Aliases for BCHE Gene
External Ids for BCHE Gene
Previous HGNC Symbols for BCHE Gene
Previous GeneCards Identifiers for BCHE Gene
This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits broad substrate specificity and is involved in the detoxification of poisons including organophosphate nerve agents and pesticides, and the metabolism of drugs including cocaine, heroin and aspirin. Humans homozygous for certain mutations in this gene exhibit prolonged apnea after administration of the muscle relaxant succinylcholine. [provided by RefSeq, Jul 2016]
GeneCards Summary for BCHE Gene
BCHE (Butyrylcholinesterase) is a Protein Coding gene. Diseases associated with BCHE include Butyrylcholinesterase Deficiency and Chorea, Benign Hereditary. Among its related pathways are Glycerophospholipid biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include identical protein binding and hydrolase activity. An important paralog of this gene is ACHE.
UniProtKB/Swiss-Prot Summary for BCHE Gene
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Cholinesterases inactivate the neurotransmitter acetylcholine by catalyzing its hydrolysis to choline and acetic acid. Acetylcholinesterase (AChE) is found in erythroid cells and at neuronal synapses, whilst butyrylcholinesterase is mostly expressed in the liver.