Aliases for BCL2 Gene
Aliases for BCL2 Gene
External Ids for BCL2 Gene
- HGNC: 990
- Entrez Gene: 596
- Ensembl: ENSG00000171791
- OMIM: 151430
- UniProtKB: P10415
Previous GeneCards Identifiers for BCL2 Gene
- GC18M060629
- GC18M060763
- GC18M058939
- GC18M058941
- GC18M057487
Summaries for BCL2 Gene
-
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
GeneCards Summary for BCL2 Gene
BCL2 (BCL2, Apoptosis Regulator) is a Protein Coding gene. Diseases associated with BCL2 include High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement and Follicular Lymphoma 1. Among its related pathways are PEDF Induced Signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and identical protein binding. An important paralog of this gene is BCL2L1.
UniProtKB/Swiss-Prot for BCL2 Gene
-
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
-
Bcl-2 family proteins contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four Bcl-2 homology domains. Certain members (Bcl-2, Bcl-XL and Mcl-1) are antiapoptotic, whilst others (Bax, Bak, Bok) are proapoptotic.
Additional gene information for BCL2 Gene
- Monarch Initiative
- Search for BCL2 at DataMed
- Search for BCL2 at HumanCyc
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2 Gene
Genomics for BCL2 Gene
GeneHancer (GH) Regulatory Elements for BCL2 Gene
Promoters and enhancers for BCL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around BCL2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the BCL2 gene promoter:
Regulatory Element Products
Genomic Locations for BCL2 Gene
Genomic Locations for BCL2 Gene
- chr18:63,123,346-63,320,128
- (GRCh38/hg38)
- Size:
- 196,783 bases
- Orientation:
- Minus strand
- chr18:60,790,579-60,987,361
- (GRCh37/hg19)
Genomic View for BCL2 Gene
Genes around BCL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q21.33 by Ensembl
- 18q21.33 by Entrez Gene
- 18q21.33 by HGNC
BCL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BCL2 Gene
Proteins for BCL2 Gene
-
Protein details for BCL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P10415-BCL2_HUMAN
- Recommended name:
- Apoptosis regulator Bcl-2
- Protein Accession:
- P10415
- C9JHD5
- P10416
- Q13842
- Q16197
Protein attributes for BCL2 Gene
- Size:
- 239 amino acids
- Molecular mass:
- 26266 Da
- Quaternary structure:
-
- Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity (PubMed:8183370). Interacts with EI24 (By similarity). Also interacts with APAF1, BBC3, BCL2L1, BNIPL, MRPL41 and TP53BP2. Binding to FKBP8 seems to target BCL2 to the mitochondria and probably interferes with the binding of BCL2 to its targets. Interacts with BAG1 in an ATP-dependent manner. Interacts with RAF1 (the Ser-338 and Ser-339 phosphorylated form). Interacts (via the BH4 domain) with EGLN3; the interaction prevents the formation of the BAX-BCL2 complex and inhibits the anti-apoptotic activity of BCL2. Interacts with G0S2; this interaction also prevents the formation of the anti-apoptotic BAX-BCL2 complex. Interacts with RTL10/BOP. Interacts with the SCF(FBXO10) complex. Interacts (via the loop between motifs BH4 and BH3) with NLRP1 (via LRR repeats), but not with NLRP2, NLRP3, NLRP4, PYCARD, nor MEFV (PubMed:17418785).
Three dimensional structures from OCA and Proteopedia for BCL2 Gene
Protein Expression for BCL2 Gene
Post-translational modifications for BCL2 Gene
- Monoubiquitinated by PRKN, leading to increase its stability. Ubiquitinated by SCF(FBXO10), leading to its degradation by the proteasome.
- Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases. Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-87, wich stimulates starvation-induced autophagy. Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity).
- Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity, causes the release of cytochrome c into the cytosol promoting further caspase activity.
Other Protein References for BCL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for BCL2 (Bcl-2)
- Cell Signaling Technology (CST) Antibodies for BCL2 (Bcl-2)
-
Custom Antibody ServicesOriGene Antibodies for BCL2
- UM870117
- UM800117
- CF806639
- TA806639
- CF806625
- TA806625
- CF806624
- TA806624
- CF806623
- TA806623
- CF806622
- TA806622
- CF806593
- TA806593
- CF806592
- TA806592
- CF806591
- TA806591
- CF806590
- TA806590
- CF806589
- TA806589
- CF803079
- TA803079
- CF803003
- TA803003
- TA590781
- TA353593
- TA353592
- TA347780
- TA333170
- TA333169
- TA332373
- TA327922
- TA327921
- TA327793
- TA327607
- TA327606
- TA327425
- TA326053
- TA325261
- TA325260
- TA325259
- TA324789
- TA323608
- TA320222
- TA318664
- TA306172
- TA306171
- TA302955
- AP55894PU-S
- AP55894PU-N
- AP26416AF-N
- AP26416AF-L
- AP26415AF-N
- AP26415AF-L
- AP21081PU-N
- AP11295PU-N
- AP06497PU-N
- AP06028PU-N
- AP05004PU-N
- AP02601PU-S
- AP02601PU-N
- AP02600PU-S
- AP02600PU-N
- AP01537PU-N
- AP01536PU-N
- AP00016PU-N
- AM50201PU-T
- AM50201PU-S
- AM50201PU-N
- AM50164PU-T
- AM50164PU-S
- AM50164PU-N
- AM50163PU-T
- AM50163PU-S
- AM50163PU-N
- AM33344PU-T
- AM33344PU-S
- AM33344PU-N
- AM33245PU-T
- AM33245PU-S
- AM33245PU-N
- AM32832PU-T
- AM32832PU-S
- AM32832PU-N
- AM32275SU-N
- AM26046RP-N
- AM26046PU-N
- AM26046FC-N
- AM26046AC-N
- AM20590PU-N
- AM09378PU-S
- AM09378PU-N
- AM06485SU-N
- Novus Biologicals Antibodies for BCL2
-
Abcam antibodies for BCL2
-
Cloud-Clone Corp. Antibodies for BCL2
- Invitrogen Antibodies for BCL2
- antibodies-online: Search results for 1129 available BCL2 Antibodies ranked by validation data
- Compare Top BCL2 Antibodies
-
Recommended
- 2 IHC (p) Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 18 FACS Antibodies (anti-mouse)
- 48 IF (p) Antibodies (anti-mouse)
- 170 WB Antibodies (anti-mouse)
- 18 FACS Antibodies (anti-rat)
- 51 IF (p) Antibodies (anti-rat)
- 134 WB Antibodies (anti-rat)
- 1 IF Antibody (anti-human)
- 1 CC Antibody (anti-human)
- 2 RIA Antibodies (anti-human)
- 2 ICS Antibodies (anti-human)
- 4 DB Antibodies (anti-human)
- 5 EIA Antibodies (anti-human)
- 6 IP Antibodies (anti-human)
- 32 FACS Antibodies (anti-human)
- 38 IHC (p) Antibodies (anti-human)
- 42 IHC Antibodies (anti-human)
- 63 IF (p) Antibodies (anti-human)
- 751 WB Antibodies (anti-human)
- GeneTex BCL2 antibody for BCL2
-
Custom Antibody ServicesProSci Antibodies for BCL2
-
Santa Cruz Biotechnology (SCBT) Antibodies for BCL2
- Sino Biological Antibodies for BCL2
Protein Products
- R&D Systems Proteins and Enzymes for BCL2 (Bcl-2)
-
OriGene Purified Proteins for BCL2
- Search Origene for MassSpec and Protein Over-expression Lysates for BCL2
- Origene Custom Protein Services for BCL2
- Sino Biological Recombinant Proteins for BCL2
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for BCL2
-
Cloud-Clone Corp. Proteins for BCL2
- Search GeneTex for Proteins for BCL2
-
Abcam proteins for BCL2
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, ELISAs, and other biochemical assays for BCL2 (Bcl-2)
- Novus Biologicals ELISA Kits for BCL2
- Cell Signaling Technology (CST) Sandwich ELISA Kits for BCL2 (Bcl-2)
- antibodies-online: Search results for 91 available BCL2 Elisa Kits ranked by validation data
- Compare Top BCL2 Elisa Kits
-
Recommended
- 1 Sheep (Ovine) ELISA Kit
- 17 Rat (Rattus) ELISA Kits
- 6 Rabbit ELISA Kits
- 9 Pig (Porcine) ELISA Kits
- 19 Mouse (Murine) ELISA Kits
- 2 Monkey ELISA Kits
- 2 Mammalian ELISA Kits
- 23 Human ELISA Kits
- 5 Guinea Pig ELISA Kits
- 1 Goat ELISA Kit
- 2 Dog (Canine) ELISA Kits
- 7 Cow (Bovine) ELISA Kits
- 3 Chicken ELISA Kits
-
Abcam assays for BCL2
- Sino Biological Assays for BCL2
No data available for DME Specific Peptides for BCL2 Gene
Domains & Families for BCL2 Gene
Gene Families for BCL2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for BCL2 Gene
Suggested Antigen Peptide Sequences for BCL2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P10415UniProtKB/Swiss-Prot:
BCL2_HUMAN :- BH1 and BH2 domains are required for the interaction with BAX and for anti-apoptotic activity.
- Belongs to the Bcl-2 family.
- Domain:
-
- BH1 and BH2 domains are required for the interaction with BAX and for anti-apoptotic activity.
- The BH4 motif is required for anti-apoptotic activity and for interaction with RAF1 and EGLN3.
- The loop between motifs BH4 and BH3 is required for the interaction with NLRP1.
- Family:
-
- Belongs to the Bcl-2 family.
Function for BCL2 Gene
Molecular function for BCL2 Gene
- GENATLAS Biochemistry:
- inner mitochondrial membrane protein,C elegans CED9 homolog,key regulator of apoptosis by inhibiting the release of cytochrome from the mitochondrial and by protecting a wide variety of cells including B cells and neuronal cells,activated by nerve growth factor,mediated by the p42/p44 MAPK cascade,inhibited by phosphorylation mediated by microtubule-damaging drugs through JNK- and cAMP-dependent protein kinases ; interacting with SMN1,also modulating CDK2 activation during thymocyte apoptosis,overexpressed in endometrial carcinoma
- UniProtKB/Swiss-Prot Function:
- Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
Phenotypes From GWAS Catalog for BCL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002020 | protease binding | IDA | 10620603 |
| GO:0005515 | protein binding | IPI | 7954800 |
| GO:0008134 | transcription factor binding | IEA | -- |
| GO:0015267 | channel activity | IDA | 9219694 |
| GO:0016248 | channel inhibitor activity | IDA | 9219694 |
Phenotypes for BCL2 Gene
- MGI mutant phenotypes for BCL2:
-
inferred from 9 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- pigmentation phenotype
- renal/urinary system phenotype
- craniofacial phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for BCL2:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
Animal Models for BCL2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for BCL2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for BCL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for BCL2 gene
- Search ViGene Biosciences for BCL2
CRISPR Products
-
OriGene CRISPR knockouts for BCL2
- genomics-online: gRNA clones - Search results for 135 available BCL2 gene related products
- Overview of 135 available BCL2 gene related products
- Applied Biological Materials CRISPR for BCL2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCL2
- GenScript: Design CRISPR guide RNA sequences for BCL2
miRNA for BCL2 Gene
- miRTarBase miRNAs that target BCL2
-
- hsa-mir-34b-5p (MIRT000065)
- hsa-mir-21-5p (MIRT000159)
- hsa-mir-204-5p (MIRT000192)
- hsa-mir-153-3p (MIRT000290)
- hsa-let-7a-5p (MIRT000418)
- hsa-mir-15a-5p (MIRT000815)
- hsa-mir-15b-5p (MIRT000978)
- hsa-mir-16-5p (MIRT001800)
- hsa-mir-34a-5p (MIRT002298)
- hsa-mir-20a-5p (MIRT003011)
- hsa-mir-17-5p (MIRT003014)
- hsa-mir-29c-3p (MIRT003289)
- hsa-mir-29b-3p (MIRT003290)
- hsa-mir-29a-3p (MIRT003291)
- hsa-mir-34b-3p (MIRT003449)
- hsa-mir-181d-5p (MIRT003498)
- hsa-mir-181c-5p (MIRT003499)
- hsa-mir-181b-5p (MIRT003500)
- hsa-mir-181a-5p (MIRT003501)
- hsa-mir-34c-5p (MIRT003979)
- hsa-mir-33b-5p (MIRT003980)
- hsa-mir-192-5p (MIRT004844)
- hsa-mir-195-5p (MIRT005362)
- hsa-mir-630 (MIRT005578)
- hsa-mir-451a (MIRT005744)
- hsa-mir-365a-3p (MIRT006243)
- hsa-mir-125b-5p (MIRT006253)
- hsa-mir-449a (MIRT006445)
- hsa-mir-200b-3p (MIRT006670)
- hsa-mir-200c-3p (MIRT006673)
- hsa-mir-429 (MIRT006674)
- hsa-mir-136-5p (MIRT006868)
- hsa-mir-7-5p (MIRT006904)
- hsa-mir-148a-3p (MIRT006975)
- hsa-mir-24-2-5p (MIRT006977)
- hsa-mir-182-5p (MIRT007063)
- hsa-mir-196b-5p (MIRT007146)
- hsa-mir-143-3p (MIRT007348)
- hsa-mir-375 (MIRT019975)
- hsa-mir-215-5p (MIRT024494)
- hsa-mir-103a-3p (MIRT027158)
- hsa-mir-96-5p (MIRT027929)
- hsa-mir-205-5p (MIRT052936)
- hsa-mir-126-3p (MIRT053253)
- hsa-mir-18a-5p (MIRT053297)
- hsa-mir-497-5p (MIRT053471)
- hsa-mir-1915-3p (MIRT054926)
- hsa-mir-206 (MIRT199194)
- hsa-mir-34a-3p (MIRT199222)
- hsa-mir-448 (MIRT369727)
- hsa-mir-125a-5p (MIRT387672)
- hsa-mir-708-5p (MIRT437391)
- hsa-mir-184 (MIRT438155)
- hsa-mir-30b-5p (MIRT438196)
- hsa-mir-135a-5p (MIRT438304)
- hsa-mir-224-5p (MIRT438617)
- hsa-mir-503-5p (MIRT438662)
- hsa-mir-494-3p (MIRT438772)
- hsa-mir-211-5p (MIRT438781)
- hsa-mir-9-5p (MIRT732216)
- hsa-mir-139-5p (MIRT732232)
- hsa-mir-26a-1-3p (MIRT733189)
- hsa-mir-1284 (MIRT733312)
- hsa-mir-376c-3p (MIRT733663)
- hsa-mir-190b (MIRT733733)
- gga-mir-16-5p (MIRT734101)
- hsa-mir-15a-3p (MIRT735398)
- hsa-mir-16-1-3p (MIRT735399)
- hsa-mir-98-5p (MIRT735452)
miRNA Products
- Search ViGene Biosciences for BCL2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for BCL2
- Browse OriGene Inhibitory RNA Products For BCL2
- genomics-online: shRNA clones - Search results for 135 available BCL2 gene related products
- Overview of 135 available BCL2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for BCL2 gene
Clone Products
- Sino Biological Human cDNA Clone for BCL2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for BCL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BCL2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for BCL2
- Applied Biological Materials Clones for BCL2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for BCL2
-
ViGene Biosciences adenoviral particle packaged cDNA for BCL2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for BCL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for BCL2 gene
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for BCL2 Gene
Localization for BCL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BCL2 Gene
- Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| endoplasmic reticulum | 5 |
| cytosol | 4 |
| plasma membrane | 1 |
- Nuclear membrane (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IDA | 7546744 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IDA | 7546744 |
| GO:0005739 | mitochondrion | IEA,IDA | 7896880 |
Pathways & Interactions for BCL2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
|
.47
|
| 2 | Apoptosis Modulation and Signaling |
.41
|
.33
|
| 3 | TGF-Beta Pathway |
.60
.57
|
.51
.40
|
| 4 | TNFR1 Pathway | ||
| 5 | Apoptotic Pathways in Synovial Fibroblasts |
.74
|
|
Pathways by source for BCL2 Gene
4 Sino Biological pathways for BCL2 Gene
3 GeneTex pathways for BCL2 Gene
1 Cell Signaling Technology pathway for BCL2 Gene
37 BioSystems pathways for BCL2 Gene
14 Reactome pathways for BCL2 Gene
3 PharmGKB pathways for BCL2 Gene
32 KEGG pathways for BCL2 Gene
15 GeneGo (Thomson Reuters) pathways for BCL2 Gene
2 R&D Systems pathways for BCL2 Gene
1 Tocris pathway for BCL2 Gene
48 Qiagen pathways for BCL2 Gene
Interacting Proteins for BCL2 Gene
Selected Interacting proteins:
ENSP00000329623
P10415-BCL2_HUMAN
for BCL2 Gene via
STRING
MINT
UniProtKB
IID
SIGNOR curated interactions for BCL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | IDA | 16717086 |
| GO:0000902 | cell morphogenesis | IEA | -- |
| GO:0001503 | ossification | IEA | -- |
| GO:0001541 | ovarian follicle development | IEA | -- |
| GO:0001656 | metanephros development | IEA | -- |
Drugs & Compounds for BCL2 Gene
(129) Drugs for BCL2 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Docetaxel | Approved May 1996, Investigational | Pharma | Target, Inhibition, inhibitor, Biomarker | Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes | 2040 | |
| Paclitaxel | Approved, Vet_approved | Pharma | Target, inhibitor, Biomarker, binder | Tubulin and Bcl2 inhibitor, Taxanes | 3027 | |
| ABT-199 | Approved, Investigational | Pharma | Target, inhibitor | Bcl-2 inhibitor,potent and selective | 0 | |
| Carboplatin | Approved | Pharma | Biomarker | Antitumor agent that forms platinum-DNA adducts., Platinum | 2141 | |
| Rasagiline | Approved | Pharma | Target, activator | 55 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| SMBA 1 |
|
906440-37-7 |
|
|
(4) Tocris Compounds for BCL2 Gene
(24) ApexBio Compounds for BCL2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| (+)-Apogossypol | 66389-74-0 | |
| ABT-199 | Bcl-2 inhibitor,potent and selective | 1257044-40-8 |
| ABT-263 (Navitoclax) | Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w | 923564-51-6 |
| ABT-737 | Bcl-2 inhibitor | 852808-04-9 |
| Apogossypolone (ApoG2) | Bcl-2 inhibitor,nonpeptidic small molecule | 886578-07-0 |
| AT-101 | BH3-mimetic,gossypol enantiomer | 90141-22-3 |
| Bax inhibitor peptide P5 | Bax inhibitor | 579492-83-4 |
| Bax inhibitor peptide V5 | Bax inhibitor | 579492-81-2 |
| Bcl Family Set I | Bcl family inhibitors | |
| BDA-366 | Selective antagonist of BCL2 BH4 domain | |
| BIM, Biotinylated | ||
| BM-1074 | Bcl-2/Bcl-xL inhibitor,potent and selective | 1391108-10-3 |
| Gossypol | PAF inhibitor;anti-fertility and anti-cancer | 303-45-7 |
| HA14-1 | Bcl-2 inhibitor,potent and cell-permeable | 65673-63-4 |
| iMAC2 | MAC inhibitor | 335166-36-4 |
| Lomustine | Antineoplastic drug | 13010-47-4 |
| Mcl1-IN-1 | Myeloid cell factor 1 inhibitor | 713492-66-1 |
| Mitomycin C | Inhibits DNA synthesis,antibiotic and antitumor agent | 1950-07-7 |
| Muristerone A | TRAIL- and hFasL-induced apoptosis inhibitor | 38778-30-2 |
| Obatoclax mesylate (GX15-070) | Potent Bcl-2 inhibitor | 803712-79-0 |
| Pyridoclax | ||
| Radotinib(IY-5511) | Bcl-Abl tyrosine kinase inhibitor | 926037-48-1 |
| Sabutoclax | pan-Bcl-2 inhibitor | 1228108-65-3 |
| TW-37 | Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1 | 877877-35-5 |
Transcripts for BCL2 Gene
mRNA/cDNA for BCL2 Gene
- (4) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (148) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for BCL2
- genomics-online: gRNA clones - Search results for 135 available BCL2 gene related products
- Overview of 135 available BCL2 gene related products
- Applied Biological Materials CRISPR for BCL2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCL2
- GenScript: Design CRISPR guide RNA sequences for BCL2
miRNA Products
- Search ViGene Biosciences for BCL2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for BCL2
- Browse OriGene Inhibitory RNA Products For BCL2
- genomics-online: shRNA clones - Search results for 135 available BCL2 gene related products
- Overview of 135 available BCL2 gene related products
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ViGene Biosciences ready-to-package AAV shRNAs for BCL2 gene
Clone Products
- Sino Biological Human cDNA Clone for BCL2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for BCL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BCL2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for BCL2
- Applied Biological Materials Clones for BCL2
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Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: |
Expression for BCL2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Tooth (Integumentary System)
- Early Ameloblasts Dental Enamel
- Odontoblasts Dentin
- Inner Enamel Epithelial Cells Dental Enamel
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Epithelial Cells
- Early Ameloblasts Dental Enamel
- Inner Enamel Epithelial Cells Dental Enamel
- Basal Keratinocytes Embryonic Epidermis
-
Bone (Muscoskeletal System)
- Prehypertrophic Chondrocytes Vertebrae
- Prechondrocytes Vertebrae
-
Cartilage (Muscoskeletal System)
- Prehypertrophic Chondrocytes Vertebrae
- Prechondrocytes Vertebrae
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Thymus (Hematopoietic System)
- T Helper Cells Thymus
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Blood (Cardiovascular System)
- T Helper Cells Thymus
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Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
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Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
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Hair
- Basal Keratinocytes Embryonic Epidermis
- Adipose (Muscoskeletal System)
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Thyroid (Endocrine System)
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Lymph (Hematopoietic System)
This gene is overexpressed in Tlymphocyte (10.5), CD8 Tcells (7.9), NK cells (6.4), and Ovary (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BCL2 Gene
NURSA nuclear receptor signaling pathways regulating expression of BCL2 Gene:
BCL2SOURCE GeneReport for Unigene cluster for BCL2 Gene:
Hs.150749mRNA Expression by UniProt/SwissProt for BCL2 Gene:
P10415-BCL2_HUMAN
Tissue specificity:
Expressed in a variety of tissues.
Evidence on tissue expression from TISSUES for BCL2 Gene
- Kidney(3.5)
Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL2 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- immune
- integumentary
- lymphatic
- nervous
Regions:
Head and neck:
- brain
- head
Abdomen:
- spleen
General:
- blood
- lymph node
- skin
- sweat gland
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for BCL2
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OriGene qPCR primer pairs and template standards for BCL2
No data available for mRNA differential expression in normal tissues for BCL2 Gene
Orthologs for BCL2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BCL2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | BCL2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | BCL2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Bcl2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Bcl2 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | BCL2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | BCL2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | BCL2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | bcl2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | BCL2 (2 of 2) 34 |
|
OneToMany | |
| bcl2 34 |
|
OneToMany |
- Species where no ortholog for BCL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for BCL2 Gene
(4) SIMAP similar genes for BCL2 Gene using alignment to 3 proteins:
Variants for BCL2 Gene
| SNP ID | Clin | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_000828 | Non-Hodgkin lymphoma | p.Pro59Ser | |||
| VAR_000829 | Non-Hodgkin lymphoma | p.Val93Ile | |||
| rs1000023499 | -- | 63,156,103(-) | A/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000050149 | -- | 63,307,167(-) | TTT/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000050989 | -- | 63,265,988(-) | C/T | genic_downstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.46;
64.20% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BCL2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL2 Gene
Disorders for BCL2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement |
|
|
| follicular lymphoma 1 |
|
|
| lymphoma |
|
|
| follicular lymphoma |
|
|
| intravascular large b-cell lymphoma |
|
|
Search BCL2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
BCL2_HUMAN- Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. {ECO:0000269 PubMed:2875799, ECO:0000269 PubMed:3285301}.
Genatlas disease for BCL2 Gene
non Hodgkin follicular lymphoma of B-cell type,diffuse large B cell lymphoma,with translocation t(14;18)(q32;q21.3),also extranodal B cell lymphoma (low grade lymphoma of mucosa associated lymphoid tissue),with translocation t(11;18)(q21;q21) and a breakpoint on chromosome 18 between BCL2 and DCC
Additional Disease Information for BCL2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Publications for BCL2 Gene
- Interaction between BCL2 and interleukin-10 gene polymorphisms alter outcomes of diffuse large B-cell lymphoma following rituximab plus CHOP chemotherapy. (PMID: 19276283) Park YH … Kim DH (Clinical cancer research : an official journal of the American Association for Cancer Research 2009) 3 22 44 58
- BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. (PMID: 10567572) Yamamoto K … Korsmeyer SJ (Molecular and cellular biology 1999) 3 4 22 58
- Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma. (PMID: 23431138) Chiorazzi M … Staudt LM (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 4 58
- Prognostic assessment of three single-nucleotide polymorphisms (GNB3 825C>T, BCL2-938C>A, MCL1-386C>G) in extrahepatic cholangiocarcinoma. (PMID: 19968497) Fingas CD … Canbay A (Cancer investigation 2010) 3 44 58
- Synergistic effect of 5-fluorouracil and the flavanoid oroxylin A on HepG2 human hepatocellular carcinoma and on H22 transplanted mice. (PMID: 19585117) Zhao L … Guo QL (Cancer chemotherapy and pharmacology 2010) 3 22 58
Products for BCL2 Gene
- R&D Systems Antibodies for BCL2 (Bcl-2)
- R&D Systems Proteins and Enzymes for BCL2 (Bcl-2)
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for BCL2 (Bcl-2)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for BCL2
- AM06485SU-N
- AM09378PU-N
- AM09378PU-S
- AM20590PU-N
- AM26046AC-N
- AM26046FC-N
- AM26046PU-N
- AM26046RP-N
- AM32275SU-N
- AM32832PU-N
- AM32832PU-S
- AM32832PU-T
- AM33245PU-N
- AM33245PU-S
- AM33245PU-T
- AM33344PU-N
- AM33344PU-S
- AM33344PU-T
- AM50163PU-N
- AM50163PU-S
- AM50163PU-T
- AM50164PU-N
- AM50164PU-S
- AM50164PU-T
- AM50201PU-N
- AM50201PU-S
- AM50201PU-T
- AP00016PU-N
- AP01536PU-N
- AP01537PU-N
- AP02600PU-N
- AP02600PU-S
- AP02601PU-N
- AP02601PU-S
- AP05004PU-N
- AP06028PU-N
- AP06497PU-N
- AP11295PU-N
- AP21081PU-N
- AP26415AF-L
- AP26415AF-N
- AP26416AF-L
- AP26416AF-N
- AP55894PU-N
- AP55894PU-S
- TA302955
- TA306171
- TA306172
- TA318664
- TA320222
- TA323608
- TA324789
- TA325259
- TA325260
- TA325261
- TA326053
- TA327425
- TA327606
- TA327607
- TA327793
- TA327921
- TA327922
- TA332373
- TA333169
- TA333170
- TA347780
- TA353592
- TA353593
- TA590781
- TA803003
- CF803003
- TA803079
- CF803079
- TA806589
- CF806589
- TA806590
- CF806590
- TA806591
- CF806591
- TA806592
- CF806592
- TA806593
- CF806593
- TA806622
- CF806622
- TA806623
- CF806623
- TA806624
- CF806624
- TA806625
- CF806625
- TA806639
- CF806639
- UM800117
- UM870117
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for BCL2
- Search Origene for MassSpec and Protein Over-expression Lysates for BCL2
- Origene Custom Protein Services for BCL2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCL2
- Browse OriGene Inhibitory RNA Products For BCL2
- OriGene qPCR primer pairs and template standards for BCL2
- OriGene qPCR primer pairs for BCL2
- OriGene CRISPR knockouts for BCL2
- OriGene ORF clones in human for BCL2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BCL2
- GenScript: Next-day shipping of latest version cDNA ORF clones for BCL2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for BCL2
- GenScript Custom Assay Services for BCL2
- GenScript Custom overexpressing Cell Line Services for BCL2
- GenScript: Design CRISPR guide RNA sequences for BCL2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for BCL2
- Cell Signaling Technology (CST) Antibodies for BCL2 (Bcl-2)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for BCL2 (Bcl-2)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for BCL2
- Sino Biological Recombinant Proteins for BCL2
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for BCL2
- Sino Biological Assays for BCL2
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for BCL2
- Novus Biologicals lysates and proteins for BCL2
- Novus Biologicals ELISA Kits for BCL2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for BCL2
- Abcam proteins for BCL2
- Abcam assays for BCL2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for BCL2
- Cloud-Clone Corp. Antibodies for BCL2
- Cloud-Clone Corp. Proteins for BCL2
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for BCL2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for BCL2
- Cyagen custom Knockout/knockin (KOKI) mouse models for BCL2
- VectorBuilder custom plasmid, inducible vectors for BCL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BCL2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for BCL2