Aliases for BACH1 Gene
Aliases for BACH1 Gene
External Ids for BACH1 Gene
- HGNC: 935
- Entrez Gene: 571
- Ensembl: ENSG00000156273
- OMIM: 602751
- UniProtKB: O14867
Previous GeneCards Identifiers for BACH1 Gene
- GC21P027248
- GC21P029591
- GC21P029593
- GC21P030671
- GC21P016079
- GC21P030567
- GC21P030570
Summaries for BACH1 Gene
-
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]
GeneCards Summary for BACH1 Gene
BACH1 (BTB Domain And CNC Homolog 1) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway and Integrated Cancer Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and heme binding. An important paralog of this gene is BACH2.
UniProtKB/Swiss-Prot for BACH1 Gene
-
Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BACH1 Gene
Genomics for BACH1 Gene
GeneHancer (GH) Regulatory Elements for BACH1 Gene
Promoters and enhancers for BACH1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around BACH1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the BACH1 gene promoter:
-
- AML1a
Regulatory Element Products
Genomic Locations for BACH1 Gene
Genomic Locations for BACH1 Gene
- chr21:29,194,071-29,630,751
- (GRCh38/hg38)
- Size:
- 436,681 bases
- Orientation:
- Plus strand
- chr21:30,566,392-31,003,071
- (GRCh37/hg19)
- Size:
- 436,680 bases
- Orientation:
- Plus strand
Genomic View for BACH1 Gene
Genes around BACH1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q21.3 by Entrez Gene
- 21q21.3 by HGNC
- 21q21.3 by Ensembl
BACH1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BACH1 Gene
Proteins for BACH1 Gene
-
Protein details for BACH1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14867-BACH1_HUMAN
- Recommended name:
- Transcription regulator protein BACH1
- Protein Accession:
- O14867
- O43285
- Q6ICU0
- O43285
- Q6ICU0
Protein attributes for BACH1 Gene
- Size:
- 736 amino acids
- Molecular mass:
- 81958 Da
- Quaternary structure:
- No Data Available
Protein Expression for BACH1 Gene
Post-translational modifications for BACH1 Gene
Other Protein References for BACH1 Gene
Antibody Products
- R&D Systems Antibodies for BACH1 (BACH1)
-
Custom Antibody ServicesOriGene Antibodies for BACH1
- Novus Biologicals Antibodies for BACH1
-
Abcam antibodies for BACH1
- Invitrogen Antibodies for BACH1 (AFLGC-BACH1)
- GeneTex BACH1 Antibody for BACH1
-
Santa Cruz Biotechnology (SCBT) Antibodies for BACH1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for BACH1
- Origene Custom Protein Services for BACH1
- antibodies-online: Search results for 5 available BACH1 Proteins ranked by validation data
- Compare Top BACH1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for BACH1
-
Abcam proteins for BACH1
Assay Products
- antibodies-online: Search results for 2 available BACH1 Elisa Kits ranked by validation data
- Compare Top BACH1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for BACH1 Gene
Domains & Families for BACH1 Gene
Gene Families for BACH1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for BACH1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for BACH1 Gene
Graphical View of Domain Structure for InterPro Entry
O14867- Family:
-
- Belongs to the bZIP family. CNC subfamily.
Function for BACH1 Gene
Molecular function for BACH1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.
- GENATLAS Biochemistry:
- murine Bac-1 transcription factor homolog,ubiquitously expressed,interacting with MAFK,transcription repressor in fibroblasts,activator in cultured erythroid cells
Phenotypes From GWAS Catalog for BACH1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | IEA,IBA | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IMP | 21555518 |
| GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | IEA | -- |
| GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding | IEA | -- |
Phenotypes for BACH1 Gene
- MGI mutant phenotypes for BACH1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for BACH1:
Animal Models for BACH1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for BACH1
-
CRISPR Products
-
OriGene CRISPR knockouts for BACH1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BACH1
- genomics-online: gRNA clones - Search results for 89 available BACH1 gene related products
- Overview of 89 available BACH1 gene related products
- Applied Biological Materials CRISPR for BACH1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BACH1
- GenScript: Design CRISPR guide RNA sequences for BACH1
miRNA for BACH1 Gene
- miRTarBase miRNAs that target BACH1
-
- hsa-mir-155-5p (MIRT001043)
- hsa-mir-196a-5p (MIRT004718)
- hsa-mir-769-5p (MIRT039211)
- hsa-mir-125b-5p (MIRT045958)
- hsa-mir-20a-5p (MIRT050569)
- hsa-mir-185-5p (MIRT084941)
- hsa-mir-190a-3p (MIRT084942)
- hsa-mir-4306 (MIRT084943)
- hsa-mir-3924 (MIRT084944)
- hsa-mir-4644 (MIRT084945)
- hsa-mir-5011-5p (MIRT084946)
- hsa-mir-8076 (MIRT084947)
- hsa-mir-302a-3p (MIRT084948)
- hsa-mir-302b-3p (MIRT084949)
- hsa-mir-302c-3p (MIRT084950)
- hsa-mir-302d-3p (MIRT084951)
- hsa-mir-372-3p (MIRT084952)
- hsa-mir-373-3p (MIRT084953)
- hsa-mir-520e (MIRT084955)
- hsa-mir-520f-3p (MIRT084956)
- hsa-mir-520a-3p (MIRT084958)
- hsa-mir-520b (MIRT084960)
- hsa-mir-520c-3p (MIRT084961)
- hsa-mir-520d-3p (MIRT084962)
- hsa-mir-539-5p (MIRT084964)
- hsa-mir-302e (MIRT084966)
- hsa-mir-4451 (MIRT084968)
- hsa-mir-6832-5p (MIRT084971)
- hsa-let-7a-5p (MIRT084972)
- hsa-let-7b-5p (MIRT084973)
- hsa-let-7c-5p (MIRT084974)
- hsa-let-7d-5p (MIRT084975)
- hsa-let-7e-5p (MIRT084976)
- hsa-let-7f-5p (MIRT084977)
- hsa-mir-98-5p (MIRT084978)
- hsa-let-7g-5p (MIRT084979)
- hsa-let-7i-5p (MIRT084980)
- hsa-mir-142-3p (MIRT084981)
- hsa-mir-196b-5p (MIRT084982)
- hsa-mir-643 (MIRT084983)
- hsa-mir-4280 (MIRT084985)
- hsa-mir-3668 (MIRT084986)
- hsa-mir-3935 (MIRT084987)
- hsa-mir-4458 (MIRT084988)
- hsa-mir-4500 (MIRT084989)
- hsa-mir-6504-3p (MIRT084991)
- hsa-mir-6728-5p (MIRT203108)
- hsa-mir-6871-5p (MIRT203109)
- hsa-mir-6516-5p (MIRT203110)
- hsa-mir-513a-3p (MIRT203131)
- hsa-mir-559 (MIRT203132)
- hsa-mir-548b-5p (MIRT203133)
- hsa-mir-590-3p (MIRT203134)
- hsa-mir-548a-5p (MIRT203135)
- hsa-mir-548c-5p (MIRT203136)
- hsa-mir-548d-5p (MIRT203137)
- hsa-mir-548j-5p (MIRT203138)
- hsa-mir-548h-5p (MIRT203139)
- hsa-mir-548i (MIRT203140)
- hsa-mir-664a-5p (MIRT203141)
- hsa-mir-513c-3p (MIRT203142)
- hsa-mir-548w (MIRT203143)
- hsa-mir-3606-3p (MIRT203144)
- hsa-mir-548y (MIRT203146)
- hsa-mir-548o-5p (MIRT203147)
- hsa-mir-548ab (MIRT203148)
- hsa-mir-548ad-5p (MIRT203149)
- hsa-mir-548ae-5p (MIRT203150)
- hsa-mir-548ak (MIRT203151)
- hsa-mir-548am-5p (MIRT203152)
- hsa-mir-4794 (MIRT203153)
- hsa-mir-548ap-5p (MIRT203154)
- hsa-mir-548aq-5p (MIRT203155)
- hsa-mir-548ar-5p (MIRT203156)
- hsa-mir-548as-5p (MIRT203157)
- hsa-mir-5580-5p (MIRT203158)
- hsa-mir-548au-5p (MIRT203159)
- hsa-mir-548ay-5p (MIRT203160)
- hsa-mir-6516-3p (MIRT203161)
- hsa-mir-548bb-5p (MIRT203162)
- hsa-mir-361-5p (MIRT235959)
- hsa-mir-944 (MIRT235960)
- hsa-mir-2115-3p (MIRT235961)
- hsa-mir-548s (MIRT235966)
- hsa-mir-3926 (MIRT235968)
- hsa-mir-580-3p (MIRT254065)
- hsa-mir-3143 (MIRT254066)
- hsa-mir-4324 (MIRT254068)
- hsa-mir-4251 (MIRT254069)
- hsa-mir-3622a-3p (MIRT254070)
- hsa-mir-3622b-3p (MIRT254071)
- hsa-mir-31-3p (MIRT298041)
- hsa-mir-511-3p (MIRT298042)
- hsa-mir-188-3p (MIRT350953)
- hsa-mir-1260a (MIRT350954)
- hsa-mir-3156-3p (MIRT350955)
- hsa-mir-1260b (MIRT350956)
- hsa-mir-4301 (MIRT350957)
- hsa-mir-96-3p (MIRT350958)
- hsa-mir-6856-5p (MIRT443654)
- hsa-mir-6758-5p (MIRT443655)
- hsa-mir-497-3p (MIRT443656)
- hsa-mir-466 (MIRT524799)
- hsa-mir-3941 (MIRT524800)
- hsa-mir-5192 (MIRT524801)
- hsa-mir-6514-5p (MIRT524802)
- hsa-mir-4802-5p (MIRT524803)
- hsa-mir-4643 (MIRT524804)
- hsa-mir-4789-3p (MIRT524805)
- hsa-mir-603 (MIRT524806)
- hsa-mir-362-3p (MIRT524807)
- hsa-mir-329-3p (MIRT524808)
- hsa-mir-8485 (MIRT524809)
- hsa-mir-6765-3p (MIRT559271)
- hsa-mir-543 (MIRT559272)
- hsa-mir-4666a-5p (MIRT568317)
- hsa-mir-4703-3p (MIRT568318)
- hsa-mir-376a-2-5p (MIRT568319)
- hsa-mir-202-3p (MIRT568320)
- hsa-mir-548l (MIRT568321)
- hsa-mir-8054 (MIRT568322)
- hsa-mir-548k (MIRT568323)
- hsa-mir-548av-5p (MIRT568324)
- hsa-mir-496 (MIRT568325)
- hsa-mir-3680-3p (MIRT568326)
- hsa-mir-557 (MIRT568327)
- hsa-mir-507 (MIRT568328)
- hsa-mir-450b-5p (MIRT568329)
- hsa-mir-629-3p (MIRT568330)
- hsa-mir-455-3p (MIRT568331)
- hsa-mir-4713-5p (MIRT568332)
- hsa-mir-6867-3p (MIRT568333)
- hsa-mir-5187-5p (MIRT568334)
- hsa-mir-4685-3p (MIRT568335)
- hsa-mir-4287 (MIRT568336)
- hsa-mir-7113-3p (MIRT568337)
- hsa-mir-4469 (MIRT568338)
- hsa-mir-4719 (MIRT611699)
- hsa-mir-8074 (MIRT705275)
- hsa-mir-1185-2-3p (MIRT705276)
- hsa-mir-1185-1-3p (MIRT705277)
- hsa-let-7f-2-3p (MIRT705278)
Transcription Factor Targets for BACH1 Gene
Targeted motifs for BACH1 Gene
HOMER Transcription Factor Regulatory Elements motif BACH1
- Consensus sequence: AWWNTGCTGAGTCAT Submotif: canonical Cell Type: K562 GEO ID: GSE31477
miRNA Products
- SwitchGear BACH1 3' UTR sequence
- SwitchGear BACH1 3' UTR sequence
- Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BACH1
- Browse OriGene Inhibitory RNA Products For BACH1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BACH1
- genomics-online: shRNA clones - Search results for 89 available BACH1 gene related products
- Overview of 89 available BACH1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for BACH1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BACH1
- Applied Biological Materials Clones for BACH1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for BACH1
No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for BACH1 Gene
Localization for BACH1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BACH1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Cytosol (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 12511571 |
| GO:0005737 | cytoplasm | HDA | 16791210 |
| GO:0005829 | colocalizes_with cytosol | HDA | 16780588 |
| GO:0031463 | Cul3-RING ubiquitin ligase complex | IBA | -- |
Pathways & Interactions for BACH1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | BRCA1 Pathway | ||
| 2 | Integrated Breast Cancer Pathway | ||
| 3 | Integrated Cancer Pathway | ||
Pathways by source for BACH1 Gene
2 BioSystems pathways for BACH1 Gene
1 Qiagen pathway for BACH1 Gene
Interacting Proteins for BACH1 Gene
Selected Interacting proteins:
ENSP00000286800
O14867-BACH1_HUMAN
for BACH1 Gene via
STRING
MINT
UniProtKB
IID
GPS-Prot Interaction Network for BACH1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle | IMP | 21555518 |
| GO:0000117 | regulation of transcription involved in G2/M transition of mitotic cell cycle | IMP | 21555518 |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP,IEA | 21555518 |
| GO:0006281 | DNA repair | IMP | 11301010 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
No data available for SIGNOR curated interactions for BACH1 Gene
Drugs & Compounds for BACH1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Isoniazid | Approved, Investigational | Pharma | 164 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
Transcripts for BACH1 Gene
mRNA/cDNA for BACH1 Gene
- (3) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (2) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000548219 325 bps (uc061zla.1)
- ENST00000550131 349 bps (uc061zld.1)
- ENST00000547141 315 bps (uc061zlc.1)
- ENST00000546469 485 bps (uc061zlb.1)
- ENST00000286800 5669 bps (uc002ynj.4)
Unigene Clusters for BACH1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for BACH1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BACH1
- genomics-online: gRNA clones - Search results for 89 available BACH1 gene related products
- Overview of 89 available BACH1 gene related products
- Applied Biological Materials CRISPR for BACH1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BACH1
- GenScript: Design CRISPR guide RNA sequences for BACH1
miRNA Products
- SwitchGear BACH1 3' UTR sequence
- SwitchGear BACH1 3' UTR sequence
- Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BACH1
- Browse OriGene Inhibitory RNA Products For BACH1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BACH1
- genomics-online: shRNA clones - Search results for 89 available BACH1 gene related products
- Overview of 89 available BACH1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for BACH1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BACH1
- Applied Biological Materials Clones for BACH1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||
| SP5: | - | - |
Expression for BACH1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
- Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for BACH1 Gene
This gene is overexpressed in Whole Blood (x5.1).
This gene is overexpressed in Peripheral blood mononuclear cells (33.7), Monocytes (12.4), and Testis (11.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BACH1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of BACH1 Gene:
BACH1SOURCE GeneReport for Unigene cluster for BACH1 Gene:
Hs.154276Primer Products
-
OriGene qPCR primer pairs for BACH1
-
OriGene qPCR primer pairs and template standards for BACH1
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BACH1 Gene
Orthologs for BACH1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BACH1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | BACH1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | BACH1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Bach1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Bach1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | BACH1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | BACH1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | BACH1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | BACH1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | bach1 33 |
|
||
| Str.14783 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.16158 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | bach1 34 |
|
OneToMany | |
| BACH1 (2 of 2) 34 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | cnc 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for BACH1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for BACH1 Gene
- ENSEMBL:
- Gene Tree for BACH1 (if available)
- TreeFam:
- Gene Tree for BACH1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BACH1: view image
Paralogs for BACH1 Gene
(20) SIMAP similar genes for BACH1 Gene using alignment to 9 proteins:
- BACH1_HUMAN
- C9IYH8_HUMAN
- C9IYR0_HUMAN
- C9JMP6_HUMAN
- F8VZL7_HUMAN
- H7C4B6_HUMAN
- M0QZP0_HUMAN
- Q6ICU0_HUMAN
- Q9BXM4_HUMAN
Variants for BACH1 Gene
| SNP ID | Clin | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000001670 | -- | 29,318,518(+) | C/T | intron_variant | |
| rs1000007242 | -- | 29,360,651(+) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000034184 | -- | 29,302,093(+) | C/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000066771 | -- | 29,317,079(+) | A/T | intron_variant | |
| rs1000078718 | -- | 29,299,116(+) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1072596 | CNV | deletion | 25765185 |
| nsv1118931 | CNV | deletion | 24896259 |
| nsv472546 | CNV | novel sequence insertion | 20440878 |
Residual Variation Intolerance Score:
24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.96;
49.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BACH1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BACH1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BACH1 Gene
Disorders for BACH1 Gene
Additional Disease Information for BACH1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for BACH1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BACH1 Gene
Publications for BACH1 Gene
- Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1. (PMID: 9479503) Ohira M … Ohara O (Genomics 1998) 2 3 4 22 58
- Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1. (PMID: 9544839) Blouin JL … Antonarakis SE (Human genetics 1998) 2 3 4 22 58
- Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. (PMID: 22158540) Wu C … Lin D (Nature genetics 2011) 3 44 58
- A role for Bach1 and HO-2 in suppression of basal and UVA-induced HO-1 expression in human keratinocytes. (PMID: 19874887) Zhong JL … Tyrrell RM (Free radical biology & medicine 2010) 3 22 58
- MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins. (PMID: 20127796) Hou W … Bonkovsky HL (Hepatology (Baltimore, Md.) 2010) 3 22 58
Products for BACH1 Gene
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Sources for BACH1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (25) HMDB
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- (28) ASD
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- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
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- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
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- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
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