Aliases for BATF2 Gene

Aliases for BATF2 Gene

  • Basic Leucine Zipper ATF-Like Transcription Factor 2 2 3 5
  • Basic Leucine Zipper Transcriptional Factor ATF-Like 2 3 4
  • Basic Leucine Zipper Transcription Factor, ATF-Like 2 2 3
  • Suppressor Of AP-1 Regulated By IFN 3 4
  • B-ATF-2 3 4
  • SARI 3 4

External Ids for BATF2 Gene

Previous GeneCards Identifiers for BATF2 Gene

  • GC11M064512
  • GC11M064755
  • GC11M061082

Summaries for BATF2 Gene

GeneCards Summary for BATF2 Gene

BATF2 (Basic Leucine Zipper ATF-Like Transcription Factor 2) is a Protein Coding gene. Diseases associated with BATF2 include Childhood Medulloblastoma and Dracunculiasis. Among its related pathways are T cell receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is FOSL1.

UniProtKB/Swiss-Prot Summary for BATF2 Gene

  • AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CCN1 promoter.

Additional gene information for BATF2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BATF2 Gene

Genomics for BATF2 Gene

GeneHancer (GH) Regulatory Elements for BATF2 Gene

Promoters and enhancers for BATF2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BATF2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BATF2

Top Transcription factor binding sites by QIAGEN in the BATF2 gene promoter:
  • ATF6
  • CP2
  • Egr-4
  • MAZR
  • POU3F2
  • RFX1
  • Spz1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for BATF2 Gene

Genomic Locations for BATF2 Gene
chr11:64,987,945-64,997,653
(GRCh38/hg38)
Size:
9,709 bases
Orientation:
Minus strand
chr11:64,755,415-64,764,517
(GRCh37/hg19)
Size:
9,103 bases
Orientation:
Minus strand

Genomic View for BATF2 Gene

Genes around BATF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BATF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BATF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BATF2 Gene

Proteins for BATF2 Gene

  • Protein details for BATF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1L9-BATF2_HUMAN
    Recommended name:
    Basic leucine zipper transcriptional factor ATF-like 2
    Protein Accession:
    Q8N1L9
    Secondary Accessions:
    • D9IC56
    • Q8NAF4
    • Q8NAL8
    • Q96EH4

    Protein attributes for BATF2 Gene

    Size:
    274 amino acids
    Molecular mass:
    29398 Da
    Quaternary structure:
    • Heterodimer; heterodimerizes with JUN family proteins.

    Alternative splice isoforms for BATF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BATF2 Gene

Post-translational modifications for BATF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BATF2 Gene

No data available for DME Specific Peptides for BATF2 Gene

Domains & Families for BATF2 Gene

Gene Families for BATF2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for BATF2 Gene

Blocks:
  • bZIP transcription factor, bZIP_1
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BATF2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54822 (B4DV37_HUMAN)
  • Basic leucine zipper transcriptional factor ATF-like 2 (BATF2_HUMAN)
  • Suppressor of AP-1 regulated by IFN (D9IC56_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N1L9

UniProtKB/Swiss-Prot:

BATF2_HUMAN :
  • Belongs to the bZIP family.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with BATF2: view

Function for BATF2 Gene

Molecular function for BATF2 Gene

UniProtKB/Swiss-Prot Function:
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CCN1 promoter.
UniProtKB/Swiss-Prot Induction:
By type I interferon. Down-regulated in most hepatocellular carcinoma tumorous tissues (at protein level).

Phenotypes From GWAS Catalog for BATF2 Gene

Gene Ontology (GO) - Molecular Function for BATF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with BATF2: view
genes like me logo Genes that share phenotypes with BATF2: view

Animal Models for BATF2 Gene

MGI Knock Outs for BATF2:

Animal Model Products

CRISPR Products

miRNA for BATF2 Gene

miRTarBase miRNAs that target BATF2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BATF2 Gene

Localization for BATF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BATF2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BATF2 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BATF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with BATF2: view

Pathways & Interactions for BATF2 Gene

PathCards logo

SuperPathways for BATF2 Gene

genes like me logo Genes that share pathways with BATF2: view

Pathways by source for BATF2 Gene

Gene Ontology (GO) - Biological Process for BATF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0030154 cell differentiation IEA --
GO:0042832 defense response to protozoan ISS --
GO:0043011 myeloid dendritic cell differentiation ISS --
genes like me logo Genes that share ontologies with BATF2: view

No data available for SIGNOR curated interactions for BATF2 Gene

Drugs & Compounds for BATF2 Gene

No Compound Related Data Available

Transcripts for BATF2 Gene

mRNA/cDNA for BATF2 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BATF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: -
SP3:

Relevant External Links for BATF2 Gene

GeneLoc Exon Structure for
BATF2

Expression for BATF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BATF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BATF2 Gene

This gene is overexpressed in Spleen (x4.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BATF2

SOURCE GeneReport for Unigene cluster for BATF2 Gene:

Hs.124840

Evidence on tissue expression from TISSUES for BATF2 Gene

  • Intestine(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with BATF2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BATF2 Gene

Orthologs for BATF2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BATF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BATF2 31 30
  • 99.03 (n)
OneToOne
cow
(Bos Taurus)
Mammalia BATF2 31 30
  • 79.93 (n)
OneToOne
dog
(Canis familiaris)
Mammalia BATF2 31 30
  • 78.8 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Batf2 17 31 30
  • 73.46 (n)
rat
(Rattus norvegicus)
Mammalia Batf2 30
  • 72.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BATF2 31
  • 39 (a)
OneToOne
Species where no ortholog for BATF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BATF2 Gene

ENSEMBL:
Gene Tree for BATF2 (if available)
TreeFam:
Gene Tree for BATF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BATF2: view image

Paralogs for BATF2 Gene

Paralogs for BATF2 Gene

(2) SIMAP similar genes for BATF2 Gene using alignment to 3 proteins:

  • BATF2_HUMAN
  • B4DV37_HUMAN
  • E9PJ73_HUMAN
genes like me logo Genes that share paralogs with BATF2: view

Variants for BATF2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BATF2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs12419103 - p.Gly6Ser

Additional dbSNP identifiers (rs#s) for BATF2 Gene

Structural Variations from Database of Genomic Variants (DGV) for BATF2 Gene

Variant ID Type Subtype PubMed ID
esv2750762 CNV loss 17666407
esv32668 CNV gain 17666407
nsv526181 CNV gain 19592680
nsv555208 CNV loss 21841781

Variation tolerance for BATF2 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BATF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BATF2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BATF2 Gene

Disorders for BATF2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for BATF2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
childhood medulloblastoma
  • pediatric medulloblastoma
dracunculiasis
  • dracontiasis
acute stress disorder
  • traumatic stress disorder
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search BATF2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BATF2

genes like me logo Genes that share disorders with BATF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BATF2 Gene

Publications for BATF2 Gene

  1. Decreased expression of BATF2 is associated with a poor prognosis in hepatocellular carcinoma. (PMID: 20473897) Ma H … Xia J (International journal of cancer 2011) 3 4 54
  2. Inhibition of AP-1 by SARI negatively regulates transformation progression mediated by CCN1. (PMID: 20531301) Dash R … Fisher PB (Oncogene 2010) 3 4 54
  3. Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN). (PMID: 19074269) Su ZZ … Fisher PB (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. "Tuberculosis in advanced HIV infection is associated with increased expression of IFNγ and its downstream targets". (PMID: 29764370) Verma S … Salgame P (BMC infectious diseases 2018) 3 54

Products for BATF2 Gene

Sources for BATF2 Gene