The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008] See more...

Aliases for BATF Gene

Aliases for BATF Gene

  • Basic Leucine Zipper ATF-Like Transcription Factor 2 3 5
  • B-ATF 2 3 4
  • SFA-2 2 3 4
  • Basic Leucine Zipper Transcriptional Factor ATF-Like 3 4
  • Basic Leucine Zipper Transcription Factor, ATF-Like 2 3
  • B-Cell-Activating Transcription Factor 3 4
  • Activating Transcription Factor B 2 3
  • SF-HT-Activated Gene 2 Protein 3 4
  • BATF1 2 3
  • SF-HT-Activated Gene 2 2
  • SFA2 3
  • BATF 5

External Ids for BATF Gene

Previous GeneCards Identifiers for BATF Gene

  • GC14P073494
  • GC14P069805
  • GC14P073978
  • GC14P075058
  • GC14P075988
  • GC14P056156

Summaries for BATF Gene

Entrez Gene Summary for BATF Gene

  • The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008]

GeneCards Summary for BATF Gene

BATF (Basic Leucine Zipper ATF-Like Transcription Factor) is a Protein Coding gene. Diseases associated with BATF include Burkitt Lymphoma. Among its related pathways are Tacrolimus/Cyclosporine Pathway, Pharmacodynamics and Interleukin-4 and 13 signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is BATF2.

UniProtKB/Swiss-Prot Summary for BATF Gene

  • AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).

Gene Wiki entry for BATF Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BATF Gene

Genomics for BATF Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BATF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J075519 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 617.6 0.0 -23 5.3 SP1 CREB1 GATAD2A POLR2A RCOR2 BACH1 ZHX2 FOXA1 LARP7 STAT3 BATF ENSG00000224721 FLVCR2 JDP2 TTLL5 FOS LOC105370572 lnc-BATF-1
GH14J075513 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 600.4 -7.2 -7162 2.8 SP1 HNRNPL CTCF ZBTB33 BACH1 RELA IKZF2 TRIM22 EED SIN3A LOC105370572 lnc-BATF-1 BATF JDP2
GH14J075494 Enhancer 1.1 FANTOM5 Ensembl ENCODE 25.6 -26.0 -26002 3.5 SP1 ZNF512 RELA REST IKZF2 EED RELB RUNX3 CBFB TCF12 BATF JDP2 ERG28 piR-32297-006 piR-39904-007
GH14J075547 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 21.7 +26.4 26446 2.2 ZNF512 STAT3 RELA IKZF2 SP1 YY1 PKNOX1 EED RELB RUNX3 BATF TTLL5 FLVCR2 ENSG00000224721 JDP2 ERG28 LOC107984653
GH14J075535 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.1 +12.0 12045 6.2 CREB1 GATAD2A ATF7 PRDM10 ZNF629 REST TFE3 LEF1 NFKBIZ ZNF692 BATF TTLL5 FLVCR2 ENSG00000224721 FOS LOC107984653
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BATF on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BATF

Top Transcription factor binding sites by QIAGEN in the BATF gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3

Genomic Locations for BATF Gene

Genomic Locations for BATF Gene
chr14:75,522,455-75,546,993
(GRCh38/hg38)
Size:
24,539 bases
Orientation:
Plus strand
chr14:75,988,768-76,013,358
(GRCh37/hg19)
Size:
24,591 bases
Orientation:
Plus strand

Genomic View for BATF Gene

Genes around BATF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BATF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BATF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BATF Gene

Proteins for BATF Gene

  • Protein details for BATF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16520-BATF_HUMAN
    Recommended name:
    Basic leucine zipper transcriptional factor ATF-like
    Protein Accession:
    Q16520

    Protein attributes for BATF Gene

    Size:
    125 amino acids
    Molecular mass:
    14120 Da
    Quaternary structure:
    • Heterodimer; mainly heterodimerizes with JUNB. The BATF-JUNB heterodimer interacts with IRF4 and IRF8. Interacts (via bZIP domain) with IRF4 and IRF8; the interaction is direct (By similarity). Also forms heterodimers with JUN and JUND. Also interacts with IFI35.

neXtProt entry for BATF Gene

Post-translational modifications for BATF Gene

  • Phosphorylated on serine and threonine residues and at least one tyrosine residue. Phosphorylation at Ser-43 inhibit DNA binding activity and transforms it as a negative regulator of AP-1 mediated transcription (By similarity).
  • Phosphorylated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BATF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BATF Gene

Domains & Families for BATF Gene

Gene Families for BATF Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for BATF Gene

InterPro:
Blocks:
  • bZIP transcription factor, bZIP_1
ProtoNet:

Suggested Antigen Peptide Sequences for BATF Gene

GenScript: Design optimal peptide antigens:
  • SF-HT-activated gene 2 protein (BATF_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16520

UniProtKB/Swiss-Prot:

BATF_HUMAN :
  • Belongs to the bZIP family.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with BATF: view

Function for BATF Gene

Molecular function for BATF Gene

UniProtKB/Swiss-Prot Function:
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated by PDCD1 following infection by HIV-1 virus, leading to inhibit T-cell functions and exhaust T-cells. Up-regulated by Epstein-Barr virus (EBV) protein EBNA2 following infection by EBV.
GENATLAS Biochemistry:
activation transcription factor expressed on B and T cells after induction respectively by EB virus and HTLV1,ATF/AP-1 family

Phenotypes From GWAS Catalog for BATF Gene

Gene Ontology (GO) - Molecular Function for BATF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA,IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA,ISS --
genes like me logo Genes that share ontologies with BATF: view
genes like me logo Genes that share phenotypes with BATF: view

Animal Models for BATF Gene

MGI Knock Outs for BATF:
  • Batf Batf<tm1.1Ejt>
  • Batf Batf<tm1.1Kmm>

Animal Model Products

CRISPR Products

miRNA for BATF Gene

miRTarBase miRNAs that target BATF
Targeted motifs for BATF Gene
HOMER Transcription Factor Regulatory Elements motif BATF
  • Consensus sequence: DATGASTCAT Submotif: canonical Cell Type: Th17 GEO ID: GSE39756

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BATF

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for BATF Gene

Localization for BATF Gene

Subcellular locations from UniProtKB/Swiss-Prot for BATF Gene

Nucleus. Cytoplasm. Note=Present in the nucleus and cytoplasm, but shows increased nuclear translocation after activation of T-cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BATF gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BATF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA,ISS --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with BATF: view

Pathways & Interactions for BATF Gene

genes like me logo Genes that share pathways with BATF: view

Pathways by source for BATF Gene

Gene Ontology (GO) - Biological Process for BATF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA,ISS --
GO:0002320 lymphoid progenitor cell differentiation IEA,ISS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA,IBA 21873635
GO:0006974 cellular response to DNA damage stimulus IEA,ISS --
genes like me logo Genes that share ontologies with BATF: view

No data available for SIGNOR curated interactions for BATF Gene

Drugs & Compounds for BATF Gene

(3) Drugs for BATF Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with BATF: view

Transcripts for BATF Gene

mRNA/cDNA for BATF Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BATF

Alternative Splicing Database (ASD) splice patterns (SP) for BATF Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for BATF Gene

GeneLoc Exon Structure for
BATF

Expression for BATF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BATF Gene

mRNA differential expression in normal tissues according to GTEx for BATF Gene

This gene is overexpressed in Whole Blood (x13.4) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for BATF Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BATF Gene



Protein tissue co-expression partners for BATF Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BATF

SOURCE GeneReport for Unigene cluster for BATF Gene:

Hs.509964

mRNA Expression by UniProt/SwissProt for BATF Gene:

Q16520-BATF_HUMAN
Tissue specificity: Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma. Strongly expressed in mature B- and T-lymphocytes. Also expressed in moderate levels in lymph node and appendix and at low levels in thymus and bone marrow (PubMed:10777209).

Evidence on tissue expression from TISSUES for BATF Gene

  • Lymph node(3)
  • Spleen(3)
  • Blood(2.7)
  • Intestine(2.5)
  • Bone marrow(2.5)
  • Lung(2)
genes like me logo Genes that share expression patterns with BATF: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for BATF Gene

Orthologs for BATF Gene

This gene was present in the common ancestor of chordates.

Orthologs for BATF Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia BATF 30 31
  • 99.73 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia BATF 30 31
  • 92.21 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia BATF 30 31
  • 91.59 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Batf 30
  • 88.79 (n)
Mouse
(Mus musculus)
Mammalia Batf 30 17 31
  • 88.47 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia BATF 31
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves BATF 30 31
  • 79.68 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia BATF 31
  • 70 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia batf 30
  • 65.25 (n)
Zebrafish
(Danio rerio)
Actinopterygii batf 30 31
  • 69.18 (n)
OneToOne
Species where no ortholog for BATF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for BATF Gene

ENSEMBL:
Gene Tree for BATF (if available)
TreeFam:
Gene Tree for BATF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BATF: view image

Paralogs for BATF Gene

Paralogs for BATF Gene

(7) SIMAP similar genes for BATF Gene using alignment to 2 proteins:

  • BATF_HUMAN
  • G3V266_HUMAN
genes like me logo Genes that share paralogs with BATF: view

Variants for BATF Gene

Additional dbSNP identifiers (rs#s) for BATF Gene

Structural Variations from Database of Genomic Variants (DGV) for BATF Gene

Variant ID Type Subtype PubMed ID
esv3634966 CNV loss 21293372
nsv1037822 CNV gain 25217958

Variation tolerance for BATF Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BATF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BATF

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BATF Gene

Disorders for BATF Gene

MalaCards: The human disease database

(1) MalaCards diseases for BATF Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
burkitt lymphoma
  • bl
- elite association - COSMIC cancer census association via MalaCards
Search BATF in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BATF

genes like me logo Genes that share disorders with BATF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BATF Gene

Publications for BATF Gene

  1. SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes. (PMID: 8630063) Hasegawa H … Fujita S (Biochemical and biophysical research communications 1996) 2 3 4 23
  2. B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family. (PMID: 8570175) Dorsey MJ … Taparowsky EJ (Oncogene 1995) 2 3 4 23
  3. EBNA2 and activated Notch induce expression of BATF. (PMID: 12719594) Johansen LM … Taparowsky EJ (Journal of virology 2003) 3 4 23
  4. B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos. (PMID: 10777209) Echlin DR … Taparowsky EJ (Oncogene 2000) 3 4 23
  5. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 41

Products for BATF Gene

  • Signalway Proteins for BATF

Sources for BATF Gene