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The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP... See more...
Aliases for BCAR1 Gene
Aliases for BCAR1 Gene
External Ids for BCAR1 Gene
- HGNC: 971
- Entrez Gene: 9564
- Ensembl: ENSG00000050820
- OMIM: 602941
- UniProtKB: P56945
Previous GeneCards Identifiers for BCAR1 Gene
- GC16M066192
- GC16M076223
- GC16M075001
- GC16M075042
- GC16M073820
- GC16M075262
- GC16M061013
Summaries for BCAR1 Gene
-
The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017]
GeneCards Summary for BCAR1 Gene
BCAR1 (BCAR1 Scaffold Protein, Cas Family Member) is a Protein Coding gene. Diseases associated with BCAR1 include Estrogen Resistance and Nephronophthisis 1. Among its related pathways are Signaling by GPCR and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and SH3 domain binding. An important paralog of this gene is NEDD9.
UniProtKB/Swiss-Prot Summary for BCAR1 Gene
-
Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12832404, PubMed:12432078). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity).
Additional gene information for BCAR1 Gene
- HGNC(971)
- Entrez Gene(9564)
- Ensembl(ENSG00000050820)
- OMIM(602941)
- UniProtKB(P56945)
- Open Targets Platform(ENSG00000050820)
- Monarch Initiative
- Search for BCAR1 at DataMed
- Search for BCAR1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BCAR1 Gene
Genomics for BCAR1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BCAR1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BCAR1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BCAR1
- Top Transcription factor binding sites by QIAGEN in the BCAR1 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- LCR-F1
Genomic Locations for BCAR1 Gene
Genomic Locations for BCAR1 Gene
- chr16:75,228,181-75,268,053
- (GRCh38/hg38)
- Size:
- 39,873 bases
- Orientation:
- Minus strand
- chr16:75,262,928-75,301,951
- (GRCh37/hg19)
- Size:
- 39,024 bases
- Orientation:
- Minus strand
Genomic View for BCAR1 Gene
Genes around BCAR1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q23.1 by HGNC
- 16q23.1 by Entrez Gene
- 16q23.1 by Ensembl
BCAR1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BCAR1 Gene
Proteins for BCAR1 Gene
-
Protein details for BCAR1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P56945-BCAR1_HUMAN
- Recommended name:
- Breast cancer anti-estrogen resistance protein 1
- Protein Accession:
- P56945
- B3KWD7
- B4DEV4
- B4DGB5
- B4DIW5
- B7Z7X7
- E9PCL5
- E9PCV2
- F5GXA2
- F5GXV6
- F5H7Z0
- F8WA69
- Q6QEF7
Protein attributes for BCAR1 Gene
- Size:
- 870 amino acids
- Molecular mass:
- 93372 Da
- Quaternary structure:
-
- Forms complexes in vivo with PTK2/FAK1, adapter protein CRKL and LYN kinase. Can heterodimerize with NEDD9. Component of a complex comprised of SH2D3C, BCAR1/CAS, and CRK (PubMed:12432078). Within the complex, interacts with SH2D3C (via C-terminus), and CRK (PubMed:12432078, PubMed:17174122). Part of a complex comprised of PTPRA, BCAR1, BCAR3 (via SH2 domain) and SRC; the formation of the complex is dependent on intergrin mediated-tyrosine phosphorylation of PTPRA (PubMed:22801373). Interacts with BCAR3 (via Ras-GEF domain); the interaction regulates adhesion-dependent serine phosphorylation (PubMed:22081014). Interacts with SMAD2 and SMAD3 (By similarity). Interacts with NPHP1 (By similarity). Interacts with PTK2B/PYK2 (PubMed:19086031). Interacts (via C-terminus) with SH2D3C/CHAT isoform 2 (via C-terminus) (PubMed:17174122, PubMed:22081014). Interacts with activated CSPG4. Interacts with BMX, INPPL1/SHIP2 and PEAK1. Part of a collagen-stimulated complex involved in cell migration made of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with TNK2 via SH3 domains.
Three dimensional structures from OCA and Proteopedia for BCAR1 Gene
Protein Expression for BCAR1 Gene
Post-translational modifications for BCAR1 Gene
- PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin-mediated adhesion of cells to the extracellular matrix.
- Dephosphorylated by PTPN14 at Tyr-128.
- Phosphorylated by SRC kinase in a EDN1- and PTK2B-mediated manner; phosphorylation strengthens its interaction with BCAR3 as part of the PTK2B/BCAR1/BCAR3/RAP1 signaling pathway.
-
Ubiquitination at Lys702
- NX_P56945 (NX_P56945-1)
- Modification sites at PhosphoSitePlus
Other Protein References for BCAR1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for BCAR1
-
Abcam antibodies for BCAR1
- Invitrogen Antibodies for BCAR1 (AFLGC-BCAR1)
- antibodies-online: Show 58 available BCAR1 Antibodies ranked by validation data
- Compare Top BCAR1 Antibodies
-
Recommended
- 150 WB Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 ICS Antibodies (anti-human)
- 95 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 95 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
-
Boster Bio Antibodies for BCAR1
-
Santa Cruz Biotechnology (SCBT) Antibodies for BCAR1
Protein Products
-
OriGene Purified Proteins for BCAR1
- Search Origene for MassSpec and Protein Over-expression Lysates for BCAR1
- Origene Custom Protein Services for BCAR1
- ProSpec Recombinant Proteins for BCAR1
-
Abcam proteins for BCAR1
Assay Products
- RayBiotech Custom Human p130Cas/BCAR1/CAS ELISA
- Novus Biologicals ELISA Kits for BCAR1
-
Signalway ELISA kits for BCAR1
No data available for DME Specific Peptides for BCAR1 Gene
Domains & Families for BCAR1 Gene
Gene Families for BCAR1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for BCAR1 Gene
- InterPro:
- Blocks:
-
- SH3 domain signature
- ProtoNet:
Suggested Antigen Peptide Sequences for BCAR1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ42535 fis, clone BRACE3003595, highly similar to Breast cancer anti-estrogen resistance protein 1 (B3KW85_HUMAN)
- cDNA FLJ55515, highly similar to Breast cancer anti-estrogen resistanceprotein 1 (B4DIW5_HUMAN)
- p130cas (BCAR1_HUMAN)
- Breast cancer anti-estrogen resistance 1, isoform CRA_a (D3DUK1_HUMAN)
- Breast cancer anti-estrogen resistance 1 (Q6P5Z4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P56945UniProtKB/Swiss-Prot:
BCAR1_HUMAN :- Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL1 SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with NEDD9 (By similarity).
- Belongs to the CAS family.
- Domain:
-
- Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL1 SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with NEDD9 (By similarity).
- A serine-rich region promotes activation of the serum response element (SRE).
- The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of PTK2/FAK11.
- Family:
-
- Belongs to the CAS family.
Function for BCAR1 Gene
Molecular function for BCAR1 Gene
- UniProtKB/Swiss-Prot Function:
- Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12832404, PubMed:12432078). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity).
Phenotypes From GWAS Catalog for BCAR1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA,IPI | 9285683 |
| GO:0017124 | SH3 domain binding | IEA | -- |
| GO:0019901 | protein kinase binding | IPI | 8070403 |
Phenotypes for BCAR1 Gene
- MGI mutant phenotypes for BCAR1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for BCAR1:
-
- no effect
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Decreased viability
- Reduced mammosphere formation
- Decreased cell migration
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Dynamic nuclei (hole, folded or small irregular), decreased viability (cell death)
Animal Models for BCAR1 Gene
- MGI Knock Outs for BCAR1:
-
- Bcar1 Bcar1<tm1Hhi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BCAR1 - Select products 50% OFF >
- * BCAR1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BCAR1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCAR1
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCAR1
miRNA for BCAR1 Gene
- miRTarBase miRNAs that target BCAR1
-
- hsa-miR-3978 (MIRT697045)
- hsa-miR-139-3p (MIRT697046)
- hsa-miR-6124 (MIRT697047)
- hsa-miR-3148 (MIRT697048)
- hsa-miR-509-3p (MIRT697049)
- hsa-miR-7853-5p (MIRT697050)
- hsa-miR-105-5p (MIRT697051)
- hsa-miR-580-5p (MIRT697052)
- hsa-miR-522-3p (MIRT697053)
- hsa-miR-224-3p (MIRT697054)
- hsa-miR-4694-3p (MIRT697055)
- hsa-miR-548t-3p (MIRT697056)
- hsa-miR-548ap-3p (MIRT697057)
- hsa-miR-548aa (MIRT697058)
- hsa-miR-24-3p (MIRT734491)
- hsa-miR-362-3p (MIRT734500)
- hsa-miR-329-3p (MIRT734501)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCAR1
- Browse OriGene Inhibitory RNA Products For BCAR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCAR1
Clone Products
- Applied Biological Materials (abm): Clones for BCAR1 - Select products 50% OFF >
- * BCAR1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG211033
- MR211033
- MR211033L3
- MR211033L4
- MR231304
- RC209133
- RC209133L1
- RC209133L2
- RC209133L3
- RC209133L4
- RC230404
- RC230404L3
- RC230404L4
- RC230457
- RC230457L3
- RC230457L4
- RC230550
- RC230550L3
- RC230550L4
- RC230552
- RC230552L3
- RC230552L4
- RC230560
- RC230560L3
- RC230560L4
- RC230561
- RC230561L3
- RC230561L4
- RC230562
- RC230562L3
- RC230562L4
- RC230582
- RC230582L3
- RC230582L4
- RG209133
- RG230404
- RG230457
- RG230550
- RG230552
- RG230560
- RG230561
- RG230562
- RG230582
- RR201266
- RR201266L3
- RR201266L4
- MR211033L3V
- MR211033L4V
- RC209133L1V
- RC209133L2V
- RC209133L3V
- RC209133L4V
- RC230404L3V
- RC230404L4V
- RC230457L3V
- RC230457L4V
- RC230550L3V
- RC230550L4V
- RC230552L3V
- RC230552L4V
- RC230560L3V
- RC230560L4V
- RC230561L3V
- RC230561L4V
- RC230562L3V
- RC230562L4V
- RC230582L3V
- RC230582L4V
- RR201266L3V
- RR201266L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BCAR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCAR1
Cell Line Products
-
Horizon Cell Lines for BCAR1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCAR1 Gene
Localization for BCAR1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BCAR1 Gene
- Cell junction, focal adhesion. Cytoplasm. Cell projection, axon. Note=Unphosphorylated form localizes in the cytoplasm (By similarity). Localizes to focal adhesion sites following integrin engagement (By similarity). {ECO:0000250 UniProtKB:Q61140}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| cytoskeleton | 4 |
| nucleus | 4 |
| plasma membrane | 3 |
| extracellular | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| mitochondrion | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001726 | ruffle | IDA | 9472046 |
| GO:0005737 | cytoplasm | IBA,IDA | 8070403 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | colocalizes_with plasma membrane | IDA | 21245381 |
| GO:0005925 | focal adhesion | IDA,ISS | -- |
Pathways & Interactions for BCAR1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling | ||
| 2 | Focal Adhesion |
.61
.61
|
|
| 3 | Sertoli-Sertoli Cell Junction Dynamics |
Germ Cell-Sertoli Cell Junction Dynamics
.38
Sertoli-Sertoli Cell Junction Dynamics
.38
|
Epithelial Tight Junctions
.36
|
| 4 | Integrin Pathway |
FAK1 Signaling
.67
Integrin Pathway
.67
|
Transendothelial Migration of Leukocytes
.38
|
| 5 | Integrin alphaIIb beta3 signaling | ||
Pathways by source for BCAR1 Gene
23 BioSystems pathways for BCAR1 Gene
12 Reactome pathways for BCAR1 Gene
1 PharmGKB pathway for BCAR1 Gene
6 GeneGo (Thomson Reuters) pathways for BCAR1 Gene
- Cell adhesion Integrin-mediated cell adhesion and migration
- Cell adhesion PLAU signaling
- Chemotaxis CXCR4 signaling pathway
- Cytoskeleton remodeling FAK signaling
- Development Angiotensin signaling via PYK2
13 Qiagen pathways for BCAR1 Gene
- CCKBR-Gastrin Stimulated Signaling
- Chemokine Signaling
- Epithelial Tight Junctions
- FAK1 Signaling
- Germ Cell-Sertoli Cell Junction Dynamics
2 Cell Signaling Technology pathways for BCAR1 Gene
Interacting Proteins for BCAR1 Gene
Selected Interacting proteins:
P56945-BCAR1_HUMAN
ENSP00000391669
for BCAR1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for BCAR1
SIGNOR curated interactions for BCAR1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001558 | regulation of cell growth | TAS | 11607844 |
| GO:0007015 | actin filament organization | IDA | 16105984 |
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IBA | 21873635 |
Transcripts for BCAR1 Gene
mRNA/cDNA for BCAR1 Gene
- 9 REFSEQ mRNAs :
- 27 NCBI additional mRNA sequence :
- 22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000393422 4064 nts (view in UCSC)
- ENST00000162330 4085 nts (view in UCSC)
- ENST00000562556 4659 nts (view in UCSC)
- ENST00000563038 2692 nts (view in UCSC)
- ENST00000566982 3024 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BCAR1 - Select products 50% OFF >
- * BCAR1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BCAR1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCAR1
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCAR1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCAR1
- Browse OriGene Inhibitory RNA Products For BCAR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCAR1
Clone Products
- Applied Biological Materials (abm): Clones for BCAR1 - Select products 50% OFF >
- * BCAR1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG211033
- MR211033
- MR211033L3
- MR211033L4
- MR231304
- RC209133
- RC209133L1
- RC209133L2
- RC209133L3
- RC209133L4
- RC230404
- RC230404L3
- RC230404L4
- RC230457
- RC230457L3
- RC230457L4
- RC230550
- RC230550L3
- RC230550L4
- RC230552
- RC230552L3
- RC230552L4
- RC230560
- RC230560L3
- RC230560L4
- RC230561
- RC230561L3
- RC230561L4
- RC230562
- RC230562L3
- RC230562L4
- RC230582
- RC230582L3
- RC230582L4
- RG209133
- RG230404
- RG230457
- RG230550
- RG230552
- RG230560
- RG230561
- RG230562
- RG230582
- RR201266
- RR201266L3
- RR201266L4
- MR211033L3V
- MR211033L4V
- RC209133L1V
- RC209133L2V
- RC209133L3V
- RC209133L4V
- RC230404L3V
- RC230404L4V
- RC230457L3V
- RC230457L4V
- RC230550L3V
- RC230550L4V
- RC230552L3V
- RC230552L4V
- RC230560L3V
- RC230560L4V
- RC230561L3V
- RC230561L4V
- RC230562L3V
- RC230562L4V
- RC230582L3V
- RC230582L4V
- RR201266L3V
- RR201266L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BCAR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCAR1
Relevant External Links for BCAR1 Gene
- GeneLoc Exon Structure for
- BCAR1
Expression for BCAR1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Testis (9.6), Plasma (9.5), Islet of Langerhans (9.1), Fetal Brain (7.3), Placenta (7.2), and Pancreas (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BCAR1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BCAR1
SOURCE GeneReport for Unigene cluster for BCAR1 Gene:
Hs.479747mRNA Expression by UniProt/SwissProt for BCAR1 Gene:
P56945-BCAR1_HUMAN
Tissue specificity:
Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line.
Evidence on tissue expression from TISSUES for BCAR1 Gene
- Eye(4.9)
- Nervous system(4.9)
- Bone(4.8)
- Lung(4.8)
- Skin(4.8)
- Muscle(4.7)
- Pancreas(4.5)
- Kidney(4.3)
- Intestine(4.2)
- Blood(3.8)
- Heart(3.5)
- Liver(3.4)
- Stomach(2.6)
- Spleen(2.4)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for BCAR1
-
OriGene qPCR primer pairs and template standards for BCAR1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCAR1 Gene
Orthologs for BCAR1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BCAR1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | BCAR1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | BCAR1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Bcar1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Bcar1 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | BCAR1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | BCAR1 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | bcar1 30 |
|
||
| Str.15275 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68466 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | bcar1 30 31 |
|
OneToOne | |
| Dr.4707 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | p130CAS 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6681 31 |
|
OneToMany |
- Species where no ortholog for BCAR1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for BCAR1 Gene
- ENSEMBL:
- Gene Tree for BCAR1 (if available)
- TreeFam:
- Gene Tree for BCAR1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BCAR1: view image
Paralogs for BCAR1 Gene
(3) SIMAP similar genes for BCAR1 Gene using alignment to 14 proteins:
- BCAR1_HUMAN
- B3KW85_HUMAN
- D3DUK1_HUMAN
- F5H855_HUMAN
- H3BN62_HUMAN
- H3BP62_HUMAN
- H3BQJ7_HUMAN
- H3BSB2_HUMAN
- H3BSY4_HUMAN
- H3BTB0_HUMAN
- H3BTL5_HUMAN
- H3BU42_HUMAN
- H3BVF0_HUMAN
- Q6P5Z4_HUMAN
Pseudogenes.org Pseudogenes for BCAR1 Gene
Variants for BCAR1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BCAR1 Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 712848 | Benign: not provided | 75,233,868(-) | T/C | MISSENSE_VARIANT | |
| 713188 | Benign: not provided | 75,235,831(-) | C/T | SYNONYMOUS_VARIANT | |
| 748970 | Likely Benign: not provided | 75,229,820(-) | G/A | SYNONYMOUS_VARIANT | |
| 768795 | Likely Benign: not provided | 75,235,064(-) | G/A | MISSENSE_VARIANT | |
| 768796 | Benign: not provided | 75,235,832(-) | G/A | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3582321 | CNV | loss | 25503493 |
| esv3582322 | CNV | loss | 25503493 |
| nsv149 | OTHER | inversion | 15895083 |
| nsv471095 | CNV | loss | 18288195 |
| nsv516504 | CNV | gain+loss | 19592680 |
| nsv523405 | CNV | loss | 19592680 |
| nsv7286 | OTHER | inversion | 18451855 |
| nsv833282 | CNV | gain+loss | 17160897 |
| nsv9459 | CNV | gain | 18304495 |
| nsv978002 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
75.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.52;
71.95% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BCAR1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCAR1 Gene
Disorders for BCAR1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| estrogen resistance |
|
|
| nephronophthisis 1 |
|
|
| cystic kidney disease |
|
|
| differentiating neuroblastoma |
|
|
| cerebral hypoxia |
|
|
Search BCAR1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BCAR1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for BCAR1 Gene
Publications for BCAR1 Gene
- BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells. (PMID: 10639512) Brinkman A … Dorssers LC (Journal of the National Cancer Institute 2000) 2 3 4 23
- Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading. (PMID: 19086031) Rufanova VA … Sorokin A (Journal of cellular physiology 2009) 3 4 23
- The 1.1 A resolution crystal structure of the p130cas SH3 domain and ramifications for ligand selectivity. (PMID: 15784259) Wisniewska M … Engh RA (Journal of molecular biology 2005) 3 4 23
- Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. (PMID: 10587647) Eisenmann KM … Iida J (Nature cell biology 1999) 3 4 23
- NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. (PMID: 22081014) Mace PD … Riedl SJ (Nature structural & molecular biology 2011) 3 4
ExternalLinks
Products for BCAR1 Gene
- Custom Antibody ServicesOriGene Antibodies for BCAR1
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- MG211033
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- RR201266L3V
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- High-throughput Antibody Production Service
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- VectorBuilder Custom and pre-made DNA vectors for BCAR1 (ie. gene expression, shRNA knockdown, CRISPR)
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- antibodies-online: Show 58 available BCAR1 Antibodies ranked by validation data
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- antibodies-online: Show 25 available BCAR1 Elisa Kits ranked by validation data
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- Santa Cruz Biotechnology (SCBT) CRISPR for BCAR1
- Horizon Cell Lines for BCAR1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCAR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCAR1
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- Boster Bio Antibodies for BCAR1
- Signalway ELISA kits for BCAR1
Sources for BCAR1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174)