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Aliases for BCAR4 Gene

Subcategory (RNA class) for BCAR4 Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for BCAR4 Gene

  • Breast Cancer Anti-Estrogen Resistance 4 2 3 5
  • Breast Cancer Anti-Estrogen Resistance 4 (Non-Protein Coding) 2 3
  • Breast Cancer Antiestrogen Resistance 4 Protein 3 13
  • HCG1814062, Isoform CRA_a 13

External Ids for BCAR4 Gene

Previous GeneCards Identifiers for BCAR4 Gene

  • GC16U900561
  • GC16M011913
  • GC16M011830

Summaries for BCAR4 Gene

Entrez Gene Summary for BCAR4 Gene

  • This gene produces a spliced long non-coding RNA (lncRNA) that has been implicated in breast cancer metastasis. It was originally identified in a screen for genes responsible for the development of resistance to anti-estrogens in breast cancer cells. It is thought that release of CCL21 enables this lncRNA to bind to the SNIP1 and PNUTS transcription factors, thereby activating a non-canonical GLI-dependent hedgehog signaling pathway that promotes cancer cell migration and invasion. A similar gene in cow expresses a protein in mature oocytes and preimplantation embryos. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2015]

GeneCards Summary for BCAR4 Gene

BCAR4 (Breast Cancer Anti-Estrogen Resistance 4) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with BCAR4 include Chondrosarcoma and Osteogenic Sarcoma.

Additional gene information for BCAR4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCAR4 Gene

Genomics for BCAR4 Gene

GeneHancer (GH) Regulatory Elements for BCAR4 Gene

Promoters and enhancers for BCAR4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J011822 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.7 +4.3 4344 5 ELF3 MNT CEBPG AHR TFE3 SP1 PPARG ZNF644 KAT8 HMG20B RSL1D1 NPIPB2 ENSG00000261560 BCAR4 PIR45623
GH16J011833 Enhancer 1.4 Ensembl ENCODE dbSUPER 0.4 -7.1 -7107 4.3 SP1 MNT CBFA2T2 POLR2A CEBPG ZBTB7A PRDM1 PKNOX1 RXRA IKZF1 GSPT1 NPIPB2 RSL1D1 ENSG00000261560 BCAR4 LOC105371084
GH16J011819 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 +8.7 8744 2.2 SMARCA4 PKNOX1 HDAC1 SOX6 MGA ZNF10 HDAC2 EHMT2 FOXK2 FOSL1 ZC3H7A NPIPB2 BCAR4 PIR45623
GH16J011809 Enhancer 1.1 ENCODE dbSUPER 0.4 +18.6 18571 1.7 ZNF652 ELF3 CEBPG SP1 HNF1A KAT8 HMG20B PRDM10 IKZF2 GATAD2A ZC3H7A ENSG00000261560 ENSG00000263307 COX6CP1 HNRNPCP4 TXNDC11 RSL1D1 ENSG00000261216 SOCS1 ENSG00000261158
GH16J011813 Enhancer 0.7 dbSUPER 0.4 +14.4 14376 1.6 CTCF ZNF384 RAD21 IKZF1 PRDM10 TRIM22 IKZF2 KLF9 FOXA2 SMC3 ENSG00000260488 BCAR4 PIR45623
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BCAR4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BCAR4 gene promoter:
  • CUTL1
  • GR
  • GR-alpha
  • GR-beta
  • HOXA3
  • ISGF-3

Genomic Locations for BCAR4 Gene

Genomic Locations for BCAR4 Gene
chr16:11,819,829-11,828,845
(GRCh38/hg38)
Size:
9,017 bases
Orientation:
Minus strand
chr16:11,913,686-11,922,702
(GRCh37/hg19)
Size:
9,017 bases
Orientation:
Minus strand

Genomic View for BCAR4 Gene

Genes around BCAR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCAR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCAR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCAR4 Gene

Proteins for BCAR4 Gene

  • Protein details for BCAR4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    D3DUG6-D3DUG6_HUMAN
    Recommended name:
    Breast cancer antiestrogen resistance 4 protein
    Protein Accession:
    D3DUG6

    Protein attributes for BCAR4 Gene

    Size:
    121 amino acids
    Molecular mass:
    13174 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BCAR4 Gene

Post-translational modifications for BCAR4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for BCAR4 Gene

Domains & Families for BCAR4 Gene

Gene Families for BCAR4 Gene

Protein Domains for BCAR4 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BCAR4: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for BCAR4 Gene

Function for BCAR4 Gene

Phenotypes From GWAS Catalog for BCAR4 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BCAR4 Gene

Localization for BCAR4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for BCAR4 Gene

Pathways & Interactions for BCAR4 Gene

PathCards logo

SuperPathways for BCAR4 Gene

No Data Available

Interacting Proteins for BCAR4 Gene

Gene Ontology (GO) - Biological Process for BCAR4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BCAR4 Gene

Drugs & Compounds for BCAR4 Gene

No Compound Related Data Available

Transcripts for BCAR4 Gene

mRNA/cDNA for BCAR4 Gene

Unigene Clusters for BCAR4 Gene

Breast cancer anti-estrogen resistance 4 (non-protein coding):
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCAR4 Gene

No ASD Table

Relevant External Links for BCAR4 Gene

GeneLoc Exon Structure for
BCAR4
ECgene alternative splicing isoforms for
BCAR4

Expression for BCAR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BCAR4 Gene

NURSA nuclear receptor signaling pathways regulating expression of BCAR4 Gene:

BCAR4

SOURCE GeneReport for Unigene cluster for BCAR4 Gene:

Hs.24611
genes like me logo Genes that share expression patterns with BCAR4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCAR4 Gene

Orthologs for BCAR4 Gene

Evolution for BCAR4 Gene

ENSEMBL:
Gene Tree for BCAR4 (if available)
TreeFam:
Gene Tree for BCAR4 (if available)

No data available for Orthologs for BCAR4 Gene

Paralogs for BCAR4 Gene

No data available for Paralogs for BCAR4 Gene

Variants for BCAR4 Gene

Sequence variations from dbSNP and Humsavar for BCAR4 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000190237 -- 11,821,483(-) G/T intron_variant
rs1000254696 -- 11,825,679(-) G/C intron_variant
rs1000357293 -- 11,830,309(-) A/G/T upstream_transcript_variant
rs1000409594 -- 11,830,097(-) T/C upstream_transcript_variant
rs1000569525 -- 11,822,170(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BCAR4 Gene

Variant ID Type Subtype PubMed ID
esv3637940 CNV loss 21293372
esv3637941 CNV loss 21293372
nsv1043909 CNV gain 25217958
nsv1120318 CNV tandem duplication 24896259

Additional Variant Information for BCAR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCAR4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for BCAR4 Gene

Disorders for BCAR4 Gene

MalaCards: The human disease database

(8) MalaCards diseases for BCAR4 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
chondrosarcoma
  • cartilaginous cancer
osteogenic sarcoma
  • osteosarcoma; osrc
cervical cancer
  • cervical cancer, somatic
breast cancer
  • breast tumor
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards
Search BCAR4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BCAR4

genes like me logo Genes that share disorders with BCAR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCAR4 Gene

Publications for BCAR4 Gene

  1. Breast-cancer anti-estrogen resistance 4 (BCAR4) encodes a novel maternal-effect protein in bovine and is expressed in the oocyte of humans and other non-rodent mammals. (PMID: 23202989) Angulo L … Dalbies-Tran R (Human reproduction (Oxford, England) 2013) 2 3 58
  2. Functional screen for genes responsible for tamoxifen resistance in human breast cancer cells. (PMID: 16778085) Meijer D … Dorssers LC (Molecular cancer research : MCR 2006) 2 3 58
  3. lncRNA BCAR4 Increases Viability, Invasion, and Migration of Non-Small Cell Lung Cancer Cells by Targeting Glioma-Associated Oncogene 2 (GLI2). (PMID: 29615150) Yang H … Song T (Oncology research 2019) 3 58
  4. Up-regulated BCAR4 contributes to proliferation and migration of cervical cancer cells. (PMID: 29937186) Zou R … Zhu H (Surgical oncology 2018) 3 58
  5. Increased Expression of Long Non-Coding RNA BCAR4 Is Predictive of Poor Prognosis in Patients with Non-Small Cell Lung Cancer. (PMID: 28077810) Gong J … Wang J (The Tohoku journal of experimental medicine 2017) 3 58

Products for BCAR4 Gene

Sources for BCAR4 Gene

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