Aliases for BCL2L10 Gene
External Ids for BCL2L10 Gene
Previous GeneCards Identifiers for BCL2L10 Gene
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]
GeneCards Summary for BCL2L10 Gene
BCL2L10 (BCL2 Like 10) is a Protein Coding gene. Diseases associated with BCL2L10 include Urethral Stricture and Urethral Diverticulum. Among its related pathways are Apoptosis and Autophagy and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity.
UniProtKB/Swiss-Prot Summary for BCL2L10 Gene
Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.