Aliases for BAG6 Gene
Aliases for BAG6 Gene
External Ids for BAG6 Gene
- HGNC: 13919
- Entrez Gene: 7917
- Ensembl: ENSG00000204463
- OMIM: 142590
- UniProtKB: P46379
Previous HGNC Symbols for BAG6 Gene
- BAT3
Previous GeneCards Identifiers for BAG6 Gene
- GC06M031392
- GC06M031632
- GC06M031636
- GC06M031643
- GC06M031648
- GC06M031666
- GC06M031697
Summaries for BAG6 Gene
-
This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for BAG6 Gene
BAG6 (BCL2 Associated Athanogene 6) is a Protein Coding gene. Diseases associated with BAG6 include Acute Diarrhea and Discrete Subaortic Stenosis. Among its related pathways are Wnt / Hedgehog / Notch. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and Hsp70 protein binding.
UniProtKB/Swiss-Prot for BAG6 Gene
-
ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:28104892, PubMed:27193484). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate to the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).
-
Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 Lys-4 dimethylation (H3K4me2) (PubMed:18765639).
-
Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
-
Mediates ricin-induced apoptosis.
Additional gene information for BAG6 Gene
- Monarch Initiative
- Search for BAG6 at DataMed
- Search for BAG6 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG6 Gene
Genomics for BAG6 Gene
GeneHancer (GH) Regulatory Elements for BAG6 Gene
Promoters and enhancers for BAG6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around BAG6 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for BAG6 Gene
Genomic Locations for BAG6 Gene
- chr6:31,639,028-31,660,767
- (GRCh38/hg38)
- Size:
- 21,740 bases
- Orientation:
- Minus strand
- chr6:31,606,805-31,620,482
- (GRCh37/hg19)
- Size:
- 13,678 bases
- Orientation:
- Minus strand
Genomic View for BAG6 Gene
Genes around BAG6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.33 by Entrez Gene
- 6p21.33 by HGNC
- 6p21.33 by Ensembl
BAG6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BAG6 Gene
Proteins for BAG6 Gene
-
Protein details for BAG6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P46379-BAG6_HUMAN
- Recommended name:
- Large proline-rich protein BAG6
- Protein Accession:
- P46379
- A2ADJ7
- A3KQ42
- A3KQ44
- A6NGY6
- A6PWF7
- B0UX84
- B4DZ12
- B4E3V4
- E7EMZ4
- F8VXY4
- O95874
- Q5HYL9
- Q5SQ35
- Q5SQ36
- Q5SQ37
- Q5SQ41
- Q5SRP8
- Q5SRP9
- Q5STC1
- Q5STX1
- Q5STX3
- Q96SA6
- Q9BCN4
Protein attributes for BAG6 Gene
- Size:
- 1132 amino acids
- Molecular mass:
- 119409 Da
- Quaternary structure:
-
- Component of the BAG6/BAT3 complex, also named BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35 (PubMed:20676083). Interacts with GET4; the interaction is direct and localizes BAG6 in the cytosol (PubMed:21636303). Interacts with AIFM1 (By similarity). Interacts with HSPA2 (By similarity). Interacts with CTCFL (PubMed:18765639). Interacts with p300/EP300 (PubMed:17403783). Interacts (via ubiquitin-like domain) with RNF126; required for BAG6-dependent ubiquitination of proteins mislocalized to the cytosol (PubMed:24981174, PubMed:27193484). Interacts (via ubiquitin-like domain) with SGTA; SGTA competes with RNF126 by binding the same region of BAG6, thereby promoting deubiquitination of BAG6-target proteins and rescuing them from degradation (PubMed:23129660, PubMed:24424410, PubMed:25179605, PubMed:27193484). Interacts with ricin A chain (PubMed:14960581). Interacts with VCP and AMFR; both form the VCP/p97-AMFR/gp78 complex (PubMed:21636303). Interacts with SYVN1 (PubMed:21636303). Interacts with USP13; the interaction is direct and may mediate UBL4A deubiquitination (PubMed:24424410). Interacts with ZFAND2B (PubMed:24160817, PubMed:26337389).
- (Microbial infection) Interacts with L. pneumophila Lpg2160 and LegU1 proteins.
- SequenceCaution:
-
- Sequence=AAD18085.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB63390.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI18318.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for BAG6 Gene
Protein Expression for BAG6 Gene
Post-translational modifications for BAG6 Gene
- Ricin can induce a cleavage by the caspase CASP3. The released C-terminal peptide induces apoptosis.
- (Microbial infection) In case of infection by L.pneumophila, ubiquitinated by the SCF(LegU1) complex.
- Ubiquitination at posLast=10721072, Lys1052, posLast=10491049, posLast=8080, Lys56, Lys40, and Lys22
- Modification sites at PhosphoSitePlus
Other Protein References for BAG6 Gene
- ENSEMBL proteins:
-
- ENSP00000416633
- ENSP00000406436
- ENSP00000406434
- ENSP00000391783
- ENSP00000396503
- ENSP00000411043
- ENSP00000354875
- ENSP00000365131
- ENSP00000365143
- ENSP00000402856
- ENSP00000411083
- ENSP00000410280
- ENSP00000397978
- ENSP00000211379
- ENSP00000391613
- ENSP00000413225
- ENSP00000401031
- ENSP00000404971
- ENSP00000406302
- ENSP00000394856
- ENSP00000413561
- ENSP00000388244
- REFSEQ proteins:
-
- XP_024302314.1
- XP_016866778.1
- XP_016866768.1
- NP_001092004.1
- XP_016866783.1
- XP_016866773.1
- XP_016866780.1
- XP_016866770.1
- XP_016866785.1
- XP_016866775.1
- XP_016866765.1
- NP_004630.3
- NP_001186627.1
- XP_016866782.1
- XP_016866772.1
- XP_016866787.1
- XP_016866767.1
- XP_016866784.1
- XP_016866774.1
- XP_016866764.1
- XP_011513194.1
- XP_024302313.1
- XP_024302315.1
- XP_016866779.1
- XP_016866769.1
- NP_001186626.1
- NP_542434.1
- NP_542433.1
- XP_016866781.1
- XP_016866771.1
- XP_016866786.1
- XP_016866776.1
- XP_016866766.1
Antibody Products
- R&D Systems Antibodies for BAG6 (BAT3/BAG6)
-
Custom Antibody ServicesOriGene Antibodies for BAG6
- Novus Biologicals Antibodies for BAG6
-
Abcam antibodies for BAG6
- Invitrogen Antibodies for BAG6
- GeneTex BAG6 Antibody for BAG6
-
Boster Bio Antibodies for BAG6
-
Santa Cruz Biotechnology (SCBT) Antibodies for BAG6
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for BAG6
- Origene Custom Protein Services for BAG6
- antibodies-online: Search results for 8 available BAT3 Proteins ranked by validation data
- Compare Top BAT3 Proteins
-
Quality Products:
- Search GeneTex for Proteins for BAG6
-
Abcam proteins for BAG6
Assay Products
- antibodies-online: Search results for 11 available BAT3 Elisa Kits ranked by validation data
- Compare Top BAT3 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for BAG6 Gene
Domains & Families for BAG6 Gene
Gene Families for BAG6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for BAG6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for BAG6 Gene
Graphical View of Domain Structure for InterPro Entry
P46379UniProtKB/Swiss-Prot:
BAG6_HUMAN :- The ubiquitin-like domain mediates interaction with the E3 ubiquitin-protein ligase RNF126 which is responsible for the BAG6-dependent ubiquitination of client proteins (PubMed:21743475, PubMed:24981174, PubMed:28104892, PubMed:27193484). SGTA also binds this domain and competes with RNF126 to antagonize client protein ubiquitination and degradation (PubMed:28104892). The ubiquitin-like domain also mediates the interaction with USP13 (PubMed:24424410).
- Domain:
-
- The ubiquitin-like domain mediates interaction with the E3 ubiquitin-protein ligase RNF126 which is responsible for the BAG6-dependent ubiquitination of client proteins (PubMed:21743475, PubMed:24981174, PubMed:28104892, PubMed:27193484). SGTA also binds this domain and competes with RNF126 to antagonize client protein ubiquitination and degradation (PubMed:28104892). The ubiquitin-like domain also mediates the interaction with USP13 (PubMed:24424410).
Function for BAG6 Gene
Molecular function for BAG6 Gene
- UniProtKB/Swiss-Prot Function:
- ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:28104892, PubMed:27193484). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate to the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).
- UniProtKB/Swiss-Prot Function:
- Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 Lys-4 dimethylation (H3K4me2) (PubMed:18765639).
- UniProtKB/Swiss-Prot Function:
- Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
- UniProtKB/Swiss-Prot Function:
- Mediates ricin-induced apoptosis.
Phenotypes From GWAS Catalog for BAG6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IPI | 18852879 |
| GO:0005515 | protein binding | IPI | 14667819 |
| GO:0030544 | Hsp70 protein binding | IEA | -- |
| GO:0031593 | polyubiquitin modification-dependent protein binding | ISS | -- |
| GO:0031625 | ubiquitin protein ligase binding | IPI | 21636303 |
Phenotypes for BAG6 Gene
- MGI mutant phenotypes for BAG6:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for BAG6:
-
- Decreased HPV16-GFP infection
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- Dynamic nuclei (hole, folded or small irregular)
- Decreased HIV-LTR-beta-galactosidase protein expression
- Increased cell death HMECs cells
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
Animal Models for BAG6 Gene
- MGI Knock Outs for BAG6:
-
- Bag6 Bag6<tm1Pmc>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for BAG6
-
CRISPR Products
-
OriGene CRISPR knockouts for BAG6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BAG6
- genomics-online: gRNA clones - Search results for available BAT3 gene related products
- Applied Biological Materials CRISPR for BAG6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BAG6
- GenScript: Design CRISPR guide RNA sequences for BAG6
miRNA for BAG6 Gene
- miRTarBase miRNAs that target BAG6
-
- hsa-mir-34a-5p (MIRT025262)
- hsa-mir-16-5p (MIRT031479)
- hsa-mir-1226-3p (MIRT036531)
- hsa-mir-760 (MIRT036783)
- hsa-mir-744-5p (MIRT037504)
- hsa-mir-615-3p (MIRT039860)
- hsa-mir-92b-3p (MIRT040645)
- hsa-mir-193b-3p (MIRT041258)
- hsa-mir-484 (MIRT041655)
- hsa-mir-331-3p (MIRT043466)
- hsa-mir-378a-5p (MIRT043997)
- hsa-mir-222-3p (MIRT046630)
- hsa-mir-92a-3p (MIRT049283)
- hsa-let-7b-5p (MIRT051911)
- hsa-mir-218-5p (MIRT441129)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BAG6
- Browse OriGene Inhibitory RNA Products For BAG6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BAG6
- genomics-online: shRNA clones - Search results for available BAT3 gene related products
Clone Products
-
OriGene ORF clones in human for BAG6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping of latest version cDNA ORF clones for BAG6 in any vector
- NM_004639.3
- XM_011514892.2
- NM_080702.2
- NM_080703.2
- NM_080703.2
- XM_017011282.1
- XM_017011286.1
- XM_017011287.1
- XM_017011296.1
- XM_017011275.1
- XM_017011293.1
- XM_017011295.1
- XM_017011298.1
- XM_017011278.1
- XM_017011290.1
- XM_017011284.1
- NM_001098534.1
- XM_017011297.1
- XM_017011291.1
- XM_017011277.1
- XM_017011279.1
- XM_017011281.1
- XM_017011285.1
- NM_001199697.1
- XM_017011294.1
- XM_017011288.1
- XM_017011276.1
- XM_017011280.1
- XM_017011283.1
- NM_001199698.1
- XM_017011289.1
- XM_017011292.1
- Sino Biological Human cDNA Clone for BAG6
- VectorBuilder custom plasmid, inducible vectors for BAG6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BAG6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BAG6
- genomics-online: cdna clones - Search results for available BAT3 gene related products
- orf clones - Search results for available BAT3 gene related products
- Applied Biological Materials Clones for BAG6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for BAG6
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BAG6 Gene
Localization for BAG6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BAG6 Gene
- Cytoplasm, cytosol. Nucleus. Secreted, exosome. Note=Normally localized in cytosol and nucleus, it can also be released extracellularly, in exosomes, by tumor and myeloid dendritic cells. {ECO:0000269 PubMed:18055229, ECO:0000269 PubMed:18852879}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| peroxisome | 1 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005634 | nucleus | IDA,IEA | 14960581 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IDA | 21636303 |
| GO:0005829 | cytosol | IDA,IEA | 17403783 |
Pathways & Interactions for BAG6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Wnt / Hedgehog / Notch | ||
Pathways by source for BAG6 Gene
1 Cell Signaling Technology pathway for BAG6 Gene
Interacting Proteins for BAG6 Gene
Selected Interacting proteins:
P46379-BAG6_HUMAN
ENSP00000365131
for BAG6 Gene via
MINT
STRING
IID
UniProtKB
GPS-Prot Interaction Network for BAG6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001822 | kidney development | ISS | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | IDA | 18852879 |
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | ISS | -- |
No data available for SIGNOR curated interactions for BAG6 Gene
Drugs & Compounds for BAG6 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Carbamazepine | Approved, Investigational | Pharma | Inhibitor of neuronal voltage-gated Na+ channels; anticonvulsant | 134 |
Drug Products
Transcripts for BAG6 Gene
mRNA/cDNA for BAG6 Gene
- (33) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (384) Selected AceView cDNA sequences:
- (29) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000464869 488 bps (uc063ndf.1)
- ENST00000464126 609 bps (uc063ndg.1)
- ENST00000422948 513 bps (uc063ndh.1)
- ENST00000441793 783 bps (uc063ndi.1)
- ENST00000375976 3644 bps (uc003nvf.4)
Unigene Clusters for BAG6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for BAG6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BAG6
- genomics-online: gRNA clones - Search results for available BAT3 gene related products
- Applied Biological Materials CRISPR for BAG6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BAG6
- GenScript: Design CRISPR guide RNA sequences for BAG6
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BAG6
- Browse OriGene Inhibitory RNA Products For BAG6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BAG6
- genomics-online: shRNA clones - Search results for available BAT3 gene related products
Clone Products
-
OriGene ORF clones in human for BAG6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping of latest version cDNA ORF clones for BAG6 in any vector
- NM_004639.3
- XM_011514892.2
- NM_080702.2
- NM_080703.2
- NM_080703.2
- XM_017011282.1
- XM_017011286.1
- XM_017011287.1
- XM_017011296.1
- XM_017011275.1
- XM_017011293.1
- XM_017011295.1
- XM_017011298.1
- XM_017011278.1
- XM_017011290.1
- XM_017011284.1
- NM_001098534.1
- XM_017011297.1
- XM_017011291.1
- XM_017011277.1
- XM_017011279.1
- XM_017011281.1
- XM_017011285.1
- NM_001199697.1
- XM_017011294.1
- XM_017011288.1
- XM_017011276.1
- XM_017011280.1
- XM_017011283.1
- NM_001199698.1
- XM_017011289.1
- XM_017011292.1
- Sino Biological Human cDNA Clone for BAG6
- VectorBuilder custom plasmid, inducible vectors for BAG6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BAG6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BAG6
- genomics-online: cdna clones - Search results for available BAT3 gene related products
- orf clones - Search results for available BAT3 gene related products
- Applied Biological Materials Clones for BAG6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for BAG6 Gene
This gene is overexpressed in Bone (23.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BAG6 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of BAG6 Gene:
BAG6SOURCE GeneReport for Unigene cluster for BAG6 Gene:
Hs.440900mRNA Expression by UniProt/SwissProt for BAG6 Gene:
P46379-BAG6_HUMAN
Tissue specificity:
Expressed by immature dendritic cells (at protein level).
Evidence on tissue expression from TISSUES for BAG6 Gene
- Blood(4.5)
- Liver(4.5)
- Kidney(4.4)
- Nervous system(4.3)
- Skin(3.8)
- Lung(3.6)
- Eye(3.3)
- Intestine(2.9)
- Muscle(2.5)
- Lymph node(2.4)
- Heart(2.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for BAG6
-
OriGene qPCR primer pairs for BAG6
- genomics-online: primer clones - Search results for available BAT3 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BAG6 Gene
Orthologs for BAG6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | BAG6 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | BAG6 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Bag6 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Bag6 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | BAG6 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | BAG6 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | bag6 33 |
|
||
| Str.61 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | bat2-A-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | bag6 34 33 |
|
OneToMany | |
| BAG6 (2 of 2) 34 |
|
OneToMany | |||
| bat3 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5950 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG7546 34 |
|
OneToOne |
- Species where no ortholog for BAG6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for BAG6 Gene
- ENSEMBL:
- Gene Tree for BAG6 (if available)
- TreeFam:
- Gene Tree for BAG6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BAG6: view image
Paralogs for BAG6 Gene
(1) SIMAP similar genes for BAG6 Gene using alignment to 17 proteins:
- BAG6_HUMAN
- B0UX83_HUMAN
- F6RG75_HUMAN
- F6S6P2_HUMAN
- F6TC96_HUMAN
- F6U1F2_HUMAN
- F6U341_HUMAN
- F6UR09_HUMAN
- F6VEM6_HUMAN
- F6WML8_HUMAN
- F6X9W3_HUMAN
- F6XTU0_HUMAN
- H0Y4L1_HUMAN
- H0Y583_HUMAN
- H0Y710_HUMAN
- H0Y759_HUMAN
- H0Y7K4_HUMAN
No data available for Paralogs for BAG6 Gene
Variants for BAG6 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000107232 | -- | 31,653,962(-) | T/G | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000475386 | -- | 31,640,406(-) | A/G | coding_sequence_variant, intron_variant, synonymous_variant | |
| rs1000784201 | -- | 31,640,085(-) | C/T | intron_variant | |
| rs1000888823 | -- | 31,643,243(-) | C/T | intron_variant | |
| rs1000903830 | -- | 31,646,469(-) | C/T | coding_sequence_variant, synonymous_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10403n54 | CNV | loss | 21841781 |
| dgv10404n54 | CNV | loss | 21841781 |
| nsv1073969 | CNV | deletion | 25765185 |
| nsv1112900 | CNV | deletion | 24896259 |
| nsv1126749 | CNV | deletion | 24896259 |
| nsv1161370 | CNV | deletion | 26073780 |
| nsv462871 | CNV | loss | 19166990 |
| nsv601942 | CNV | loss | 21841781 |
| nsv830627 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
1.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.35;
41.81% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BAG6 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAG6 Gene
Disorders for BAG6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acute diarrhea |
|
|
| discrete subaortic stenosis |
|
|
| primary amebic meningoencephalitis |
|
|
| subvalvular aortic stenosis |
|
|
| fructose-1,6-bisphosphatase deficiency |
|
|
Search BAG6 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BAG6
No data available for UniProtKB/Swiss-Prot and Genatlas for BAG6 Gene
Publications for BAG6 Gene
- A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain. (PMID: 2156268) Banerji J … Spies T (Proceedings of the National Academy of Sciences of the United States of America 1990) 2 3 4 22 58
- Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells. (PMID: 18055229) Pogge von Strandmann E … Engert A (Immunity 2007) 3 4 22 58
- Structural and functional insights into the E3 ligase, RNF126. (PMID: 27193484) Krysztofinska EM … Isaacson RL (Scientific reports 2016) 3 4 58
- Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP. (PMID: 26565908) Kadowaki H … Nishitoh H (Cell reports 2015) 3 4 58
- Proteasomal degradation of preemptive quality control (pQC) substrates is mediated by an AIRAPL-p97 complex. (PMID: 26337389) Braunstein I … Stanhill A (Molecular biology of the cell 2015) 3 4 58
Products for BAG6 Gene
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- GenScript: Next-day shipping of latest version cDNA ORF clones for BAG6 in any vector
- NM_004639.3
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- XM_017011281.1
- XM_017011285.1
- NM_001199697.1
- XM_017011294.1
- XM_017011288.1
- XM_017011276.1
- XM_017011280.1
- XM_017011283.1
- NM_001199698.1
- XM_017011289.1
- XM_017011292.1
- GenScript Custom Purified and Recombinant Proteins Services for BAG6
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- Sino Biological Human cDNA Clone for BAG6
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
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- Abcam antibodies for BAG6
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- Browse Primary Antibodies
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- VectorBuilder custom plasmid, inducible vectors for BAG6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BAG6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 71 available BAT3 Antibodies ranked by validation data
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- antibodies-online: Search results for 11 available BAT3 Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Search results for 8 available BAT3 Proteins ranked by validation data
- Compare Top BAT3 Proteins
- Quality Products:
- GeneTex BAG6 Antibody for BAG6
- Search GeneTex for Proteins for BAG6
- Santa Cruz Biotechnology (SCBT) Antibodies for BAG6
- Search Santa Cruz Biotechnology (SCBT) for BAG6 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BAG6
- Horizon Cell Lines for BAG6
- genomics-online: cdna clones - Search results for available BAT3 gene related products
- orf clones - Search results for available BAT3 gene related products
- genomics-online: gRNA clones - Search results for available BAT3 gene related products
- genomics-online: primer clones - Search results for available BAT3 gene related products
- genomics-online: shRNA clones - Search results for available BAT3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BAG6
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- GeneCopoeia miRNA 3'UTR Target clone products for BAG6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BAG6
- Boster Bio Antibodies for BAG6
- Browse Boster Bio ELISA Kits
Sources for BAG6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer