This gene produces a spliced long non-coding RNA (lncRNA) that has been implicated in breast cancer metastasis. It was originally identified in a screen for genes responsible for the development of resistance to anti-estrogens in breast cancer cells. It is thought that release of CCL21 enables this lncRNA to bind to the SNIP1 and PNUTS transcription factors, thereby activating ... See more...

Aliases for BCAR4 Gene

Subcategory (RNA class) for BCAR4 Gene

lncRNA

Number of RNA Genes sources:

3 / 17

Aliases for BCAR4 Gene

  • Breast Cancer Anti-Estrogen Resistance 4 2 3 5
  • BCAR4 2 5 165
  • Breast Cancer Anti-Estrogen Resistance 4 (Non-Protein Coding) 2 3
  • Breast Cancer Antiestrogen Resistance 4 Protein 3 13
  • HCG1814062, Isoform CRA_a 13
  • NONHSAG018621.2 91
  • HSALNG0109621 164

External Ids for BCAR4 Gene

Previous GeneCards Identifiers for BCAR4 Gene

  • GC16U900561
  • GC16M011913
  • GC16M011830

Summaries for BCAR4 Gene

Entrez Gene Summary for BCAR4 Gene

  • This gene produces a spliced long non-coding RNA (lncRNA) that has been implicated in breast cancer metastasis. It was originally identified in a screen for genes responsible for the development of resistance to anti-estrogens in breast cancer cells. It is thought that release of CCL21 enables this lncRNA to bind to the SNIP1 and PNUTS transcription factors, thereby activating a non-canonical GLI-dependent hedgehog signaling pathway that promotes cancer cell migration and invasion. A similar gene in cow expresses a protein in mature oocytes and preimplantation embryos. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2015]

GeneCards Summary for BCAR4 Gene

BCAR4 (Breast Cancer Anti-Estrogen Resistance 4) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with BCAR4 include Chondrosarcoma and Osteogenic Sarcoma.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BCAR4 Gene

Genomics for BCAR4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BCAR4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J011828 Promoter 0.6 EPDnew 600.7 0.0 -7 0.1 FOXA1 ZBTB20 ZFP64 BCAR4 HSALNG0109622 RSL1D1 ZC3H7A
GH16J011822 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.7 +4.6 4597 4.3 GATAD2A TFE3 NFKBIZ RCOR2 RXRB SP1 CEBPA TCF12 FOXK2 SCRT2 piR-32214-238 RSL1D1 NPIPB2 ENSG00000261560 BCAR4 ZC3H7A
GH16J011819 Enhancer 1 Ensembl ENCODE dbSUPER 0.4 +9.0 9044 1.6 JUND PKNOX1 BRD9 HDAC1 SOX6 MGA HMBOX1 ZNF10 FOXK2 HDAC2 ZC3H7A piR-32214-238 BCAR4 piR-51624 RSL1D1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BCAR4 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the BCAR4 gene promoter:
  • CUTL1
  • GR
  • GR-alpha
  • GR-beta
  • HOXA3
  • ISGF-3

Genomic Locations for BCAR4 Gene

Genomic Locations for BCAR4 Gene
chr16:11,818,293-11,828,845
(GRCh38/hg38)
Size:
10,553 bases
Orientation:
Minus strand
chr16:11,913,686-11,922,702
(GRCh37/hg19)
Size:
9,017 bases
Orientation:
Minus strand

Genomic View for BCAR4 Gene

Genes around BCAR4 on UCSC Golden Path with GeneCards custom track
BCAR4 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
BCAR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCAR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCAR4 Gene

Proteins for BCAR4 Gene

  • Protein details for BCAR4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    D3DUG6-D3DUG6_HUMAN
    Recommended name:
    Breast cancer antiestrogen resistance 4 protein
    Protein Accession:
    D3DUG6

    Protein attributes for BCAR4 Gene

    Size:
    121 amino acids
    Molecular mass:
    13174 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BCAR4 Gene

Post-translational modifications for BCAR4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for BCAR4 Gene

Domains & Families for BCAR4 Gene

Gene Families for BCAR4 Gene

Protein Domains for BCAR4 Gene

ProtoNet:
genes like me logo Genes that share domains with BCAR4: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BCAR4 Gene

Function for BCAR4 Gene

Phenotypes From GWAS Catalog for BCAR4 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BCAR4 Gene

Localization for BCAR4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCAR4 gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for BCAR4 Gene

Pathways & Interactions for BCAR4 Gene

PathCards logo

SuperPathways for BCAR4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCAR4 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for BCAR4 Gene

Drugs & Compounds for BCAR4 Gene

No Compound Related Data Available

Transcripts for BCAR4 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for BCAR4 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00001269AB_9606 lncRNA 470 4

Ensembl: ENST00000574028 (view in UCSC) ,

LncBook: HSALNT0227774,

LNCipedia: BCAR4:7,

NONCODE: NONHSAT140596.2,

URS0000344188_9606 lncRNA 378 4

Ensembl: ENST00000577041 (view in UCSC) ,

LncBook: HSALNT0227777,

LNCipedia: BCAR4:9,

NONCODE: NONHSAT140597.2,

URS000075E333_9606 lncRNA 1314 3

HGNC: 22170,

RefSeq: NR_024049,

LNCipedia: BCAR4:20,

URS00003A7954_9606 lncRNA 887 3

Ensembl: ENST00000573037 (view in UCSC) ,

LNCipedia: BCAR4:3,

NONCODE: NONHSAT140593.2,

URS00005291DE_9606 lncRNA 791 3

Ensembl: ENST00000571158 (view in UCSC) ,

LNCipedia: BCAR4:1,

NONCODE: NONHSAT140595.2,

BCAR4 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for BCAR4 Gene

6 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCAR4 Gene

No ASD Table

Relevant External Links for BCAR4 Gene

GeneLoc Exon Structure for
BCAR4

Expression for BCAR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BCAR4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BCAR4

SOURCE GeneReport for Unigene cluster for BCAR4 Gene:

Hs.24611
genes like me logo Genes that share expression patterns with BCAR4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCAR4 Gene

Orthologs for BCAR4 Gene

Evolution for BCAR4 Gene

ENSEMBL:
Gene Tree for BCAR4 (if available)
TreeFam:
Gene Tree for BCAR4 (if available)

No data available for Orthologs for BCAR4 Gene

Paralogs for BCAR4 Gene

No data available for Paralogs for BCAR4 Gene

Variants for BCAR4 Gene

Additional dbSNP identifiers (rs#s) for BCAR4 Gene

Structural Variations from Database of Genomic Variants (DGV) for BCAR4 Gene

Variant ID Type Subtype PubMed ID
esv3637940 CNV loss 21293372
esv3637941 CNV loss 21293372
nsv1043909 CNV gain 25217958
nsv1120318 CNV tandem duplication 24896259

Additional Variant Information for BCAR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCAR4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for BCAR4 Gene

Disorders for BCAR4 Gene

MalaCards: The human disease database

(9) MalaCards diseases for BCAR4 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
chondrosarcoma
  • cartilaginous cancer
osteogenic sarcoma
  • osteosarcoma; osrc
cervical cancer
  • cervical cancer, somatic
breast cancer
  • breast lobular carcinoma
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search BCAR4 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with BCAR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCAR4 Gene

Publications for BCAR4 Gene

  1. Breast-cancer anti-estrogen resistance 4 (BCAR4) encodes a novel maternal-effect protein in bovine and is expressed in the oocyte of humans and other non-rodent mammals. (PMID: 23202989) Angulo L … Dalbies-Tran R (Human reproduction (Oxford, England) 2013) 2 3
  2. Functional screen for genes responsible for tamoxifen resistance in human breast cancer cells. (PMID: 16778085) Meijer D … Dorssers LC (Molecular cancer research : MCR 2006) 2 3
  3. Long noncoding RNA Breast cancer antiestrogen resistance 4 is associated with cancer progression and its significant prognostic value. (PMID: 30537165) Zhao W … Fang J (Journal of cellular physiology 2019) 3
  4. lncRNA BCAR4 Increases Viability, Invasion, and Migration of Non-Small Cell Lung Cancer Cells by Targeting Glioma-Associated Oncogene 2 (GLI2). (PMID: 29615150) Yang H … Song T (Oncology research 2019) 3
  5. Up-regulated BCAR4 contributes to proliferation and migration of cervical cancer cells. (PMID: 29937186) Zou R … Zhu H (Surgical oncology 2018) 3

Products for BCAR4 Gene

Sources for BCAR4 Gene