This gene encodes a member of the homeobox transcription factor family. A highly related protein in mouse has been shown to influence cellular processes that control cell adhesion and remodeling of the actin cytoskeleton in myoblast fusion and chondrogenesis. The encoded protein may also play a role in cancer progression. [provided by RefSeq, Jul 2008] See more...
Aliases for BARX2 Gene
Aliases for BARX2 Gene
External Ids for BARX2 Gene
- HGNC: 956
- Entrez Gene: 8538
- Ensembl: ENSG00000043039
- OMIM: 604823
- UniProtKB: Q9UMQ3
Previous GeneCards Identifiers for BARX2 Gene
- GC11P131246
- GC11P130758
- GC11P129279
- GC11P128783
- GC11P128751
- GC11P125197
Summaries for BARX2 Gene
-
This gene encodes a member of the homeobox transcription factor family. A highly related protein in mouse has been shown to influence cellular processes that control cell adhesion and remodeling of the actin cytoskeleton in myoblast fusion and chondrogenesis. The encoded protein may also play a role in cancer progression. [provided by RefSeq, Jul 2008]
GeneCards Summary for BARX2 Gene
BARX2 (BARX Homeobox 2) is a Protein Coding gene. Among its related pathways are Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is BARX1.
UniProtKB/Swiss-Prot Summary for BARX2 Gene
-
Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity).
Additional gene information for BARX2 Gene
- Monarch Initiative
- Search for BARX2 at DataMed
- Search for BARX2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BARX2 Gene
Genomics for BARX2 Gene
GeneHancer (GH) Regulatory Elements for BARX2 Gene
Promoters and enhancers for BARX2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BARX2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the BARX2 gene promoter:
-
- Evi-1
- MyoD
- SEF-1 (1)
- SRF
- SRF (504 AA)
Genomic Locations for BARX2 Gene
Genomic Locations for BARX2 Gene
- chr11:129,375,238-129,452,279
- (GRCh38/hg38)
- Size:
- 77,042 bases
- Orientation:
- Plus strand
- chr11:129,245,835-129,322,174
- (GRCh37/hg19)
- Size:
- 76,340 bases
- Orientation:
- Plus strand
Genomic View for BARX2 Gene
Genes around BARX2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q24.3 by HGNC
- 11q24.3 by Entrez Gene
- 11q24.3 by Ensembl
BARX2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BARX2 Gene
Proteins for BARX2 Gene
-
Protein details for BARX2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UMQ3-BARX2_HUMAN
- Recommended name:
- Homeobox protein BarH-like 2
- Protein Accession:
- Q9UMQ3
- O43518
- Q6NT51
Protein attributes for BARX2 Gene
- Size:
- 279 amino acids
- Molecular mass:
- 31188 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAC04705.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC04705.1; Type=Frameshift; Positions=11; Evidence={ECO:0000305}; Sequence=AAF09453.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF09453.1; Type=Frameshift; Positions=11; Evidence={ECO:0000305};
Post-translational modifications for BARX2 Gene
Other Protein References for BARX2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-BARX2 Antibody
- Novus Biologicals Antibodies for BARX2
-
Abcam antibodies for BARX2
- Invitrogen Antibodies for BARX2 (AFLGC-BARX2)
-
Santa Cruz Biotechnology (SCBT) Antibodies for BARX2
Protein Products
- Atlas Antibodies PrEST Antigen BARX2
-
OriGene Purified Proteins for BARX2
- Search Origene for MassSpec and Protein Over-expression Lysates for BARX2
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- antibodies-online: Show 4 available BARX2 Proteins ranked by validation data
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-
Quality Products:
-
Abcam proteins for BARX2
No data available for DME Specific Peptides for BARX2 Gene
Domains & Families for BARX2 Gene
Gene Families for BARX2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for BARX2 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for BARX2 Gene
- GenScript: Design optimal peptide antigens:
-
- Homeobox protein BarH-like 2 (BARX2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UMQ3- Family:
-
- Belongs to the BAR homeobox family.
Function for BARX2 Gene
Molecular function for BARX2 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity).
- GENATLAS Biochemistry:
- Bar H-like homeobox 2,expressed in craniofacial structures during development
Phenotypes From GWAS Catalog for BARX2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IMP | 14744868 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IMP | 14744868 |
| GO:0003677 | DNA binding | IDA | 10854790 |
| GO:0003682 | chromatin binding | IEA | -- |
Phenotypes for BARX2 Gene
- MGI mutant phenotypes for BARX2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for BARX2:
Animal Models for BARX2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BARX2 - Select products 50% OFF >
- * BARX2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for BARX2
miRNA for BARX2 Gene
- miRTarBase miRNAs that target BARX2
-
- hsa-mir-335-5p (MIRT017365)
- hsa-mir-769-5p (MIRT039194)
- hsa-mir-1236-3p (MIRT736281)
- hsa-mir-1587 (MIRT737913)
- hsa-mir-3620-5p (MIRT741741)
- hsa-mir-378g (MIRT742757)
- hsa-mir-4492 (MIRT745273)
- hsa-mir-4498 (MIRT745354)
- hsa-mir-4656 (MIRT746646)
- hsa-mir-4675 (MIRT746875)
- hsa-mir-4741 (MIRT748112)
- hsa-mir-5001-5p (MIRT749347)
- hsa-mir-6515-3p (MIRT753275)
- hsa-mir-6726-3p (MIRT753905)
- hsa-mir-6762-3p (MIRT754968)
- hsa-mir-6829-5p (MIRT757097)
- hsa-mir-762 (MIRT759489)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for BARX2
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Clone Products
- Applied Biological Materials (abm): Clones for BARX2 - Select products 50% OFF >
- * BARX2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * BARX2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for BARX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BARX2
- genomics-online: cdna clones - Search results for available BARX2 gene related products
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Cell Line Products
-
Horizon Cell Lines for BARX2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BARX2 Gene
Localization for BARX2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BARX2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| cytoskeleton | 1 |
- Nucleoplasm (3)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005667 | transcription factor complex | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for BARX2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Preimplantation Embryo | ||
Pathways by source for BARX2 Gene
1 BioSystems pathway for BARX2 Gene
Interacting Proteins for BARX2 Gene
GPS-Prot Interaction Network for BARX2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0001502 | cartilage condensation | IBA | 21873635 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0009888 | tissue development | IBA | 21873635 |
No data available for SIGNOR curated interactions for BARX2 Gene
Drugs & Compounds for BARX2 Gene
No Compound Related Data Available
Drug Products
- Atlas Antibodies PrEST Antigen BARX2
Transcripts for BARX2 Gene
mRNA/cDNA for BARX2 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (21) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000281437 1813 bps (ENST00000281437.5)
- ENST00000605151 2148 bps (ENST00000605151.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BARX2 - Select products 50% OFF >
- * BARX2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * BARX2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for BARX2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BARX2
- genomics-online: gRNA clones - Search results for available BARX2 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for BARX2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for BARX2
- Browse OriGene Inhibitory RNA Products For BARX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BARX2
- genomics-online: shRNA clones - Search results for available BARX2 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for BARX2 - Select products 50% OFF >
- * BARX2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * BARX2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for BARX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BARX2
- genomics-online: cdna clones - Search results for available BARX2 gene related products
- orf clones - Search results for available BARX2 gene related products
Expression for BARX2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
-
Epithelial Cells
- Dental Placode Cells Dental Placode
- Gut Tube (Gastrointestinal Tract)
- Limb (Muscoskeletal System)
-
Esophagus (Gastrointestinal Tract)
-
Larynx (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for BARX2 Gene
This gene is overexpressed in Esophagus - Mucosa (x17.0), Minor Salivary Gland (x11.1), Vagina (x7.1), and Skin - Not Sun Exposed (Suprapubic) (x4.2).
NURSA nuclear receptor signaling pathways regulating expression of BARX2 Gene:
BARX2SOURCE GeneReport for Unigene cluster for BARX2 Gene:
Hs.591944mRNA Expression by UniProt/SwissProt for BARX2 Gene:
Q9UMQ3-BARX2_HUMAN
Tissue specificity:
Highly expressed in adult salivary gland and at much lower levels in mammary gland, kidney and placenta.
Evidence on tissue expression from TISSUES for BARX2 Gene
- Intestine(4.2)
Primer Products
-
OriGene qPCR primer pairs for BARX2
- genomics-online: primer clones - Search results for available BARX2 gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for BARX2 Gene
Orthologs for BARX2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BARX2 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | BARX2 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | BARX2 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Barx2 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Barx2 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | BARX2 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | BARX2 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | BARX2 32 |
|
||
| BARX2B 33 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | BARX2 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | barx2 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | barx2 33 32 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
- Species where no ortholog for BARX2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for BARX2 Gene
- ENSEMBL:
- Gene Tree for BARX2 (if available)
- TreeFam:
- Gene Tree for BARX2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BARX2: view image
Paralogs for BARX2 Gene
Variants for BARX2 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000008292 | -- | 129,391,842(+) | G/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000009695 | -- | 129,433,384(+) | C/A/T | intron_variant | |
| rs1000064457 | -- | 129,430,706(+) | C/T | intron_variant | |
| rs1000216046 | -- | 129,394,403(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000269925 | -- | 129,394,149(+) | C/G | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3579967 | CNV | loss | 25503493 |
| nsv1036787 | CNV | gain | 25217958 |
| nsv1046731 | CNV | gain | 25217958 |
| nsv475507 | CNV | novel sequence insertion | 20440878 |
| nsv546 | CNV | insertion | 18451855 |
| nsv952761 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.13;
38.75% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BARX2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BARX2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BARX2 Gene
Disorders for BARX2 Gene
Additional Disease Information for BARX2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for BARX2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BARX2 Gene
Publications for BARX2 Gene
- The human BARX2 gene: genomic structure, chromosomal localization, and single nucleotide polymorphisms. (PMID: 10644443) Hjalt TA … Murray JC (Genomics 1999) 2 3 4 56
- Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 43 56
- Cloning and chromosomal localization of the human BARX2 homeobox protein gene. (PMID: 10854790) Krasner A … Nelkin BD (Gene 2000) 3 4 56
- Downregulation of BarH-like homeobox 2 promotes cell proliferation, migration and aerobic glycolysis through Wnt/β-catenin signaling, and predicts a poor prognosis in non-small cell lung carcinoma. (PMID: 29341468) Chen H … Chen B (Thoracic cancer 2018) 3 56
- Down-regulation of Barx2 predicts poor survival in colorectal cancer. (PMID: 27453340) Mi Y … Wen Y (Biochemical and biophysical research communications 2016) 3 56
ExternalLinks
Products for BARX2 Gene
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- antibodies-online: Show 4 available BARX2 Proteins ranked by validation data
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- Quality Products:
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- Search Santa Cruz Biotechnology (SCBT) for BARX2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BARX2
- Horizon Cell Lines for BARX2
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Sources for BARX2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
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