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This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
BANP (BTG3 Associated Nuclear Protein) is a Protein Coding gene. Diseases associated with BANP include Keratoconus. Among its related pathways are Regulation of TP53 Activity and Gene Expression. Gene Ontology (GO) annotations related to this gene include p53 binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002039 | p53 binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 16189514 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0016604 | nuclear body | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of TP53 Activity | ||
2 | Gene Expression |
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006325 | chromatin organization | IEA | -- |
GO:0007049 | cell cycle | IEA | -- |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0034504 | protein localization to nucleus | IBA | 21873635 |
GO:0042177 | negative regulation of protein catabolic process | IBA | 21873635 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - |
ExUns: | 17 | ^ | 18 |
---|---|---|---|
SP1: | |||
SP2: | |||
SP3: | |||
SP4: | |||
SP5: | |||
SP6: | |||
SP7: | |||
SP8: | |||
SP9: | |||
SP10: | |||
SP11: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | BANP 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Banp 17 33 32 |
|
||
cow (Bos Taurus) |
Mammalia | BANP 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | BANP 33 32 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Banp 32 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | BANP 33 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | BANP 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | BANP 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | BANP 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | banp 32 |
|
||
MGC76079 32 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.16198 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | banp 33 32 |
|
OneToOne |
SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1555586650 | uncertain-significance, Ependymoma | 88,018,464(+) | A/G | 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs1000021724 | -- | 88,051,021(+) | G/C | genic_downstream_transcript_variant, intron_variant | |
rs1000021849 | -- | 87,955,033(+) | G/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000025888 | -- | 88,026,943(+) | G/A | intron_variant, non_coding_transcript_variant | |
rs1000048018 | -- | 87,958,834(+) | T/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant |
Disorder | Aliases | PubMed IDs |
---|---|---|
keratoconus |
|
|