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The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. The association and the ratio of BAX to BCL2 also determines survival or d... See more...
Aliases for BAX Gene
Aliases for BAX Gene
External Ids for BAX Gene
- HGNC: 959
- Entrez Gene: 581
- Ensembl: ENSG00000087088
- OMIM: 600040
- UniProtKB: Q07812
Previous GeneCards Identifiers for BAX Gene
- GC19P050116
- GC19P049826
- GC19P054135
- GC19P054149
- GC19P049458
- GC19P045835
Summaries for BAX Gene
-
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. The association and the ratio of BAX to BCL2 also determines survival or death of a cell following an apoptotic stimulus. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Dec 2019]
GeneCards Summary for BAX Gene
BAX (BCL2 Associated X, Apoptosis Regulator) is a Protein Coding gene. Diseases associated with BAX include T-Cell Acute Lymphoblastic Leukemia and Colorectal Cancer. Among its related pathways are Apoptosis Modulation and Signaling and Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is BOK.
UniProtKB/Swiss-Prot Summary for BAX Gene
-
Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
-
Bcl-2 family proteins contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four Bcl-2 homology domains. Certain members (Bcl-2, Bcl-XL and Mcl-1) are antiapoptotic, whilst others (Bax, Bak, Bok) are proapoptotic.
Additional gene information for BAX Gene
- HGNC(959)
- Entrez Gene(581)
- Ensembl(ENSG00000087088)
- OMIM(600040)
- UniProtKB(Q07812)
- Open Targets Platform(ENSG00000087088)
- Monarch Initiative
- Search for BAX at DataMed
- Search for BAX at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BAX Gene
Genomics for BAX Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BAX Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BAX on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BAX
- Top Transcription factor binding sites by QIAGEN in the BAX gene promoter:
-
- STAT1
Genomic Locations for BAX Gene
Genomic Locations for BAX Gene
- chr19:48,954,815-48,961,798
- (GRCh38/hg38)
- Size:
- 6,984 bases
- Orientation:
- Plus strand
- chr19:49,458,072-49,465,055
- (GRCh37/hg19)
- Size:
- 6,984 bases
- Orientation:
- Plus strand
Genomic View for BAX Gene
Genes around BAX on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
BAX Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BAX Gene
Proteins for BAX Gene
-
Protein details for BAX Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q07812-BAX_HUMAN
- Recommended name:
- Apoptosis regulator BAX
- Protein Accession:
- Q07812
- A8K4W1
- P55269
- Q07814
- Q07815
- Q8WZ49
- Q9NR76
- Q9NYG7
- Q9UCZ6
- Q9UCZ7
- Q9UQD6
Protein attributes for BAX Gene
- Size:
- 192 amino acids
- Molecular mass:
- 21184 Da
- Quaternary structure:
-
- Homodimer. Forms higher oligomers under stress conditions. Forms heterooligomers with BAK (PubMed:29531808). Interacts with BCL2L11. Interaction with BCL2L11 promotes BAX oligomerization and association with mitochondrial membranes, with subsequent release of cytochrome c. Forms heterodimers with BCL2, BCL2L1 isoform Bcl-X(L), BCL2L2, MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions, JNK-mediated phosphorylation of SFN and YWHAZ, releases BAX to mitochondria. Isoform Sigma interacts with BCL2A1 and BCL2L1 isoform Bcl-X(L). Interacts with RNF144B, which regulates the ubiquitin-dependent stability of BAX. Interacts with CLU under stress conditions that cause a conformation change leading to BAX oligomerization and association with mitochondria. Does not interact with CLU in unstressed cells. Interacts with FAIM2/LFG2. Interacts with RTL10/BOP. Interacts (via a C-terminal 33 residues) with NOL3 (via CARD domain); inhibits BAX activation and translocation and consequently cytochrome c release from mitochondria. Interacts with GIMAP3/IAN4 and GIMAP5/IAN5; this interaction is increased, when cells initiate apoptosis upon IL2 withdrawal (PubMed:16509771).
- (Microbial infection) Interacts with adenovirus E1B 19K protein; this interaction blocks BAX oligomerization (PubMed:11462023).
- (Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein vMIA/UL37.
- (Microbial infection) Interacts with enterovirus protein 2B; this interaction activates BAX-induced apoptosis.
Three dimensional structures from OCA and Proteopedia for BAX Gene
Alternative splice isoforms for BAX Gene
- UniProtKB/Swiss-Prot:
Protein Expression for BAX Gene
Post-translational modifications for BAX Gene
Other Protein References for BAX Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- SouthernBiotech Mouse Anti-Bax-UNLB and Mouse Anti-Human Bax-UNLB
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-
Custom Antibody ServicesOriGene Antibodies for BAX
- AB0164-200
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- AP00015PU-N
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- AP06027PU-N
- AP07277PU-N
- AP08384PU-N
- AP11294PU-N
- AP21052PU-N
- AP23289PU-N
- AP31829PU-N
- AP55712PU-N
- AP55712PU-S
- CF810334
- CF810335
- TA306176
- TA312594
- TA312595
- TA312596
- TA312598
- TA312599
- TA312600
- TA321641
- TA321642
- TA325255
- TA326770
- TA328048
- TA328050
- TA346891
- TA347321
- TA354262
- TA590174
- TA810334
- TA810334S
- TA810335
- TA810335S
- TA890001
- TA890001S
- Novus Biologicals Antibodies for BAX
- Invitrogen Antibodies for BAX (AFLGC-BAX)
- antibodies-online: Show 269 available BAX Antibodies ranked by validation data
- Compare Top BAX Antibodies
-
Recommended
- 429 WB Antibodies (anti-human)
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- 9 IF Antibodies (anti-human)
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- 168 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 10 IHC Antibodies (anti-mouse)
- 9 IP Antibodies (anti-mouse)
- 7 FACS Antibodies (anti-mouse)
- 7 IF Antibodies (anti-mouse)
- 2 IF/ICC Antibodies (anti-mouse)
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- 138 WB Antibodies (anti-rat)
- 36 IF (p) Antibodies (anti-rat)
- 9 IHC Antibodies (anti-rat)
- 8 IP Antibodies (anti-rat)
- 7 IF Antibodies (anti-rat)
- 5 FACS Antibodies (anti-rat)
- 2 IF/ICC Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
-
Boster Bio Antibodies for BAX
-
Custom Antibody ServicesProSci Antibodies for BAX
-
Santa Cruz Biotechnology (SCBT) Antibodies for BAX
- Sino Biological Antibodies for BAX
Protein Products
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- antibodies-online: Show 24 available BAX Proteins ranked by validation data
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-
ProSci Proteins for BAX
-
Abcam proteins for BAX
Assay Products
- RayBiotech Custom Human bax ELISA
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- antibodies-online: Show 85 available BAX Elisa Kits ranked by validation data
- Compare Top BAX Elisa Kits
-
Quality Products:
- ABIN1113683
- ABIN365025
- ABIN414428
- ABIN1028199
- ABIN5522920
- ABIN5669039
- ABIN511230
- ABIN1380947
- ABIN6385401
- ABIN5690828
- ABIN1113694
- ABIN424766
- ABIN832356
- ABIN1568585
- ABIN5522921
- ABIN5670035
- ABIN510150
- ABIN5593508
- ABIN5652166
- ABIN1113684
- ABIN416240
- ABIN1000131
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-
Boster Bio ELISA Kits for BAX
-
Abcam assays for BAX
No data available for DME Specific Peptides for BAX Gene
Domains & Families for BAX Gene
Gene Families for BAX Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transporters
Protein Domains for BAX Gene
- InterPro:
- Blocks:
-
- Apoptosis regulator Bcl-2 protein, BH
- ProtoNet:
Suggested Antigen Peptide Sequences for BAX Gene
- GenScript: Design optimal peptide antigens:
-
- Bcl-2-like protein 4 (BAX_HUMAN)
- Bax protein (Q5ZPJ0_HUMAN)
- Bax protein (Q5ZPJ1_HUMAN)
- BCL2-associated X protein (Q8WXU1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q07812UniProtKB/Swiss-Prot:
BAX_HUMAN :- Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
- Belongs to the Bcl-2 family.
- Domain:
-
- Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
- Family:
-
- Belongs to the Bcl-2 family.
Function for BAX Gene
Molecular function for BAX Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
- GENATLAS Biochemistry:
- BCL2-associated X protein,promoting of apoptosis,21kDa,extensively homolog to BCL2,translocated and inserted into the mitochondrial membrane binding permeability transition pore and increasing the release of cytochrome c,leading to cell death after homodimerization with BCL2,modulating CDK2 activation during thymocyte apoptosis,mutated in gastric carcinomas and in endometrial atypical hyperplasia,determinant of chemo-sensitivity in tumor cell-lines,maybe involved in the tumorigenesis of HNPCC with microsatellite instability and in the uterine cancer,not mutated in acquired immunodeficiency syndrome-related non Hodgkin lymphoma
Phenotypes From GWAS Catalog for BAX Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 9027312 |
| GO:0008289 | lipid binding | IDA | 14522999 |
| GO:0015267 | channel activity | IDA | 9219694 |
| GO:0030544 | Hsp70 protein binding | IEA | -- |
| GO:0042802 | identical protein binding | IEA,IPI | 10620504 |
Phenotypes for BAX Gene
- MGI mutant phenotypes for BAX:
-
inferred from 4 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- renal/urinary system phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- hematopoietic system phenotype
- GenomeRNAi human phenotypes for BAX:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
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OriGene CRISPR knockouts for BAX
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BAX
-
Santa Cruz Biotechnology (SCBT) CRISPR for BAX
miRNA for BAX Gene
- miRTarBase miRNAs that target BAX
-
- hsa-miR-504-5p (MIRT016249)
- hsa-miR-148b-3p (MIRT019436)
- hsa-miR-122-5p (MIRT023402)
- hsa-miR-1-3p (MIRT023989)
- hsa-miR-30a-5p (MIRT028651)
- hsa-miR-365a-3p (MIRT044018)
- hsa-miR-128-3p (MIRT437798)
- hsa-miR-214-3p (MIRT438124)
- hsa-miR-766-3p (MIRT438137)
- hsa-miR-298 (MIRT438317)
- mmu-miR-27a-3p (MIRT438521)
- mmu-miR-23a-3p (MIRT438522)
- hsa-miR-7-5p (MIRT731976)
- hsa-miR-34a-5p (MIRT731977)
- hsa-miR-181a-5p (MIRT733283)
- mmu-miR-467a-5p (MIRT733317)
- hsa-miR-15b-5p (MIRT733878)
- hsa-miR-148a-3p (MIRT734355)
miRNA Products
Inhibitory RNA Products
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Clone Products
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- MG201841
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- RC219954
- RC219954L1
- RC219954L2
- RC219954L3
- RC219954L4
- RC222409
- RC222409L1
- RC222409L2
- RC222409L3
- RC222409L4
- RC229114
- RC229114L3
- RC229114L4
- RC235706
- RC235977
- RC236324
- RC236678
- RG204369
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- RR212518
- RR212518L3
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- MR201841L3V
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- RC204369L1V
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- RC204369L4V
- RC219954L1V
- RC219954L2V
- RC219954L3V
- RC219954L4V
- RC222409L1V
- RC222409L2V
- RC222409L3V
- RC222409L4V
- RC229114L3V
- RC229114L4V
- RR212518L3V
- RR212518L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BAX
- Addgene plasmids for BAX
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BAX
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for BAX Gene
Localization for BAX Gene
Subcellular locations from UniProtKB/Swiss-Prot for BAX Gene
- [Isoform Alpha]: Mitochondrion outer membrane. Single-pass membrane protein. Cytoplasm. Note=Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane.
- [Isoform Beta]: Cytoplasm.
- [Isoform Gamma]: Cytoplasm.
- [Isoform Delta]: Cytoplasm.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| endoplasmic reticulum | 5 |
| cytosol | 5 |
| extracellular | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| lysosome | 2 |
| endosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005623 | cell | IEA | -- |
| GO:0005634 | nucleus | IDA,IMP | 15102863 |
| GO:0005635 | nuclear envelope | IDA | 12925958 |
| GO:0005737 | cytoplasm | IEA,IDA | 16302269 |
| GO:0005739 | mitochondrion | IEA,IDA | 11912183 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for BAX Gene
Pathways & Interactions for BAX Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
| 2 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
| 3 | Apoptosis Modulation and Signaling |
.41
|
Apoptosis and survival Apoptotic TNF-family pathways
.35
.31
|
| 4 | Endometrial cancer |
.36
|
|
| 5 | TNFR1 Pathway |
Apoptosis and survival TNFR1 signaling pathway
.52
Apoptotic Pathways Triggered By HIV1
.42
Apoptosis through Death Receptors
.42
|
|
Pathways by source for BAX Gene
3 Sino Biological pathways for BAX Gene
25 BioSystems pathways for BAX Gene
11 Reactome pathways for BAX Gene
2 PharmGKB pathways for BAX Gene
48 KEGG pathways for BAX Gene
12 GeneGo (Thomson Reuters) pathways for BAX Gene
- Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
- Apoptosis and survival Apoptotic TNF-family pathways
- Apoptosis and survival BAD phosphorylation
- Apoptosis and survival Caspase cascade
- Apoptosis and survival FAS signaling cascades
2 R&D Systems pathways for BAX Gene
2 Tocris pathways for BAX Gene
39 Qiagen pathways for BAX Gene
- 14-3-3 and Regulation of BAD Activity
- Akt Signaling
- all-trans-Retinoic Acid Signaling in Brain
- Antioxidant Action of Vitamin-C
- Apoptosis through Death Receptors
1 Cell Signaling Technology pathway for BAX Gene
3 GeneTex pathways for BAX Gene
Interacting Proteins for BAX Gene
Selected Interacting proteins:
Q07812-BAX_HUMAN
ENSP00000293288
for BAX Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for BAX
SIGNOR curated interactions for BAX Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001541 | ovarian follicle development | IEA | -- |
| GO:0001764 | neuron migration | IEA | -- |
| GO:0001776 | leukocyte homeostasis | IEA | -- |
| GO:0001777 | T cell homeostatic proliferation | IEA | -- |
| GO:0001782 | B cell homeostasis | IEA | -- |
Drugs & Compounds for BAX Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| AT-101 | Approved, Investigational | Pharma | BH3-mimetic,gossypol enantiomer, BCL-2 inhibitors | 86 | ||
| Gossypol | Investigational | Pharma | PAF inhibitor;anti-fertility and anti-cancer | 24 | ||
| BAM7 | Pharma | BAX activator,direct and selective, Selective Bax activator; induces Bax-mediated apoptosis | 0 | |||
| Bax channel blocker | Pharma | Inhibitor of Bax-mediated mitochondrial cytochrome c release | 0 | |||
| Bax inhibitor peptide P5 | Pharma | Bax inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| AT 101 |
|
90141-22-3 |
|
|
||
| SMBA 1 |
|
906440-37-7 |
|
|
(4) Tocris Compounds for BAX Gene
(8) ApexBio Compounds for BAX Gene
| Compound | Action | Cas Number |
|---|---|---|
| AT-101 | BH3-mimetic,gossypol enantiomer | 90141-22-3 |
| BAM7 | BAX activator,direct and selective | 331244-89-4 |
| Bax channel blocker | Inhibitor of Bax-mediated mitochondrial cytochrome c release | 335165-68-9 |
| Bax inhibitor peptide P5 | Bax inhibitor | 579492-83-4 |
| Bax inhibitor peptide V5 | Bax inhibitor | 579492-81-2 |
| Bax inhibitor peptide, negative control | Peptide inhibit Bax translocation to mitochondria | 1315378-74-5 |
| Gossypol | PAF inhibitor;anti-fertility and anti-cancer | 303-45-7 |
| PRIMA-1 | BAX inhibitor | 5608-24-2 |
Transcripts for BAX Gene
mRNA/cDNA for BAX Gene
- 9 REFSEQ mRNAs :
- 23 NCBI additional mRNA sequence :
- 13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000502487 1346 nts (view in UCSC)
- ENST00000345358 795 nts (view in UCSC)
- ENST00000513545 775 nts (view in UCSC)
- ENST00000515540 300 nts (view in UCSC)
- ENST00000356483 677 nts (view in UCSC)
CRISPR Products
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BAX
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BAX
-
Santa Cruz Biotechnology (SCBT) CRISPR for BAX
miRNA Products
Inhibitory RNA Products
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Clone Products
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG201841
- MR201841
- MR201841L3
- MR201841L4
- RC204369
- RC204369L1
- RC204369L2
- RC204369L3
- RC204369L4
- RC219954
- RC219954L1
- RC219954L2
- RC219954L3
- RC219954L4
- RC222409
- RC222409L1
- RC222409L2
- RC222409L3
- RC222409L4
- RC229114
- RC229114L3
- RC229114L4
- RC235706
- RC235977
- RC236324
- RC236678
- RG204369
- RG219954
- RG222409
- RG229114
- RR212518
- RR212518L3
- RR212518L4
- MR201841L3V
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- RC204369L1V
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- RC222409L3V
- RC222409L4V
- RC229114L3V
- RC229114L4V
- RR212518L3V
- RR212518L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BAX
- Addgene plasmids for BAX
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BAX
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | - | ||||||||||||||
| SP3: |
Relevant External Links for BAX Gene
- GeneLoc Exon Structure for
- BAX
Expression for BAX Gene
mRNA differential expression in normal tissues according to GTEx for BAX Gene
This gene is overexpressed in Whole Blood (x4.5).
This gene is overexpressed in Bone (24.6) and Tlymphocyte (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BAX Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BAX
SOURCE GeneReport for Unigene cluster for BAX Gene:
Hs.624291mRNA Expression by UniProt/SwissProt for BAX Gene:
Q07812-BAX_HUMAN
Tissue specificity:
Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines.
Evidence on tissue expression from TISSUES for BAX Gene
- Nervous system(4.6)
- Skin(4.6)
- Muscle(3.4)
- Intestine(3.2)
- Liver(3)
- Kidney(3)
- Blood(2.9)
- Lung(2.9)
- Heart(2.9)
- Stomach(2.9)
- Spleen(2.8)
- Lymph node(2.7)
- Bone marrow(2.7)
- Adrenal gland(2.6)
- Pancreas(2.4)
- Thyroid gland(2.3)
- Eye(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for BAX Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- immune
- reproductive
- urinary
Regions:
Abdomen:
- intestine
- kidney
- large intestine
- stomach
Pelvis:
- anus
- rectum
- ureter
- urethra
- urinary bladder
- uterus
General:
- blood
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for BAX
-
OriGene qPCR primer pairs and template standards for BAX
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for BAX Gene
Orthologs for BAX Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BAX 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | BAX 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | BAX 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Bax 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Bax 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | BAX 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | bax 30 |
|
||
| MGC76049 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | bax-A 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | baxa 30 31 31 |
|
OneToMany | |
| BAX (3 of 5) 31 |
|
OneToMany | |||
| baxb 31 |
|
OneToMany | |||
| BAX (5 of 5) 31 |
|
OneToMany | |||
| bax 30 |
|
- Species where no ortholog for BAX was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for BAX Gene
- ENSEMBL:
- Gene Tree for BAX (if available)
- TreeFam:
- Gene Tree for BAX (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BAX: view image
Paralogs for BAX Gene
(4) SIMAP similar genes for BAX Gene using alignment to 7 proteins:
- BAX_HUMAN
- H0YA56_HUMAN
- I6LPK7_HUMAN
- K4JQN1_HUMAN
- Q5ZPJ0_HUMAN
- Q5ZPJ1_HUMAN
- Q8WXU1_HUMAN
