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Aliases for BAG1 Gene

Aliases for BAG1 Gene

  • BCL2 Associated Athanogene 1 2 3 5
  • BAG-1 3 4
  • HAP 3 4
  • Glucocortoid Receptor-Associated Protein RAP46 3
  • BAG Family Molecular Chaperone Regulator 1 3
  • Bcl-2 Associating Athanogene-1 Protein 3
  • Receptor-Associated Protein, 46-KD 3
  • Bcl-2-Associated Athanogene 1 4
  • BCL2 Associated Athanogene 2
  • BCL2-Associated Athanogene 3
  • Bcl-2-Binding Protein 3
  • RAP46 3

External Ids for BAG1 Gene

Previous GeneCards Identifiers for BAG1 Gene

  • GC09M033567
  • GC09M033423
  • GC09M033244

Summaries for BAG1 Gene

Entrez Gene Summary for BAG1 Gene

  • The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]

GeneCards Summary for BAG1 Gene

BAG1 (BCL2 Associated Athanogene 1) is a Protein Coding gene. Diseases associated with BAG1 include Lung Cancer and Coccidiosis. Among its related pathways are Protein processing in endoplasmic reticulum and Cellular response to heat stress. Gene Ontology (GO) annotations related to this gene include chaperone binding and phosphoprotein binding.

UniProtKB/Swiss-Prot for BAG1 Gene

  • Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631).

Gene Wiki entry for BAG1 Gene

Additional gene information for BAG1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG1 Gene

Genomics for BAG1 Gene

GeneHancer (GH) Regulatory Elements for BAG1 Gene

Promoters and enhancers for BAG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I033262 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 557 +0.3 276 3.6 HDGF FOXA2 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 IRF4 YY1 BAG1 CHMP5 GC09M033264 NFX1 GC09M033252 GC09M033166 GC09M033167 GC09M033168
GH09I033286 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 17.5 -28.4 -28366 13 CLOCK MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC MEF2D NFX1 PIR32325 B4GALT1 BAG1 ENSG00000228352 DFFBP1 ANXA2P2 SMU1 CHMP5 DDX58
GH09I033226 Enhancer 1.4 Ensembl ENCODE dbSUPER 17.4 +32.8 32770 11 PKNOX1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A ZBTB7B IRF4 BRCA1 ZNF121 NFX1 SMU1 BAG1 ASS1P12 DFFBP1 TCEA1P4 TOPORS ENSG00000228352 CHMP5 NOL6
GH09I033075 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.1 +188.3 188288 2.2 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 ZNF143 SMU1 B4GALT1 NOL6 NFX1 ANXA2P2 BAG1 CHMP5 TOPORS B4GALT1-AS1 RNU4ATAC15P
GH09I033318 Enhancer 1.1 Ensembl ENCODE dbSUPER 17.6 -56.1 -56061 4.8 PAF1 STAT1 JUN SIX5 CEBPB SIN3A EP300 SP1 MAFF JUND NFX1 BAG1 CHMP5 AQP7 LOC105376020 AQP3 B4GALT1 B4GALT1-AS1 GC09M033166 PIR45697
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BAG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BAG1 gene promoter:

Genomic Locations for BAG1 Gene

Genomic Locations for BAG1 Gene
chr9:33,247,820-33,264,761
(GRCh38/hg38)
Size:
16,942 bases
Orientation:
Minus strand
chr9:33,247,818-33,264,761
(GRCh37/hg19)

Genomic View for BAG1 Gene

Genes around BAG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BAG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BAG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAG1 Gene

Proteins for BAG1 Gene

  • Protein details for BAG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99933-BAG1_HUMAN
    Recommended name:
    BAG family molecular chaperone regulator 1
    Protein Accession:
    Q99933
    Secondary Accessions:
    • O75315
    • Q14414
    • Q53H32
    • Q5VZE8
    • Q5VZE9
    • Q5VZF0
    • Q96TG2
    • Q9Y2V4

    Protein attributes for BAG1 Gene

    Size:
    345 amino acids
    Molecular mass:
    38779 Da
    Quaternary structure:
    • Homodimer. Forms a heteromeric complex with HSP70/HSC70 (PubMed:9305631). Binds to the ATPase domain of HSP/HSC70 chaperones. Isoform 1, isoform 3 and isoform 4 but not isoform 2 interact with HSPA8/HSC70 (PubMed:27474739, PubMed:24318877, PubMed:9305631, PubMed:9679980). Interacts with NR3C1 (PubMed:10477749). Interacts with the N-terminal region of STK19 (PubMed:15986447). Interacts with PPP1R15A (PubMed:12724406). Interacts with BCL2 in an ATP-dependent manner. Isoform 2 does not interact with BCL2 (PubMed:9305631). Interacts with SIAH1 (PubMed:9582267). Interacts with HSPA8 (via NBD) (PubMed:27474739, PubMed:24318877). Interacts with HSPA1A (via NBD) and HSPA1B (via NBD) (PubMed:24318877). Interacts with SIAH2 (By similarity).
    SequenceCaution:
    • Sequence=AAD11467.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD25045.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD96469.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAA84624.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH72516.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH72518.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH72741.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH72742.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW58515.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BAG1 Gene

    Alternative splice isoforms for BAG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAG1 Gene

Post-translational modifications for BAG1 Gene

  • Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
  • Ubiquitination at posLast=273273

No data available for DME Specific Peptides for BAG1 Gene

Domains & Families for BAG1 Gene

Gene Families for BAG1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for BAG1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BAG1: view

No data available for UniProtKB/Swiss-Prot for BAG1 Gene

Function for BAG1 Gene

Molecular function for BAG1 Gene

GENATLAS Biochemistry:
BCL2-associated athanogene 1 (antiapoptotic),negative regulator of Hsp70 chaperone activity,multifunctional protein interacting with several types of proteins,including BCL2 family proteins,certain tyrosine-kinase receptors such as hepatocyte growth factor receptor (MET) and PDGFR and steroid receptors,mouse Bag1 homolog,with four isoforms (50,46 (RAP46),33 and 29kDa),overexpressed in cervical,breast (invasive carcinomas) and lung cancer cell lines
UniProtKB/Swiss-Prot Function:
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631).
UniProtKB/Swiss-Prot Induction:
Up-regulated during differentiation of bladder epithelial cells and down-regulated during differentiation of prostate epithelium.

Phenotypes From GWAS Catalog for BAG1 Gene

Gene Ontology (GO) - Molecular Function for BAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000774 adenyl-nucleotide exchange factor activity TAS --
GO:0005057 signal transducer activity, downstream of receptor TAS 8947043
GO:0005515 protein binding IPI 9305631
GO:0051087 chaperone binding IEA --
genes like me logo Genes that share ontologies with BAG1: view
genes like me logo Genes that share phenotypes with BAG1: view

Animal Models for BAG1 Gene

MGI Knock Outs for BAG1:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BAG1 Gene

Localization for BAG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAG1 Gene

Isoform 1: Nucleus. Cytoplasm. Note=Isoform 1 localizes predominantly to the nucleus.
Isoform 2: Cytoplasm. Nucleus. Note=Isoform 2 localizes to the cytoplasm and shuttles into the nucleus in response to heat shock.
Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BAG1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9679980
GO:0005737 cytoplasm TAS 8947043
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with BAG1: view

Pathways & Interactions for BAG1 Gene

genes like me logo Genes that share pathways with BAG1: view

Pathways by source for BAG1 Gene

Gene Ontology (GO) - Biological Process for BAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007166 cell surface receptor signaling pathway TAS 8947043
GO:0043066 negative regulation of apoptotic process TAS 8947043
GO:0050790 regulation of catalytic activity IEA --
GO:0051085 chaperone cofactor-dependent protein refolding IDA 12853476
genes like me logo Genes that share ontologies with BAG1: view

No data available for SIGNOR curated interactions for BAG1 Gene

Drugs & Compounds for BAG1 Gene

(15) Drugs for BAG1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Experimental Pharma Target 0

(5) Additional Compounds for BAG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BAG1: view

Transcripts for BAG1 Gene

Unigene Clusters for BAG1 Gene

BCL2-associated athanogene:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BAG1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: - - -
SP2:
SP3: -
SP4:
SP5: - -

Relevant External Links for BAG1 Gene

GeneLoc Exon Structure for
BAG1
ECgene alternative splicing isoforms for
BAG1

Expression for BAG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BAG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BAG1 Gene

This gene is overexpressed in Heart (19.4), Peripheral blood mononuclear cells (13.6), and Retina (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BAG1 Gene



Protein tissue co-expression partners for BAG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of BAG1 Gene:

BAG1

SOURCE GeneReport for Unigene cluster for BAG1 Gene:

Hs.377484

mRNA Expression by UniProt/SwissProt for BAG1 Gene:

Q99933-BAG1_HUMAN
Tissue specificity: Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level).

Evidence on tissue expression from TISSUES for BAG1 Gene

  • Lung(4.6)
  • Liver(4.4)
  • Blood(4.3)
  • Nervous system(3.5)
  • Muscle(3.1)
  • Heart(2.3)
  • Kidney(2.2)
  • Intestine(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with BAG1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BAG1 Gene

Orthologs for BAG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BAG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAG1 33 34
  • 99.42 (n)
cow
(Bos Taurus)
Mammalia BAG1 33 34
  • 88.09 (n)
dog
(Canis familiaris)
Mammalia BAG1 33 34
  • 87.81 (n)
mouse
(Mus musculus)
Mammalia Bag1 33 16 34
  • 81.64 (n)
rat
(Rattus norvegicus)
Mammalia Bag1 33
  • 81.16 (n)
oppossum
(Monodelphis domestica)
Mammalia BAG1 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves BAG1 33 34
  • 71.66 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia bag1 33
  • 66.5 (n)
Str.17686 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19139 33
zebrafish
(Danio rerio)
Actinopterygii bag1 33 34
  • 62.78 (n)
Species where no ortholog for BAG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAG1 Gene

ENSEMBL:
Gene Tree for BAG1 (if available)
TreeFam:
Gene Tree for BAG1 (if available)

Paralogs for BAG1 Gene

Pseudogenes.org Pseudogenes for BAG1 Gene

genes like me logo Genes that share paralogs with BAG1: view

No data available for Paralogs for BAG1 Gene

Variants for BAG1 Gene

Sequence variations from dbSNP and Humsavar for BAG1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000234535 -- 33,263,396(-) C/G intron_variant
rs1000774456 -- 33,257,209(-) G/A intron_variant
rs1000982073 -- 33,264,981(-) G/A upstream_transcript_variant
rs1001269373 -- 33,253,698(-) G/T 3_prime_UTR_variant
rs1001287597 -- 33,264,657(-) C/A/G/T 5_prime_UTR_variant, coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for BAG1 Gene

Variant ID Type Subtype PubMed ID
nsv614146 CNV gain 21841781
nsv519369 CNV gain 19592680
nsv1023246 CNV gain 25217958
esv2762813 CNV gain 21179565
esv2463163 CNV deletion 19546169
dgv7516n100 CNV gain 25217958

Variation tolerance for BAG1 Gene

Residual Variation Intolerance Score: 82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.93; 49.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BAG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BAG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAG1 Gene

Disorders for BAG1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for BAG1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, susceptibility to
coccidiosis
  • intestinal coccidiosis
wilms tumor 1
  • wt1
- elite association - COSMIC cancer census association via MalaCards
Search BAG1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BAG1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with BAG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BAG1 Gene

Publications for BAG1 Gene

  1. Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions. (PMID: 12724406) Hung WJ … Wu DY (Molecular and cellular biology 2003) 3 4 22 58
  2. Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. (PMID: 9679980) Takayama S … Reed JC (Cancer research 1998) 3 4 22 58
  3. p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1. (PMID: 9582267) Matsuzawa S … Reed JC (The EMBO journal 1998) 3 4 22 58
  4. BAG-1 modulates the chaperone activity of Hsp70/Hsc70. (PMID: 9305631) Takayama S … Reed JC (The EMBO journal 1997) 3 4 22 58
  5. Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation. (PMID: 9396724) Packham G … Cleveland JL (The Biochemical journal 1997) 3 4 22 58

Products for BAG1 Gene

Sources for BAG1 Gene

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