Aliases for BAG2 Gene
External Ids for BAG2 Gene
Previous GeneCards Identifiers for BAG2 Gene
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
GeneCards Summary for BAG2 Gene
BAG2 (BAG Cochaperone 2) is a Protein Coding gene. Diseases associated with BAG2 include Carpenter Syndrome 1 and Spindle Cell Hemangioma. Among its related pathways are Cellular response to heat stress and Protein processing in endoplasmic reticulum. Gene Ontology (GO) annotations related to this gene include identical protein binding and chaperone binding.
UniProtKB/Swiss-Prot Summary for BAG2 Gene
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).