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This gene encodes a tumor antigen recognized by autologous cytolytic lymphocytes (CTL). [provided by RefSeq, Jul 2008] See more...
Aliases for BAGE Gene
Aliases for BAGE Gene
Previous GeneCards Identifiers for BAGE Gene
- GC21M007820
- GC21M010080
- GC21M010047
- GC07M151408
- GC21M010079
- GC21M011000
Summaries for BAGE Gene
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This gene encodes a tumor antigen recognized by autologous cytolytic lymphocytes (CTL). [provided by RefSeq, Jul 2008]
GeneCards Summary for BAGE Gene
BAGE (B Melanoma Antigen) is a Protein Coding gene. Diseases associated with BAGE include Melanoma.
UniProtKB/Swiss-Prot Summary for BAGE Gene
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Unknown. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BAGE Gene
Proteins for BAGE Gene
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Protein details for BAGE Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13072-BAGE1_HUMAN
- Recommended name:
- B melanoma antigen 1
- Protein Accession:
- Q13072
- A4IF47
Protein attributes for BAGE Gene
- Size:
- 43 amino acids
- Molecular mass:
- 4810 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the KMT2C/MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.
Alternative splice isoforms for BAGE Gene
- UniProtKB/Swiss-Prot:
Protein Expression for BAGE Gene
Post-translational modifications for BAGE Gene
No Post-translational modifications
Other Protein References for BAGE Gene
- REFSEQ proteins:
Antibody Products
- antibodies-online: Show 12 available BAGE Antibodies ranked by validation data
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for BAGE
- Origene Custom Protein Services for BAGE
- antibodies-online: Search results for available BAGE related products ranked by validation data
No data available for DME Specific Peptides for BAGE Gene
Domains & Families for BAGE Gene
Gene Families for BAGE Gene
- HGNC:
Suggested Antigen Peptide Sequences for BAGE Gene
- GenScript: Design optimal peptide antigens:
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- Cancer/testis antigen 2.1 (BAGE1_HUMAN)
- BAGE protein (Q29RY1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q13072- Family:
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- Belongs to the BAGE family.
Function for BAGE Gene
Molecular function for BAGE Gene
- UniProtKB/Swiss-Prot Function:
- Unknown. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
Phenotypes From GWAS Catalog for BAGE Gene
Phenotypes for BAGE Gene
- GenomeRNAi human phenotypes for BAGE:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BAGE - Select products 50% OFF >
- * BAGE CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BAGE
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BAGE
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Santa Cruz Biotechnology (SCBT) CRISPR for BAGE
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BAGE
- Browse OriGene Inhibitory RNA Products For BAGE
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BAGE
Clone Products
- Applied Biological Materials (abm): Clones for BAGE - Select products 50% OFF >
- * BAGE as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for BAGE
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BAGE
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BAGE Gene
Localization for BAGE Gene
Subcellular locations from UniProtKB/Swiss-Prot for BAGE Gene
- Secreted.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for BAGE Gene
Transcripts for BAGE Gene
mRNA/cDNA for BAGE Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BAGE - Select products 50% OFF >
- * BAGE CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BAGE
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BAGE
-
Santa Cruz Biotechnology (SCBT) CRISPR for BAGE
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BAGE
- Browse OriGene Inhibitory RNA Products For BAGE
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BAGE
Clone Products
- Applied Biological Materials (abm): Clones for BAGE - Select products 50% OFF >
- * BAGE as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for BAGE
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BAGE
Expression for BAGE Gene
This gene is overexpressed in Heart (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BAGE Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BAGE
SOURCE GeneReport for Unigene cluster for BAGE Gene:
Hs.545789mRNA Expression by UniProt/SwissProt for BAGE Gene:
Q13072-BAGE1_HUMAN
Tissue specificity:
Not expressed in normal tissues, except in testis. Expressed with significant proportion in melanomas, but also in tumors of various histological origins, such as bladder carcinomas, head and neck squamous cell carcinomas, lung and breast carcinomas. Not expressed in renal, colorectal and prostatic carcinomas, leukemias and lymphomas. More frequently expressed in metastatic melanomas than in primary melanomas.
Primer Products
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OriGene qPCR primer pairs and template standards for BAGE
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BAGE Gene
Orthologs for BAGE Gene
No data available for Orthologs and Evolution for BAGE Gene
Paralogs for BAGE Gene
(4) SIMAP similar genes for BAGE Gene using alignment to 2 proteins:
- BAGE1_HUMAN
- Q29RY1_HUMAN
No data available for Paralogs for BAGE Gene
Variants for BAGE Gene
Additional Variant Information for BAGE Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BAGE
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) and Variation tolerance for BAGE Gene
Disorders for BAGE Gene
Search BAGE in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BAGE
No data available for UniProtKB/Swiss-Prot and Genatlas for BAGE Gene
Publications for BAGE Gene
- BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes. (PMID: 7895173) Boël P … van der Bruggen P (Immunity 1995) 2 3 4 23
- New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile. (PMID: 12461691) Ruault M … De Sario A (European journal of human genetics : EJHG 2002) 3 4 23
- Expression of tumor-specific antigen MAGE, GAGE and BAGE in ovarian cancer tissues and cell lines. (PMID: 20423514) Zhang S … Yu Y (BMC cancer 2010) 3 23
- BAGE hypomethylation, a new epigenetic biomarker for colon cancer detection. (PMID: 18541613) Grunau C … De Sario A (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 23
- Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer. (PMID: 15704127) Grunau C … De Sario A (Genes, chromosomes & cancer 2005) 3 23
ExternalLinks
Products for BAGE Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for BAGE
- Origene Custom Protein Services for BAGE
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BAGE
- Browse OriGene Inhibitory RNA Products For BAGE
- OriGene qPCR primer pairs and template standards for BAGE
- OriGene CRISPR knockouts for BAGE
- OriGene ORF clones in human for BAGE
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BAGE
- Sino Biological Human cDNA Clone for BAGE
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- VectorBuilder Custom and pre-made DNA vectors for BAGE (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for BAGE (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for BAGE (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for BAGE CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for BAGE
- antibodies-online: Show 12 available BAGE Antibodies ranked by validation data
- antibodies-online: Search results for available BAGE related products ranked by validation data
- antibodies-online: Search results for available BAGE related products ranked by validation data
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BAGE
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BAGE
- Search GeneCopoeia for miRNA 3'UTR Target clone products for BAGE
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BAGE
Sources for BAGE Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
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- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
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- (128) SNPedia
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- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
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- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
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- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
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- (175) Open Targets Platform
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- (177) snoDB
- (178) MirGeneDB