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BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase ... See more...
Aliases for BAG2 Gene
Aliases for BAG2 Gene
External Ids for BAG2 Gene
- HGNC: 938
- Entrez Gene: 9532
- Ensembl: ENSG00000112208
- OMIM: 603882
- UniProtKB: O95816
Previous GeneCards Identifiers for BAG2 Gene
- GC06P057039
- GC06P057083
- GC06P057084
- GC06P057145
- GC06P056871
Summaries for BAG2 Gene
-
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
GeneCards Summary for BAG2 Gene
BAG2 (BAG Cochaperone 2) is a Protein Coding gene. Diseases associated with BAG2 include Carpenter Syndrome 1 and Spindle Cell Hemangioma. Among its related pathways are Cellular response to heat stress and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include identical protein binding and chaperone binding.
UniProtKB/Swiss-Prot Summary for BAG2 Gene
-
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).
Additional gene information for BAG2 Gene
- HGNC(938)
- Entrez Gene(9532)
- Ensembl(ENSG00000112208)
- OMIM(603882)
- UniProtKB(O95816)
- Open Targets Platform(ENSG00000112208)
- Search for BAG2 at DataMed
- Search for BAG2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BAG2 Gene
Genomics for BAG2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BAG2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BAG2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BAG2
- Top Transcription factor binding sites by QIAGEN in the BAG2 gene promoter:
-
- AML1a
- AREB6
- c-Myb
- HNF-4alpha1
- HNF-4alpha2
- Lmo2
- POU2F1
- POU2F1a
- POU2F1b
- POU2F1c
Genomic Locations for BAG2 Gene
Genomic Locations for BAG2 Gene
- chr6:57,172,326-57,189,833
- (GRCh38/hg38)
- Size:
- 17,508 bases
- Orientation:
- Plus strand
- chr6:57,037,104-57,054,631
- (GRCh37/hg19)
- Size:
- 17,528 bases
- Orientation:
- Plus strand
Genomic View for BAG2 Gene
Genes around BAG2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p12.1 by HGNC
- 6p12.1 by Entrez Gene
- 6p12.1 by Ensembl
BAG2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BAG2 Gene
Proteins for BAG2 Gene
-
Protein details for BAG2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95816-BAG2_HUMAN
- Recommended name:
- BAG family molecular chaperone regulator 2
- Protein Accession:
- O95816
- B4DXE2
- Q08AS9
- Q6FID0
Protein attributes for BAG2 Gene
- Size:
- 211 amino acids
- Molecular mass:
- 23772 Da
- Quaternary structure:
-
- Binds to the ATPase domain of HSP/HSC70 chaperones (PubMed:9873016). May interact with NWD1 (PubMed:24681825). Interacts with HSPA1A (via NBD), HSPA1B (via NBD) and HSPA8 (PubMed:24318877).
Protein Expression for BAG2 Gene
Post-translational modifications for BAG2 Gene
Other Protein References for BAG2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- GeneTex Anti-BAG2 antibody and Anti-BAG2 antibody [N1C3-2]
- NSJ Bioreagents BAG2 Antibody
- Novus Biologicals Antibodies for BAG2
-
Abcam antibodies for BAG2
- Invitrogen Antibodies for BAG2 (AFLGC-BAG2)
-
Santa Cruz Biotechnology (SCBT) Antibodies for BAG2
Protein Products
-
OriGene Purified Proteins for BAG2
- Search Origene for MassSpec and Protein Over-expression Lysates for BAG2
- Origene Custom Protein Services for BAG2
- ProSpec Recombinant Proteins for BAG2
- antibodies-online: Show 11 available BAG2 Proteins ranked by validation data
- Compare Top BAG2 Proteins
-
Quality Products:
-
Signalway Proteins for BAG2
-
ProSci Proteins for BAG2
-
Abcam proteins for BAG2
No data available for DME Specific Peptides for BAG2 Gene
Domains & Families for BAG2 Gene
Gene Families for BAG2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for BAG2 Gene
- InterPro:
- Blocks:
-
- Apoptosis regulator Bcl-2 protein, BAG
- ProtoNet:
Suggested Antigen Peptide Sequences for BAG2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ50277, highly similar to BAG family molecular chaperone regulator 2 (B4DXE2_HUMAN)
- Bcl-2-associated athanogene 2 (BAG2_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BAG2 Gene
Function for BAG2 Gene
Molecular function for BAG2 Gene
- UniProtKB/Swiss-Prot Function:
- Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).
- GENATLAS Biochemistry:
- BCL2-associated athanogene 2 (antiapoptotic). Negative regulator of Hsp70 chaperone activity
Phenotypes From GWAS Catalog for BAG2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000774 | adenyl-nucleotide exchange factor activity | IDA | 24318877 |
| GO:0005515 | protein binding | IPI | 16207813 |
| GO:0031072 | heat shock protein binding | IEA | -- |
| GO:0031625 | ubiquitin protein ligase binding | IEA | -- |
| GO:0042802 | identical protein binding | IPI | 22365833 |
Phenotypes for BAG2 Gene
- GenomeRNAi human phenotypes for BAG2:
-
- no effect
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 25%
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased NF-kappaB reporter expression
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Increased viability with MLN4924 (a NAE inhibitor)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BAG2 - Select products 50% OFF >
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-
Santa Cruz Biotechnology (SCBT) CRISPR for BAG2
miRNA for BAG2 Gene
- miRTarBase miRNAs that target BAG2
-
- hsa-miR-128-3p (MIRT021988)
- hsa-miR-181a-5p (MIRT025092)
- hsa-miR-93-5p (MIRT048797)
- hsa-miR-5004-3p (MIRT448979)
- hsa-miR-223-3p (MIRT448980)
- hsa-miR-4328 (MIRT448981)
- hsa-miR-5002-5p (MIRT448982)
- hsa-miR-5590-3p (MIRT448983)
- hsa-miR-142-5p (MIRT448984)
- hsa-miR-6507-3p (MIRT448985)
- hsa-miR-6514-3p (MIRT628692)
- hsa-miR-6847-3p (MIRT628693)
- hsa-miR-6811-3p (MIRT628694)
- hsa-miR-214-5p (MIRT628695)
- hsa-miR-486-5p (MIRT628696)
- hsa-miR-339-5p (MIRT628697)
- hsa-miR-4446-5p (MIRT722348)
- hsa-miR-4755-5p (MIRT722349)
- hsa-miR-5006-3p (MIRT722350)
- hsa-miR-6883-3p (MIRT722351)
- hsa-miR-27b-3p (MIRT722352)
- hsa-miR-27a-3p (MIRT722353)
- hsa-miR-513a-5p (MIRT722354)
- hsa-miR-627-3p (MIRT722355)
- hsa-miR-3681-3p (MIRT722356)
- hsa-miR-130b-5p (MIRT722357)
- hsa-miR-216a-3p (MIRT722358)
- hsa-miR-6750-3p (MIRT722359)
miRNA Products
Inhibitory RNA Products
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Clone Products
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- Sino Biological Human cDNA Clone for BAG2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BAG2
Cell Line Products
-
Horizon Cell Lines for BAG2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BAG2 Gene
Localization for BAG2 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 4 |
| cytoskeleton | 3 |
| extracellular | 2 |
| endoplasmic reticulum | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0005874 | colocalizes_with microtubule | IEA,ISS | 19228967 |
| GO:0030424 | axon | IEA,ISS | 19228967 |
| GO:0030425 | dendrite | ISS | 19228967 |
| GO:0101031 | chaperone complex | IPI | 16207813 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for BAG2 Gene
Pathways & Interactions for BAG2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular response to heat stress | ||
| 2 | Regulation of degradation of deltaF508 CFTR in CF |
Regulation of degradation of deltaF508 CFTR in CF
.58
|
Regulation of degradation of wt-CFTR
.58
|
| 3 | Protein processing in endoplasmic reticulum | ||
| 4 | Cellular Senescence (REACTOME) | ||
Pathways by source for BAG2 Gene
3 Reactome pathways for BAG2 Gene
1 KEGG pathway for BAG2 Gene
2 GeneGo (Thomson Reuters) pathways for BAG2 Gene
- Regulation of degradation of deltaF508 CFTR in CF
- Regulation of degradation of wt-CFTR
Interacting Proteins for BAG2 Gene
Selected Interacting proteins:
O95816-BAG2_HUMAN
ENSP00000359727
for BAG2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for BAG2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006457 | protein folding | TAS | 9873016 |
| GO:0010954 | positive regulation of protein processing | IMP | 16207813 |
| GO:0019538 | protein metabolic process | IDA | 9873015 |
| GO:0031397 | negative regulation of protein ubiquitination | ISS | 19228967 |
| GO:0032091 | negative regulation of protein binding | IDA | 16207813 |
Transcripts for BAG2 Gene
mRNA/cDNA for BAG2 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000370693 6651 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BAG2 - Select products 50% OFF >
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-
OriGene CRISPR knockouts for BAG2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BAG2
-
Santa Cruz Biotechnology (SCBT) CRISPR for BAG2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BAG2
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Clone Products
- Applied Biological Materials (abm): Clones for BAG2 - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for BAG2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BAG2
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||
| SP5: | - | - |
Relevant External Links for BAG2 Gene
- GeneLoc Exon Structure for
- BAG2
Expression for BAG2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Uterus (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for BAG2 Gene
This gene is overexpressed in Colon - Sigmoid (x5.0).
This gene is overexpressed in Colon muscle (11.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BAG2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BAG2
SOURCE GeneReport for Unigene cluster for BAG2 Gene:
Hs.745046Evidence on tissue expression from TISSUES for BAG2 Gene
- Liver(4.4)
- Muscle(3)
- Nervous system(2.5)
- Heart(2.3)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for BAG2
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BAG2 Gene
Orthologs for BAG2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BAG2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | BAG2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | BAG2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | BAG2 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Bag2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Bag2 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | BAG2 30 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | BAG2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | BAG2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | bag2 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.17323 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | bag2 30 31 |
|
OneToOne | |
| zgc64195 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.396 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010983 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG7945 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | unc-23 30 31 |
|
OneToOne |
- Species where no ortholog for BAG2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for BAG2 Gene
- ENSEMBL:
- Gene Tree for BAG2 (if available)
- TreeFam:
- Gene Tree for BAG2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BAG2: view image
Paralogs for BAG2 Gene
No data available for Paralogs for BAG2 Gene
Variants for BAG2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BAG2 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 809961 | Uncertain Significance: not provided | 57,182,140(+) | C/T | SYNONYMOUS_VARIANT | |
| 908519 | Benign: Carpenter syndrome 1 | 57,187,131(+) | T/C | NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT | |
| 908520 | Uncertain Significance: Carpenter syndrome 1 | 57,187,163(+) | T/C | NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT | |
| 908521 | Likely Benign: Carpenter syndrome 1 | 57,187,272(+) | A/G | NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT | |
| 908522 | Uncertain Significance: Carpenter syndrome 1 | 57,187,332(+) | C/G | NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT |
Residual Variation Intolerance Score:
41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.41;
9.10% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BAG2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BAG2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAG2 Gene
Disorders for BAG2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| carpenter syndrome 1 |
|
|
| spindle cell hemangioma |
|
|
| retinitis pigmentosa 73 |
|
|
Search BAG2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BAG2
No data available for UniProtKB/Swiss-Prot and Genatlas for BAG2 Gene
Publications for BAG2 Gene
- An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PMID: 9873016) Takayama S … Reed JC (The Journal of biological chemistry 1999) 2 3 4 23
- Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. (PMID: 24318877) Rauch JN … Gestwicki JE (The Journal of biological chemistry 2014) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
ExternalLinks
Products for BAG2 Gene
- Custom Antibody Services
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- Browse Primary Antibodies
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- VectorBuilder Custom and pre-made DNA vectors for BAG2 (ie. gene expression, shRNA knockdown, CRISPR)
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- antibodies-online: Show 20 available BAG2 Antibodies ranked by validation data
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- antibodies-online: Show 11 available BAG2 Proteins ranked by validation data
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- Quality Products:
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- Signalway Proteins for BAG2
Sources for BAG2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB