
Species where no ortholog for BCL2L11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BCL2L11 Gene

Gene Tree for BCL2L11 (if available)
Gene Tree for BCL2L11 (if available)

Paralogs for BCL2L11 Gene

No data available for Paralogs for BCL2L11 Gene

Variants for BCL2L11 Gene

Sequence variations from dbSNP and Humsavar for BCL2L11 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000051965 -- 111,132,891(+) T/A genic_downstream_transcript_variant, intron_variant
rs1000162427 -- 111,161,935(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000266649 -- 111,146,536(+) A/G downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000276609 -- 111,162,194(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000391173 -- 111,128,916(+) G/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BCL2L11 Gene

Variant ID Type Subtype PubMed ID
dgv4047n100 CNV loss 25217958
esv2667742 CNV deletion 23128226
esv2720516 CNV deletion 23290073
esv2759083 CNV gain+loss 17122850
esv3591978 CNV loss 21293372
nsv1149522 OTHER inversion 26484159
nsv428402 CNV loss 18775914
nsv521956 CNV loss 19592680
nsv582699 CNV loss 21841781
nsv829618 CNV gain 20364138
nsv829619 CNV loss 20364138
nsv834331 CNV loss 17160897
nsv963952 CNV deletion 23825009

Variation tolerance for BCL2L11 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BCL2L11 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL2L11 Gene

Disorders for BCL2L11 Gene

MalaCards: The human disease database

(7) MalaCards diseases for BCL2L11 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ocular hyperemia
  • hyperemia eye
spastic hemiplegia
  • congenital hemiplegia
autoimmune lymphoproliferative syndrome
  • css
burkitt lymphoma
  • bl
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for BCL2L11

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with BCL2L11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCL2L11 Gene

Publications for BCL2L11 Gene

  1. Over-expression of Bim alpha3, a novel isoform of human Bim, result in cell apoptosis. (PMID: 15147734) Chen JZ … Mao YM (The international journal of biochemistry & cell biology 2004) 3 4 22 58
  2. Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim. (PMID: 12019181) Liu JW … Tang DG (Cancer research 2002) 3 4 22 58
  3. Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family. (PMID: 11734221) U M … Yamada M (FEBS letters 2001) 3 4 22 58
  4. Bim: a novel member of the Bcl-2 family that promotes apoptosis. (PMID: 9430630) O'Connor L … Huang DC (The EMBO journal 1998) 2 3 4 58
  5. The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. (PMID: 27013495) Weber A … Häcker G (EMBO reports 2016) 3 4 58

Products for BCL2L11 Gene

Sources for BCL2L11 Gene

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