Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- an... See more...
Aliases for BACH1 Gene
Aliases for BACH1 Gene
External Ids for BACH1 Gene
- HGNC: 935
- Entrez Gene: 571
- Ensembl: ENSG00000156273
- OMIM: 602751
- UniProtKB: O14867
Previous GeneCards Identifiers for BACH1 Gene
- GC21P027248
- GC21P029591
- GC21P029593
- GC21P030671
- GC21P016079
- GC21P030567
- GC21P030570
Summaries for BACH1 Gene
-
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]
GeneCards Summary for BACH1 Gene
BACH1 (BTB Domain And CNC Homolog 1) is a Protein Coding gene. Diseases associated with BACH1 include Breast Cancer. Among its related pathways are BRCA1 Pathway and Integrated Cancer Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and heme binding. An important paralog of this gene is BACH2.
UniProtKB/Swiss-Prot Summary for BACH1 Gene
-
Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498).
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BACH1 Gene
Genomics for BACH1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BACH1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BACH1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BACH1
- Top Transcription factor binding sites by QIAGEN in the BACH1 gene promoter:
-
- AML1a
Genomic Locations for BACH1 Gene
Genomic Locations for BACH1 Gene
- chr21:29,194,071-29,630,751
- (GRCh38/hg38)
- Size:
- 436,681 bases
- Orientation:
- Plus strand
- chr21:30,566,392-31,003,071
- (GRCh37/hg19)
- Size:
- 436,680 bases
- Orientation:
- Plus strand
Genomic View for BACH1 Gene
Genes around BACH1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q21.3 by HGNC
- 21q21.3 by Entrez Gene
- 21q21.3 by Ensembl
BACH1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BACH1 Gene
Proteins for BACH1 Gene
-
Protein details for BACH1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14867-BACH1_HUMAN
- Recommended name:
- Transcription regulator protein BACH1
- Protein Accession:
- O14867
- O43285
- Q6ICU0
Protein attributes for BACH1 Gene
- Size:
- 736 amino acids
- Molecular mass:
- 81958 Da
- Quaternary structure:
-
- Heterodimer of BACH1 and MAFK.
Protein Expression for BACH1 Gene
Post-translational modifications for BACH1 Gene
- Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteasome.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for BACH1 Gene
Antibody Products
- G Biosciences Immunotag™ BACH1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for BACH1
- Novus Biologicals Antibodies for BACH1
-
Abcam antibodies for BACH1
- Invitrogen Antibodies for BACH1 (AFLGC-BACH1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for BACH1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for BACH1
- Origene Custom Protein Services for BACH1
- antibodies-online: Show 5 available BACH1 Proteins ranked by validation data
- Compare Top BACH1 Proteins
-
Quality Products:
-
Abcam proteins for BACH1
Assay Products
- antibodies-online: Show 3 available BACH1 Elisa Kits ranked by validation data
- Compare Top BACH1 Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for BACH1
No data available for DME Specific Peptides for BACH1 Gene
Domains & Families for BACH1 Gene
Gene Families for BACH1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for BACH1 Gene
- InterPro:
- Blocks:
-
- BTB/POZ domain
- bZIP transcription factor, bZIP_1
- ProtoNet:
Suggested Antigen Peptide Sequences for BACH1 Gene
- GenScript: Design optimal peptide antigens:
-
- HA2303 (BACH1_HUMAN)
- cDNA, FLJ94404, Homo sapiens BTB and CNC homology 1, basic leucine zippertranscription factor 1 (BACH1), mRNA (Q6ICU0_HUMAN)
- Transcription factor BACH1t (Q9BXM4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O14867- Family:
-
- Belongs to the bZIP family. CNC subfamily.
Function for BACH1 Gene
Molecular function for BACH1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498).
- GENATLAS Biochemistry:
- murine Bac-1 transcription factor homolog,ubiquitously expressed,interacting with MAFK,transcription repressor in fibroblasts,activator in cultured erythroid cells
Phenotypes From GWAS Catalog for BACH1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA,IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IMP | 21555518 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for BACH1 Gene
- MGI mutant phenotypes for BACH1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for BACH1:
Animal Models for BACH1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BACH1 - Select products 50% OFF >
- * BACH1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BACH1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BACH1
-
Santa Cruz Biotechnology (SCBT) CRISPR for BACH1
miRNA for BACH1 Gene
- miRTarBase miRNAs that target BACH1
-
- hsa-miR-155-5p (MIRT001043)
- mmu-miR-122-5p (MIRT003121)
- hsa-miR-196a-5p (MIRT004718)
- mmu-miR-541-5p (MIRT008209)
- mmu-let-7b-5p (MIRT012221)
- mmu-miR-30e-5p (MIRT013376)
- mmu-miR-181a-5p (MIRT014158)
- mmu-miR-149-5p (MIRT014638)
- hsa-miR-769-5p (MIRT039211)
- hsa-miR-125b-5p (MIRT045958)
- hsa-miR-20a-5p (MIRT050569)
- mmu-miR-155-5p (MIRT053258)
- hsa-miR-185-5p (MIRT084941)
- hsa-miR-190a-3p (MIRT084942)
- hsa-miR-4306 (MIRT084943)
- hsa-miR-3924 (MIRT084944)
- hsa-miR-4644 (MIRT084945)
- hsa-miR-5011-5p (MIRT084946)
- hsa-miR-8076 (MIRT084947)
- hsa-miR-302a-3p (MIRT084948)
- hsa-miR-302b-3p (MIRT084949)
- hsa-miR-302c-3p (MIRT084950)
- hsa-miR-302d-3p (MIRT084951)
- hsa-miR-372-3p (MIRT084952)
- hsa-miR-373-3p (MIRT084953)
- hsa-miR-520e (MIRT084955)
- hsa-miR-520f-3p (MIRT084956)
- hsa-miR-520a-3p (MIRT084958)
- hsa-miR-520b (MIRT084960)
- hsa-miR-520c-3p (MIRT084961)
- hsa-miR-520d-3p (MIRT084962)
- hsa-miR-539-5p (MIRT084964)
- hsa-miR-302e (MIRT084966)
- hsa-miR-4451 (MIRT084968)
- hsa-miR-6832-5p (MIRT084971)
- hsa-let-7a-5p (MIRT084972)
- hsa-let-7b-5p (MIRT084973)
- hsa-let-7c-5p (MIRT084974)
- hsa-let-7d-5p (MIRT084975)
- hsa-let-7e-5p (MIRT084976)
- hsa-let-7f-5p (MIRT084977)
- hsa-miR-98-5p (MIRT084978)
- hsa-let-7g-5p (MIRT084979)
- hsa-let-7i-5p (MIRT084980)
- hsa-miR-142-3p (MIRT084981)
- hsa-miR-196b-5p (MIRT084982)
- hsa-miR-643 (MIRT084983)
- hsa-miR-4280 (MIRT084985)
- hsa-miR-3668 (MIRT084986)
- hsa-miR-3935 (MIRT084987)
- hsa-miR-4458 (MIRT084988)
- hsa-miR-4500 (MIRT084989)
- hsa-miR-6504-3p (MIRT084991)
- hsa-miR-6728-5p (MIRT203108)
- hsa-miR-6871-5p (MIRT203109)
- hsa-miR-6516-5p (MIRT203110)
- hsa-miR-513a-3p (MIRT203131)
- hsa-miR-559 (MIRT203132)
- hsa-miR-548b-5p (MIRT203133)
- hsa-miR-590-3p (MIRT203134)
- hsa-miR-548a-5p (MIRT203135)
- hsa-miR-548c-5p (MIRT203136)
- hsa-miR-548d-5p (MIRT203137)
- hsa-miR-548j-5p (MIRT203138)
- hsa-miR-548h-5p (MIRT203139)
- hsa-miR-548i (MIRT203140)
- hsa-miR-664a-5p (MIRT203141)
- hsa-miR-513c-3p (MIRT203142)
- hsa-miR-548w (MIRT203143)
- hsa-miR-3606-3p (MIRT203144)
- hsa-miR-548y (MIRT203146)
- hsa-miR-548o-5p (MIRT203147)
- hsa-miR-548ab (MIRT203148)
- hsa-miR-548ad-5p (MIRT203149)
- hsa-miR-548ae-5p (MIRT203150)
- hsa-miR-548ak (MIRT203151)
- hsa-miR-548am-5p (MIRT203152)
- hsa-miR-4794 (MIRT203153)
- hsa-miR-548ap-5p (MIRT203154)
- hsa-miR-548aq-5p (MIRT203155)
- hsa-miR-548ar-5p (MIRT203156)
- hsa-miR-548as-5p (MIRT203157)
- hsa-miR-5580-5p (MIRT203158)
- hsa-miR-548au-5p (MIRT203159)
- hsa-miR-548ay-5p (MIRT203160)
- hsa-miR-6516-3p (MIRT203161)
- hsa-miR-548bb-5p (MIRT203162)
- hsa-miR-361-5p (MIRT235959)
- hsa-miR-944 (MIRT235960)
- hsa-miR-2115-3p (MIRT235961)
- hsa-miR-548s (MIRT235966)
- hsa-miR-3926 (MIRT235968)
- hsa-miR-580-3p (MIRT254065)
- hsa-miR-3143 (MIRT254066)
- hsa-miR-4324 (MIRT254068)
- hsa-miR-4251 (MIRT254069)
- hsa-miR-3622a-3p (MIRT254070)
- hsa-miR-3622b-3p (MIRT254071)
- hsa-miR-31-3p (MIRT298041)
- hsa-miR-511-3p (MIRT298042)
- hsa-miR-188-3p (MIRT350953)
- hsa-miR-1260a (MIRT350954)
- hsa-miR-3156-3p (MIRT350955)
- hsa-miR-1260b (MIRT350956)
- hsa-miR-4301 (MIRT350957)
- hsa-miR-96-3p (MIRT350958)
- hsa-miR-6856-5p (MIRT443654)
- hsa-miR-6758-5p (MIRT443655)
- hsa-miR-497-3p (MIRT443656)
- hsa-miR-466 (MIRT524799)
- hsa-miR-3941 (MIRT524800)
- hsa-miR-5192 (MIRT524801)
- hsa-miR-6514-5p (MIRT524802)
- hsa-miR-4802-5p (MIRT524803)
- hsa-miR-4643 (MIRT524804)
- hsa-miR-4789-3p (MIRT524805)
- hsa-miR-603 (MIRT524806)
- hsa-miR-362-3p (MIRT524807)
- hsa-miR-329-3p (MIRT524808)
- hsa-miR-8485 (MIRT524809)
- hsa-miR-6765-3p (MIRT559271)
- hsa-miR-543 (MIRT559272)
- hsa-miR-4666a-5p (MIRT568317)
- hsa-miR-4703-3p (MIRT568318)
- hsa-miR-376a-2-5p (MIRT568319)
- hsa-miR-202-3p (MIRT568320)
- hsa-miR-548l (MIRT568321)
- hsa-miR-8054 (MIRT568322)
- hsa-miR-548k (MIRT568323)
- hsa-miR-548av-5p (MIRT568324)
- hsa-miR-496 (MIRT568325)
- hsa-miR-3680-3p (MIRT568326)
- hsa-miR-557 (MIRT568327)
- hsa-miR-507 (MIRT568328)
- hsa-miR-450b-5p (MIRT568329)
- hsa-miR-629-3p (MIRT568330)
- hsa-miR-455-3p (MIRT568331)
- hsa-miR-4713-5p (MIRT568332)
- hsa-miR-6867-3p (MIRT568333)
- hsa-miR-5187-5p (MIRT568334)
- hsa-miR-4685-3p (MIRT568335)
- hsa-miR-4287 (MIRT568336)
- hsa-miR-7113-3p (MIRT568337)
- hsa-miR-4469 (MIRT568338)
- hsa-miR-4719 (MIRT611699)
- hsa-miR-8074 (MIRT705275)
- hsa-miR-1185-2-3p (MIRT705276)
- hsa-miR-1185-1-3p (MIRT705277)
- hsa-let-7f-2-3p (MIRT705278)
Transcription Factor Targets for BACH1 Gene
Targeted motifs for BACH1 Gene
HOMER Transcription Factor Regulatory Elements motif BACH1
- Consensus sequence: AWWNTGCTGAGTCAT Submotif: canonical Cell Type: K562 GEO ID: GSE31477
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BACH1
- Browse OriGene Inhibitory RNA Products For BACH1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BACH1
Clone Products
- Applied Biological Materials (abm): Clones for BACH1 - Select products 50% OFF >
- * BACH1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210390
- MR210390
- MR210390L3
- MR210390L4
- RC209275
- RC209275L1
- RC209275L2
- RC209275L3
- RC209275L4
- RC221628
- RC221628L1
- RC221628L2
- RC221628L3
- RC221628L4
- RG209275
- RG221628
- RR211703
- RR211703L3
- RR211703L4
- MR210390L3V
- MR210390L4V
- RC209275L1V
- RC209275L2V
- RC209275L3V
- RC209275L4V
- RC221628L1V
- RC221628L2V
- RC221628L3V
- RC221628L4V
- RR211703L3V
- RR211703L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BACH1
- Addgene plasmids for BACH1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BACH1
Cell Line Products
-
Horizon Cell Lines for BACH1
No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for BACH1 Gene
Localization for BACH1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BACH1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IEA,IDA | 12511571 |
| GO:0005737 | cytoplasm | HDA | 16791210 |
| GO:0005829 | colocalizes_with cytosol | HDA | 16780588 |
Pathways & Interactions for BACH1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | BRCA1 Pathway |
BRCA1 Pathway
-
|
|
| 2 | Integrated Breast Cancer Pathway | ||
| 3 | Integrated Cancer Pathway | ||
Pathways by source for BACH1 Gene
2 BioSystems pathways for BACH1 Gene
1 Qiagen pathway for BACH1 Gene
- BRCA1 Pathway
Interacting Proteins for BACH1 Gene
Selected Interacting proteins:
O14867-BACH1_HUMAN
ENSP00000382805
for BACH1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for BACH1
SIGNOR curated interactions for BACH1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle | IMP | 21555518 |
| GO:0000117 | regulation of transcription involved in G2/M transition of mitotic cell cycle | IMP | 21555518 |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA,IMP | 21555518 |
| GO:0006281 | DNA repair | IMP | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA,ISS | -- |
Drugs & Compounds for BACH1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Isoniazid | Approved, Investigational | Pharma | 215 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for BACH1 Gene
mRNA/cDNA for BACH1 Gene
- 3 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000548219 325 nts (view in UCSC)
- ENST00000550131 349 nts (view in UCSC)
- ENST00000547141 315 nts (view in UCSC)
- ENST00000546469 485 nts (view in UCSC)
- ENST00000286800 5618 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BACH1 - Select products 50% OFF >
- * BACH1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BACH1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BACH1
-
Santa Cruz Biotechnology (SCBT) CRISPR for BACH1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BACH1
- Browse OriGene Inhibitory RNA Products For BACH1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BACH1
Clone Products
- Applied Biological Materials (abm): Clones for BACH1 - Select products 50% OFF >
- * BACH1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210390
- MR210390
- MR210390L3
- MR210390L4
- RC209275
- RC209275L1
- RC209275L2
- RC209275L3
- RC209275L4
- RC221628
- RC221628L1
- RC221628L2
- RC221628L3
- RC221628L4
- RG209275
- RG221628
- RR211703
- RR211703L3
- RR211703L4
- MR210390L3V
- MR210390L4V
- RC209275L1V
- RC209275L2V
- RC209275L3V
- RC209275L4V
- RC221628L1V
- RC221628L2V
- RC221628L3V
- RC221628L4V
- RR211703L3V
- RR211703L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BACH1
- Addgene plasmids for BACH1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BACH1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||
| SP5: | - | - |
Relevant External Links for BACH1 Gene
- GeneLoc Exon Structure for
- BACH1
Expression for BACH1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
- Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for BACH1 Gene
This gene is overexpressed in Whole Blood (x5.1).
This gene is overexpressed in Peripheral blood mononuclear cells (33.7), Monocytes (12.4), and Testis (11.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BACH1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BACH1
SOURCE GeneReport for Unigene cluster for BACH1 Gene:
Hs.154276Evidence on tissue expression from TISSUES for BACH1 Gene
- Nervous system(2.4)
- Lung(2.3)
- Liver(2.3)
- Intestine(2.2)
- Spleen(2.1)
- Heart(2.1)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for BACH1
-
OriGene qPCR primer pairs and template standards for BACH1
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BACH1 Gene
Orthologs for BACH1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BACH1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | BACH1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | BACH1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Bach1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Bach1 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | BACH1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | BACH1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | BACH1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | BACH1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | bach1 30 |
|
||
| Str.14783 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.16158 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | bach1 31 |
|
OneToMany | |
| BACH1 (2 of 2) 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | cnc 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for BACH1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for BACH1 Gene
- ENSEMBL:
- Gene Tree for BACH1 (if available)
- TreeFam:
- Gene Tree for BACH1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BACH1: view image
Paralogs for BACH1 Gene
Paralogs for BACH1 Gene
- BACH2 5
- KLHL28 5
- KLHL5 5
- KLHL22 5
- KLHL1 5
- KLHL20 5
- KLHL12 5
- KLHL8 5
- KLHL17 5
- KLHL9 5
- KLHL2 5
- KLHL6 5
- KLHL24 5
- KLHL18 5
- KLHL30 5
- KBTBD3 5
- KLHL4 5
- KLHL32 5
- KLHL13 5
- KLHL3 5
- KLHL10 5
- KLHL36 5
- KLHL41 5
- KLHL23 5
- KLHL14 5
- KEAP1 5
- KLHL21 5
- KLHL7 5
- KBTBD6 5
- KBTBD7 5
- KLHL35 5
- KLHL38 5
- KLHL26 5
- KBTBD2 5
- KLHL29 5
- IPP 5
- KBTBD12 5
- KLHL15 5
- KBTBD11 5
- BTBD18 5
- KLHL34 5
- IVNS1ABP 5
- KLHL31 5
- KBTBD8 5
- KLHL40 5
- KBTBD13 5
- KLHL42 5
- KLHDC7A 5
- CCIN 5
- KLHL33 5
- GAN 5
- KLHDC8B 5
- KLHDC7B 5
- KLHDC8A 5
- ENSG00000277971 5
(20) SIMAP similar genes for BACH1 Gene using alignment to 9 proteins:
- BACH1_HUMAN
- C9IYH8_HUMAN
- C9IYR0_HUMAN
- C9JMP6_HUMAN
- F8VZL7_HUMAN
- H7C4B6_HUMAN
- M0QZP0_HUMAN
- Q6ICU0_HUMAN
- Q9BXM4_HUMAN
Variants for BACH1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BACH1 Gene
| SNP ID | Clinical significance and condition | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1569017478 | Uncertain Significance: Cerebellar vermis hypoplasia | 29,329,641(+) | G/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| rs35474725 | - | p.Ser314Pro |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1072596 | CNV | deletion | 25765185 |
| nsv1118931 | CNV | deletion | 24896259 |
| nsv472546 | CNV | novel sequence insertion | 20440878 |
Residual Variation Intolerance Score:
24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.96;
49.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BACH1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BACH1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BACH1 Gene
Disorders for BACH1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast cancer |
|
|
Search BACH1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BACH1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for BACH1 Gene
Publications for BACH1 Gene
- Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1. (PMID: 9479503) Ohira M … Ohara O (Genomics 1998) 2 3 4 23
- Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1. (PMID: 9544839) Blouin JL … Antonarakis SE (Human genetics 1998) 2 3 4 23
- Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. (PMID: 24035498) Tan MK … Harper JW (Molecular cell 2013) 3 4
- Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. (PMID: 22158540) Wu C … Lin D (Nature genetics 2011) 3 41
- MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins. (PMID: 20127796) Hou W … Bonkovsky HL (Hepatology (Baltimore, Md.) 2010) 3 23
ExternalLinks
Products for BACH1 Gene
- Custom Antibody ServicesOriGene Antibodies for BACH1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for BACH1
- Origene Custom Protein Services for BACH1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BACH1
- Browse OriGene Inhibitory RNA Products For BACH1
- OriGene qPCR primer pairs for BACH1
- OriGene qPCR primer pairs and template standards for BACH1
- OriGene CRISPR knockouts for BACH1
- MG210390
- MR210390
- MR210390L3
- MR210390L4
- RC209275
- RC209275L1
- RC209275L2
- RC209275L3
- RC209275L4
- RC221628
- RC221628L1
- RC221628L2
- RC221628L3
- RC221628L4
- RG209275
- RG221628
- RR211703
- RR211703L3
- RR211703L4
- MR210390L3V
- MR210390L4V
- RC209275L1V
- RC209275L2V
- RC209275L3V
- RC209275L4V
- RC221628L1V
- RC221628L2V
- RC221628L3V
- RC221628L4V
- RR211703L3V
- RR211703L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BACH1
- Sino Biological Human cDNA Clone for BACH1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for BACH1
- Novus Biologicals proteins and lysates for BACH1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for BACH1
- Abcam proteins for BACH1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for BACH1 (AFLGC-BACH1)
- VectorBuilder Custom and pre-made DNA vectors for BACH1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for BACH1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for BACH1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for BACH1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for BACH1
- Addgene plasmids for BACH1
- antibodies-online: Show 64 available BACH1 Antibodies ranked by validation data
- Compare Top BACH1 Antibodies
- antibodies-online: Show 3 available BACH1 Elisa Kits ranked by validation data
- Compare Top BACH1 Elisa Kits
- Quality Products:
- antibodies-online: Show 5 available BACH1 Proteins ranked by validation data
- Compare Top BACH1 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for BACH1
- Search Santa Cruz Biotechnology (SCBT) for BACH1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BACH1
- Horizon Cell Lines for BACH1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BACH1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BACH1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for BACH1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BACH1
Sources for BACH1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB