The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG... See more...

Aliases for BAG4 Gene

Aliases for BAG4 Gene

  • BAG Cochaperone 4 2 3
  • BCL2 Associated Athanogene 4 2 3 5
  • Silencer Of Death Domains 2 3 4
  • BAG Family Molecular Chaperone Regulator 4 3 4
  • Bcl-2-Associated Athanogene 4 3 4
  • BAG-4 3 4
  • SODD 3 4

External Ids for BAG4 Gene

Previous GeneCards Identifiers for BAG4 Gene

  • GC08P037574
  • GC08P038162
  • GC08P037775
  • GC08P038051
  • GC08P038153
  • GC08P036568

Summaries for BAG4 Gene

Entrez Gene Summary for BAG4 Gene

  • The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

GeneCards Summary for BAG4 Gene

BAG4 (BAG Cochaperone 4) is a Protein Coding gene. Among its related pathways are FGFR1 mutant receptor activation and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is BAG3.

UniProtKB/Swiss-Prot Summary for BAG4 Gene

  • Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria.

Gene Wiki entry for BAG4 Gene

Additional gene information for BAG4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BAG4 Gene

Genomics for BAG4 Gene

GeneHancer (GH) Regulatory Elements for BAG4 Gene

Promoters and enhancers for BAG4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J038170 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 501.9 -1.1 -1107 9 ZBTB40 EP300 CTCF SIN3A NRF1 POLR2G USF1 SP1 NCOR1 GTF2E2 BAG4 LSM1 piR-50444-449 DDHD2 LETM2 ADGRA2 ERLIN2 FGFR1 NSD3 RF00017-6970
GH08J037880 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.2 -292.7 -292673 8.2 RXRA ZBTB40 SIN3A SP1 JUND TEAD4 FOS ZNF10 EP300 ZIC2 RAB11FIP1 NSD3 BAG4 piR-33804-116 RF00017-6955 RF00017-6953
GH08J037505 Enhancer 0.2 Ensembl 4.9 -670.7 -670733 0.4 BAG4 lnc-ZNF703-4 ENSG00000253388 LINC01605
GH08J038184 Enhancer 0.8 ENCODE 0.4 +8.1 8075 0.2 FOXK2 CTCF ZSCAN5C FOXA1 REST TGIF2 RAD21 SKI ZBTB26 SMC3 LETM2 DDHD2 ENSG00000254898 RAB11FIP1 BAG4 LSM1 RF00017-6971 RF00017-6966 RF00017-6968 RF00017-6967
GH08J038195 Enhancer 0.9 Ensembl ENCODE 0.4 +19.4 19368 1.8 EP300 BCL11A CBFB ARNT MEF2B EZH2 BATF IKZF1 NR2F1 NFATC3 RNU6-323P LETM2 RF00017-6971 BAG4 LSM1 RF00017-6966 RF00017-6968 RF00017-6967
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BAG4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BAG4

Top Transcription factor binding sites by QIAGEN in the BAG4 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun

Genomic Locations for BAG4 Gene

Genomic Locations for BAG4 Gene
chr8:38,176,533-38,213,301
(GRCh38/hg38)
Size:
36,769 bases
Orientation:
Plus strand
chr8:38,034,051-38,070,819
(GRCh37/hg19)
Size:
36,769 bases
Orientation:
Plus strand

Genomic View for BAG4 Gene

Genes around BAG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BAG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BAG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAG4 Gene

Proteins for BAG4 Gene

  • Protein details for BAG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95429-BAG4_HUMAN
    Recommended name:
    BAG family molecular chaperone regulator 4
    Protein Accession:
    O95429
    Secondary Accessions:
    • B4E217
    • O95818

    Protein attributes for BAG4 Gene

    Size:
    457 amino acids
    Molecular mass:
    49594 Da
    Quaternary structure:
    • Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to the death domain of TNFRSF1A in the absence of TNF and thereby prevents binding of adapter molecules such as TRADD or TRAF2. Binds to the death domain of TNFRSF12. Interacts with PRKN.

    Three dimensional structures from OCA and Proteopedia for BAG4 Gene

    Alternative splice isoforms for BAG4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAG4 Gene

Post-translational modifications for BAG4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BAG4 Gene

No data available for DME Specific Peptides for BAG4 Gene

Domains & Families for BAG4 Gene

Gene Families for BAG4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BAG4 Gene

Blocks:
  • Apoptosis regulator Bcl-2 protein, BAG
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BAG4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50950, highly similar to BAG family molecular chaperone regulator 4 (B4E217_HUMAN)
  • Silencer of death domains (BAG4_HUMAN)
genes like me logo Genes that share domains with BAG4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BAG4 Gene

Function for BAG4 Gene

Molecular function for BAG4 Gene

UniProtKB/Swiss-Prot Function:
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria.
GENATLAS Biochemistry:
BCL2-associated athanogene 4 (antiapoptotic). Negative regulator of Hsp70 chaperone activity

Phenotypes From GWAS Catalog for BAG4 Gene

Gene Ontology (GO) - Molecular Function for BAG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0005515 protein binding IPI 25036637
GO:0031625 ubiquitin protein ligase binding IPI 24270810
GO:0051087 chaperone binding IEA --
genes like me logo Genes that share ontologies with BAG4: view
genes like me logo Genes that share phenotypes with BAG4: view

Animal Models for BAG4 Gene

MGI Knock Outs for BAG4:

Animal Model Products

CRISPR Products

miRNA for BAG4 Gene

miRTarBase miRNAs that target BAG4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BAG4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BAG4 Gene

Localization for BAG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAG4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BAG4 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
mitochondrion 2
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for BAG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21712384
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA 21712384
genes like me logo Genes that share ontologies with BAG4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BAG4 Gene

Pathways & Interactions for BAG4 Gene

genes like me logo Genes that share pathways with BAG4: view

Pathways by source for BAG4 Gene

1 GeneGo (Thomson Reuters) pathway for BAG4 Gene
  • Apoptosis and survival TNFR1 signaling pathway
1 R&D Systems pathway for BAG4 Gene
4 Qiagen pathways for BAG4 Gene
  • DR3 Signaling
  • TNF Signaling
  • TNFR1 Pathway
  • TWEAK Pathway

SIGNOR curated interactions for BAG4 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for BAG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 9873016
GO:0010763 positive regulation of fibroblast migration IEA --
GO:0030838 positive regulation of actin filament polymerization IEA --
GO:0033138 positive regulation of peptidyl-serine phosphorylation IEA --
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with BAG4: view

Drugs & Compounds for BAG4 Gene

No Compound Related Data Available

Transcripts for BAG4 Gene

mRNA/cDNA for BAG4 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BAG4

Alternative Splicing Database (ASD) splice patterns (SP) for BAG4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for BAG4 Gene

GeneLoc Exon Structure for
BAG4

Expression for BAG4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BAG4 Gene

Protein differential expression in normal tissues from HIPED for BAG4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (36.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BAG4 Gene



Protein tissue co-expression partners for BAG4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BAG4

SOURCE GeneReport for Unigene cluster for BAG4 Gene:

Hs.194726

mRNA Expression by UniProt/SwissProt for BAG4 Gene:

O95429-BAG4_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for BAG4 Gene

  • Nervous system(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with BAG4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BAG4 Gene

Orthologs for BAG4 Gene

This gene was present in the common ancestor of animals.

Orthologs for BAG4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAG4 31
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAG4 31 30
  • 88.62 (n)
OneToOne
cow
(Bos Taurus)
Mammalia BAG4 31 30
  • 87.45 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bag4 30
  • 84.62 (n)
mouse
(Mus musculus)
Mammalia Bag4 17 31 30
  • 84.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BAG4 31
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 61 (a)
OneToMany
-- 31
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves BAG4 31 30
  • 56.06 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BAG4 31
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bag4 30
  • 50.4 (n)
zebrafish
(Danio rerio)
Actinopterygii bag4 31
  • 34 (a)
OneToOne
wufd20a04 30
fruit fly
(Drosophila melanogaster)
Insecta stv 31
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5020 31
  • 20 (a)
OneToMany
Species where no ortholog for BAG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAG4 Gene

ENSEMBL:
Gene Tree for BAG4 (if available)
TreeFam:
Gene Tree for BAG4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BAG4: view image

Paralogs for BAG4 Gene

Paralogs for BAG4 Gene

Pseudogenes.org Pseudogenes for BAG4 Gene

genes like me logo Genes that share paralogs with BAG4: view

Variants for BAG4 Gene

Additional dbSNP identifiers (rs#s) for BAG4 Gene

Structural Variations from Database of Genomic Variants (DGV) for BAG4 Gene

Variant ID Type Subtype PubMed ID
dgv7162n100 CNV gain 25217958
dgv7163n100 CNV gain 25217958
dgv7164n100 CNV gain 25217958
dgv7165n100 CNV loss 25217958
esv3421040 CNV insertion 20981092
esv3430937 CNV insertion 20981092
nsv1117823 CNV deletion 24896259
nsv397579 CNV deletion 16902084
nsv967580 CNV duplication 23825009

Variation tolerance for BAG4 Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BAG4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BAG4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BAG4 Gene

Disorders for BAG4 Gene

Additional Disease Information for BAG4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for BAG4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BAG4 Gene

Publications for BAG4 Gene

  1. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. (PMID: 9915703) Jiang Y … Goeddel DV (Science (New York, N.Y.) 1999) 2 3 4 23 54
  2. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PMID: 9873016) Takayama S … Reed JC (The Journal of biological chemistry 1999) 2 3 4 23 54
  3. BAG4/SODD protein contains a short BAG domain. (PMID: 12058034) Briknarová K … Ely KR (The Journal of biological chemistry 2002) 3 4 23 54
  4. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson SA … Youle RJ (Nature 2013) 3 4 54
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54

Products for BAG4 Gene

Sources for BAG4 Gene