Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BCAP29 Gene

Aliases for BCAP29 Gene

  • B Cell Receptor Associated Protein 29 2 3
  • B-Cell Receptor-Associated Protein 29 2 3
  • BCR-Associated Protein 29 3 4
  • BAP29 3 4
  • B-Cell Receptor Associated Protein 29 5

External Ids for BCAP29 Gene

Previous GeneCards Identifiers for BCAP29 Gene

  • GC07P106781
  • GC07P106814
  • GC07P107007
  • GC07P107220
  • GC07P101581

Summaries for BCAP29 Gene

GeneCards Summary for BCAP29 Gene

BCAP29 (B Cell Receptor Associated Protein 29) is a Protein Coding gene. Among its related pathways are AKT Signaling Pathway and B Cell Receptor Signaling Pathway (sino). An important paralog of this gene is BCAP31.

UniProtKB/Swiss-Prot for BCAP29 Gene

  • May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity).

Gene Wiki entry for BCAP29 Gene

Additional gene information for BCAP29 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCAP29 Gene

Genomics for BCAP29 Gene

GeneHancer (GH) Regulatory Elements for BCAP29 Gene

Promoters and enhancers for BCAP29 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I107579 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.7 680 2.9 SMAD1 ARNT SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B ZNF213 E2F8 BCAP29 ENSG00000272854 ENSG00000272072 RPL7P32 ENSG00000273055 CBLL1 THAP5 HBP1 COG5 PIR46022
GH07I107178 Enhancer 1.2 Ensembl ENCODE dbSUPER 4.4 -399.8 -399774 2.5 PKNOX1 NFIB INSM2 FEZF1 RFX5 ZNF121 EGR1 ZNF366 FOS DEK COG5 BCAP29 ENSG00000272072 HBP1
GH07I107594 Enhancer 1 Ensembl ENCODE 0.4 +16.0 15992 3.7 PKNOX1 MZF1 FEZF1 RFX5 ZNF366 ZSCAN5C OVOL3 CEBPB ZNF398 ZEB2 PIR46022 COG5 SLC26A4 SLC26A4-AS1 DUS4L ENSG00000238832 BCAP29
GH07I107622 Enhancer 0.6 ENCODE 0.3 +42.7 42694 1.2 RXRA POLR2A ETV1 IKZF1 SCRT2 CEBPB CEBPG ZNF24 NR2F2 GC07M107613 COG5 SLC26A4 SLC26A4-AS1 WBP1LP2 BCAP29
GH07I107591 Enhancer 0.3 ENCODE 0.4 +12.5 12466 1 MNT PIR46022 SLC26A4 SLC26A4-AS1 COG5 DUS4L ENSG00000272854 BCAP29
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BCAP29 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BCAP29 gene promoter:

Genomic Locations for BCAP29 Gene

Genomic Locations for BCAP29 Gene
chr7:107,579,977-107,629,170
(GRCh38/hg38)
Size:
49,194 bases
Orientation:
Plus strand
chr7:107,220,422-107,269,615
(GRCh37/hg19)

Genomic View for BCAP29 Gene

Genes around BCAP29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCAP29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCAP29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCAP29 Gene

Proteins for BCAP29 Gene

  • Protein details for BCAP29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHQ4-BAP29_HUMAN
    Recommended name:
    B-cell receptor-associated protein 29
    Protein Accession:
    Q9UHQ4
    Secondary Accessions:
    • G5E9L4
    • O95003

    Protein attributes for BCAP29 Gene

    Size:
    241 amino acids
    Molecular mass:
    28320 Da
    Quaternary structure:
    • Homodimer (PubMed:25327138). Heterodimer with BCAP31. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II (By similarity).

    Three dimensional structures from OCA and Proteopedia for BCAP29 Gene

    Alternative splice isoforms for BCAP29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCAP29 Gene

Post-translational modifications for BCAP29 Gene

  • Ubiquitination at posLast=9696, Lys157, and Lys209
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BCAP29 Gene

Domains & Families for BCAP29 Gene

Gene Families for BCAP29 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for BCAP29 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UHQ4

UniProtKB/Swiss-Prot:

BAP29_HUMAN :
  • Belongs to the BCAP29/BCAP31 family.
Family:
  • Belongs to the BCAP29/BCAP31 family.
genes like me logo Genes that share domains with BCAP29: view

Function for BCAP29 Gene

Molecular function for BCAP29 Gene

UniProtKB/Swiss-Prot Function:
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity).

Phenotypes From GWAS Catalog for BCAP29 Gene

genes like me logo Genes that share phenotypes with BCAP29: view

Animal Model Products

miRNA for BCAP29 Gene

miRTarBase miRNAs that target BCAP29

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BCAP29 Gene

Localization for BCAP29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCAP29 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCAP29 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BCAP29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0016020 membrane IEA,HDA 16210410
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BCAP29: view

Pathways & Interactions for BCAP29 Gene

genes like me logo Genes that share pathways with BCAP29: view

Pathways by source for BCAP29 Gene

2 Sino Biological pathways for BCAP29 Gene

Gene Ontology (GO) - Biological Process for BCAP29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation HDA 16210410
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IBA,IEA --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with BCAP29: view

No data available for SIGNOR curated interactions for BCAP29 Gene

Drugs & Compounds for BCAP29 Gene

No Compound Related Data Available

Transcripts for BCAP29 Gene

Unigene Clusters for BCAP29 Gene

B-cell receptor-associated protein 29:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCAP29 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - -
SP2: - - - - -
SP3: -
SP4: -
SP5:
SP6: -

Relevant External Links for BCAP29 Gene

GeneLoc Exon Structure for
BCAP29
ECgene alternative splicing isoforms for
BCAP29

Expression for BCAP29 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BCAP29 Gene

Protein differential expression in normal tissues from HIPED for BCAP29 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.2) and Frontal cortex (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BCAP29 Gene



Protein tissue co-expression partners for BCAP29 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BCAP29 Gene:

BCAP29

SOURCE GeneReport for Unigene cluster for BCAP29 Gene:

Hs.303787

Evidence on tissue expression from TISSUES for BCAP29 Gene

  • Nervous system(4.5)
  • Adrenal gland(4.3)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with BCAP29: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCAP29 Gene

Orthologs for BCAP29 Gene

This gene was present in the common ancestor of animals.

Orthologs for BCAP29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCAP29 33 34
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia BCAP29 33 34
  • 88.24 (n)
cow
(Bos Taurus)
Mammalia BCAP29 33 34
  • 88.1 (n)
rat
(Rattus norvegicus)
Mammalia Bcap29 33
  • 83.54 (n)
mouse
(Mus musculus)
Mammalia Bcap29 33 16 34
  • 82.92 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BCAP29 34
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 37 (a)
ManyToMany
chicken
(Gallus gallus)
Aves BCAP29 33 34
  • 63.49 (n)
lizard
(Anolis carolinensis)
Reptilia BCAP29 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bcap29 33
  • 65.42 (n)
zebrafish
(Danio rerio)
Actinopterygii bcap29 33 34
  • 57 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13887 34
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y54G2A.18 34
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10894 34
  • 37 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13833 33
Species where no ortholog for BCAP29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BCAP29 Gene

ENSEMBL:
Gene Tree for BCAP29 (if available)
TreeFam:
Gene Tree for BCAP29 (if available)

Paralogs for BCAP29 Gene

Paralogs for BCAP29 Gene

genes like me logo Genes that share paralogs with BCAP29: view

Variants for BCAP29 Gene

Sequence variations from dbSNP and Humsavar for BCAP29 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000136549 -- 107,583,401(+) T/C intron_variant
rs1000219322 -- 107,591,897(+) T/C intron_variant
rs1000241756 -- 107,611,299(+) G/A intron_variant
rs1000297434 -- 107,583,157(+) G/A intron_variant
rs1000380425 -- 107,597,351(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BCAP29 Gene

Variant ID Type Subtype PubMed ID
esv1284866 CNV insertion 17803354
esv3572051 CNV loss 25503493
esv3614462 CNV gain 21293372
nsv366928 CNV deletion 16902084
nsv608074 CNV loss 21841781

Variation tolerance for BCAP29 Gene

Residual Variation Intolerance Score: 44.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BCAP29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCAP29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCAP29 Gene

Disorders for BCAP29 Gene

Additional Disease Information for BCAP29

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for BCAP29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BCAP29 Gene

Publications for BCAP29 Gene

  1. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. (PMID: 21378988) Coronary Artery Disease (C4D) Genetics Consortium (Nature genetics 2011) 3 44 58
  2. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. (PMID: 21068099) Evangelou E … Translation Research in Europe Applied Technologies for Osteoarthritis (TreatOA) (Annals of the rheumatic diseases 2011) 3 44 58
  3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58

Products for BCAP29 Gene

Sources for BCAP29 Gene

Content
Loading form....