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This gene encodes an unspliced long non-coding RNA transcribed from the opposite strand to BACE1. The encoded transcript is thought to form an RNA duplex with BACE1 mRNA thereby regulating its expression and is also thought to promote post-transcriptional feed-forward regulation of BACE1. This may lead to increased levels of beta amyloid and increased senile plaque deposition, and therefore may play a role in the pathophysiology of Alzheimer's disease. [provided by RefSeq, Jan 2015]
BACE1-AS (BACE1 Antisense RNA) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with BACE1-AS include Inclusion Body Myositis and Heart Disease.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J117287 | Enhancer | 0.2 | ENCODE | 600.7 | -0.6 | -553 | 1 | BACE1-AS piR-32555 piR-30641 piR-36956 ENSG00000252992 PCSK7 RNF214 ENSG00000254851 BACE1 CEP164 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000077B5A3_9606 | lncRNA | 520 | 3 |
Ensembl: ENST00000614401 (view in UCSC) , LncBook: HSALNT0181747, NONCODE: NONHSAT159735.1, |
URS00007E3977_9606 | antisense_RNA | 825 | 2 |
HGNC: 37125, RefSeq: NR_037803, |
URS0000776338_9606 | lncRNA | 774 | 2 |
Ensembl: ENST00000618857 (view in UCSC) , NONCODE: NONHSAT159736.1, |
URS00009AEE9C_9606 | lncRNA | 2646 | 1 |
NONCODE: NONHSAT159734.1, |
URS00001B7C60_9606 | antisense_RNA | 1336 | 1 |
ENA: AB488782.1:1..1344:ncRNA, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1038815 | CNV | gain | 25217958 |
nsv509443 | CNV | insertion | 20534489 |
Disorder | Aliases | PubMed IDs |
---|---|---|
inclusion body myositis |
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heart disease |
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alzheimer disease |
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ovarian cancer |
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colorectal cancer |
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