Aliases for BCL2L10 Gene
External Ids for BCL2L10 Gene
Previous GeneCards Identifiers for BCL2L10 Gene
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]
GeneCards Summary for BCL2L10 Gene
BCL2L10 (BCL2 Like 10) is a Protein Coding gene. Diseases associated with BCL2L10 include Urethral Diverticulum and Urethral Stricture. Among its related pathways are Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins and Regulation of Apoptosis by Parathyroid Hormone-related Protein. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity.
UniProtKB/Swiss-Prot Summary for BCL2L10 Gene
Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.