This gene encodes a tumor antigen recognized by autologous cytolytic lymphocytes (CTL). [provided by RefSeq, Jul 2008] See more...

Aliases for BAGE Gene

Aliases for BAGE Gene

  • B Melanoma Antigen 2 3 4
  • BAGE1 2 3 4
  • CT2.1 2 3 4
  • Cancer/Testis Antigen Family 2, Member 1 2 3
  • Cancer/Testis Antigen 2.1 3 4
  • B Melanoma Antigen 1 3 4
  • Antigen MZ2-BA 3 4

External Ids for BAGE Gene

Previous GeneCards Identifiers for BAGE Gene

  • GC21M007820
  • GC21M010080
  • GC21M010047
  • GC07M151408
  • GC21M010079
  • GC21M011000

Summaries for BAGE Gene

Entrez Gene Summary for BAGE Gene

  • This gene encodes a tumor antigen recognized by autologous cytolytic lymphocytes (CTL). [provided by RefSeq, Jul 2008]

GeneCards Summary for BAGE Gene

BAGE (B Melanoma Antigen) is a Protein Coding gene. Diseases associated with BAGE include Melanoma.

UniProtKB/Swiss-Prot Summary for BAGE Gene

  • Unknown. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Additional gene information for BAGE Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BAGE Gene

Genomics for BAGE Gene

Genomic Locations for BAGE Gene

Genomic Locations for BAGE Gene
Unknown strand

Genomic View for BAGE Gene

Cytogenetic band:
GeneLoc Logo Gene Density

No data available for GeneHancer (GH) Regulatory Elements and RefSeq DNA sequence for BAGE Gene

Proteins for BAGE Gene

  • Protein details for BAGE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    B melanoma antigen 1
    Protein Accession:
    Secondary Accessions:
    • A4IF47

    Protein attributes for BAGE Gene

    43 amino acids
    Molecular mass:
    4810 Da
    Quaternary structure:
    No Data Available
    • The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the KMT2C/MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.

    Alternative splice isoforms for BAGE Gene


neXtProt entry for BAGE Gene

Post-translational modifications for BAGE Gene

No Post-translational modifications

Other Protein References for BAGE Gene

REFSEQ proteins:

No data available for DME Specific Peptides for BAGE Gene

Domains & Families for BAGE Gene

Gene Families for BAGE Gene


Protein Domains for BAGE Gene

  • B melanoma antigen

Suggested Antigen Peptide Sequences for BAGE Gene

GenScript: Design optimal peptide antigens:
  • Cancer/testis antigen 2.1 (BAGE1_HUMAN)
  • BAGE protein (Q29RY1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BAGE family.
  • Belongs to the BAGE family.
genes like me logo Genes that share domains with BAGE: view

Function for BAGE Gene

Molecular function for BAGE Gene

UniProtKB/Swiss-Prot Function:
Unknown. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Phenotypes From GWAS Catalog for BAGE Gene

genes like me logo Genes that share phenotypes with BAGE: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BAGE

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BAGE Gene

Localization for BAGE Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAGE Gene


Gene Ontology (GO) - Cellular Components for BAGE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with BAGE: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for BAGE Gene

Pathways & Interactions for BAGE Gene

PathCards logo

SuperPathways for BAGE Gene

No Data Available

Interacting Proteins for BAGE Gene

Gene Ontology (GO) - Biological Process for BAGE Gene


No data available for Pathways by source and SIGNOR curated interactions for BAGE Gene

Drugs & Compounds for BAGE Gene

(1) Additional Compounds for BAGE Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BAGE: view

Transcripts for BAGE Gene

mRNA/cDNA for BAGE Gene

8 NCBI additional mRNA sequence :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BAGE

Alternative Splicing Database (ASD) splice patterns (SP) for BAGE Gene

No ASD Table

Expression for BAGE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BAGE Gene

Protein differential expression in normal tissues from HIPED for BAGE Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BAGE Gene

Protein tissue co-expression partners for BAGE Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BAGE

SOURCE GeneReport for Unigene cluster for BAGE Gene:


mRNA Expression by UniProt/SwissProt for BAGE Gene:

Tissue specificity: Not expressed in normal tissues, except in testis. Expressed with significant proportion in melanomas, but also in tumors of various histological origins, such as bladder carcinomas, head and neck squamous cell carcinomas, lung and breast carcinomas. Not expressed in renal, colorectal and prostatic carcinomas, leukemias and lymphomas. More frequently expressed in metastatic melanomas than in primary melanomas.
genes like me logo Genes that share expression patterns with BAGE: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BAGE Gene

Orthologs for BAGE Gene

No data available for Orthologs and Evolution for BAGE Gene

Paralogs for BAGE Gene

(4) SIMAP similar genes for BAGE Gene using alignment to 2 proteins:

  • Q29RY1_HUMAN
genes like me logo Genes that share paralogs with BAGE: view

No data available for Paralogs for BAGE Gene

Variants for BAGE Gene

Structural Variations from Database of Genomic Variants (DGV) for BAGE Gene

Variant ID Type Subtype PubMed ID
dgv2349n106 CNV duplication 24896259
dgv2351n106 CNV deletion 24896259
dgv2352n106 CNV deletion 24896259
dgv2353n106 CNV deletion 24896259
dgv2354n106 CNV deletion 24896259
dgv2468e59 CNV duplication 20981092
dgv4354n100 CNV gain+loss 25217958
dgv4355n100 CNV gain 25217958
dgv4356n100 CNV loss 25217958
dgv4358n100 CNV gain 25217958
dgv4363n100 CNV loss 25217958
dgv4367n100 CNV gain 25217958
dgv4368n100 CNV gain+loss 25217958
dgv4369n100 CNV gain 25217958
dgv4370n100 CNV loss 25217958
dgv4371n100 CNV gain 25217958
dgv4372n100 CNV loss 25217958
dgv4373n100 CNV gain+loss 25217958
dgv712n67 CNV gain 20364138
dgv73n16 CNV deletion 17901297
dgv7728n54 CNV gain 21841781
dgv7729n54 CNV gain 21841781
dgv7743n54 CNV gain 21841781
esv1000174 CNV deletion 20482838
esv1001067 CNV insertion 20482838
esv1002199 CNV deletion 20482838
esv2474693 CNV deletion 19546169
esv2563009 CNV deletion 19546169
esv2661615 CNV deletion 23128226
esv2675165 CNV deletion 23128226
esv2758808 CNV gain+loss 17122850
esv2760704 CNV gain 21179565
esv2763681 CNV gain+loss 21179565
esv28756 CNV gain+loss 19812545
esv29976 CNV gain 17803354
esv32564 CNV gain+loss 17666407
esv3557434 CNV deletion 23714750
esv3646371 CNV loss 21293372
esv7291 CNV loss 19470904
esv991443 OTHER inversion 20482838
esv999403 CNV deletion 20482838
esv999554 CNV insertion 20482838
nsv1057510 CNV loss 25217958
nsv1059291 CNV loss 25217958
nsv1060052 CNV loss 25217958
nsv1071408 CNV deletion 25765185
nsv1071738 CNV deletion 25765185
nsv1071739 CNV deletion 25765185
nsv1071740 CNV deletion 25765185
nsv1071741 CNV deletion 25765185
nsv1072155 CNV deletion 25765185
nsv1072156 CNV deletion 25765185
nsv1072757 CNV deletion 25765185
nsv1073110 CNV deletion 25765185
nsv1073111 CNV deletion 25765185
nsv1078497 CNV duplication 25765185
nsv1109407 CNV deletion 24896259
nsv1114259 CNV deletion 24896259
nsv1116897 CNV deletion 24896259
nsv1136590 CNV deletion 24896259
nsv1136592 CNV deletion 24896259
nsv1136593 CNV deletion 24896259
nsv1138994 CNV deletion 24896259
nsv1138995 CNV deletion 24896259
nsv1138996 CNV deletion 24896259
nsv1138997 CNV deletion 24896259
nsv1143010 CNV tandem duplication 24896259
nsv1150038 CNV deletion 26484159
nsv1151660 CNV duplication 26484159
nsv3451 CNV insertion 18451855
nsv428382 CNV gain+loss 18775914
nsv435743 CNV deletion 17901297
nsv436329 CNV deletion 17901297
nsv436336 CNV deletion 17901297
nsv437841 CNV loss 16327808
nsv469643 CNV loss 16826518
nsv471421 CNV gain 19718026
nsv498974 CNV loss 21111241
nsv512628 CNV loss 21212237
nsv512629 CNV loss 21212237
nsv512630 CNV loss 21212237
nsv586978 CNV gain 21841781
nsv586980 CNV loss 21841781
nsv820736 CNV duplication 20802225
nsv828818 CNV gain 20364138
nsv834041 CNV gain 17160897
nsv953331 CNV duplication 24416366
nsv953332 CNV duplication 24416366
nsv954302 CNV deletion 24416366
nsv964473 CNV duplication 23825009
nsv979515 CNV duplication 23825009
nsv9838 CNV gain+loss 18304495

Additional Variant Information for BAGE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) and Variation tolerance for BAGE Gene

Disorders for BAGE Gene

MalaCards: The human disease database

(1) MalaCards diseases for BAGE Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards
Search BAGE in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BAGE

genes like me logo Genes that share disorders with BAGE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BAGE Gene

Publications for BAGE Gene

  1. BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes. (PMID: 7895173) Boël P … van der Bruggen P (Immunity 1995) 2 3 4 23
  2. New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile. (PMID: 12461691) Ruault M … De Sario A (European journal of human genetics : EJHG 2002) 3 4 23
  3. Expression of tumor-specific antigen MAGE, GAGE and BAGE in ovarian cancer tissues and cell lines. (PMID: 20423514) Zhang S … Yu Y (BMC cancer 2010) 3 23
  4. BAGE hypomethylation, a new epigenetic biomarker for colon cancer detection. (PMID: 18541613) Grunau C … De Sario A (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 23
  5. Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer. (PMID: 15704127) Grunau C … De Sario A (Genes, chromosomes & cancer 2005) 3 23

Products for BAGE Gene

Sources for BAGE Gene