This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.[provided by RefSeq, Feb 2009] See more...

Aliases for BATF3 Gene

Aliases for BATF3 Gene

  • Basic Leucine Zipper ATF-Like Transcription Factor 3 2 3 5
  • SNFT 2 3 4
  • Basic Leucine Zipper Transcriptional Factor ATF-Like 3 3 4
  • Basic Leucine Zipper Transcription Factor, ATF-Like 3 2 3
  • 21 KDa Small Nuclear Factor Isolated From T-Cells 3 4
  • Jun Dimerization Protein P21SNFT 3 4
  • Jun Dimerization Protein 1 2 3
  • B-ATF-3 3 4
  • JUNDM1 2 3
  • JDP1 2 3
  • 21-KD Small Nuclear Factor Isolated From T Cells 3
  • BATF3 5

External Ids for BATF3 Gene

Previous GeneCards Identifiers for BATF3 Gene

  • GC01M210927
  • GC01M212859
  • GC01M183536

Summaries for BATF3 Gene

Entrez Gene Summary for BATF3 Gene

  • This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.[provided by RefSeq, Feb 2009]

GeneCards Summary for BATF3 Gene

BATF3 (Basic Leucine Zipper ATF-Like Transcription Factor 3) is a Protein Coding gene. Among its related pathways are Preimplantation Embryo and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is BATF.

UniProtKB/Swiss-Prot Summary for BATF3 Gene

  • AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BATF3 Gene

Genomics for BATF3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BATF3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J212698 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 610.9 -0.1 -58 3.6 HNRNPL CTCF PRDM10 ZNF512 RFX1 IKZF1 KDM1A ZNF692 BACH1 LARP7 BATF3 lnc-BATF3-4 FLVCR1-DT SPATA45 VASH2 piR-42694-015 TATDN3
GH01J212789 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 611.1 -91.7 -91654 4.4 SP1 HNRNPL GATAD2A TEAD4 PRDM10 REST ZNF629 TFE3 ZNF512 SIX5 TATDN3 BATF3 NONHSAG004244.2 NSL1 FLVCR1 FLVCR1-DT ANGEL2 RPS28P2 ENSG00000235182 VASH2
GH01J212691 Enhancer 0.7 FANTOM5 40 +8.1 8128 0.6 PKNOX1 DPF2 RUNX3 ARNT IKZF1 BMI1 NR2F1 JUNB BATF EBF1 RF00026-102 BATF3 lnc-BATF3-4 lnc-FAM71A-1 FAM71A
GH01J212605 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.9 +91.7 91749 6 RNF2 CEBPG HNRNPL CREB1 GATAD2A CTCF ATF7 PRDM10 ZNF629 REST ATF3 lnc-BATF3-8 ANGEL2 DTL FLVCR1 BATF3 FAM71A
GH01J212670 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE 18 +28.4 28419 1.3 PRDM10 ZNF629 ZNF692 ZNF174 JUND POLR2A PATZ1 ZNF600 ZNF341 ZNF792 BATF3 ATF3 RPS6KC1 lnc-FAM71A-1 RF00026-102 FAM71A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BATF3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BATF3

Top Transcription factor binding sites by QIAGEN in the BATF3 gene promoter:
  • AhR
  • AML1a
  • AP-1
  • ATF6
  • C/EBPbeta
  • SREBP-1b
  • SREBP-1c
  • Zic3

Genomic Locations for BATF3 Gene

Genomic Locations for BATF3 Gene
chr1:212,686,417-212,699,943
(GRCh38/hg38)
Size:
13,527 bases
Orientation:
Minus strand
chr1:212,859,759-212,873,327
(GRCh37/hg19)
Size:
13,569 bases
Orientation:
Minus strand

Genomic View for BATF3 Gene

Genes around BATF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BATF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BATF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BATF3 Gene

Proteins for BATF3 Gene

  • Protein details for BATF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR55-BATF3_HUMAN
    Recommended name:
    Basic leucine zipper transcriptional factor ATF-like 3
    Protein Accession:
    Q9NR55

    Protein attributes for BATF3 Gene

    Size:
    127 amino acids
    Molecular mass:
    14468 Da
    Quaternary structure:
    • Heterodimer; heterodimerizes with JUN family proteins. Interacts with JUN.

neXtProt entry for BATF3 Gene

Post-translational modifications for BATF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BATF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for BATF3
  • Boster Bio Antibodies for BATF3

No data available for DME Specific Peptides for BATF3 Gene

Domains & Families for BATF3 Gene

Gene Families for BATF3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for BATF3 Gene

InterPro:
Blocks:
  • bZIP transcription factor, bZIP_1
ProtoNet:

Suggested Antigen Peptide Sequences for BATF3 Gene

GenScript: Design optimal peptide antigens:
  • Jun dimerization protein p21SNFT (BATF3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NR55

UniProtKB/Swiss-Prot:

BATF3_HUMAN :
  • Belongs to the bZIP family.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with BATF3: view

Function for BATF3 Gene

Molecular function for BATF3 Gene

UniProtKB/Swiss-Prot Function:
AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.

Phenotypes From GWAS Catalog for BATF3 Gene

Gene Ontology (GO) - Molecular Function for BATF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 15467742
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 15467742
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity TAS 10878360
genes like me logo Genes that share ontologies with BATF3: view
genes like me logo Genes that share phenotypes with BATF3: view

Animal Models for BATF3 Gene

MGI Knock Outs for BATF3:

Animal Model Products

CRISPR Products

miRNA for BATF3 Gene

miRTarBase miRNAs that target BATF3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BATF3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BATF3 Gene

Localization for BATF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BATF3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BATF3 gene
Compartment Confidence
nucleus 4
plasma membrane 2
extracellular 2
endosome 2
cytosol 2
lysosome 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BATF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus TAS,IBA 21873635
genes like me logo Genes that share ontologies with BATF3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BATF3 Gene

Pathways & Interactions for BATF3 Gene

genes like me logo Genes that share pathways with BATF3: view

Gene Ontology (GO) - Biological Process for BATF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 15467742
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0006366 transcription by RNA polymerase II TAS 10878360
GO:0009615 response to virus IEA,ISS --
genes like me logo Genes that share ontologies with BATF3: view

No data available for SIGNOR curated interactions for BATF3 Gene

Drugs & Compounds for BATF3 Gene

No Compound Related Data Available

Transcripts for BATF3 Gene

mRNA/cDNA for BATF3 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BATF3

Alternative Splicing Database (ASD) splice patterns (SP) for BATF3 Gene

No ASD Table

Relevant External Links for BATF3 Gene

GeneLoc Exon Structure for
BATF3

Expression for BATF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BATF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BATF3 Gene



Protein tissue co-expression partners for BATF3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BATF3

SOURCE GeneReport for Unigene cluster for BATF3 Gene:

Hs.62919

Evidence on tissue expression from TISSUES for BATF3 Gene

  • Lung(4.4)
  • Spleen(3.4)
  • Lymph node(3.1)
  • Blood(2.8)
  • Nervous system(2.6)
  • Intestine(2.4)
  • Bone marrow(2.4)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with BATF3: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BATF3 Gene

Orthologs for BATF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BATF3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia BATF3 30 31
  • 99.66 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia BATF3 30 31
  • 91.41 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia BATF3 30 31
  • 90.48 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Batf3 30
  • 87.5 (n)
Mouse
(Mus musculus)
Mammalia Batf3 30 17 31
  • 84.18 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia BATF3 31
  • 84 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia BATF3 31
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves BATF3 30 31
  • 70.94 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia BATF3 31
  • 83 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia batf3 30
  • 66.4 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33771 30
Zebrafish
(Danio rerio)
Actinopterygii batf3 30 31
  • 65 (n)
OneToOne
Species where no ortholog for BATF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for BATF3 Gene

ENSEMBL:
Gene Tree for BATF3 (if available)
TreeFam:
Gene Tree for BATF3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BATF3: view image

Paralogs for BATF3 Gene

Paralogs for BATF3 Gene

(5) SIMAP similar genes for BATF3 Gene using alignment to 1 proteins:

  • BATF3_HUMAN
genes like me logo Genes that share paralogs with BATF3: view

Variants for BATF3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BATF3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs2202683 - p.Val11Ile

Additional dbSNP identifiers (rs#s) for BATF3 Gene

Structural Variations from Database of Genomic Variants (DGV) for BATF3 Gene

Variant ID Type Subtype PubMed ID
nsv4465 CNV insertion 18451855
nsv549139 CNV gain 21841781

Variation tolerance for BATF3 Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.75; 83.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BATF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BATF3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BATF3 Gene

Disorders for BATF3 Gene

Additional Disease Information for BATF3

No disorders were found for BATF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BATF3 Gene

Publications for BATF3 Gene

  1. Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions. (PMID: 12087103) Bower KE … McGuire KL (The Journal of biological chemistry 2002) 2 3 4
  2. Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein. (PMID: 10878360) Iacobelli M … McGuire KL (Journal of immunology (Baltimore, Md. : 1950) 2000) 2 3 4
  3. Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells. (PMID: 15467742) Bower KE … McGuire KL (Oncogene 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Oncogenic kinase inhibition limits Batf3-dependent dendritic cell development and antitumor immunity. (PMID: 31000683) Medina BD … DeMatteo RP (The Journal of experimental medicine 2019) 3

Products for BATF3 Gene

Sources for BATF3 Gene