Aliases for BACH1 Gene
External Ids for BACH1 Gene
Previous GeneCards Identifiers for BACH1 Gene
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]
GeneCards Summary for BACH1 Gene
BACH1 (BTB Domain And CNC Homolog 1) is a Protein Coding gene. Diseases associated with BACH1 include Breast Cancer. Among its related pathways are BRCA1 Pathway and Integrated Cancer Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and heme binding. An important paralog of this gene is BACH2.
UniProtKB/Swiss-Prot Summary for BACH1 Gene
Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498).