Aliases for BCAN Gene
External Ids for BCAN Gene
Previous GeneCards Identifiers for BCAN Gene
This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
GeneCards Summary for BCAN Gene
BCAN (Brevican) is a Protein Coding gene. Diseases associated with BCAN include Low-Grade Astrocytoma. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and hyaluronic acid binding. An important paralog of this gene is ACAN.
UniProtKB/Swiss-Prot Summary for BCAN Gene
May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.