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The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]
BAX (BCL2 Associated X, Apoptosis Regulator) is a Protein Coding gene. Diseases associated with BAX include Precursor T-Cell Acute Lymphoblastic Leukemia and Colorectal Cancer. Among its related pathways are Endometrial cancer and Overview of nanoparticle effects. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is MCL1.
Bcl-2 family proteins contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four Bcl-2 homology domains. Certain members (Bcl-2, Bcl-XL and Mcl-1) are antiapoptotic, whilst others (Bax, Bak, Bok) are proapoptotic.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 9027312 |
GO:0008289 | lipid binding | IDA | 14522999 |
GO:0015267 | channel activity | IDA | 9219694 |
GO:0030544 | Hsp70 protein binding | IEA | -- |
GO:0042802 | identical protein binding | IPI | 10620504 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA,IMP | 15102863 |
GO:0005635 | nuclear envelope | IDA | 12925958 |
GO:0005737 | cytoplasm | IEA,IDA | 16302269 |
GO:0005739 | mitochondrion | IDA,IEA | 11912183 |
GO:0005741 | mitochondrial outer membrane | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
2 | Apoptosis Modulation and Signaling |
.41
|
.31
|
3 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.40
|
4 | Endometrial cancer |
.36
|
|
5 | Glioma |
.50
|
.46
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001541 | ovarian follicle development | IEA | -- |
GO:0001764 | neuron migration | IEA | -- |
GO:0001776 | leukocyte homeostasis | IEA | -- |
GO:0001777 | T cell homeostatic proliferation | IEA | -- |
GO:0001782 | B cell homeostasis | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
AT-101 | Approved, Investigational | Pharma | BH3-mimetic,gossypol enantiomer, BCL-2 inhibitors | 74 | ||
Gossypol | Investigational | Pharma | PAF inhibitor;anti-fertility and anti-cancer | 24 | ||
BAM7 | Pharma | BAX activator,direct and selective, Selective Bax activator; induces Bax-mediated apoptosis | 0 | |||
Bax channel blocker | Pharma | Inhibitor of Bax-mediated mitochondrial cytochrome c release | 0 | |||
Bax inhibitor peptide P5 | Pharma | Bax inhibitor | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
AT 101 |
|
90141-22-3 |
|
|
||
SMBA 1 |
|
906440-37-7 |
|
|
Compound | Action | Cas Number |
---|---|---|
AT-101 | BH3-mimetic,gossypol enantiomer | 90141-22-3 |
BAM7 | BAX activator,direct and selective | 331244-89-4 |
Bax channel blocker | Inhibitor of Bax-mediated mitochondrial cytochrome c release | 335165-68-9 |
Bax inhibitor peptide P5 | Bax inhibitor | 579492-83-4 |
Bax inhibitor peptide V5 | Bax inhibitor | 579492-81-2 |
Bax inhibitor peptide, negative control | Peptide inhibit Bax translocation to mitochondria | 1315378-74-5 |
Gossypol | PAF inhibitor;anti-fertility and anti-cancer | 303-45-7 |
PRIMA-1 | BAX inhibitor | 5608-24-2 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||
SP2: | - | ||||||||||||||
SP3: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | BAX 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | BAX 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | BAX 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Bax 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Bax 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | BAX 33 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
OneToMany | |
-- 33 |
|
OneToMany | |||
tropical clawed frog (Silurana tropicalis) |
Amphibia | bax 32 |
|
||
MGC76049 32 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia |