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This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
BCAN (Brevican) is a Protein Coding gene. Diseases associated with BCAN include Low-Grade Astrocytoma. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and hyaluronic acid binding. An important paralog of this gene is ACAN.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005540 | hyaluronic acid binding | IEA | -- |
GO:0030246 | carbohydrate binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005796 | Golgi lumen | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0031012 | extracellular matrix | IBA | 21873635 |
GO:0031225 | anchored component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Chondroitin sulfate/dermatan sulfate metabolism | ||
2 | Glycosaminoglycan metabolism | ||
3 | Degradation of the extracellular matrix | ||
4 | HIV Life Cycle |
.45
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5 | Diseases of glycosylation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001501 | skeletal system development | IBA | 21873635 |
GO:0007155 | cell adhesion | IEA | -- |
GO:0007417 | central nervous system development | IBA | 21873635 |
GO:0021766 | hippocampus development | IEA | -- |
GO:0030198 | extracellular matrix organization | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Hyaluronic acid | Approved, Vet_approved | Pharma | 717 |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP12: |
ExUns: | 18a | · | 18b |
---|---|---|---|
SP1: | |||
SP2: | |||
SP3: | |||
SP4: | |||
SP5: | |||
SP6: | |||
SP7: | |||
SP8: | |||
SP9: | |||
SP10: | |||
SP11: | |||
SP12: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | BCAN 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | BCAN 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | BCAN 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Bcan 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Bcan 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | BCAN 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | BCAN 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | BCAN 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100486298 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | bcan 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | clec-149 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
721309 | Likely Benign: not provided | 156,659,093(+) | G/A | MISSENSE_VARIANT | |
733328 | Benign: not provided | 156,656,292(+) | C/T | SYNONYMOUS_VARIANT | |
777939 | Benign: not provided | 156,652,733(+) | C/A | MISSENSE_VARIANT | |
787577 | Likely Benign: not provided | 156,657,004(+) | G/T | MISSENSE_VARIANT | |
rs115373136 | Benign: not specified | 156,647,022(+) | C/G | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
low-grade astrocytoma |
|
|