Aliases for BAG4 Gene
External Ids for BAG4 Gene
Previous GeneCards Identifiers for BAG4 Gene
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
GeneCards Summary for BAG4 Gene
BAG4 (BAG Cochaperone 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Cellular response to heat stress. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is BAG3.
UniProtKB/Swiss-Prot Summary for BAG4 Gene
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria.