Aliases for BAIAP3 Gene
External Ids for BAIAP3 Gene
Previous GeneCards Identifiers for BAIAP3 Gene
This p53-target gene encodes a brain-specific angiogenesis inhibitor. The protein is a seven-span transmembrane protein and a member of the secretin receptor family. It interacts with the cytoplasmic region of brain-specific angiogenesis inhibitor 1. This protein also contains two C2 domains, which are often found in proteins involved in signal transduction or membrane trafficking. Its expression pattern and similarity to other proteins suggest that it may be involved in synaptic functions. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for BAIAP3 Gene
BAIAP3 (BAI1 Associated Protein 3) is a Protein Coding gene. Diseases associated with BAIAP3 include Alpha Thalassemia-Intellectual Disability Syndrome Type 1. Among its related pathways are Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include protein C-terminus binding. An important paralog of this gene is UNC13D.
UniProtKB/Swiss-Prot Summary for BAIAP3 Gene
Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans-Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters including NPY and serotonin and hormones like insulin (PubMed:28626000). Proposed to play a role in hypothalamic neuronal firing by modulating gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission (By similarity).