Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intrace... See more...

Aliases for BCAR3 Gene

Aliases for BCAR3 Gene

  • BCAR3 Adaptor Protein, NSP Family Member 2 3 5
  • SH2D3B 2 3 4
  • NSP2 2 3 4
  • Breast Cancer Anti-Estrogen Resistance Protein 3 3 4
  • Breast Cancer Anti-Estrogen Resistance 3 2 3
  • BCAR3, NSP Family Adaptor Protein 2 3
  • SH2 Domain-Containing Protein 3B 3 4
  • Novel SH2-Containing Protein 2 3 4
  • Migration Inducting Gene-7 2 3
  • AND-34 2 3
  • MIG7 2 3
  • DJ1033H22.2 (Breast Cancer Anti-Estrogen Resistance 3) 3
  • Breast Cancer Antiestrogen Resistance 3 Protein 3
  • Epididymis Secretory Sperm Binding Protein 3
  • Mig-7 3
  • BCAR3 5

External Ids for BCAR3 Gene

Previous GeneCards Identifiers for BCAR3 Gene

  • GC01M094433
  • GC01M093233
  • GC01M093377
  • GC01M093499
  • GC01M093739
  • GC01M093799
  • GC01M094027
  • GC01M092148

Summaries for BCAR3 Gene

Entrez Gene Summary for BCAR3 Gene

  • Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for BCAR3 Gene

BCAR3 (BCAR3 Adaptor Protein, NSP Family Member) is a Protein Coding gene. Diseases associated with BCAR3 include Estrogen Resistance and Breast Cancer. Among its related pathways are Tyrosine Kinases / Adaptors and Regulation of CDC42 activity. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is SH2D3C.

UniProtKB/Swiss-Prot Summary for BCAR3 Gene

  • Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014).

Gene Wiki entry for BCAR3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BCAR3 Gene

Genomics for BCAR3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BCAR3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BCAR3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BCAR3

Top Transcription factor binding sites by QIAGEN in the BCAR3 gene promoter:
  • AREB6
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • HNF-3beta
  • Ik-2
  • NF-Y
  • STAT5A

Genomic Locations for BCAR3 Gene

Latest Assembly
chr1:93,561,741-93,847,219
(GRCh38/hg38)
Size:
285,479 bases
Orientation:
Minus strand

Previous Assembly
chr1:94,027,298-94,312,775
(GRCh37/hg19 by Entrez Gene)
Size:
285,478 bases
Orientation:
Minus strand

chr1:94,027,347-94,312,706
(GRCh37/hg19 by Ensembl)
Size:
285,360 bases
Orientation:
Minus strand

Genomic View for BCAR3 Gene

Genes around BCAR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCAR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCAR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCAR3 Gene

Proteins for BCAR3 Gene

  • Protein details for BCAR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75815-BCAR3_HUMAN
    Recommended name:
    Breast cancer anti-estrogen resistance protein 3
    Protein Accession:
    O75815
    Secondary Accessions:
    • D3DT43
    • Q5TEW3
    • Q6UW40
    • Q9BR50

    Protein attributes for BCAR3 Gene

    Size:
    825 amino acids
    Molecular mass:
    92566 Da
    Quaternary structure:
    • Part of a complex comprised of PTPRA, BCAR1, BCAR3 (via SH2 domain) and SRC; the formation of the complex is dependent on integrin mediated-tyrosine phosphorylation of PTPRA (PubMed:22801373). Within the complex, interacts (via SH2 domain) with PTPRA (when phosphorylated on 'Tyr-798') (PubMed:22801373). Interacts (via Ras-GEF domain) with BCAR1 (PubMed:18722344, PubMed:19086031, PubMed:22081014). Interacts (via Ras-GEF domain) with NEDD9 (By similarity). Interacts with PTK2/FAK1 (By similarity). Interacts with PTPN1. Interacts (via SH2 domain) with EGFR (when tyrosine-phosphorylated) (PubMed:18722344).
    Miscellaneous:
    • Overexpression confers anti-estrogen resistance via RRAS-independent activation of the PI3K pathway, and activation of the cyclin D1 promoter in breast cancer cell lines (PubMed:9582273). Plays a role in insulin-mediated ERK activation and DNA synthesis in breast cancer cells (PubMed:24216110).

    Three dimensional structures from OCA and Proteopedia for BCAR3 Gene

    Alternative splice isoforms for BCAR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCAR3 Gene

Post-translational modifications for BCAR3 Gene

No data available for DME Specific Peptides for BCAR3 Gene

Domains & Families for BCAR3 Gene

Gene Families for BCAR3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BCAR3 Gene

InterPro:
Blocks:
  • SH2 domain signature
  • Guanine-nucleotide dissociation stimulator CDC25

Suggested Antigen Peptide Sequences for BCAR3 Gene

GenScript: Design optimal peptide antigens:
  • SH2 domain-containing protein 3B (BCAR3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75815

UniProtKB/Swiss-Prot:

BCAR3_HUMAN :
  • The SH2 domain mediates interaction with tyrosine-phosphorylated proteins (PubMed:18722344). However, not involved in the binding to phosphorylated BCAR1 (PubMed:18722344). Required for cell cycle progression in response to INS/insulin (PubMed:24216110). Required for regulation of EFR-induced DNA synthesis (PubMed:18722344).
Domain:
  • The SH2 domain mediates interaction with tyrosine-phosphorylated proteins (PubMed:18722344). However, not involved in the binding to phosphorylated BCAR1 (PubMed:18722344). Required for cell cycle progression in response to INS/insulin (PubMed:24216110). Required for regulation of EFR-induced DNA synthesis (PubMed:18722344).
  • The Ras-GEF domain appears to adopt a closed conformation rendering it incapable of carrying out canonical exchange factor function, this closed conformation is probably required for interaction with BCAR1.
genes like me logo Genes that share domains with BCAR3: view

Function for BCAR3 Gene

Molecular function for BCAR3 Gene

UniProtKB/Swiss-Prot Function:
Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014).

Phenotypes From GWAS Catalog for BCAR3 Gene

Gene Ontology (GO) - Molecular Function for BCAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine residue binding IMP 24216110
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 16273093
GO:0019900 kinase binding IPI 18722344
genes like me logo Genes that share ontologies with BCAR3: view
genes like me logo Genes that share phenotypes with BCAR3: view

Animal Models for BCAR3 Gene

MGI Knock Outs for BCAR3:

miRNA for BCAR3 Gene

miRTarBase miRNAs that target BCAR3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCAR3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCAR3 Gene

Localization for BCAR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCAR3 Gene

Cytoplasm. Cell junction, focal adhesion. Note=Localization to focal adhesions depends on interaction with PTPRA. {ECO:0000250 UniProtKB:Q9QZK2}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCAR3 gene
Compartment Confidence
cytosol 4
plasma membrane 3
cytoskeleton 3
nucleus 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BCAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005925 focal adhesion ISS --
GO:0016020 membrane ISS --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with BCAR3: view

Pathways & Interactions for BCAR3 Gene

genes like me logo Genes that share pathways with BCAR3: view

Pathways by source for BCAR3 Gene

1 BioSystems pathway for BCAR3 Gene
1 Cell Signaling Technology pathway for BCAR3 Gene

Gene Ontology (GO) - Biological Process for BCAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002089 lens morphogenesis in camera-type eye IEA --
GO:0007165 signal transduction TAS 9582273
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008286 insulin receptor signaling pathway IMP 24216110
GO:0033138 positive regulation of peptidyl-serine phosphorylation IBA 21873635
genes like me logo Genes that share ontologies with BCAR3: view

No data available for SIGNOR curated interactions for BCAR3 Gene

Drugs & Compounds for BCAR3 Gene

(1) Drugs for BCAR3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with BCAR3: view

Transcripts for BCAR3 Gene

mRNA/cDNA for BCAR3 Gene

5 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCAR3

Alternative Splicing Database (ASD) splice patterns (SP) for BCAR3 Gene

No ASD Table

Relevant External Links for BCAR3 Gene

GeneLoc Exon Structure for
BCAR3

Expression for BCAR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BCAR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BCAR3 Gene

This gene is overexpressed in Placenta (42.6) and Testis (26.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BCAR3 Gene



Protein tissue co-expression partners for BCAR3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BCAR3

SOURCE GeneReport for Unigene cluster for BCAR3 Gene:

Hs.36958

mRNA Expression by UniProt/SwissProt for BCAR3 Gene:

O75815-BCAR3_HUMAN
Tissue specificity: Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue.

Evidence on tissue expression from TISSUES for BCAR3 Gene

  • Kidney(4.4)
  • Heart(4.3)
  • Lung(4.3)
  • Liver(4.3)
  • Nervous system(3)
genes like me logo Genes that share expression patterns with BCAR3: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCAR3 Gene

Orthologs for BCAR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BCAR3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia BCAR3 29 30
  • 99.31 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia BCAR3 29 30
  • 86.99 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia BCAR3 29 30
  • 86.91 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 86 (a)
OneToMany
-- 30
  • 81 (a)
OneToMany
-- 30
  • 22 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Bcar3 29
  • 84.93 (n)
Mouse
(Mus musculus)
Mammalia Bcar3 29 16 30
  • 84.57 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia BCAR3 30
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves BCAR3 29 30
  • 68.67 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia BCAR3 30
  • 63 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia bcar3 29
  • 64.85 (n)
Zebrafish
(Danio rerio)
Actinopterygii bcar3 29 30
  • 61.9 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG9098 30 31
  • 22 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10354 30
  • 32 (a)
OneToMany
Species where no ortholog for BCAR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for BCAR3 Gene

ENSEMBL:
Gene Tree for BCAR3 (if available)
TreeFam:
Gene Tree for BCAR3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BCAR3: view image
Alliance of Genome Resources:
Additional Orthologs for BCAR3

Paralogs for BCAR3 Gene

Paralogs for BCAR3 Gene

(2) SIMAP similar genes for BCAR3 Gene using alignment to 1 proteins:

  • BCAR3_HUMAN
genes like me logo Genes that share paralogs with BCAR3: view

Variants for BCAR3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BCAR3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
993628 Uncertain Significance: none provided 93,582,914(-) C/T
NM_003567.4(BCAR3):c.1073G>A (p.Ser358Asn)
MISSENSE
993827 Uncertain Significance: none provided 93,567,305(-) C/T
NM_003567.4(BCAR3):c.2273G>A (p.Arg758Gln)
MISSENSE
rs113172289 Likely Benign: not provided 93,589,278(-) C/T
NM_003567.4(BCAR3):c.628G>A (p.Glu210Lys)
MISSENSE
rs116760841 Benign: not provided 93,582,469(-) C/T
NM_003567.4(BCAR3):c.1518G>A (p.Thr506=)
SYNONYMOUS
rs146602562 Benign: not provided 93,571,710(-) T/C
NM_003567.4(BCAR3):c.1934A>G (p.Tyr645Cys)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for BCAR3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for BCAR3 Gene

Variant ID Type Subtype PubMed ID
dgv127n106 CNV deletion 24896259
dgv368n54 CNV gain+loss 21841781
dgv369n54 CNV loss 21841781
dgv370n54 CNV loss 21841781
dgv371n54 CNV loss 21841781
dgv372n54 CNV gain 21841781
dgv373n54 CNV loss 21841781
dgv374n54 CNV loss 21841781
dgv4e180 CNV loss 20482838
dgv56n67 CNV loss 20364138
esv1003322 CNV deletion 20482838
esv1005153 CNV deletion 20482838
esv1011314 CNV deletion 20482838
esv1112742 CNV deletion 17803354
esv2062392 CNV deletion 18987734
esv2442893 CNV deletion 19546169
esv2595696 CNV deletion 19546169
esv2657590 CNV deletion 23128226
esv2660297 CNV deletion 23128226
esv2676089 CNV deletion 23128226
esv2714884 CNV deletion 23290073
esv2714895 CNV deletion 23290073
esv27447 CNV gain+loss 19812545
esv27510 CNV loss 19812545
esv2850902 CNV deletion 24192839
esv33428 CNV loss 17666407
esv33739 CNV gain+loss 17666407
esv3565915 CNV deletion 23714750
esv3565926 CNV deletion 23714750
esv3586831 CNV loss 21293372
esv3586832 CNV loss 21293372
esv3586833 CNV loss 21293372
esv5334 CNV loss 18987735
esv8088 CNV loss 19470904
esv8503 CNV gain 19470904
nsv1011853 CNV loss 25217958
nsv1133879 CNV deletion 24896259
nsv1146358 CNV deletion 26484159
nsv160444 CNV deletion 16902084
nsv1877 CNV deletion 18451855
nsv508415 CNV deletion 20534489
nsv546822 CNV gain 21841781
nsv546829 CNV gain+loss 21841781
nsv546830 CNV loss 21841781
nsv821520 CNV deletion 20802225
nsv955753 CNV deletion 24416366
nsv998755 CNV loss 25217958

Variation tolerance for BCAR3 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.95; 67.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BCAR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCAR3
Leiden Open Variation Database (LOVD)
BCAR3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCAR3 Gene

Disorders for BCAR3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for BCAR3 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
estrogen resistance
  • estrr
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search BCAR3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BCAR3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with BCAR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCAR3 Gene

Publications for BCAR3 Gene

  1. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. (PMID: 9582273) van Agthoven T … Dorssers LC (The EMBO journal 1998) 2 3 4 22
  2. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. (PMID: 22081014) Mace PD … Riedl SJ (Nature structural & molecular biology 2011) 2 3 4
  3. BCAR3 regulates EGF-induced DNA synthesis in normal human breast MCF-12A cells. (PMID: 18722344) Oh MJ … Jhun BH (Biochemical and biophysical research communications 2008) 3 4 22
  4. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway. (PMID: 10187783) Lu Y … Stewart TA (The Journal of biological chemistry 1999) 3 4 22
  5. Functional roles of BCAR3 in the signaling pathways of insulin leading to DNA synthesis, membrane ruffling and GLUT4 translocation. (PMID: 24216110) Oh MJ … Jhun BH (Biochemical and biophysical research communications 2013) 3 4

Products for BCAR3 Gene

  • Boster Bio Antibodies for BCAR3
  • Boster Bio ELISA Kits for BCAR3

Sources for BCAR3 Gene