Aliases for BCAM Gene
External Ids for BCAM Gene
Previous HGNC Symbols for BCAM Gene
Previous GeneCards Identifiers for BCAM Gene
This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
GeneCards Summary for BCAM Gene
BCAM (Basal Cell Adhesion Molecule (Lutheran Blood Group)) is a Protein Coding gene. Diseases associated with BCAM include Lutheran Null and Sickle Cell Disease. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and laminin binding. An important paralog of this gene is MCAM.
UniProtKB/Swiss-Prot Summary for BCAM Gene
Laminin alpha-5 receptor. May mediate intracellular signaling.