Aliases for BAIAP2 Gene
- BAR/IMD Domain Containing Adaptor Protein 2 2 3
- BAI1 Associated Protein 2 2 3 5
- Brain-Specific Angiogenesis Inhibitor 1-Associated Protein 2 3 4
- Insulin Receptor Substrate Protein Of 53 KDa 3 4
- Insulin Receptor Substrate Of 53 KDa 2 3
- Insulin Receptor Substrate P53/P58 3 4
- Fas Ligand-Associated Factor 3 3 4
- IRSp53/58 3 4
External Ids for BAIAP2 Gene
Previous GeneCards Identifiers for BAIAP2 Gene
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
GeneCards Summary for BAIAP2 Gene
BAIAP2 (BAR/IMD Domain Containing Adaptor Protein 2) is a Protein Coding gene. Diseases associated with BAIAP2 include Dentatorubral-Pallidoluysian Atrophy and Attention Deficit-Hyperactivity Disorder. Among its related pathways are Adherens junction and G-protein signaling RAC1 in cellular process. Gene Ontology (GO) annotations related to this gene include identical protein binding and SH3 domain binding. An important paralog of this gene is BAIAP2L1.
UniProtKB/Swiss-Prot Summary for BAIAP2 Gene
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.