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Aliases for BAG2 Gene

Aliases for BAG2 Gene

  • BCL2 Associated Athanogene 2 2 3 5
  • Bcl-2-Associated Athanogene 2 3 4
  • BAG-2 3 4
  • DJ417I1.2 (BAG-Family Molecular Chaperone Regulator 2) 3
  • BAG Family Molecular Chaperone Regulator 2 3
  • DJ417I1.2 3

External Ids for BAG2 Gene

Previous GeneCards Identifiers for BAG2 Gene

  • GC06P057039
  • GC06P057083
  • GC06P057084
  • GC06P056871

Summaries for BAG2 Gene

Entrez Gene Summary for BAG2 Gene

  • BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

GeneCards Summary for BAG2 Gene

BAG2 (BCL2 Associated Athanogene 2) is a Protein Coding gene. Diseases associated with BAG2 include Spindle Cell Hemangioma. Among its related pathways are Protein processing in endoplasmic reticulum and Cellular response to heat stress. Gene Ontology (GO) annotations related to this gene include identical protein binding and chaperone binding.

UniProtKB/Swiss-Prot for BAG2 Gene

  • Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).

Gene Wiki entry for BAG2 Gene

Additional gene information for BAG2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG2 Gene

Genomics for BAG2 Gene

GeneHancer (GH) Regulatory Elements for BAG2 Gene

Promoters and enhancers for BAG2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I057171 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +1.5 1504 5 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 BAG2 LOC101927211 KIAA1586 ZNF451 PRIM2 LINC00680
GH06I057312 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 10.3 +143.0 143048 6.4 PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 IRF4 PRIM2 BEND6 BAG2 LOC101927211 DST RAB23 GC06P057297 GC06M057367
GH06I057045 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.2 -125.3 -125318 2 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 KIAA1586 GC06M057041 PRIM2 BEND6 ZNF451 BAG2 LOC101927211 ENSG00000272316 PIR59769
GH06I057241 Enhancer 1.3 Ensembl ENCODE dbSUPER 15.7 +70.5 70462 1.7 FOXA2 INSM2 KLF17 ZNF76 FEZF1 ZNF2 RFX5 ZNF213 ZNF366 ZSCAN5C GC06M057241 ZNF451 PRIM2 BAG2 GUSBP4 ENSG00000272316 KIAA1586 LOC101927211 BEND6 GC06P057245
GH06I057257 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 16.2 +86.2 86226 2.4 RNF2 CEBPB BAG2 LOC101927211 RAB23 KIAA1586 LOC100506188 GC06M057222 GC06P057245
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BAG2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BAG2 gene promoter:

Genomic Locations for BAG2 Gene

Genomic Locations for BAG2 Gene
chr6:57,172,306-57,189,833
(GRCh38/hg38)
Size:
17,528 bases
Orientation:
Plus strand
chr6:57,037,104-57,054,631
(GRCh37/hg19)

Genomic View for BAG2 Gene

Genes around BAG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BAG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BAG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAG2 Gene

Proteins for BAG2 Gene

  • Protein details for BAG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95816-BAG2_HUMAN
    Recommended name:
    BAG family molecular chaperone regulator 2
    Protein Accession:
    O95816
    Secondary Accessions:
    • B4DXE2
    • Q08AS9
    • Q6FID0

    Protein attributes for BAG2 Gene

    Size:
    211 amino acids
    Molecular mass:
    23772 Da
    Quaternary structure:
    • Binds to the ATPase domain of HSP/HSC70 chaperones (PubMed:9873016). May interact with NWD1 (PubMed:24681825). Interacts with HSPA1A (via NBD), HSPA1B (via NBD) and HSPA8 (PubMed:24318877).

    Alternative splice isoforms for BAG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAG2 Gene

Post-translational modifications for BAG2 Gene

  • Ubiquitination at Lys5, Lys123, Lys154, and Lys200
  • Modification sites at PhosphoSitePlus

Other Protein References for BAG2 Gene

No data available for DME Specific Peptides for BAG2 Gene

Domains & Families for BAG2 Gene

Gene Families for BAG2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for BAG2 Gene

Suggested Antigen Peptide Sequences for BAG2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BAG2: view

No data available for UniProtKB/Swiss-Prot for BAG2 Gene

Function for BAG2 Gene

Molecular function for BAG2 Gene

GENATLAS Biochemistry:
BCL2-associated athanogene 2 (antiapoptotic). Negative regulator of Hsp70 chaperone activity
UniProtKB/Swiss-Prot Function:
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).

Gene Ontology (GO) - Molecular Function for BAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000774 adenyl-nucleotide exchange factor activity TAS --
GO:0005515 protein binding IPI 18457437
GO:0042802 identical protein binding IPI 22365833
GO:0051087 chaperone binding IEA --
genes like me logo Genes that share ontologies with BAG2: view
genes like me logo Genes that share phenotypes with BAG2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BAG2 Gene

Localization for BAG2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BAG2 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with BAG2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BAG2 Gene

Pathways & Interactions for BAG2 Gene

genes like me logo Genes that share pathways with BAG2: view

SIGNOR curated interactions for BAG2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for BAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 9873016
GO:0019538 protein metabolic process IDA 9873015
GO:0050790 regulation of catalytic activity IEA --
GO:1900034 regulation of cellular response to heat TAS --
genes like me logo Genes that share ontologies with BAG2: view

Drugs & Compounds for BAG2 Gene

No Compound Related Data Available

Transcripts for BAG2 Gene

mRNA/cDNA for BAG2 Gene

Unigene Clusters for BAG2 Gene

BCL2-associated athanogene 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BAG2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5: - -

Relevant External Links for BAG2 Gene

GeneLoc Exon Structure for
BAG2
ECgene alternative splicing isoforms for
BAG2

Expression for BAG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BAG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BAG2 Gene

This gene is overexpressed in Colon - Sigmoid (x5.0).

Protein differential expression in normal tissues from HIPED for BAG2 Gene

This gene is overexpressed in Colon muscle (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BAG2 Gene



Protein tissue co-expression partners for BAG2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BAG2 Gene:

BAG2

SOURCE GeneReport for Unigene cluster for BAG2 Gene:

Hs.745046

Evidence on tissue expression from TISSUES for BAG2 Gene

  • Liver(4.2)
  • Muscle(3)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with BAG2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BAG2 Gene

Orthologs for BAG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BAG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAG2 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia BAG2 33 34
  • 94.31 (n)
oppossum
(Monodelphis domestica)
Mammalia BAG2 34
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BAG2 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bag2 33 16 34
  • 85.56 (n)
rat
(Rattus norvegicus)
Mammalia Bag2 33
  • 85.08 (n)
cow
(Bos Taurus)
Mammalia BAG2 33 34
  • 84.2 (n)
chicken
(Gallus gallus)
Aves BAG2 33 34
  • 77.78 (n)
lizard
(Anolis carolinensis)
Reptilia BAG2 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bag2 33
  • 68.38 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17323 33
zebrafish
(Danio rerio)
Actinopterygii bag2 33 34
  • 66.67 (n)
zgc64195 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.396 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010983 33
  • 47.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7945 33 34
  • 46.47 (n)
worm
(Caenorhabditis elegans)
Secernentea unc-23 33 34
  • 47.37 (n)
Species where no ortholog for BAG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BAG2 Gene

ENSEMBL:
Gene Tree for BAG2 (if available)
TreeFam:
Gene Tree for BAG2 (if available)

Paralogs for BAG2 Gene

No data available for Paralogs for BAG2 Gene

Variants for BAG2 Gene

Sequence variations from dbSNP and Humsavar for BAG2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000195032 -- 57,171,476(+) C/T upstream_transcript_variant
rs1000513353 -- 57,175,297(+) T/G intron_variant
rs1000700013 -- 57,171,825(+) G/A upstream_transcript_variant
rs1000734649 -- 57,176,253(+) C/T intron_variant
rs1000804002 -- 57,178,014(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BAG2 Gene

Variant ID Type Subtype PubMed ID
nsv462949 CNV loss 19166990
nsv603190 CNV loss 21841781

Variation tolerance for BAG2 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BAG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BAG2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAG2 Gene

Disorders for BAG2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BAG2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spindle cell hemangioma
  • sch
- elite association - COSMIC cancer census association via MalaCards
Search BAG2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BAG2

genes like me logo Genes that share disorders with BAG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BAG2 Gene

Publications for BAG2 Gene

  1. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PMID: 9873016) Takayama S … Reed JC (The Journal of biological chemistry 1999) 2 3 4 22 58
  2. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. (PMID: 24318877) Rauch JN … Gestwicki JE (The Journal of biological chemistry 2014) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58

Products for BAG2 Gene

Sources for BAG2 Gene

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