Aliases for BANF1 Gene
External Ids for BANF1 Gene
Previous GeneCards Identifiers for BANF1 Gene
The protein encoded by this gene was first identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The protein forms a homodimer which localizes to both the nucleus and cytoplasm and is specifically associated with chromosomes during mitosis. This protein binds to double stranded DNA in a non-specific manner and also binds to LEM-domain containing proteins of the nuclear envelope. This protein is thought to facilitate nuclear reassembly by binding with both DNA and inner nuclear membrane proteins and thereby recruit chromatin to the nuclear periphery. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Jan 2009]
GeneCards Summary for BANF1 Gene
BANF1 (Barrier To Autointegration Factor 1) is a Protein Coding gene. Diseases associated with BANF1 include Nestor-Guillermo Progeria Syndrome and Vaccinia. Among its related pathways are Mitotic Prophase and HIV Life Cycle. An important paralog of this gene is BANF2.
UniProtKB/Swiss-Prot for BANF1 Gene
Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging.
(Microbial infection) Exploited by retroviruses for inhibiting self-destructing autointegration of retroviral DNA, thereby promoting integration of viral DNA into the host chromosome. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD.
(Microbial infection) In case of poxvirus infection, has an antiviral activity by blocking viral DNA replication.