This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] See more...

Aliases for BANP Gene

Aliases for BANP Gene

  • BTG3 Associated Nuclear Protein 2 3 5
  • BEND1 2 3 4
  • SMAR1 2 3 4
  • Scaffold/Matrix-Associated Region-1-Binding Protein 3 4
  • BEN Domain-Containing Protein 1 3 4
  • Protein BANP 3 4
  • SMARBP1 2 3
  • Btg3-Associated Nuclear Protein 4
  • BEN Domain Containing 1 2
  • DKFZp761H172 2
  • FLJ20538 2
  • FLJ10177 2
  • BANP 5

External Ids for BANP Gene

Previous GeneCards Identifiers for BANP Gene

  • GC18M011860
  • GC16P089015
  • GC16P087725
  • GC16P087766
  • GC16P086542
  • GC16P087984
  • GC16P073724

Summaries for BANP Gene

Entrez Gene Summary for BANP Gene

  • This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for BANP Gene

BANP (BTG3 Associated Nuclear Protein) is a Protein Coding gene. Diseases associated with BANP include 16Q24.3 Microdeletion Syndrome and Brittle Cornea Syndrome. Among its related pathways are Regulation of TP53 Activity and Gene Expression. Gene Ontology (GO) annotations related to this gene include p53 binding.

UniProtKB/Swiss-Prot Summary for BANP Gene

  • Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity).

Gene Wiki entry for BANP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BANP Gene

Genomics for BANP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BANP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BANP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BANP

Top Transcription factor binding sites by QIAGEN in the BANP gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • p53

Genomic Locations for BANP Gene

Latest Assembly
chr16:87,949,216-88,077,318
(GRCh38/hg38)
Size:
128,103 bases
Orientation:
Plus strand

Previous Assembly
chr16:87,982,844-88,110,924
(GRCh37/hg19 by Entrez Gene)
Size:
128,081 bases
Orientation:
Plus strand

chr16:87,982,850-88,110,924
(GRCh37/hg19 by Ensembl)
Size:
128,075 bases
Orientation:
Plus strand

Genomic View for BANP Gene

Genes around BANP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BANP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BANP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BANP Gene

Proteins for BANP Gene

  • Protein details for BANP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9N5-BANP_HUMAN
    Recommended name:
    Protein BANP
    Protein Accession:
    Q8N9N5
    Secondary Accessions:
    • A8MU25
    • A8MX25
    • B2RCF7
    • B4DNJ9
    • F5GZM0
    • Q96GJ7
    • Q9NWY1

    Protein attributes for BANP Gene

    Size:
    519 amino acids
    Molecular mass:
    56494 Da
    Quaternary structure:
    • Interacts with TP53 and CUX1/CDP (By similarity). Interacts with HDAC1. Part of a corepressor complex containing BANP, HDAC1, SIN3A, SIN3B, RBL1 and RBL2.
    SequenceCaution:
    • Sequence=BAC04296.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for BANP Gene

neXtProt entry for BANP Gene

Post-translational modifications for BANP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

  • Abcam antibodies for BANP
  • Boster Bio Antibodies for BANP

No data available for DME Specific Peptides for BANP Gene

Domains & Families for BANP Gene

Gene Families for BANP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BANP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BANP Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ96046, Homo sapiens BTG3 associated nuclear protein (BANP), transcriptvariant 2, mRNA (B2RCF7_HUMAN)
  • cDNA FLJ59359, highly similar to Homo sapiens BTG3 associated nuclear protein (BANP), transcript variant 2, mRNA (B4DNJ9_HUMAN)
  • Scaffold/matrix-associated region-1-binding protein (BANP_HUMAN)
  • BTG3 associated nuclear protein, isoform CRA_a (D3DUN6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N9N5

UniProtKB/Swiss-Prot:

BANP_HUMAN :
  • Belongs to the BANP/SMAR1 family.
Family:
  • Belongs to the BANP/SMAR1 family.
genes like me logo Genes that share domains with BANP: view

Function for BANP Gene

Molecular function for BANP Gene

UniProtKB/Swiss-Prot Function:
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity).

Phenotypes From GWAS Catalog for BANP Gene

Gene Ontology (GO) - Molecular Function for BANP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI --
genes like me logo Genes that share ontologies with BANP: view
genes like me logo Genes that share phenotypes with BANP: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BANP

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BANP Gene

Localization for BANP Gene

Subcellular locations from UniProtKB/Swiss-Prot for BANP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BANP gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BANP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with BANP: view

Pathways & Interactions for BANP Gene

genes like me logo Genes that share pathways with BANP: view

Gene Ontology (GO) - Biological Process for BANP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0007049 cell cycle IEA --
GO:0007275 multicellular organism development IEA --
GO:0034504 protein localization to nucleus IBA 21873635
GO:0042177 negative regulation of protein catabolic process IBA 21873635
genes like me logo Genes that share ontologies with BANP: view

No data available for SIGNOR curated interactions for BANP Gene

Drugs & Compounds for BANP Gene

No Compound Related Data Available

Transcripts for BANP Gene

mRNA/cDNA for BANP Gene

32 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
27 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BANP

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for BANP Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - - - - - - - - - - - - -
SP2: -
SP3: - - -
SP4: - - - - - - -
SP5: -
SP6: - - - - - - - -
SP7:
SP8:
SP9:
SP10: -
SP11: -

ExUns: 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for BANP Gene

GeneLoc Exon Structure for
BANP

Expression for BANP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BANP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BANP Gene

This gene is overexpressed in Retina (15.2), Blymphocyte (15.0), NK cells (12.6), Testis (6.9), CD8 Tcells (6.8), and Ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BANP Gene



Protein tissue co-expression partners for BANP Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BANP

SOURCE GeneReport for Unigene cluster for BANP Gene:

Hs.461705

mRNA Expression by UniProt/SwissProt for BANP Gene:

Q8N9N5-BANP_HUMAN
Tissue specificity: Down-regulated in breast cancer cell lines.

Evidence on tissue expression from TISSUES for BANP Gene

  • Blood(4.4)
  • Liver(4.3)
  • Muscle(4.2)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with BANP: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BANP Gene

Orthologs for BANP Gene

This gene was present in the common ancestor of chordates.

Orthologs for BANP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia BANP 30 31
  • 99.16 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Banp 30 17 31
  • 88.08 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia BANP 30 31
  • 87.81 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia BANP 30 31
  • 87.29 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Banp 30
  • 87.15 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia BANP 31
  • 84 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia BANP 31
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves BANP 30 31
  • 78.42 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia BANP 31
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia banp 30
  • 71.57 (n)
MGC76079 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.16198 30
Zebrafish
(Danio rerio)
Actinopterygii banp 30 31
  • 70.1 (n)
OneToOne
Species where no ortholog for BANP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for BANP Gene

ENSEMBL:
Gene Tree for BANP (if available)
TreeFam:
Gene Tree for BANP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BANP: view image

Paralogs for BANP Gene

(1) SIMAP similar genes for BANP Gene using alignment to 11 proteins:

  • BANP_HUMAN
  • C9J811_HUMAN
  • C9JF73_HUMAN
  • C9JGM9_HUMAN
  • C9JLS0_HUMAN
  • C9JLT2_HUMAN
  • C9JTM8_HUMAN
  • C9JYB6_HUMAN
  • D3DUN6_HUMAN
  • E9PIP2_HUMAN
  • E9PJI6_HUMAN

Pseudogenes.org Pseudogenes for BANP Gene

genes like me logo Genes that share paralogs with BANP: view

No data available for Paralogs for BANP Gene

Variants for BANP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BANP Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs1555586650 Uncertain Significance: Ependymoma 88,018,464(+) A/G
NM_079837.3(BANP):c.575A>G (p.Asn192Ser)
MISSENSE
rs200770109 Benign: not provided 88,027,562(+) G/A
NM_079837.3(BANP):c.858G>A (p.Thr286=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for BANP Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for BANP Gene

Variant ID Type Subtype PubMed ID
dgv36n68 CNV loss 17160897
esv1227822 CNV deletion 17803354
esv22847 CNV loss 19812545
esv23831 CNV loss 19812545
esv2672889 CNV deletion 23128226
esv2714946 CNV deletion 23290073
esv2714947 CNV deletion 23290073
esv2714948 CNV deletion 23290073
esv2714949 CNV deletion 23290073
esv2714950 CNV deletion 23290073
esv2714952 CNV deletion 23290073
esv2714953 CNV deletion 23290073
esv2714954 CNV deletion 23290073
esv2714955 CNV deletion 23290073
esv2758668 CNV loss 17122850
esv3364175 CNV duplication 20981092
esv3892935 CNV loss 25118596
esv997568 CNV deletion 20482838
nsv103533 CNV deletion 16902084
nsv1058465 CNV gain 25217958
nsv1058708 CNV gain 25217958
nsv1059786 CNV gain 25217958
nsv1062946 CNV gain 25217958
nsv1066924 CNV loss 25217958
nsv1077833 CNV duplication 25765185
nsv1123082 CNV deletion 24896259
nsv1132444 CNV duplication 24896259
nsv1919 CNV deletion 18451855
nsv1920 CNV deletion 18451855
nsv510431 OTHER sequence alteration 20534489
nsv512450 CNV loss 21212237
nsv821078 CNV deletion 20802225
nsv9472 CNV loss 18304495
nsv9473 CNV loss 18304495
nsv978008 CNV duplication 23825009
nsv978010 CNV duplication 23825009

Variation tolerance for BANP Gene

Residual Variation Intolerance Score: 30% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.57; 72.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BANP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BANP

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BANP Gene

Disorders for BANP Gene

MalaCards: The human disease database

(3) MalaCards diseases for BANP Gene - From: CVR, COP, and GCD

Disorder Aliases PubMed IDs
16q24.3 microdeletion syndrome
  • chromosome 16q24.3 microdeletion syndrome
brittle cornea syndrome
  • corneal fragility, keratoglobus, blue sclerae, joint hyperextensibility
keratoconus
  • conical cornea
- elite association - COSMIC cancer census association via MalaCards
Search BANP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BANP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with BANP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BANP Gene

Publications for BANP Gene

  1. Identification and molecular analysis of BANP. (PMID: 10940556) Birot A … Rouault J (Gene 2000) 2 3 4 23
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8. (PMID: 20719862) Vitart V … Wright A (Human molecular genetics 2010) 3 41
  4. SMAR1 forms a ternary complex with p53-MDM2 and negatively regulates p53-mediated transcription. (PMID: 19303885) Pavithra L … Chattopadhyay S (Journal of molecular biology 2009) 3 23
  5. Loci at chromosomes 13, 19 and 20 influence age at natural menopause. (PMID: 19448619) Stolk L … Uitterlinden AG (Nature genetics 2009) 3 41

Products for BANP Gene

Sources for BANP Gene