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This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate... See more...
Aliases for BCAN Gene
Aliases for BCAN Gene
External Ids for BCAN Gene
- HGNC: 23059
- Entrez Gene: 63827
- Ensembl: ENSG00000132692
- OMIM: 600347
- UniProtKB: Q96GW7
Previous GeneCards Identifiers for BCAN Gene
- GC01P154481
- GC01P152377
- GC01P153390
- GC01P153828
- GC01P153424
- GC01P154878
- GC01P156611
- GC01P127969
Summaries for BCAN Gene
-
This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
GeneCards Summary for BCAN Gene
BCAN (Brevican) is a Protein Coding gene. Diseases associated with BCAN include Low-Grade Astrocytoma. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and hyaluronic acid binding. An important paralog of this gene is ACAN.
UniProtKB/Swiss-Prot Summary for BCAN Gene
-
May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.
Additional gene information for BCAN Gene
- HGNC(23059)
- Entrez Gene(63827)
- Ensembl(ENSG00000132692)
- OMIM(600347)
- UniProtKB(Q96GW7)
- Open Targets Platform(ENSG00000132692)
- Search for BCAN at DataMed
- Search for BCAN at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BCAN Gene
Genomics for BCAN Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BCAN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BCAN on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BCAN
- Top Transcription factor binding sites by QIAGEN in the BCAN gene promoter:
-
- AhR
- Arnt
- NRSF form 1
- NRSF form 2
- p300
- p53
- STAT5A
- YY1
Genomic Locations for BCAN Gene
Genomic Locations for BCAN Gene
- chr1:156,641,390-156,659,532
- (GRCh38/hg38)
- Size:
- 18,143 bases
- Orientation:
- Plus strand
- chr1:156,611,182-156,629,324
- (GRCh37/hg19)
- Size:
- 18,143 bases
- Orientation:
- Plus strand
Genomic View for BCAN Gene
Genes around BCAN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q23.1 by HGNC
- 1q23.1 by Entrez Gene
- 1q23.1 by Ensembl
BCAN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BCAN Gene
Proteins for BCAN Gene
-
Protein details for BCAN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96GW7-PGCB_HUMAN
- Recommended name:
- Brevican core protein
- Protein Accession:
- Q96GW7
- D3DVC2
- Q5SZ10
- Q5T3I5
- Q8TBB9
- Q9HBK1
- Q9HBK4
Protein attributes for BCAN Gene
- Size:
- 911 amino acids
- Molecular mass:
- 99118 Da
- Quaternary structure:
-
- Interacts with TNR.
Protein Expression for BCAN Gene
Post-translational modifications for BCAN Gene
- Contains mostly chondroitin sulfate (By similarity). O-glycosylated with a core 1 or possibly core 8 glycan.
-
Glycosylation at Asn130, Asn337, Thr540, Thr542, Ser905, and Ser906
- NX_Q96GW7 (NX_Q96GW7-1)
- Modification sites at PhosphoSitePlus
Other Protein References for BCAN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-BCAN monoclonal antibody
- Novus Biologicals Antibodies for BCAN
-
Abcam antibodies for BCAN
- Invitrogen Antibodies for BCAN (AFLGC-Bcan)
-
Boster Bio Antibodies for BCAN
-
Santa Cruz Biotechnology (SCBT) Antibodies for BCAN
- Sino Biological Antibodies for BCAN
Protein Products
- G Biosciences Human Brevican core protein/BCAN, Lyophilized
-
OriGene Purified Proteins for BCAN
- Search Origene for MassSpec and Protein Over-expression Lysates for BCAN
- Origene Custom Protein Services for BCAN
-
ProSci Proteins for BCAN
-
Abcam proteins for BCAN
Assay Products
- G Biosciences Immunotag™ Human BCAN (Brevican) ELISA
- RayBiotech Human Brevican ELISA
-
Custom Assay ServicesOriGene ELISA Kits for BCAN
- Novus Biologicals ELISA Kits for BCAN
-
Boster Bio ELISA Kits for BCAN
-
Signalway ELISA kits for BCAN
No data available for DME Specific Peptides for BCAN Gene
Domains & Families for BCAN Gene
Gene Families for BCAN Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted secreted proteins
Protein Domains for BCAN Gene
- InterPro:
- Blocks:
-
- Immunoglobulin V-set
- Sushi domain/SCR domain/CCP module
- Link domain
- Type II antifreeze protein signature
- ProtoNet:
Suggested Antigen Peptide Sequences for BCAN Gene
- GenScript: Design optimal peptide antigens:
-
- Chondroitin sulfate proteoglycan 7 (PGCB_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96GW7- Family:
-
- Belongs to the aggrecan/versican proteoglycan family.
Function for BCAN Gene
Molecular function for BCAN Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.
Phenotypes From GWAS Catalog for BCAN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005540 | hyaluronic acid binding | IEA | -- |
| GO:0030246 | carbohydrate binding | IEA | -- |
Phenotypes for BCAN Gene
- MGI mutant phenotypes for BCAN:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for BCAN:
Animal Models for BCAN Gene
- MGI Knock Outs for BCAN:
-
- Bcan Bcan<tm1Ref>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BCAN - Select products 50% OFF >
- * BCAN CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BCAN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCAN
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCAN
miRNA for BCAN Gene
- miRTarBase miRNAs that target BCAN
-
- mmu-miR-136-5p (MIRT014999)
- hsa-miR-133a-3p (MIRT021697)
- hsa-miR-5006-3p (MIRT489331)
- hsa-miR-4755-5p (MIRT489332)
- hsa-miR-3978 (MIRT489333)
- hsa-miR-211-5p (MIRT489334)
- hsa-miR-204-5p (MIRT489335)
- hsa-miR-6124 (MIRT489336)
- hsa-miR-623 (MIRT489337)
- hsa-miR-3148 (MIRT489338)
- hsa-miR-2276-3p (MIRT489339)
- hsa-miR-6780b-3p (MIRT489340)
- hsa-miR-4780 (MIRT489341)
- hsa-miR-3938 (MIRT489342)
- hsa-miR-548as-3p (MIRT489344)
- hsa-miR-4793-5p (MIRT529928)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCAN
- Browse OriGene Inhibitory RNA Products For BCAN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCAN
Clone Products
- Applied Biological Materials (abm): Clones for BCAN - Select products 50% OFF >
- * BCAN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG211054
- MG223800
- MR211054
- MR211054L3
- MR211054L4
- MR223800
- MR223800L3
- MR223800L4
- RC205148
- RC205148L3
- RC205148L4
- RC221334
- RC221334L3
- RC221334L4
- RG205148
- RG221334
- RR200422
- RR200422L3
- RR200422L4
- RR200423
- RR200423L3
- RR200423L4
- MR211054L3V
- MR211054L4V
- MR223800L3V
- MR223800L4V
- RC205148L3V
- RC205148L4V
- RC221334L3V
- RC221334L4V
- RR200422L3V
- RR200422L4V
- RR200423L3V
- RR200423L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BCAN
- Addgene plasmids for BCAN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCAN
Cell Line Products
-
Horizon Cell Lines for BCAN
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCAN Gene
Localization for BCAN Gene
Subcellular locations from UniProtKB/Swiss-Prot for BCAN Gene
- [Isoform 1]: Secreted, extracellular space, extracellular matrix.
- [Isoform 2]: Membrane. Lipid-anchor, GPI-anchor.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| lysosome | 4 |
| golgi apparatus | 4 |
| plasma membrane | 3 |
| nucleus | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005796 | Golgi lumen | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0031012 | extracellular matrix | IBA | 21873635 |
| GO:0031225 | anchored component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for BCAN Gene
Pathways & Interactions for BCAN Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chondroitin sulfate/dermatan sulfate metabolism | ||
| 2 | Glycosaminoglycan metabolism | ||
| 3 | Degradation of the extracellular matrix | ||
| 4 | HIV Life Cycle |
.45
|
|
| 5 | Diseases of glycosylation | ||
Pathways by source for BCAN Gene
1 BioSystems pathway for BCAN Gene
1 GeneGo (Thomson Reuters) pathway for BCAN Gene
- Cell adhesion_Cell-matrix glycoconjugates
Interacting Proteins for BCAN Gene
GPS-Prot Interaction Network for BCAN
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | IBA | 21873635 |
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0007417 | central nervous system development | IBA | 21873635 |
| GO:0021766 | hippocampus development | IEA | -- |
| GO:0030198 | extracellular matrix organization | TAS | -- |
No data available for SIGNOR curated interactions for BCAN Gene
Drugs & Compounds for BCAN Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Hyaluronic acid | Approved, Vet_approved | Pharma | 717 |
Drug Products
- G Biosciences Human Brevican core protein/BCAN, Lyophilized
Transcripts for BCAN Gene
mRNA/cDNA for BCAN Gene
- 2 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000441358 600 nts (view in UCSC)
- ENST00000329117 3297 nts (view in UCSC)
- ENST00000457777 807 nts (view in UCSC)
- ENST00000424639 844 nts (view in UCSC)
- ENST00000479949 1705 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BCAN - Select products 50% OFF >
- * BCAN CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BCAN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCAN
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCAN
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCAN
- Browse OriGene Inhibitory RNA Products For BCAN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCAN
Clone Products
- Applied Biological Materials (abm): Clones for BCAN - Select products 50% OFF >
- * BCAN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG211054
- MG223800
- MR211054
- MR211054L3
- MR211054L4
- MR223800
- MR223800L3
- MR223800L4
- RC205148
- RC205148L3
- RC205148L4
- RC221334
- RC221334L3
- RC221334L4
- RG205148
- RG221334
- RR200422
- RR200422L3
- RR200422L4
- RR200423
- RR200423L3
- RR200423L4
- MR211054L3V
- MR211054L4V
- MR223800L3V
- MR223800L4V
- RC205148L3V
- RC205148L4V
- RC221334L3V
- RC221334L4V
- RR200422L3V
- RR200422L4V
- RR200423L3V
- RR200423L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BCAN
- Addgene plasmids for BCAN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCAN
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 18a | · | 18b |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: | |||
| SP11: | |||
| SP12: |
Relevant External Links for BCAN Gene
- GeneLoc Exon Structure for
- BCAN
Expression for BCAN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Adult Endothelial Cells Blood Brain Barrier
- Protoplasmic Astrocyte Cells Neocortex
- Hypothalamus
- Neural Tube (Nervous System)
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Adult Endothelial Cells Blood Brain Barrier
- Endothelial-like cells(James D et. al. 2010)
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
- Granulosa Cells Primary Follicle
- Glial Cells
- Spinal Cord (Nervous System)
- Inner Cell Mass (Early Embryonic Tissues)
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
- Oligodendrocytes (Nervous System)
-
Colon (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for BCAN Gene
This gene is overexpressed in Brain - Amygdala (x7.3), Brain - Caudate (basal ganglia) (x5.2), Brain - Hippocampus (x5.2), Brain - Putamen (basal ganglia) (x5.1), Brain - Nucleus accumbens (basal ganglia) (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.1), and Brain - Substantia nigra (x4.0).
This gene is overexpressed in Frontal cortex (30.7), Brain (19.6), and Cerebrospinal fluid (8.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BCAN Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BCAN
SOURCE GeneReport for Unigene cluster for BCAN Gene:
Hs.516904mRNA Expression by UniProt/SwissProt for BCAN Gene:
Q96GW7-PGCB_HUMAN
Tissue specificity:
Expressed in the retina, specifically in the inner nuclear layer, inner plexiform layer and ganglion cell layer (at protein level).
Evidence on tissue expression from TISSUES for BCAN Gene
- Nervous system(5)
- Skin(2.4)
- Eye(2.2)
Primer Products
-
OriGene qPCR primer pairs for BCAN
-
OriGene qPCR primer pairs and template standards for BCAN
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BCAN Gene
Orthologs for BCAN Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BCAN 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | BCAN 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | BCAN 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Bcan 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Bcan 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | BCAN 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | BCAN 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | BCAN 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100486298 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | bcan 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | clec-149 31 |
|
OneToMany |
- Species where no ortholog for BCAN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for BCAN Gene
- ENSEMBL:
- Gene Tree for BCAN (if available)
- TreeFam:
- Gene Tree for BCAN (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BCAN: view image
Paralogs for BCAN Gene
(9) SIMAP similar genes for BCAN Gene using alignment to 7 proteins:
- PGCB_HUMAN
- L8E931_HUMAN
- Q5T3I6_HUMAN
- Q5T3I7_HUMAN
- Q5T3I8_HUMAN
- V9GXZ8_HUMAN
- V9GY88_HUMAN
Variants for BCAN Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BCAN Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 721309 | Likely Benign: not provided | 156,659,093(+) | G/A | MISSENSE_VARIANT | |
| 733328 | Benign: not provided | 156,656,292(+) | C/T | SYNONYMOUS_VARIANT | |
| 777939 | Benign: not provided | 156,652,733(+) | C/A | MISSENSE_VARIANT | |
| 787577 | Likely Benign: not provided | 156,657,004(+) | G/T | MISSENSE_VARIANT | |
| rs115373136 | Benign: not specified | 156,647,022(+) | C/G | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.82;
86.88% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BCAN Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BCAN
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCAN Gene
Disorders for BCAN Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| low-grade astrocytoma |
|
|
Search BCAN in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BCAN
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for BCAN Gene
Publications for BCAN Gene
- Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23. (PMID: 11873941) Nomoto H … Ninomiya Y (Acta medica Okayama 2002) 2 3 23
- cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma. (PMID: 11054543) Gary SC … Hockfield S (Gene 2000) 2 3 4
- Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke. (PMID: 19910543) Ding H … Wang DW (Stroke 2010) 3 41
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
ExternalLinks
Products for BCAN Gene
- Custom Antibody Services
- Custom Assay ServicesOriGene ELISA Kits for BCAN
- OriGene Purified Proteins for BCAN
- Search Origene for MassSpec and Protein Over-expression Lysates for BCAN
- Origene Custom Protein Services for BCAN
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- Browse OriGene Inhibitory RNA Products For BCAN
- OriGene qPCR primer pairs for BCAN
- OriGene qPCR primer pairs and template standards for BCAN
- OriGene CRISPR knockouts for BCAN
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BCAN
- Sino Biological Human cDNA Clone for BCAN
- Browse Sino Biological Recombinant Proteins
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- Sino Biological Antibodies for BCAN
- Browse Sino Biological Assays
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- Novus Biologicals proteins and lysates for BCAN
- Novus Biologicals ELISA Kits for BCAN
- Browse Antibodies
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- Browse Primary Antibodies
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- Invitrogen Antibodies for BCAN (AFLGC-Bcan)
- VectorBuilder Custom and pre-made DNA vectors for BCAN (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for BCAN (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for BCAN (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for BCAN CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for BCAN
- Addgene plasmids for BCAN
- antibodies-online: Show 50 available BCAN Antibodies ranked by validation data
- Compare Top BCAN Antibodies
- antibodies-online: Show 40 available BCAN Elisa Kits ranked by validation data
- Compare Top BCAN Elisa Kits
- antibodies-online: Show 7 available BCAN Proteins ranked by validation data
- Compare Top BCAN Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for BCAN
- Search Santa Cruz Biotechnology (SCBT) for BCAN siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BCAN
- Search for BCAN Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for BCAN
- Horizon Cell Lines for BCAN
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCAN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCAN
- Search GeneCopoeia for miRNA 3'UTR Target clone products for BCAN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCAN
Sources for BCAN Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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- (44) Atlas
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- (50) miRBase
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- (62) Qiagen
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- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
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- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
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- (77) ESI-BIO
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- (83) Illumina
- (84) COMPARTMENTS
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- (86) PaxDb
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- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
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- (109) Disease Ontology
- (110) Genetics Home Reference
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- (112) MedlinePlus
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- (115) NCBI Bookshelf
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- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
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- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
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- (163) LncBase
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- (165) LNCipedia
- (166) Modomics
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- (172) GENCODE
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- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB