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Aliases for BANF2 Gene

Aliases for BANF2 Gene

  • Barrier To Autointegration Factor 2 2 3 5
  • C20orf179 3 4
  • BAF-L 3 4
  • BAFL 3 4
  • Barrier-To-Autointegration Factor-Like Protein 3
  • Testis Secretory Sperm-Binding Protein Li 212a 3
  • Chromosome 20 Open Reading Frame 179 2
  • Barrier-To-Autointegration Factor 2 4
  • BAF2 3

External Ids for BANF2 Gene

Previous HGNC Symbols for BANF2 Gene

  • C20orf179

Previous GeneCards Identifiers for BANF2 Gene

  • GC20P017630

Summaries for BANF2 Gene

GeneCards Summary for BANF2 Gene

BANF2 (Barrier To Autointegration Factor 2) is a Protein Coding gene. An important paralog of this gene is BANF1.

UniProtKB/Swiss-Prot for BANF2 Gene

  • May play a role in BANF1 regulation and influence tissue-specific roles of BANF1.

Additional gene information for BANF2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BANF2 Gene

Genomics for BANF2 Gene

GeneHancer (GH) Regulatory Elements for BANF2 Gene

Promoters and enhancers for BANF2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I017699 Promoter/Enhancer 0.9 EPDnew ENCODE 550.4 +6.5 6481 1.2 CTCF BACH1 LOC105372547 BANF2 RRBP1 GC20M017851
GH20I017693 Promoter 0.5 EPDnew 550.8 -0.1 -108 0.1 BANF2 RRBP1
GH20I017694 Enhancer 0.2 Ensembl 555.7 +0.2 229 0.2 BANF2 RRBP1 LOC105372547
GH20I017566 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.2 -123.4 -123428 6.5 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF207 DSTN BFSP1 RRBP1 ZNF133 POLR3F BANF2 RN7SKP69 GC20M017577
GH20I017858 Enhancer 1.8 VISTA FANTOM5 Ensembl ENCODE dbSUPER 11 +165.9 165909 2.2 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 ETS1 YY1 TCF12 SLC30A9 RRBP1 BANF2 SNX5 MGME1 GC20M017851 LOC105372548
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BANF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BANF2 gene promoter:

Genomic Locations for BANF2 Gene

Genomic Locations for BANF2 Gene
42,201 bases
Plus strand

Genomic View for BANF2 Gene

Genes around BANF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BANF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BANF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BANF2 Gene

Proteins for BANF2 Gene

  • Protein details for BANF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Barrier-to-autointegration factor-like protein
    Protein Accession:
    Secondary Accessions:
    • D3DW25
    • F5H3F6
    • Q7Z4M6

    Protein attributes for BANF2 Gene

    90 amino acids
    Molecular mass:
    10309 Da
    Quaternary structure:
    • Homodimer. Heterodimerizes with BANF1.

    Alternative splice isoforms for BANF2 Gene


neXtProt entry for BANF2 Gene

Post-translational modifications for BANF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BANF2 Gene

Domains & Families for BANF2 Gene

Gene Families for BANF2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BANF2 Gene

Suggested Antigen Peptide Sequences for BANF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BAF family.
  • Belongs to the BAF family.
genes like me logo Genes that share domains with BANF2: view

Function for BANF2 Gene

Molecular function for BANF2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in BANF1 regulation and influence tissue-specific roles of BANF1.

Phenotypes From GWAS Catalog for BANF2 Gene

Gene Ontology (GO) - Molecular Function for BANF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with BANF2: view

Phenotypes for BANF2 Gene

genes like me logo Genes that share phenotypes with BANF2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BANF2 Gene

Localization for BANF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BANF2 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BANF2 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 2

Gene Ontology (GO) - Cellular Components for BANF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA,IEA 21630459
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BANF2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BANF2 Gene

Pathways & Interactions for BANF2 Gene

SuperPathways for BANF2 Gene

No Data Available

Interacting Proteins for BANF2 Gene

Gene Ontology (GO) - Biological Process for BANF2 Gene


No data available for Pathways by source and SIGNOR curated interactions for BANF2 Gene

Drugs & Compounds for BANF2 Gene

No Compound Related Data Available

Transcripts for BANF2 Gene

Unigene Clusters for BANF2 Gene

Barrier to autointegration factor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for BANF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - -

Relevant External Links for BANF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BANF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BANF2 Gene

mRNA differential expression in normal tissues according to GTEx for BANF2 Gene

This gene is overexpressed in Testis (x50.7).

Protein differential expression in normal tissues from HIPED for BANF2 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BANF2 Gene

Protein tissue co-expression partners for BANF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of BANF2 Gene:


SOURCE GeneReport for Unigene cluster for BANF2 Gene:


mRNA Expression by UniProt/SwissProt for BANF2 Gene:

Tissue specificity: Expressed strongly in testis and pancreas. Also detected in brain, colon, liver, lung, ovary, placenta, prostate, small intestine, spleen and thymus. Not detected in heart, kidney and skeletal muscle.
genes like me logo Genes that share expression patterns with BANF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BANF2 Gene

Orthologs for BANF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BANF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BANF2 33 34
  • 98.89 (n)
(Canis familiaris)
Mammalia BANF2 33 34
  • 88.89 (n)
(Rattus norvegicus)
Mammalia Banf2 33
  • 86.23 (n)
(Mus musculus)
Mammalia Banf2 33 16 34
  • 85.56 (n)
(Bos Taurus)
Mammalia BANF2 33 34
  • 84.07 (n)
(Monodelphis domestica)
Mammalia BANF2 34
  • 59 (a)
(Anolis carolinensis)
Reptilia BANF2 34
  • 46 (a)
(Danio rerio)
Actinopterygii si:dkey-211g8.4 34
  • 35 (a)
(Caenorhabditis elegans)
Secernentea baf-1 34
  • 37 (a)
Species where no ortholog for BANF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for BANF2 Gene

Gene Tree for BANF2 (if available)
Gene Tree for BANF2 (if available)

Paralogs for BANF2 Gene

Paralogs for BANF2 Gene

(1) SIMAP similar genes for BANF2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BANF2: view

Variants for BANF2 Gene

Sequence variations from dbSNP and Humsavar for BANF2 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000073854 -- 17,716,334(+) T/C intron_variant
rs1000164618 -- 17,692,663(+) C/A/T upstream_transcript_variant
rs1000232907 -- 17,695,025(+) A/T genic_upstream_transcript_variant, intron_variant
rs1000328598 -- 17,723,356(+) C/T intron_variant
rs1000418175 -- 17,704,133(+) G/A/C intron_variant

Variation tolerance for BANF2 Gene

Residual Variation Intolerance Score: 60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.97; 89.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BANF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BANF2 Gene

Disorders for BANF2 Gene

Additional Disease Information for BANF2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for BANF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BANF2 Gene

Publications for BANF2 Gene

  1. Barrier-to-autointegration factor-like (BAF-L): a proposed regulator of BAF. (PMID: 16337940) Tifft KE … Wilson KL (Experimental cell research 2006) 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  5. Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. (PMID: 7829101) Robertson NG … Morton CC (Genomics 1994) 3 4 58

Products for BANF2 Gene

Sources for BANF2 Gene

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