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The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]
BAK1 (BCL2 Antagonist/Killer 1) is a Protein Coding gene. Diseases associated with BAK1 include Absolute Glaucoma and Keratoacanthoma. Among its related pathways are MAPK Signaling: Oxidative Stress Pathway and DNA Damage Response (only ATM dependent). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is BCL2L1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
GO:0005515 | protein binding | IPI | 9027312 |
GO:0031072 | heat shock protein binding | IEA | -- |
GO:0042802 | identical protein binding | IPI | 10950869 |
GO:0042803 | protein homodimerization activity | IBA,IDA | 23028632 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IDA | 9843949 |
GO:0005741 | mitochondrial outer membrane | TAS | -- |
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005829 | cytosol | IEA | -- |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Endometrial cancer |
.36
|
|
2 | Apoptosis Modulation and Signaling |
.41
|
.31
|
3 | Nanomaterial induced apoptosis | ||
4 | Gastric cancer |
.62
.62
|
|
5 | Measles |
.35
|
.33
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001776 | leukocyte homeostasis | IEA | -- |
GO:0001782 | B cell homeostasis | IEA | -- |
GO:0001783 | B cell apoptotic process | IEA | -- |
GO:0001836 | release of cytochrome c from mitochondria | IGI | 21041309 |
GO:0001974 | blood vessel remodeling | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | BAK1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LOC481744 30 |
|
||
BAK1 31 |
|
OneToOne | |||
Cow (Bos Taurus) |
Mammalia | BAK1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Bak1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Bak1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | BAK1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | BAK1 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | BAK1 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
absolute glaucoma |
|
|
keratoacanthoma |
|
|
benign mammary dysplasia |
|
|
central pontine myelinolysis |
|
|
kaposi sarcoma |
|
|