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This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] See more...
Aliases for BCL2 Gene
Aliases for BCL2 Gene
External Ids for BCL2 Gene
- HGNC: 990
- Entrez Gene: 596
- Ensembl: ENSG00000171791
- OMIM: 151430
- UniProtKB: P10415
Previous GeneCards Identifiers for BCL2 Gene
- GC18M060629
- GC18M060763
- GC18M058939
- GC18M058941
- GC18M057487
Summaries for BCL2 Gene
-
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
GeneCards Summary for BCL2 Gene
BCL2 (BCL2 Apoptosis Regulator) is a Protein Coding gene. Diseases associated with BCL2 include High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement and Follicular Lymphoma 1. Among its related pathways are Apoptosis Modulation and Signaling and Nur77 Signaling in T-Cell. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and identical protein binding. An important paralog of this gene is BCL2L1.
UniProtKB/Swiss-Prot Summary for BCL2 Gene
-
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
-
Bcl-2 family proteins contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four Bcl-2 homology domains. Certain members (Bcl-2, Bcl-XL and Mcl-1) are antiapoptotic, whilst others (Bax, Bak, Bok) are proapoptotic.
Additional gene information for BCL2 Gene
- HGNC(990)
- Entrez Gene(596)
- Ensembl(ENSG00000171791)
- OMIM(151430)
- UniProtKB(P10415)
- Open Targets Platform(ENSG00000171791)
- Monarch Initiative
- Search for BCL2 at DataMed
- Search for BCL2 at HumanCyc
No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BCL2 Gene
Genomics for BCL2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BCL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BCL2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BCL2
- Top Transcription factor binding sites by QIAGEN in the BCL2 gene promoter:
-
- AP-2alpha
- AP-2alpha isoform 2
- AP-2alpha isoform 3
- AP-2alpha isoform 4
- AP-2alphaA
Genomic Locations for BCL2 Gene
Genomic Locations for BCL2 Gene
- chr18:63,123,346-63,320,280
- (GRCh38/hg38)
- Size:
- 196,935 bases
- Orientation:
- Minus strand
- chr18:60,790,579-60,987,361
- (GRCh37/hg19)
- Size:
- 196,783 bases
- Orientation:
- Minus strand
Genomic View for BCL2 Gene
Genes around BCL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q21.33 by HGNC
- 18q21.33 by Entrez Gene
- 18q21.33 by Ensembl
BCL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BCL2 Gene
Proteins for BCL2 Gene
-
Protein details for BCL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P10415-BCL2_HUMAN
- Recommended name:
- Apoptosis regulator Bcl-2
- Protein Accession:
- P10415
- C9JHD5
- P10416
- Q13842
- Q16197
Protein attributes for BCL2 Gene
- Size:
- 239 amino acids
- Molecular mass:
- 26266 Da
- Quaternary structure:
-
- Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity (PubMed:8183370). Interacts with EI24 (By similarity). Also interacts with APAF1, BBC3, BCL2L1, BNIPL, MRPL41 and TP53BP2. Binding to FKBP8 seems to target BCL2 to the mitochondria and probably interferes with the binding of BCL2 to its targets. Interacts with BAG1 in an ATP-dependent manner. Interacts with RAF1 (the 'Ser-338' and 'Ser-339' phosphorylated form). Interacts (via the BH4 domain) with EGLN3; the interaction prevents the formation of the BAX-BCL2 complex and inhibits the anti-apoptotic activity of BCL2. Interacts with G0S2; this interaction also prevents the formation of the anti-apoptotic BAX-BCL2 complex. Interacts with RTL10/BOP. Interacts with the SCF(FBXO10) complex. Interacts (via the loop between motifs BH4 and BH3) with NLRP1 (via LRR repeats), but not with NLRP2, NLRP3, NLRP4, PYCARD, nor MEFV (PubMed:17418785). Interacts with GIMAP3/IAN4, GIMAP4/IAN1 and GIMAP5/IAN5 (By similarity).
Three dimensional structures from OCA and Proteopedia for BCL2 Gene
Protein Expression for BCL2 Gene
Post-translational modifications for BCL2 Gene
- Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases. Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-87, wich stimulates starvation-induced autophagy. Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity).
- Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity, causes the release of cytochrome c into the cytosol promoting further caspase activity.
- Monoubiquitinated by PRKN, leading to increase its stability. Ubiquitinated by SCF(FBXO10), leading to its degradation by the proteasome.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for BCL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences BCL2 / Bcl-2 Antibody and BCL2 / Bcl-2 Monoclonal Antibody
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-
Creative Biolabs
- Recombinant Anti-human BCL2 VHH Single Domain Antibody
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-
BioLegend
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- Direct-Blot(TM) Bcl-2 Antibody (633514)
- Direct-Blot(TM) Bcl-2 Antibody (633513)
-
Custom Antibody ServicesOriGene Antibodies for BCL2
- AM06485SU-N
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- AM20590PU-N
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- AM26046FC-N
- AM26046PU-N
- AM26046RP-N
- AM32275SU-N
- AM32832PU-S
- AM32832PU-T
- AM33245PU-S
- AM33245PU-T
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- AM33344PU-T
- AM50163PU-S
- AM50163PU-T
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- AM50164PU-T
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- AP00016PU-N
- AP01536PU-N
- AP01537PU-N
- AP02600PU-N
- AP02600PU-S
- AP02601PU-N
- AP02601PU-S
- AP05004PU-N
- AP06028PU-N
- AP06497PU-N
- AP11295PU-N
- AP21081PU-N
- AP26415AF-L
- AP26415AF-N
- AP26416AF-L
- AP26416AF-N
- AP55894PU-N
- AP55894PU-S
- CF803003
- CF803079
- CF806589
- CF806590
- CF806591
- CF806592
- CF806593
- CF806622
- CF806623
- CF806624
- CF806625
- CF806639
- TA302955
- TA306171
- TA306172
- TA318664
- TA320222
- TA323608
- TA324789
- TA325259
- TA325260
- TA325261
- TA326053
- TA327425
- TA327606
- TA327607
- TA327793
- TA327922
- TA332373
- TA333169
- TA333170
- TA347780
- TA352999L
- TA353000L
- TA353001L
- TA354256
- TA354330
- TA354422
- TA354569
- TA354647
- TA354658
- TA590781
- TA803003
- TA803003S
- TA803079
- TA803079S
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- TA806639S
- UM800117
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- Novus Biologicals Antibodies for BCL2
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-
Boster Bio Antibodies for BCL2
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- Sino Biological Antibodies for BCL2
Protein Products
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-
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-
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Assay Products
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-
Quality Products:
- ABIN6574202
- ABIN6720540
- ABIN1113655
- ABIN414423
- ABIN366834
- ABIN1028187
- ABIN4947389
- ABIN5522888
- ABIN4993797
- ABIN5026957
- ABIN1113656
- ABIN415401
- ABIN367654
- ABIN1568594
- ABIN5522889
- ABIN2945377
- ABIN5670033
- ABIN5593485
- ABIN627575
- ABIN1380195
- ABIN416111
- ABIN811440
- ABIN1568595
- ABIN1113654
- ABIN5522893
- ABIN5670699
- ABIN5593486
- ABIN626745
- ABIN1380949
- ABIN989424
- ABIN1122267
-
Abcam assays for BCL2
- Sino Biological Assays for BCL2
No data available for DME Specific Peptides for BCL2 Gene
Domains & Families for BCL2 Gene
Gene Families for BCL2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for BCL2 Gene
- InterPro:
- Blocks:
-
- Apoptosis regulator Bcl-2 protein, BH
- Apoptosis regulator Bcl-2 protein, BH4
- ProtoNet:
Suggested Antigen Peptide Sequences for BCL2 Gene
- GenScript: Design optimal peptide antigens:
-
- BCL2 protein (A0N771_HUMAN)
- Apoptosis regulator Bcl-2 (BCL2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P10415UniProtKB/Swiss-Prot:
BCL2_HUMAN :- BH1 and BH2 domains are required for the interaction with BAX and for anti-apoptotic activity.
- Belongs to the Bcl-2 family.
- Domain:
-
- BH1 and BH2 domains are required for the interaction with BAX and for anti-apoptotic activity.
- The BH4 motif is required for anti-apoptotic activity and for interaction with RAF1 and EGLN3.
- The loop between motifs BH4 and BH3 is required for the interaction with NLRP1.
- Family:
-
- Belongs to the Bcl-2 family.
Function for BCL2 Gene
Molecular function for BCL2 Gene
- UniProtKB/Swiss-Prot Function:
- Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
- GENATLAS Biochemistry:
- inner mitochondrial membrane protein,C elegans CED9 homolog,key regulator of apoptosis by inhibiting the release of cytochrome from the mitochondrial and by protecting a wide variety of cells including B cells and neuronal cells,activated by nerve growth factor,mediated by the p42/p44 MAPK cascade,inhibited by phosphorylation mediated by microtubule-damaging drugs through JNK- and cAMP-dependent protein kinases ; interacting with SMN1,also modulating CDK2 activation during thymocyte apoptosis,overexpressed in endometrial carcinoma
Phenotypes From GWAS Catalog for BCL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002020 | protease binding | IDA | 10620603 |
| GO:0005515 | protein binding | IPI | 7954800 |
| GO:0008134 | transcription factor binding | IEA | -- |
| GO:0015267 | channel activity | IDA | 9219694 |
| GO:0016248 | channel inhibitor activity | IDA | 9219694 |
Phenotypes for BCL2 Gene
- MGI mutant phenotypes for BCL2:
-
inferred from 9 alleles
- nervous system phenotype
- immune system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- renal/urinary system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- pigmentation phenotype
- craniofacial phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for BCL2:
-
- Decreased hepcidin::fluc mRNA expression
- Increased vaccinia virus (VACV) infection
- no effect
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance (Z-score < -2)
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 25%
- Increased shRNA abundance (Z-score > 2)
- Decreased viability (cell death)
Animal Models for BCL2 Gene
Animal Model Products
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CRISPR Products
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miRNA for BCL2 Gene
- miRTarBase miRNAs that target BCL2
-
- hsa-miR-34b-5p (MIRT000065)
- hsa-miR-21-5p (MIRT000159)
- hsa-miR-204-5p (MIRT000192)
- hsa-miR-153-3p (MIRT000290)
- hsa-let-7a-5p (MIRT000418)
- hsa-miR-15a-5p (MIRT000815)
- hsa-miR-15b-5p (MIRT000978)
- mmu-miR-16-5p (MIRT001066)
- mmu-miR-15a-5p (MIRT001069)
- mmu-miR-181a-5p (MIRT001684)
- hsa-miR-16-5p (MIRT001800)
- hsa-miR-34a-5p (MIRT002298)
- hsa-miR-20a-5p (MIRT003011)
- hsa-miR-17-5p (MIRT003014)
- mmu-miR-497a-5p (MIRT003283)
- hsa-miR-29c-3p (MIRT003289)
- hsa-miR-29b-3p (MIRT003290)
- hsa-miR-29a-3p (MIRT003291)
- hsa-miR-34b-3p (MIRT003449)
- hsa-miR-181d-5p (MIRT003498)
- hsa-miR-181c-5p (MIRT003499)
- hsa-miR-181b-5p (MIRT003500)
- hsa-miR-181a-5p (MIRT003501)
- hsa-miR-34c-5p (MIRT003979)
- hsa-miR-33b-5p (MIRT003980)
- mmu-miR-34a-5p (MIRT004257)
- hsa-miR-192-5p (MIRT004844)
- rno-miR-1-3p (MIRT005069)
- rno-miR-15b-5p (MIRT005084)
- rno-miR-16-5p (MIRT005085)
- mmu-miR-503-5p (MIRT005116)
- hsa-miR-195-5p (MIRT005362)
- hsa-miR-630 (MIRT005578)
- hsa-miR-451a (MIRT005744)
- hsa-miR-365a-3p (MIRT006243)
- hsa-miR-125b-5p (MIRT006253)
- hsa-miR-449a (MIRT006445)
- hsa-miR-200b-3p (MIRT006670)
- hsa-miR-200c-3p (MIRT006673)
- hsa-miR-429 (MIRT006674)
- hsa-miR-136-5p (MIRT006868)
- hsa-miR-7-5p (MIRT006904)
- hsa-miR-148a-3p (MIRT006975)
- hsa-miR-24-2-5p (MIRT006977)
- hsa-miR-182-5p (MIRT007063)
- mmu-miR-449a-5p (MIRT007077)
- hsa-miR-196b-5p (MIRT007146)
- mmu-miR-210-3p (MIRT007182)
- hsa-miR-143-3p (MIRT007348)
- mmu-miR-340-5p (MIRT010453)
- mmu-miR-195a-5p (MIRT013557)
- hsa-miR-375 (MIRT019975)
- hsa-miR-215-5p (MIRT024494)
- hsa-miR-103a-3p (MIRT027158)
- hsa-miR-96-5p (MIRT027929)
- hsa-miR-205-5p (MIRT052936)
- hsa-miR-126-3p (MIRT053253)
- hsa-miR-18a-5p (MIRT053297)
- mmu-miR-204-5p (MIRT053314)
- hsa-miR-497-5p (MIRT053471)
- hsa-miR-1915-3p (MIRT054926)
- hsa-miR-206 (MIRT199194)
- hsa-miR-34a-3p (MIRT199222)
- hsa-miR-448 (MIRT369727)
- hsa-miR-125a-5p (MIRT387672)
- hsa-miR-708-5p (MIRT437391)
- hsa-miR-184 (MIRT438155)
- hsa-miR-30b-5p (MIRT438196)
- hsa-miR-135a-5p (MIRT438304)
- hsa-miR-224-5p (MIRT438617)
- hsa-miR-503-5p (MIRT438662)
- hsa-miR-494-3p (MIRT438772)
- hsa-miR-211-5p (MIRT438781)
- rno-miR-34a-5p (MIRT438922)
- mmu-miR-466k (MIRT590535)
- mmu-miR-466d-5p (MIRT590536)
- mmu-miR-466i-5p (MIRT590537)
- mmu-miR-3098-3p (MIRT590538)
- mmu-miR-1904 (MIRT590539)
- mmu-miR-3105-3p (MIRT590540)
- mmu-miR-466p-5p (MIRT591440)
- mmu-miR-1187 (MIRT591441)
- mmu-miR-466a-5p (MIRT591442)
- mmu-miR-466e-5p (MIRT591443)
- mmu-miR-466l-5p (MIRT591444)
- hsa-miR-9-5p (MIRT732216)
- hsa-miR-139-5p (MIRT732232)
- hsa-miR-26a-1-3p (MIRT733189)
- hsa-miR-1284 (MIRT733312)
- hsa-miR-376c-3p (MIRT733663)
- hsa-miR-190b (MIRT733733)
- gga-miR-16-5p (MIRT734101)
- mmu-miR-429-3p (MIRT734717)
- hsa-miR-15a-3p (MIRT735398)
- hsa-miR-16-1-3p (MIRT735399)
- hsa-miR-98-5p (MIRT735452)
miRNA Products
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No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for BCL2 Gene
Localization for BCL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BCL2 Gene
- Mitochondrion outer membrane. Single-pass membrane protein. Nucleus membrane. Single-pass membrane protein. Endoplasmic reticulum membrane. Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| endoplasmic reticulum | 5 |
| cytosol | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Nuclear membrane (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005623 | cell | IEA | -- |
| GO:0005634 | nucleus | IDA | 7546744 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IDA | 7546744 |
| GO:0005739 | mitochondrion | IEA,IDA | 7896880 |
Pathways & Interactions for BCL2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
| 2 | TNFR1 Pathway |
Apoptosis and survival TNFR1 signaling pathway
.52
Apoptotic Pathways Triggered By HIV1
.42
|
Apoptosis through Death Receptors
.42
.34
|
| 3 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
| 4 | Apoptosis Modulation and Signaling |
.41
|
Apoptosis and survival Apoptotic TNF-family pathways
.35
.31
|
| 5 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
|
p53 Mediated Apoptosis
.84
DHA Signaling
.74
|
Pathways by source for BCL2 Gene
5 Sino Biological pathways for BCL2 Gene
37 BioSystems pathways for BCL2 Gene
14 Reactome pathways for BCL2 Gene
3 PharmGKB pathways for BCL2 Gene
40 KEGG pathways for BCL2 Gene
15 GeneGo (Thomson Reuters) pathways for BCL2 Gene
- Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
- Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
- Apoptosis and survival Apoptotic TNF-family pathways
- Apoptosis and survival APRIL and BAFF signaling
- Apoptosis and survival BAD phosphorylation
4 R&D Systems pathways for BCL2 Gene
1 Tocris pathway for BCL2 Gene
48 Qiagen pathways for BCL2 Gene
- 14-3-3 and Regulation of BAD Activity
- 14-3-3 Induced Apoptosis
- Akt Signaling
- all-trans-Retinoic Acid Signaling in Brain
- Antioxidant Action of Vitamin-C
1 Cell Signaling Technology pathway for BCL2 Gene
3 GeneTex pathways for BCL2 Gene
Interacting Proteins for BCL2 Gene
Selected Interacting proteins:
P10415-BCL2_HUMAN
ENSP00000381185
for BCL2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for BCL2
SIGNOR curated interactions for BCL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | IDA | 16717086 |
| GO:0000902 | cell morphogenesis | IEA | -- |
| GO:0001503 | ossification | IEA | -- |
| GO:0001541 | ovarian follicle development | IEA | -- |
| GO:0001656 | metanephros development | IEA | -- |
Drugs & Compounds for BCL2 Gene
(134) Drugs for BCL2 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Paclitaxel | Approved, Vet_approved | Pharma | Target, inhibitor, Biomarker, binder | Tubulin and Bcl2 inhibitor, Taxanes | 3701 | |
| Docetaxel | Approved, Investigational | Pharma | Target, Inhibition, inhibitor, Biomarker | Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes | 2330 | |
| AT-101 | Approved, Investigational | Pharma | Target, inhibitor | BH3-mimetic,gossypol enantiomer, BCL-2 inhibitors | 86 | |
| Venetoclax | Approved, Investigational | Pharma | Target, inhibitor | Bcl-2 inhibitor,potent and selective | 245 | |
| Carboplatin | Approved | Pharma | Biomarker | Antitumor agent that forms platinum-DNA adducts., Platinum | 2588 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| AT 101 |
|
90141-22-3 |
|
|
||
| SMBA 1 |
|
906440-37-7 |
|
|
(4) Tocris Compounds for BCL2 Gene
(21) ApexBio Compounds for BCL2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| (+)-Apogossypol | 66389-74-0 | |
| ABT-199 | Bcl-2 inhibitor,potent and selective | 1257044-40-8 |
| ABT-263 (Navitoclax) | Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w | 923564-51-6 |
| ABT-737 | Bcl-2 inhibitor | 852808-04-9 |
| Apogossypolone (ApoG2) | Bcl-2 inhibitor,nonpeptidic small molecule | 886578-07-0 |
| AT-101 | BH3-mimetic,gossypol enantiomer | 90141-22-3 |
| Bax inhibitor peptide P5 | Bax inhibitor | 579492-83-4 |
| Bax inhibitor peptide V5 | Bax inhibitor | 579492-81-2 |
| Bcl Family Set I | Bcl family inhibitors | |
| BDA-366 | Selective antagonist of BCL2 BH4 domain | |
| BIM, Biotinylated | ||
| Gossypol | PAF inhibitor;anti-fertility and anti-cancer | 303-45-7 |
| HA14-1 | Bcl-2 inhibitor,potent and cell-permeable | 65673-63-4 |
| Lomustine | Antineoplastic drug | 13010-47-4 |
| Mitomycin C | Inhibits DNA synthesis,antibiotic and antitumor agent | 1950-07-7 |
| Muristerone A | TRAIL- and hFasL-induced apoptosis inhibitor | 38778-30-2 |
| Obatoclax mesylate (GX15-070) | Potent Bcl-2 inhibitor | 803712-79-0 |
| Pyridoclax | ||
| Radotinib(IY-5511) | Bcl-Abl tyrosine kinase inhibitor | 926037-48-1 |
| Sabutoclax | pan-Bcl-2 inhibitor | 1228108-65-3 |
| TW-37 | Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1 | 877877-35-5 |
Drug Products
- G Biosciences Human Apoptosis Regulator Bcl-2, Liquid
- Creative Biomart Recombinant Human BCL2, BH2 domain, His-tagged
- ApexBio compounds for BCL2
Transcripts for BCL2 Gene
mRNA/cDNA for BCL2 Gene
- 2 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000398117 7461 nts (view in UCSC)
- ENST00000333681 6881 nts (view in UCSC)
- ENST00000590515 572 nts (view in UCSC)
- ENST00000589955 5011 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BCL2 - Select products 50% OFF >
- * BCL2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BCL2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCL2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCL2
- Browse OriGene Inhibitory RNA Products For BCL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL2
Clone Products
- Applied Biological Materials (abm): Clones for BCL2 - Select products 50% OFF >
- * BCL2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG226785
- MR212128
- MR212128L3
- MR212128L4
- MR226785
- MR226785L3
- MR226785L4
- RC204498
- RC204498L1
- RC204498L2
- RC204498L3
- RC204498L4
- RC212055
- RC212055L1
- RC212055L2
- RC212055L3
- RC212055L4
- RG204498
- RG212055
- RR214182
- RR214182L3
- RR214182L4
- MR212128L3V
- MR212128L4V
- MR226785L3V
- MR226785L4V
- RC204498L1V
- RC204498L2V
- RC204498L3V
- RC204498L4V
- RC212055L1V
- RC212055L2V
- RC212055L3V
- RC212055L4V
- RR214182L3V
- RR214182L4V
- RC402543
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BCL2
- Addgene plasmids for BCL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCL2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: |
Relevant External Links for BCL2 Gene
- GeneLoc Exon Structure for
- BCL2
Expression for BCL2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Tooth (Integumentary System)
- Early Ameloblasts Dental Enamel
- Odontoblasts Dentin
- Inner Enamel Epithelial Cells Dental Enamel
-
Epithelial Cells
- Early Ameloblasts Dental Enamel
- Inner Enamel Epithelial Cells Dental Enamel
- Basal Keratinocytes Embryonic Epidermis
-
Bone (Muscoskeletal System)
- Prehypertrophic Chondrocytes Vertebrae
- Prechondrocytes Vertebrae
-
Cartilage (Muscoskeletal System)
- Prehypertrophic Chondrocytes Vertebrae
- Prechondrocytes Vertebrae
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
-
Blood (Cardiovascular System)
- T Helper Cells Thymus
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
-
Hair
- Basal Keratinocytes Embryonic Epidermis
- Adipose (Muscoskeletal System)
-
Thyroid (Endocrine System)
-
Lymph (Hematopoietic System)
This gene is overexpressed in Tlymphocyte (10.5), CD8 Tcells (7.9), NK cells (6.4), and Ovary (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BCL2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BCL2
SOURCE GeneReport for Unigene cluster for BCL2 Gene:
Hs.150749mRNA Expression by UniProt/SwissProt for BCL2 Gene:
P10415-BCL2_HUMAN
Tissue specificity:
Expressed in a variety of tissues.
Evidence on tissue expression from TISSUES for BCL2 Gene
- Kidney(3.8)
- Nervous system(2.5)
- Blood(2.5)
- Intestine(2.4)
- Spleen(2.3)
- Lymph node(2.3)
- Thyroid gland(2.3)
- Heart(2.2)
- Muscle(2.2)
- Skin(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL2 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- immune
- integumentary
- lymphatic
- nervous
Regions:
Head and neck:
- brain
- head
Abdomen:
- spleen
General:
- blood
- lymph node
- skin
- sweat gland
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for BCL2
-
OriGene qPCR primer pairs and template standards for BCL2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for BCL2 Gene
Orthologs for BCL2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BCL2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | BCL2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | BCL2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Bcl2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Bcl2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | BCL2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | BCL2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | BCL2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | bcl2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | BCL2 (2 of 2) 31 |
|
OneToMany | |
| bcl2 31 |
|
OneToMany |
- Species where no ortholog for BCL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for BCL2 Gene
- ENSEMBL:
- Gene Tree for BCL2 (if available)
- TreeFam:
- Gene Tree for BCL2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BCL2: view image
Paralogs for BCL2 Gene
Variants for BCL2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BCL2 Gene
| SNP ID | Clinical significance and condition | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 709183 | Likely Benign: not provided | 63,318,208(-) | G/A | SYNONYMOUS_VARIANT | |
| VAR_000828 | Non-Hodgkin lymphoma | p.Pro59Ser | |||
| VAR_000829 | Non-Hodgkin lymphoma | p.Val93Ile | |||
| rs1800477 | - | p.Ala43Thr | |||
| VAR_000827 | - | p.Thr7Ser |
Residual Variation Intolerance Score:
38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.46;
64.20% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BCL2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL2 Gene
Disorders for BCL2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement |
|
|
| follicular lymphoma 1 |
|
|
| intravascular large b-cell lymphoma |
|
|
| lymphoma |
|
|
| follicular lymphoma |
|
Search BCL2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
BCL2_HUMAN- Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. {ECO:0000269 PubMed:2875799, ECO:0000269 PubMed:3285301}.
Genatlas disease for BCL2 Gene
non Hodgkin follicular lymphoma of B-cell type,diffuse large B cell lymphoma,with translocation t(14;18)(q32;q21.3),also extranodal B cell lymphoma (low grade lymphoma of mucosa associated lymphoid tissue),with translocation t(11;18)(q21;q21) and a breakpoint on chromosome 18 between BCL2 and DCC
Additional Disease Information for BCL2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
Publications for BCL2 Gene
- Genetic variation in chromosomal translocation breakpoint and immune function genes and risk of non-Hodgkin lymphoma. (PMID: 20087644) Fernberg P … Ekström Smedby K (Cancer causes & control : CCC 2010) 3 23 41
- Interaction between BCL2 and interleukin-10 gene polymorphisms alter outcomes of diffuse large B-cell lymphoma following rituximab plus CHOP chemotherapy. (PMID: 19276283) Park YH … Kim DH (Clinical cancer research : an official journal of the American Association for Cancer Research 2009) 3 23 41
- Apoptotic gene analysis in idiopathic talipes equinovarus (clubfoot). (PMID: 17534194) Ester AR … Hecht JT (Clinical orthopaedics and related research 2007) 3 23 41
- p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association. (PMID: 15849194) Jin S … Field J (The Journal of biological chemistry 2005) 3 4 23
- Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine. (PMID: 16148027) Bar-Am O … Youdim MB (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005) 3 23 26
ExternalLinks
Products for BCL2 Gene
- View all 10 R&D Systems BCL2 (Bcl-2) Products
- View all R&D Systems BCL2 (Bcl-2) Proteins and Enzymes
- View all 5 R&D Systems BCL2 (Bcl-2) Primary Antibodies
- View all R&D Systems BCL2 (Bcl-2) ELISAs
- View all 3 R&D Systems BCL2 (Bcl-2) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom BCL2 antibody, protein, and immunoassay development services
- OriGene Antibodies for BCL2
- AM06485SU-N
- AM09378PU-N
- AM09378PU-S
- AM20590PU-N
- AM26046AC-N
- AM26046FC-N
- AM26046PU-N
- AM26046RP-N
- AM32275SU-N
- AM32832PU-S
- AM32832PU-T
- AM33245PU-S
- AM33245PU-T
- AM33344PU-S
- AM33344PU-T
- AM50163PU-S
- AM50163PU-T
- AM50164PU-S
- AM50164PU-T
- AM50201PU-S
- AM50201PU-T
- AP00016PU-N
- AP01536PU-N
- AP01537PU-N
- AP02600PU-N
- AP02600PU-S
- AP02601PU-N
- AP02601PU-S
- AP05004PU-N
- AP06028PU-N
- AP06497PU-N
- AP11295PU-N
- AP21081PU-N
- AP26415AF-L
- AP26415AF-N
- AP26416AF-L
- AP26416AF-N
- AP55894PU-N
- AP55894PU-S
- CF803003
- CF803079
- CF806589
- CF806590
- CF806591
- CF806592
- CF806593
- CF806622
- CF806623
- CF806624
- CF806625
- CF806639
- TA302955
- TA306171
- TA306172
- TA318664
- TA320222
- TA323608
- TA324789
- TA325259
- TA325260
- TA325261
- TA326053
- TA327425
- TA327606
- TA327607
- TA327793
- TA327922
- TA332373
- TA333169
- TA333170
- TA347780
- TA352999L
- TA353000L
- TA353001L
- TA354256
- TA354330
- TA354422
- TA354569
- TA354647
- TA354658
- TA590781
- TA803003
- TA803003S
- TA803079
- TA803079S
- TA806589
- TA806589S
- TA806590
- TA806590S
- TA806591
- TA806591S
- TA806592
- TA806592S
- TA806593
- TA806593S
- TA806622
- TA806622S
- TA806623