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The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and t... See more...
Aliases for BCL2L11 Gene
Aliases for BCL2L11 Gene
External Ids for BCL2L11 Gene
- HGNC: 994
- NCBI Entrez Gene: 10018
- Ensembl: ENSG00000153094
- OMIM®: 603827
- UniProtKB/Swiss-Prot: O43521
Previous GeneCards Identifiers for BCL2L11 Gene
- GC02P109111
- GC02P109802
- GC02P111785
- GC02P111976
- GC02P111597
- GC02P111876
- GC02P104757
Summaries for BCL2L11 Gene
-
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]
GeneCards Summary for BCL2L11 Gene
BCL2L11 (BCL2 Like 11) is a Protein Coding gene. Diseases associated with BCL2L11 include Interleukin-7 Receptor Alpha Deficiency and Autoimmune Lymphoproliferative Syndrome. Among its related pathways are Apoptosis Modulation and Signaling and Apoptosis and survival Caspase cascade. Gene Ontology (GO) annotations related to this gene include microtubule binding. An important paralog of this gene is MEI1.
UniProtKB/Swiss-Prot Summary for BCL2L11 Gene
-
Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
-
Bcl-2 family proteins contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four Bcl-2 homology domains. Certain members (Bcl-2, Bcl-XL and Mcl-1) are antiapoptotic, whilst others (Bax, Bak, Bok) are proapoptotic.
Additional gene information for BCL2L11 Gene
- HGNC (994)
- NCBI Entrez Gene (10018)
- Ensembl (ENSG00000153094)
- OMIM® (603827)
- UniProtKB/Swiss-Prot (O43521)
- Open Targets Platform(ENSG00000153094)
- Monarch Initiative
- Alliance of Genome Resources
- Search for BCL2L11 at DataMed
- Search for BCL2L11 at HumanCyc
No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BCL2L11 Gene
Genomics for BCL2L11 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BCL2L11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BCL2L11 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BCL2L11
- Top Transcription factor binding sites by QIAGEN in the BCL2L11 gene promoter:
-
- AML1a
- C/EBPalpha
- CHOP-10
- Chx10
- CREB
- deltaCREB
- Pax-5
- RSRFC4
Genomic Locations for BCL2L11 Gene
Latest Assembly
- chr2:111,119,378-111,168,445
- (GRCh38/hg38)
- Size:
- 49,068 bases
- Orientation:
- Plus strand
Previous Assembly
- chr2:111,878,491-111,926,022
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 47,532 bases
- Orientation:
- Plus strand
Genomic View for BCL2L11 Gene
Genes around BCL2L11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q13 by HGNC
- 2q13 by Entrez Gene
- 2q13 by Ensembl
BCL2L11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BCL2L11 Gene
Proteins for BCL2L11 Gene
-
Protein details for BCL2L11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43521-B2L11_HUMAN
- Recommended name:
- Bcl-2-like protein 11
- Protein Accession:
- O43521
- A8K2W2
- O43522
- Q0MSE7
- Q0MSE8
- Q0MSE9
- Q53R28
- Q6JTU6
- Q6T851
- Q6TE14
- Q6TE15
- Q6TE16
- Q6V402
- Q8WYL6
- Q8WYL7
- Q8WYL8
- Q8WYL9
- Q8WYM0
- Q8WYM1
Protein attributes for BCL2L11 Gene
- Size:
- 198 amino acids
- Molecular mass:
- 22171 Da
- Quaternary structure:
-
- Forms heterodimers with a number of antiapoptotic Bcl-2 proteins, including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1, BHRF1, and BCL2L2/BCLW (PubMed:11997495, PubMed:27013495, PubMed:18812174). Isoform BimS and isoform Bim-alpha3 interact with BAX; this interaction may lead to BAX activation through conformational change (PubMed:11997495). Does not heterodimerize with proapoptotic proteins such as BAD, BOK or BAK. Identified in a complex containing BCL2L11, DYNLL1 and BCL2L1 isoform Bcl-X(L); BH3 integrity is required for BCL2L1-binding. Interacts with YWHAZ. When phosphorylated, interacts with TRIM2; this interaction is associated with ubiquitination and degradation (PubMed:21478148). Interacts with MCL1; may sequester BCL2L11 to prevent its pro-apoptotic activity (PubMed:27013495, PubMed:17389404). When phosphorylated, isoform BimEL interacts with USP27X; this interaction leads to BCL2L11 deubiquitination and stabilization (PubMed:27013495). Interacts with GIMAP5 (PubMed:16509771).
Three dimensional structures from OCA and Proteopedia for BCL2L11 Gene
Protein Expression for BCL2L11 Gene
Post-translational modifications for BCL2L11 Gene
- Phosphorylation at Ser-69 by MAPK1/MAPK3 leads to interaction with TRIM2 and polyubiquitination, followed by proteasomal degradation (PubMed:15486195, PubMed:21478148). Deubiquitination catalyzed by USP27X stabilizes the protein (By similarity).
- Ubiquitination by TRIM2 following phosphorylation by MAPK1/MAPK3 leads to proteasomal degradation. Conversely, deubiquitination catalyzed by USP27X stabilizes the protein.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for BCL2L11 Gene
- ENSEMBL proteins:
-
- ENSP00000411870
- ENSP00000338374
- ENSP00000350398
- ENSP00000309226
- ENSP00000376943
- ENSP00000481030
- ENSP00000481423
- ENSP00000479714
- ENSP00000478133
- ENSP00000481652
- ENSP00000482175
- ENSP00000484360
- ENSP00000376941
- ENSP00000401662
- ENSP00000384641
- ENSP00000354879
- ENSP00000393781
- ENSP00000403727
- ENSP00000412892
- ENSP00000391292
- ENSP00000394640
- ENSP00000411137
- ENSP00000389225
- O43521.193
- REFSEQ proteins:
-
- XP_005263607.1
- XP_005263608.1
- XP_005263609.1
- XP_005263610.1
- XP_005263611.1
- XP_005263612.1
- XP_005263613.1
- XP_005263614.1
- XP_005263616.1
- XP_005263618.1
- XP_011508763.1
- XP_011508766.1
- XP_016858590.1
- XP_016858591.1
- NP_001191035.1
- NP_001191036.1
- NP_001191037.1
- NP_001191038.1
- NP_001191039.1
- NP_001191040.1
- NP_001191041.1
- NP_001191042.1
- NP_006529.1
- NP_619527.1
- NP_619528.1
- NP_619529.1
- NP_619530.1
- NP_619531.1
- NP_619532.1
- NP_619533.1
- NP_996885.1
- NP_996886.1
Antibodies for research
- LifeSpan BioSciences BCL2L11 / BIM Antibody (LS-B1337) and BCL2L11 / BIM Antibody (LS-B10712)
- RayBiotech Rabbit anti-Bim and Rabbit Anti-Human BIM
- GeneTex Anti-Bim antibody [SU0318] and Anti-Bim antibody [GT1234]
- NSJ Bioreagents Bim Antibody
-
Custom Antibody ServicesOriGene Antibodies for BCL2L11
- Novus Biologicals Antibodies for BCL2L11
-
Abcam antibodies for BCL2L11
- Invitrogen Antibodies for BCL2L11 (AFLGC-BCL2L11)
- antibodies-online: Show 150 available BIM Antibodies ranked by validation data
- Compare Top BIM Antibodies
-
Recommended
- 336 WB Antibodies (anti-human)
- 25 IHC Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 227 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 16 IHC Antibodies (anti-mouse)
- 4 IF Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 210 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 13 IHC Antibodies (anti-rat)
- 2 IF Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for BCL2L11
- BCL2-like 11 (apoptosis facilitator) [2065]
- BCL2-like 11 (apoptosis facilitator) [3405]
- BCL2-like 11 (apoptosis facilitator) [7421]
- BCL2-like 11 (apoptosis facilitator) [18-657]
- BCL2-like 11 (apoptosis facilitator) [45-330]
- BCL2-like 11 (apoptosis facilitator) [79-398]
- BCL2-like 11 (apoptosis facilitator) [PM-4819]
- BCL2-like 11 (apoptosis facilitator) [PM-4821]
-
Santa Cruz Biotechnology (SCBT) Antibodies for BCL2L11
- Sino Biological Antibodies for BCL2L11
Protein products for research
- G Biosciences Human Bcl-2-like Protein 11/BIML, Liquid
-
OriGene Purified Proteins for BCL2L11
- Search Origene for MassSpec and Protein Over-expression Lysates for BCL2L11
- Origene Custom Protein Services for BCL2L11
- Sino Biological Recombinant Proteins for BCL2L11
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for BCL2L11
- antibodies-online: Show 15 available BIM Proteins ranked by validation data
- Compare Top BIM Proteins
-
Abcam proteins for BCL2L11
Assay products for research
- G Biosciences Immunotag™ Human Bcl2L11 (Bcl-2 Like Protein 11) ELISA
- Novus Biologicals ELISA Kits for BCL2L11
-
Boster Bio ELISA Kits for BCL2L11
No data available for DME Specific Peptides for BCL2L11 Gene
Domains & Families for BCL2L11 Gene
Gene Families for BCL2L11 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transporters
Protein Domains for BCL2L11 Gene
- InterPro:
- Blocks:
-
- Bim, N-terminal
Suggested Antigen Peptide Sequences for BCL2L11 Gene
- GenScript: Design optimal peptide antigens:
-
- Bcl2-interacting mediator of cell death (B2L11_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O43521UniProtKB/Swiss-Prot:
B2L11_HUMAN :- The BH3 motif is required for interaction with Bcl-2 proteins and cytotoxicity.
- Belongs to the Bcl-2 family.
- Domain:
-
- The BH3 motif is required for interaction with Bcl-2 proteins and cytotoxicity.
- Family:
-
- Belongs to the Bcl-2 family.
Function for BCL2L11 Gene
Molecular function for BCL2L11 Gene
- UniProtKB/Swiss-Prot Function:
- Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
- UniProtKB/Swiss-Prot Induction:
- By ER stress in a DDIT3/CHOP-dependent manner.
Phenotypes From GWAS Catalog for BCL2L11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 14596824 |
| GO:0008017 | microtubule binding | IEA | -- |
| GO:0019901 | protein kinase binding | IEA | -- |
Phenotypes for BCL2L11 Gene
- MGI mutant phenotypes for BCL2L11:
-
inferred from 17 alleles
- normal phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- immune system phenotype
- mortality/aging
- renal/urinary system phenotype
- hematopoietic system phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- limbs/digits/tail phenotype
- hearing/vestibular/ear phenotype
- integument phenotype
- pigmentation phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for BCL2L11:
-
- Increased vaccinia virus (VACV) infection
- Increased G1 DNA content
- Decreased viability
- no effect
- Decreased shRNA abundance (Z-score < -2)
- Increased IL-8 secretion
- Increased shRNA abundance (Z-score > 2)
- Increased viability with MLN4924 (a NAE inhibitor)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- G0/1 arrest
Animal Models for BCL2L11 Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for BCL2L11
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for BCL2L11 - Starting at $85 >
- * BCL2L11 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for BCL2L11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCL2L11
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCL2L11
miRNA for BCL2L11 Gene
- miRTarBase miRNAs that target BCL2L11
-
- hsa-miR-222-3p (MIRT000134)
- hsa-miR-221-3p (MIRT000140)
- hsa-miR-195-5p (MIRT000785)
- hsa-miR-17-5p (MIRT001206)
- hsa-miR-25-3p (MIRT003413)
- hsa-miR-32-5p (MIRT003739)
- rno-miR-221-3p (MIRT004033)
- rno-miR-222-3p (MIRT004034)
- hsa-miR-19a-3p (MIRT004452)
- hsa-miR-19b-3p (MIRT004523)
- hsa-miR-20a-5p (MIRT004570)
- hsa-miR-106b-5p (MIRT004571)
- hsa-miR-93-5p (MIRT004572)
- mmu-miR-29b-3p (MIRT005637)
- hsa-miR-181a-5p (MIRT005767)
- mmu-miR-24-3p (MIRT006093)
- hsa-miR-92a-3p (MIRT006148)
- hsa-miR-10b-5p (MIRT006366)
- mmu-miR-10a-5p (MIRT006700)
- mmu-miR-106b-5p (MIRT006701)
- mmu-miR-17-5p (MIRT006702)
- hsa-miR-494-3p (MIRT006981)
- mmu-miR-541-5p (MIRT008147)
- hsa-miR-340-5p (MIRT019539)
- hsa-miR-375 (MIRT019675)
- hsa-miR-24-3p (MIRT030547)
- hsa-let-7a-5p (MIRT052551)
- hsa-miR-301a-3p (MIRT054105)
- rno-miR-24-3p (MIRT054361)
- hsa-miR-214-3p (MIRT054876)
- hsa-miR-363-3p (MIRT084532)
- hsa-miR-367-3p (MIRT084533)
- hsa-miR-92b-3p (MIRT084534)
- hsa-miR-3161 (MIRT084536)
- hsa-miR-4517 (MIRT084539)
- hsa-miR-4698 (MIRT084549)
- hsa-miR-8063 (MIRT084553)
- hsa-miR-148a-3p (MIRT084562)
- hsa-miR-105-5p (MIRT084572)
- hsa-miR-187-5p (MIRT084573)
- hsa-miR-570-3p (MIRT084575)
- hsa-miR-548v (MIRT084576)
- hsa-miR-5589-5p (MIRT084578)
- hsa-miR-6508-5p (MIRT084579)
- hsa-miR-7853-5p (MIRT084580)
- hsa-miR-8067 (MIRT084581)
- hsa-miR-125b-2-3p (MIRT084583)
- hsa-miR-301b-3p (MIRT084586)
- hsa-miR-16-1-3p (MIRT084599)
- hsa-miR-10a-5p (MIRT084600)
- hsa-miR-339-5p (MIRT084601)
- hsa-miR-4275 (MIRT084602)
- hsa-miR-3688-5p (MIRT084603)
- hsa-miR-4796-3p (MIRT084604)
- hsa-miR-708-3p (MIRT118987)
- hsa-miR-4460 (MIRT118988)
- hsa-miR-203b-5p (MIRT118991)
- hsa-miR-5587-5p (MIRT118993)
- hsa-miR-6718-5p (MIRT118994)
- hsa-miR-192-5p (MIRT155023)
- hsa-miR-215-5p (MIRT155024)
- hsa-miR-4760-3p (MIRT155044)
- hsa-miR-3609 (MIRT297338)
- hsa-miR-548ah-5p (MIRT297340)
- hsa-miR-92a-2-5p (MIRT388460)
- hsa-miR-9-5p (MIRT438753)
- hsa-miR-4762-3p (MIRT480908)
- hsa-miR-3192-3p (MIRT480909)
- hsa-miR-4502 (MIRT480910)
- hsa-miR-6874-3p (MIRT480911)
- hsa-miR-148b-5p (MIRT480912)
- hsa-miR-140-5p (MIRT480913)
- hsa-miR-101-3p (MIRT480914)
- hsa-miR-144-3p (MIRT480915)
- hsa-miR-599 (MIRT480916)
- hsa-miR-8057 (MIRT480917)
- hsa-miR-4284 (MIRT480918)
- hsa-miR-5583-3p (MIRT480919)
- hsa-miR-3120-3p (MIRT494535)
- hsa-miR-20b-5p (MIRT494536)
- hsa-miR-519d-3p (MIRT494537)
- hsa-miR-526b-3p (MIRT494538)
- hsa-miR-106a-5p (MIRT494539)
- hsa-miR-7848-3p (MIRT549221)
- hsa-miR-504-5p (MIRT549222)
- hsa-miR-8064 (MIRT549223)
- mmu-miR-362-3p (MIRT584589)
- mmu-miR-329-3p (MIRT584590)
- mmu-miR-1941-5p (MIRT584591)
- mmu-miR-344-3p (MIRT584592)
- mmu-miR-344c-3p (MIRT584593)
- mmu-miR-878-5p (MIRT584594)
- mmu-miR-3071-5p (MIRT590530)
- mmu-miR-338-5p (MIRT590531)
- mmu-miR-500-3p (MIRT590532)
- mmu-miR-501-3p (MIRT590533)
- mmu-miR-466q (MIRT590534)
- mmu-miR-466i-3p (MIRT591967)
- mmu-miR-654-3p (MIRT592814)
- mmu-miR-9-5p (MIRT592815)
- mmu-miR-1188-5p (MIRT592816)
- mmu-miR-466l-5p (MIRT592817)
- mmu-miR-466k (MIRT592818)
- mmu-miR-466i-5p (MIRT592819)
- mmu-miR-466d-5p (MIRT592820)
- hsa-miR-181b-5p (MIRT733657)
- hsa-miR-34a-5p (MIRT733972)
- hsa-miR-423-3p (MIRT734110)
- hsa-miR-488-3p (MIRT735430)
- hsa-miR-1207-5p (MIRT761255)
- hsa-miR-1233-5p (MIRT761467)
- hsa-miR-1266-5p (MIRT761745)
- hsa-miR-200b-3p (MIRT763661)
- hsa-miR-200c-3p (MIRT763670)
- hsa-miR-2053 (MIRT763719)
- hsa-miR-208a-3p (MIRT763737)
- hsa-miR-208b-3p (MIRT763744)
- hsa-miR-30a-3p (MIRT764551)
- hsa-miR-30c-1-3p (MIRT764647)
- hsa-miR-30c-2-3p (MIRT764692)
- hsa-miR-30d-3p (MIRT764740)
- hsa-miR-30e-3p (MIRT764745)
- hsa-miR-3617-5p (MIRT766097)
- hsa-miR-3664-3p (MIRT766465)
- hsa-miR-374c-5p (MIRT767338)
- hsa-miR-3942-3p (MIRT767856)
- hsa-miR-429 (MIRT768484)
- hsa-miR-4424 (MIRT768875)
- hsa-miR-4433a-3p (MIRT768982)
- hsa-miR-4459 (MIRT769239)
- hsa-miR-4481 (MIRT769583)
- hsa-miR-4518 (MIRT769938)
- hsa-miR-4524a-3p (MIRT769998)
- hsa-miR-4524b-3p (MIRT770030)
- hsa-miR-4653-3p (MIRT770750)
- hsa-miR-4745-5p (MIRT771902)
- hsa-miR-4763-3p (MIRT772011)
- hsa-miR-499a-5p (MIRT772882)
- hsa-miR-5003-3p (MIRT772929)
- hsa-miR-5692a (MIRT775016)
- hsa-miR-569 (MIRT775197)
- hsa-miR-641 (MIRT776155)
- hsa-miR-655-3p (MIRT777297)
- hsa-miR-6731-5p (MIRT777975)
- hsa-miR-6778-5p (MIRT778849)
- hsa-miR-6788-5p (MIRT779224)
- hsa-miR-6792-5p (MIRT779314)
- hsa-miR-6878-5p (MIRT780768)
- hsa-miR-8085 (MIRT782418)
- hsa-miR-92b-5p (MIRT782749)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCL2L11
- Browse OriGene Inhibitory RNA Products For BCL2L11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL2L11
Clone products for research
- Applied Biological Materials (abm): Clones for BCL2L11 - Starting at $45 >
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- MG201922
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- MR201922L3
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- MR223081L3
- MR223081L4
- MR224664
- MR224664L3
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- MR227799
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- RC207559
- RC207559L1
- RC207559L2
- RC207559L3
- RC207559L4
- RC212528
- RC212528L3
- RC212528L4
- RC224938
- RC224938L3
- RC224938L4
- RC231512
- RC231548
- RC231549
- RC231563
- RC231564
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BCL2L11
- Addgene plasmids for BCL2L11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCL2L11
Cell Lines for research
-
Horizon Cell Lines for BCL2L11
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCL2L11 Gene
Localization for BCL2L11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BCL2L11 Gene
- Endomembrane system. Peripheral membrane protein. Note=Associated with intracytoplasmic membranes. {ECO:0000250}.
- [Isoform BimEL]: Mitochondrion. Note=Translocates from microtubules to mitochondria on loss of cell adherence.
- [Isoform BimL]: Mitochondrion.
- [Isoform BimS]: Mitochondrion.
- [Isoform Bim-alpha1]: Mitochondrion.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| cytosol | 5 |
| nucleus | 4 |
| plasma membrane | 3 |
| extracellular | 3 |
| cytoskeleton | 3 |
| endoplasmic reticulum | 3 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Mitochondria (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IBA | 21873635 |
| GO:0005741 | mitochondrial outer membrane | TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005874 | microtubule | IDA | -- |
Pathways & Interactions for BCL2L11 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of BH3-only proteins | ||
| 2 | Apoptosis Modulation and Signaling |
.41
|
.31
|
| 3 | p75 NTR receptor-mediated signalling | ||
| 4 | ErbB signaling pathway | ||
| 5 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
|
Mitochondrial Apoptosis
.85
|
Pathways by source for BCL2L11 Gene
1 Sino Biological pathway for BCL2L11 Gene
10 BioSystems pathways for BCL2L11 Gene
17 Reactome pathways for BCL2L11 Gene
10 KEGG pathways for BCL2L11 Gene
3 GeneGo (Thomson Reuters) pathways for BCL2L11 Gene
- Apoptosis and survival FAS signaling cascades
- Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins
- Signal transduction AKT signaling
2 R&D Systems pathways for BCL2L11 Gene
4 Qiagen pathways for BCL2L11 Gene
- 14-3-3 and Regulation of BAD Activity
- Cellular Apoptosis Pathway
- Mitochondrial Apoptosis
- Molecular Mechanisms of Cancer
1 Cell Signaling Technology pathway for BCL2L11 Gene
2 GeneTex pathways for BCL2L11 Gene
Interacting Proteins for BCL2L11 Gene
Selected Interacting proteins:
O43521-B2L11_HUMAN
ENSP00000376943
for BCL2L11 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for BCL2L11
SIGNOR curated interactions for BCL2L11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0001776 | leukocyte homeostasis | IEA | -- |
| GO:0001782 | B cell homeostasis | IEA | -- |
| GO:0001783 | B cell apoptotic process | IEA | -- |
| GO:0001822 | kidney development | IEA | -- |
Drugs & Compounds for BCL2L11 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| imatinib | Approved | Pharma | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 0 | ||
| corticosteroids | Pharma | 0 | ||||
| BAM7 | Pharma | BAX activator,direct and selective, Selective Bax activator; induces Bax-mediated apoptosis | 0 | |||
| TW 37 | Pharma | Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1, Bcl-2 inhibitor; induces apoptosis | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| AT 101 |
|
90141-22-3 |
|
|
||
| SMBA 1 |
|
906440-37-7 |
|
|
(4) Tocris Compounds for BCL2L11 Gene
Drug products for research
- G Biosciences Human Bcl-2-like Protein 11/BIML, Liquid
Transcripts for BCL2L11 Gene
mRNA/cDNA for BCL2L11 Gene
- 18 REFSEQ mRNAs :
- 30 NCBI additional mRNA sequence :
- 23 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000308659 1522 nts (view in UCSC)
- ENST00000337565 720 nts (view in UCSC)
- ENST00000357757 947 nts (view in UCSC)
- ENST00000361493 443 nts (view in UCSC)
- ENST00000393252 482 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for BCL2L11 - Starting at $85 >
- * BCL2L11 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for BCL2L11
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCL2L11
- Browse OriGene Inhibitory RNA Products For BCL2L11
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Clone products for research
- Applied Biological Materials (abm): Clones for BCL2L11 - Starting at $45 >
- * BCL2L11 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BCL2L11
- Addgene plasmids for BCL2L11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCL2L11
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||
| SP3: | - | - | |||||||||||||||||
| SP4: | - | - | |||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||
| SP6: | |||||||||||||||||||
| SP7: | - | - | - | - | - | ||||||||||||||
| SP8: | - | - | - | - | - | - |
Relevant External Links for BCL2L11 Gene
- GeneLoc Exon Structure for
- BCL2L11
Expression for BCL2L11 Gene
This gene is overexpressed in Blymphocyte (30.1), Placenta (26.3), and Ovary (11.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BCL2L11 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BCL2L11
SOURCE GeneReport for Unigene cluster for BCL2L11 Gene:
Hs.469658mRNA Expression by UniProt/SwissProt for BCL2L11 Gene:
O43521-B2L11_HUMAN
Tissue specificity:
Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.
Evidence on tissue expression from TISSUES for BCL2L11 Gene
- Blood(4.6)
- Spleen(4.6)
- Liver(3.2)
- Bone marrow(3)
- Lymph node(2.9)
- Intestine(2.9)
- Kidney(2.8)
- Lung(2.7)
- Nervous system(2.7)
- Pancreas(2.5)
- Skin(2.5)
- Muscle(2.5)
- Heart(2.5)
- Thyroid gland(2.4)
- Stomach(2.2)
- Adrenal gland(2.2)
Primer products for research
-
OriGene qPCR primer pairs for BCL2L11
-
OriGene qPCR primer pairs and template standards for BCL2L11
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL2L11 Gene
Orthologs for BCL2L11 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BCL2L11 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | LOC612867 29 |
|
||
| BCL2L11 30 |
|
OneToOne | |||
| Mouse (Mus musculus) |
Mammalia | Bcl2l11 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Bcl2l11 29 |
|
||
| Cow (Bos Taurus) |
Mammalia | BCL2L11 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | BCL2L11 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | BCL2L11 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | BCL2L11 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | bcl2l11 29 |
|
- Species where no ortholog for BCL2L11 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for BCL2L11 Gene
- ENSEMBL:
- Gene Tree for BCL2L11 (if available)
- TreeFam:
- Gene Tree for BCL2L11 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BCL2L11: view image
- Alliance of Genome Resources:
- Additional Orthologs for BCL2L11
Paralogs for BCL2L11 Gene
Variants for BCL2L11 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BCL2L11 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs112446582 | Benign: not provided | 111,123,784(+) |
C/T NM_138621.5(BCL2L11):c.39C>T (p.Asp13=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4047n100 | CNV | loss | 25217958 |
| esv2667742 | CNV | deletion | 23128226 |
| esv2720516 | CNV | deletion | 23290073 |
| esv2759083 | CNV | gain+loss | 17122850 |
| esv3591978 | CNV | loss | 21293372 |
| nsv1149522 | OTHER | inversion | 26484159 |
| nsv428402 | CNV | loss | 18775914 |
| nsv521956 | CNV | loss | 19592680 |
| nsv582699 | CNV | loss | 21841781 |
| nsv829618 | CNV | gain | 20364138 |
| nsv829619 | CNV | loss | 20364138 |
| nsv834331 | CNV | loss | 17160897 |
| nsv963952 | CNV | deletion | 23825009 |
Residual Variation Intolerance Score:
31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.26;
5.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BCL2L11 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL2L11 Gene
Disorders for BCL2L11 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| interleukin-7 receptor alpha deficiency |
|
|
| autoimmune lymphoproliferative syndrome |
|
|
| mantle cell lymphoma |
|
|
| lymphoproliferative syndrome |
|
|
| colorectal cancer |
|
|
Search BCL2L11 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BCL2L11
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for BCL2L11 Gene
Publications for BCL2L11 Gene
- Over-expression of Bim alpha3, a novel isoform of human Bim, result in cell apoptosis. (PMID: 15147734) Chen JZ … Mao YM (The international journal of biochemistry & cell biology 2004) 3 4 22
- Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim. (PMID: 12019181) Liu JW … Tang DG (Cancer research 2002) 3 4 22
- Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family. (PMID: 11734221) U M … Yamada M (FEBS letters 2001) 3 4 22
- Bim: a novel member of the Bcl-2 family that promotes apoptosis. (PMID: 9430630) O'Connor L … Huang DC (The EMBO journal 1998) 2 3 4
- The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. (PMID: 27013495) Weber A … Häcker G (EMBO reports 2016) 3 4
ExternalLinks
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