Aliases for BAZ2A Gene
External Ids for BAZ2A Gene
Previous GeneCards Identifiers for BAZ2A Gene
GeneCards Summary for BAZ2A Gene
BAZ2A (Bromodomain Adjacent To Zinc Finger Domain 2A) is a Protein Coding gene. Diseases associated with BAZ2A include Acute Maxillary Sinusitis and Epidermodysplasia Verruciformis 1. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Gene Expression. Gene Ontology (GO) annotations related to this gene include RNA binding and lysine-acetylated histone binding. An important paralog of this gene is BAZ2B.
UniProtKB/Swiss-Prot Summary for BAZ2A Gene
Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).