Aliases for BAZ1A Gene
External Ids for BAZ1A Gene
Previous GeneCards Identifiers for BAZ1A Gene
The BAZ1A gene encodes the accessory subunit of the ATP-dependent chromatin assembly factor (ACF), a member of the ISWI ('imitation switch') family of chromatin remodeling complexes (summarized by Racki et al., 2009 [PubMed 20033039]).[supplied by OMIM, Apr 2010]
GeneCards Summary for BAZ1A Gene
BAZ1A (Bromodomain Adjacent To Zinc Finger Domain 1A) is a Protein Coding gene. Diseases associated with BAZ1A include Chromosome 14Q11-Q22 Deletion Syndrome and Vater/Vacterl Association. Among its related pathways are Chromatin Regulation / Acetylation and Ectoderm Differentiation. Gene Ontology (GO) annotations related to this gene include histone acetyltransferase activity. An important paralog of this gene is BAZ2B.
UniProtKB/Swiss-Prot Summary for BAZ1A Gene
Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression.
Component of the histone-fold protein complex CHRAC complex which facilitates nucleosome sliding by the ACF complex and enhances ACF-mediated chromatin assembly. The C-terminal regions of both CHRAC1 and POLE1 are required for these functions.