This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the ... See more...

Aliases for BARD1 Gene

Aliases for BARD1 Gene

  • BRCA1 Associated RING Domain 1 2 3 5
  • RING-Type E3 Ubiquitin Transferase BARD1 3 4
  • BRCA1-Associated RING Domain Protein 1 3 4
  • BRCA1-Associated RING Domain Gene 1 3
  • EC 2.3.2.27 4
  • BARD-1 4
  • BARD1 5

External Ids for BARD1 Gene

Previous GeneCards Identifiers for BARD1 Gene

  • GC02M213755
  • GC02M214317
  • GC02M215556
  • GC02M215795
  • GC02M215418
  • GC02M215301
  • GC02M207449

Summaries for BARD1 Gene

Entrez Gene Summary for BARD1 Gene

  • This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

CIViC Summary for BARD1 Gene

GeneCards Summary for BARD1 Gene

BARD1 (BRCA1 Associated RING Domain 1) is a Protein Coding gene. Diseases associated with BARD1 include Breast Cancer and Rare Breast Tumor. Among its related pathways are Homologous DNA Pairing and Strand Exchange and DNA damage_ATM/ATR regulation of G1/S checkpoint. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot Summary for BARD1 Gene

  • E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.

Gene Wiki entry for BARD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BARD1 Gene

Genomics for BARD1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BARD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J214806 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 628.7 +1.0 977 5.4 SP1 HNRNPL GATAD2A PRDM10 TFE3 ZNF512 SOX13 NFKBIZ POLR2A ZNF692 BARD1 SNHG31 SNORA70I RPL10P6 piR-52261-153 VWC2L
GH02J214837 Enhancer 0.6 Ensembl ENCODE 23.2 -28.2 -28218 1.4 SMARCA4 NANOG POU5F1 lnc-VWC2L-4 BARD1 piR-32559-236 SNHG31 ABCA12
GH02J214774 Enhancer 0.4 Ensembl 27.5 +35.2 35182 1 JUND FOS JUN BARD1 piR-52261-153 lnc-ABCA12-2 VWC2L
GH02J214813 Enhancer 0.4 Ensembl 26.4 -4.3 -4318 0.8 TEAD4 IKZF1 SCRT2 BARD1 SNORA70I RPL10P6 SNHG31 FJ601684-262 ABCA12
GH02J214729 Enhancer 0.4 Ensembl 21.8 +79.0 78982 1.8 FEZF1 PRDM6 PKNOX1 lnc-ABCA12-2 BARD1 lnc-VWC2L-3 VWC2L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BARD1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BARD1

Top Transcription factor binding sites by QIAGEN in the BARD1 gene promoter:
  • aMEF-2
  • FOXF2
  • FOXL1
  • MEF-2A
  • p53
  • POU2F1
  • POU2F1a
  • RP58
  • Sox9
  • Sp1

Genomic Locations for BARD1 Gene

Genomic Locations for BARD1 Gene
chr2:214,725,645-214,809,683
(GRCh38/hg38)
Size:
84,039 bases
Orientation:
Minus strand
chr2:215,590,370-215,674,428
(GRCh37/hg19)
Size:
84,059 bases
Orientation:
Minus strand

Genomic View for BARD1 Gene

Genes around BARD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BARD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BARD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BARD1 Gene

Proteins for BARD1 Gene

  • Protein details for BARD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99728-BARD1_HUMAN
    Recommended name:
    BRCA1-associated RING domain protein 1
    Protein Accession:
    Q99728
    Secondary Accessions:
    • F6MDH7
    • F6MDH8
    • F6MDH9
    • O43574
    • Q53SS5

    Protein attributes for BARD1 Gene

    Size:
    777 amino acids
    Molecular mass:
    86648 Da
    Quaternary structure:
    • Homo- and heterodimer. Heterodimer (RING-type zinc finger) with BRCA1. Heterodimer (via ANK repeats and BRCT domains) with CSTF1/CSTF-50. Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts with UBXN1.

    Three dimensional structures from OCA and Proteopedia for BARD1 Gene

    Alternative splice isoforms for BARD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BARD1 Gene

Post-translational modifications for BARD1 Gene

  • Processed during apoptosis. The homodimer is more susceptible to proteolytic cleavage than the BARD1/BRCA1 heterodimer.
  • Ubiquitination at Lys160 and Lys110
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BARD1 Gene

Domains & Families for BARD1 Gene

Gene Families for BARD1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for BARD1 Gene

InterPro:
Blocks:
  • Zn-finger, RING
  • Ankyrin repeat signature
  • BRCT domain
ProtoNet:

Suggested Antigen Peptide Sequences for BARD1 Gene

GenScript: Design optimal peptide antigens:
  • BRCA1 associated RING domain 1 (A0AVN2_HUMAN)
  • BRCA1-associated RING domain protein 1 (BARD1_HUMAN)
  • BRCA1 associated RING domain 1 isoform alfa (F6MDH7_HUMAN)
  • BRCA1 associated RING domain 1 isoform beta (F6MDH8_HUMAN)
  • BRCA1 associated RING domain 1 isoform gamma (F6MDH9_HUMAN)
genes like me logo Genes that share domains with BARD1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BARD1 Gene

Function for BARD1 Gene

Molecular function for BARD1 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:20351172};.
GENATLAS Biochemistry:
BRCA1 associated RING domain (BARD1) protein,potentially involved in DNA repair and/or transcriptional activation

Enzyme Numbers (IUBMB) for BARD1 Gene

Phenotypes From GWAS Catalog for BARD1 Gene

Gene Ontology (GO) - Molecular Function for BARD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 12419249
GO:0004842 ubiquitin-protein transferase activity NAS 15905410
GO:0005515 protein binding IPI 8944023
GO:0016740 transferase activity IEA --
GO:0019900 kinase binding NAS 15782130
genes like me logo Genes that share ontologies with BARD1: view
genes like me logo Genes that share phenotypes with BARD1: view

Human Phenotype Ontology for BARD1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for BARD1 Gene

MGI Knock Outs for BARD1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BARD1

No data available for Transcription Factor Targets and HOMER Transcription for BARD1 Gene

Localization for BARD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BARD1 Gene

Nucleus. Note=During S phase of the cell cycle, colocalizes with BRCA1 into discrete subnuclear foci. Can translocate to the cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs). recruitment to DNA damage sites is mediated by the BRCA1-A complex.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BARD1 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
  • Cytoplasmic bodies (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BARD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 14976165
GO:0005634 nucleus IMP 15632137
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 15265711
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with BARD1: view

Pathways & Interactions for BARD1 Gene

genes like me logo Genes that share pathways with BARD1: view

Pathways by source for BARD1 Gene

3 GeneGo (Thomson Reuters) pathways for BARD1 Gene
  • Cell cycle Transition and termination of DNA replication
  • DNA damage_ATM/ATR regulation of G1/S checkpoint
  • DNA damage_Role of Brca1 and Brca2 in DNA repair
3 Qiagen pathways for BARD1 Gene
  • BRCA1 Pathway
  • DNA Repair Mechanisms
  • Fanconi's Anaemia Pathway

UniProtKB/Swiss-Prot Q99728-BARD1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for BARD1 Gene

Activates:

Gene Ontology (GO) - Biological Process for BARD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000729 DNA double-strand break processing TAS --
GO:0001894 tissue homeostasis TAS 15782130
GO:0006260 DNA replication TAS --
GO:0006281 DNA repair IEA --
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
genes like me logo Genes that share ontologies with BARD1: view

Drugs & Compounds for BARD1 Gene

(7) Drugs for BARD1 Gene - From: PharmGKB, ClinicalTrials, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 2588
Docetaxel Approved, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 2330
Trastuzumab Approved, Investigational Pharma HER2 antagonist, HER2 Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 1006
Rucaparib Approved, Investigational Pharma PARP inhibitor, PARP Inhibitors, Other 57
Cola Pharma 2481
genes like me logo Genes that share compounds with BARD1: view

Transcripts for BARD1 Gene

mRNA/cDNA for BARD1 Gene

5 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BARD1

Alternative Splicing Database (ASD) splice patterns (SP) for BARD1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - - -
SP2: -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for BARD1 Gene

GeneLoc Exon Structure for
BARD1

Expression for BARD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BARD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BARD1 Gene

This gene is overexpressed in NK cells (53.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BARD1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BARD1

SOURCE GeneReport for Unigene cluster for BARD1 Gene:

Hs.591642

Evidence on tissue expression from TISSUES for BARD1 Gene

  • Nervous system(4.5)
  • Intestine(2.3)
  • Blood(2.3)
  • Skin(2.2)
  • Muscle(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for BARD1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • integumentary
  • reproductive
  • skeletal muscle
Regions:
Thorax:
  • breast
genes like me logo Genes that share expression patterns with BARD1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for BARD1 Gene

Orthologs for BARD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BARD1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia BARD1 30 31
  • 99.61 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia BARD1 30 31
  • 86.62 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia BARD1 31
  • 86 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia BARD1 30 31
  • 85.23 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Bard1 30 17 31
  • 78.83 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Bard1 30
  • 77.68 (n)
Oppossum
(Monodelphis domestica)
Mammalia BARD1 31
  • 60 (a)
OneToOne
Chicken
(Gallus gallus)
Aves BARD1 30 31
  • 62.19 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia BARD1 31
  • 49 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia bard1 30
  • 58.13 (n)
African clawed frog
(Xenopus laevis)
Amphibia BARD1 30
Zebrafish
(Danio rerio)
Actinopterygii LOC100147913 30
  • 48.08 (n)
bard1 31
  • 40 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG10984 31
  • 10 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
OneToMany
Species where no ortholog for BARD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for BARD1 Gene

ENSEMBL:
Gene Tree for BARD1 (if available)
TreeFam:
Gene Tree for BARD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BARD1: view image

Paralogs for BARD1 Gene

(7) SIMAP similar genes for BARD1 Gene using alignment to 14 proteins:

  • BARD1_HUMAN
  • A0AVN2_HUMAN
  • C9IYG1_HUMAN
  • C9J6M1_HUMAN
  • E7EUI3_HUMAN
  • F6MDH7_HUMAN
  • F6MDH8_HUMAN
  • F6MDH9_HUMAN
  • F6MDI0_HUMAN
  • F6MDI1_HUMAN
  • F6MDI2_HUMAN
  • F6MDI3_HUMAN
  • F6MDI4_HUMAN
  • F8WCG2_HUMAN
genes like me logo Genes that share paralogs with BARD1: view

No data available for Paralogs for BARD1 Gene

Variants for BARD1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BARD1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
215471 Benign/Likely Benign: Hereditary cancer-predisposing syndrome; Familial cancer of breast; not specified 214,767,531(-) CA/TG MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
571479 Pathogenic: Familial cancer of breast 214,744,326(-) CCTAAAAATACTGGAT SPLICE_ACCEPTOR_VARIANT,SPLICE_DONOR_VARIANT,INTRON_VARIANT
639108 Conflicting Interpretations: Hereditary cancer-predisposing syndrome; Familial cancer of breast 214,745,742(-) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
639113 Uncertain Significance: Familial cancer of breast 214,781,497(-) T/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
640241 Uncertain Significance: Familial cancer of breast 214,809,512(-) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for BARD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for BARD1 Gene

Variant ID Type Subtype PubMed ID
esv2658008 CNV deletion 23128226
esv2661707 CNV deletion 23128226
esv3594266 CNV loss 21293372
esv3594267 CNV loss 21293372
esv3893552 CNV gain 25118596
nsv584436 CNV gain 21841781
nsv821897 CNV loss 20364138

Variation tolerance for BARD1 Gene

Residual Variation Intolerance Score: 15.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.91; 95.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BARD1 Gene

Human Gene Mutation Database (HGMD)
BARD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BARD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BARD1 Gene

Disorders for BARD1 Gene

MalaCards: The human disease database

(12) MalaCards diseases for BARD1 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast lobular carcinoma
rare breast tumor
hereditary breast ovarian cancer syndrome
  • brca1- and brca2-associated hereditary breast and ovarian cancer
inherited cancer-predisposing syndrome
  • hereditary cancer-predisposing syndrome
ovarian cancer
  • ovarian cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search BARD1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BARD1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with BARD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BARD1 Gene

Publications for BARD1 Gene

  1. Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers. (PMID: 9425226) Thai TH … Bowcock AM (Human molecular genetics 1998) 2 3 4 41
  2. Cancer predisposing missense and protein truncating BARD1 mutations in non-BRCA1 or BRCA2 breast cancer families. (PMID: 20077502) De Brakeleer S … Teugels E (Human mutation 2010) 3 23 41
  3. Genetic sequence variations of BRCA1-interacting genes AURKA, BAP1, BARD1 and DHX9 in French Canadian families with high risk of breast cancer. (PMID: 19197335) Guénard F … INHERIT BRCAs (Journal of human genetics 2009) 3 23 41
  4. Polymorphisms in HPV E6/E7 protein interacted genes and risk of cervical cancer in Chinese women: a case-control analysis. (PMID: 19482343) Zhou X … Shen H (Gynecologic oncology 2009) 3 23 41
  5. Crystal structure of the BARD1 ankyrin repeat domain and its functional consequences. (PMID: 18480049) Fox D … Klevit RE (The Journal of biological chemistry 2008) 3 4 23

Products for BARD1 Gene

Sources for BARD1 Gene