Aliases for BAMBI Gene
External Ids for BAMBI Gene
Previous GeneCards Identifiers for BAMBI Gene
This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for BAMBI Gene
BAMBI (BMP And Activin Membrane Bound Inhibitor) is a Protein Coding gene. Diseases associated with BAMBI include Wolfram Syndrome and Gnathodiaphyseal Dysplasia. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and TGF-beta receptor signaling activates SMADs. Gene Ontology (GO) annotations related to this gene include frizzled binding and transmembrane receptor protein serine/threonine kinase activity. An important paralog of this gene is CATIP.
UniProtKB/Swiss-Prot Summary for BAMBI Gene
Negatively regulates TGF-beta signaling.