BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase ... See more...

Aliases for BAG2 Gene

Aliases for BAG2 Gene

  • BAG Cochaperone 2 2 3 5
  • BAG Family Molecular Chaperone Regulator 2 3 4
  • Bcl-2-Associated Athanogene 2 3 4
  • BCL2 Associated Athanogene 2 2 3
  • BAG-2 3 4
  • DJ417I1.2 (BAG-Family Molecular Chaperone Regulator 2) 3
  • DJ417I1.2 3
  • BAG2 5

External Ids for BAG2 Gene

Previous GeneCards Identifiers for BAG2 Gene

  • GC06P057039
  • GC06P057083
  • GC06P057084
  • GC06P057145
  • GC06P056871

Summaries for BAG2 Gene

Entrez Gene Summary for BAG2 Gene

  • BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

GeneCards Summary for BAG2 Gene

BAG2 (BAG Cochaperone 2) is a Protein Coding gene. Diseases associated with BAG2 include Carpenter Syndrome 1 and Spindle Cell Hemangioma. Among its related pathways are Cellular response to heat stress and Protein processing in endoplasmic reticulum. Gene Ontology (GO) annotations related to this gene include identical protein binding and chaperone binding.

UniProtKB/Swiss-Prot Summary for BAG2 Gene

  • Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).

Gene Wiki entry for BAG2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BAG2 Gene

Genomics for BAG2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BAG2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J057171 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 261.9 +1.3 1340 5.3 BCLAF1 SP1 ZNF207 NCOR1 MYC ZNF600 IKZF1 SIX5 SSRP1 JUND BAG2 ZNF451-AS1 KIAA1586 ZNF451 PRIM2 LINC00680 GUSBP4 ENSG00000272316 HSALNG0050810 RAB23
GH06J057170 Promoter 0.3 EPDnew 250.7 -2.3 -2257 0.1 BAG2 HSALNG0050810 ZNF451-AS1 MN298114-202 ZNF451
GH06J057312 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.3 +143.4 143362 7 BCLAF1 MYC ZNF654 IKZF1 JUND ZNF580 KLF9 POLR2A NFIC YY1 PRIM2 BEND6 BAG2 ZNF451-AS1 DST RAB23 piR-38352-471
GH06J057045 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.2 -124.7 -124725 3.6 NCOR1 MYC IKZF1 ZNF600 ZNF580 ZNF592 KLF9 POLR2A ZNF10 NFIC KIAA1586 ZNF451 HSALNG0050804 BEND6 PRIM2 ZNF451-AS1 BAG2 ENSG00000272316 piR-38580-285
GH06J057241 Enhancer 1.2 Ensembl ENCODE dbSUPER 15.7 +70.6 70575 2.2 ATF2 CEBPB FEZF1 ZNF639 ZNF513 EP300 FOXA2 ZNF610 RFX5 STAT3 ZNF451 PRIM2 BAG2 GUSBP4 ENSG00000272316 KIAA1586 ZNF451-AS1 BEND6 HSALNG0050816 lnc-RAB23-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BAG2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BAG2

Top Transcription factor binding sites by QIAGEN in the BAG2 gene promoter:
  • AML1a
  • AREB6
  • c-Myb
  • HNF-4alpha1
  • HNF-4alpha2
  • Lmo2
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c

Genomic Locations for BAG2 Gene

Latest Assembly
chr6:57,172,326-57,189,833
(GRCh38/hg38)
Size:
17,508 bases
Orientation:
Plus strand

Previous Assembly
chr6:57,037,124-57,054,631
(GRCh37/hg19 by Entrez Gene)
Size:
17,508 bases
Orientation:
Plus strand

chr6:57,037,124-57,054,631
(GRCh37/hg19 by Ensembl)
Size:
17,508 bases
Orientation:
Plus strand

Genomic View for BAG2 Gene

Genes around BAG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BAG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BAG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAG2 Gene

Proteins for BAG2 Gene

  • Protein details for BAG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95816-BAG2_HUMAN
    Recommended name:
    BAG family molecular chaperone regulator 2
    Protein Accession:
    O95816
    Secondary Accessions:
    • B4DXE2
    • Q08AS9
    • Q6FID0

    Protein attributes for BAG2 Gene

    Size:
    211 amino acids
    Molecular mass:
    23772 Da
    Quaternary structure:
    • Binds to the ATPase domain of HSP/HSC70 chaperones (PubMed:9873016). May interact with NWD1 (PubMed:24681825). Interacts with HSPA1A (via NBD), HSPA1B (via NBD) and HSPA8 (PubMed:24318877).

    Alternative splice isoforms for BAG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAG2 Gene

Post-translational modifications for BAG2 Gene

  • Ubiquitination at Lys5, Lys123, Lys154, and Lys200
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BAG2 Gene

Domains & Families for BAG2 Gene

Gene Families for BAG2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for BAG2 Gene

InterPro:
Blocks:
  • Apoptosis regulator Bcl-2 protein, BAG

Suggested Antigen Peptide Sequences for BAG2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50277, highly similar to BAG family molecular chaperone regulator 2 (B4DXE2_HUMAN)
  • Bcl-2-associated athanogene 2 (BAG2_HUMAN)
genes like me logo Genes that share domains with BAG2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BAG2 Gene

Function for BAG2 Gene

Molecular function for BAG2 Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).
GENATLAS Biochemistry:
BCL2-associated athanogene 2 (antiapoptotic). Negative regulator of Hsp70 chaperone activity

Phenotypes From GWAS Catalog for BAG2 Gene

Gene Ontology (GO) - Molecular Function for BAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000774 adenyl-nucleotide exchange factor activity IDA 24318877
GO:0005515 protein binding IPI 16207813
GO:0031072 heat shock protein binding IEA --
GO:0031625 ubiquitin protein ligase binding IEA --
GO:0042802 identical protein binding IPI 22365833
genes like me logo Genes that share ontologies with BAG2: view
genes like me logo Genes that share phenotypes with BAG2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BAG2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BAG2 Gene

Localization for BAG2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BAG2 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 3
extracellular 2
endoplasmic reticulum 2
plasma membrane 1
mitochondrion 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005874 colocalizes_with microtubule IEA,ISS 19228967
GO:0030424 axon IEA,ISS 19228967
GO:0030425 dendrite IEA,ISS 19228967
GO:0101031 chaperone complex IPI 16207813
genes like me logo Genes that share ontologies with BAG2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BAG2 Gene

Pathways & Interactions for BAG2 Gene

genes like me logo Genes that share pathways with BAG2: view

Pathways by source for BAG2 Gene

2 GeneGo (Thomson Reuters) pathways for BAG2 Gene
  • Regulation of degradation of deltaF508 CFTR in CF
  • Regulation of degradation of wt-CFTR

SIGNOR curated interactions for BAG2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for BAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 9873016
GO:0010954 positive regulation of protein processing IMP 16207813
GO:0019538 protein metabolic process IDA 9873015
GO:0031397 negative regulation of protein ubiquitination ISS 19228967
GO:0032091 negative regulation of protein binding IDA 16207813
genes like me logo Genes that share ontologies with BAG2: view

Drugs & Compounds for BAG2 Gene

No Compound Related Data Available

Transcripts for BAG2 Gene

mRNA/cDNA for BAG2 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BAG2

Alternative Splicing Database (ASD) splice patterns (SP) for BAG2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5: - -

Relevant External Links for BAG2 Gene

GeneLoc Exon Structure for
BAG2

Expression for BAG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BAG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BAG2 Gene

This gene is overexpressed in Colon - Sigmoid (x5.0).

Protein differential expression in normal tissues from HIPED for BAG2 Gene

This gene is overexpressed in Colon muscle (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BAG2 Gene



Protein tissue co-expression partners for BAG2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BAG2

SOURCE GeneReport for Unigene cluster for BAG2 Gene:

Hs.745046

Evidence on tissue expression from TISSUES for BAG2 Gene

  • Liver(4.3)
  • Muscle(2.8)
  • Nervous system(2.4)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with BAG2: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BAG2 Gene

Orthologs for BAG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BAG2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia BAG2 29 30
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia BAG2 29 30
  • 94.31 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia BAG2 30
  • 92 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia BAG2 30
  • 89 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Bag2 29 16 30
  • 85.56 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Bag2 29
  • 85.08 (n)
Cow
(Bos Taurus)
Mammalia BAG2 29 30
  • 84.2 (n)
OneToOne
Chicken
(Gallus gallus)
Aves BAG2 29 30
  • 77.78 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia BAG2 30
  • 70 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia bag2 29
  • 68.38 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17323 29
Zebrafish
(Danio rerio)
Actinopterygii bag2 29 30
  • 66.67 (n)
OneToOne
zgc64195 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.396 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010983 29
  • 47.11 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG7945 29 30
  • 46.47 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea unc-23 29 30
  • 47.37 (n)
OneToOne
Species where no ortholog for BAG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for BAG2 Gene

ENSEMBL:
Gene Tree for BAG2 (if available)
TreeFam:
Gene Tree for BAG2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BAG2: view image
Alliance of Genome Resources:
Additional Orthologs for BAG2

Paralogs for BAG2 Gene

No data available for Paralogs for BAG2 Gene

Variants for BAG2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BAG2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
908519 Benign: Carpenter syndrome 1 57,187,131(+) T/C
NM_016277.5(RAB23):c.*3330A>G
NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR
908520 Uncertain Significance: Carpenter syndrome 1 57,187,163(+) T/C
NM_016277.5(RAB23):c.*3298A>G
NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR
908521 Likely Benign: Carpenter syndrome 1 57,187,272(+) A/G
NM_016277.5(RAB23):c.*3189T>C
NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR
908522 Uncertain Significance: Carpenter syndrome 1 57,187,332(+) C/G
NM_016277.5(RAB23):c.*3129G>C
NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR
908590 Uncertain Significance: Carpenter syndrome 1 57,189,330(+) G/C
NM_016277.5(RAB23):c.*1131C>G
NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for BAG2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for BAG2 Gene

Variant ID Type Subtype PubMed ID
nsv462949 CNV loss 19166990
nsv603190 CNV loss 21841781

Variation tolerance for BAG2 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BAG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BAG2
Leiden Open Variation Database (LOVD)
BAG2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAG2 Gene

Disorders for BAG2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for BAG2 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards
Search BAG2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BAG2

genes like me logo Genes that share disorders with BAG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BAG2 Gene

Publications for BAG2 Gene

  1. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PMID: 9873016) Takayama S … Reed JC (The Journal of biological chemistry 1999) 2 3 4 22
  2. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. (PMID: 24318877) Rauch JN … Gestwicki JE (The Journal of biological chemistry 2014) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4

Products for BAG2 Gene

Sources for BAG2 Gene