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This gene encodes an unspliced long non-coding RNA transcribed from the opposite strand to BACE1. The encoded transcript is thought to form an RNA duplex with BACE1 mRNA thereby regulating its expression and is also thought to promote post-transcriptional feed-forward regulation of BACE1. This may lead to increased levels of beta amyloid and increased senile plaque deposition, ... See more...
Aliases for BACE1-AS Gene
Subcategory (RNA class) for BACE1-AS Gene
lncRNA
Number of RNA Genes sources:
3 / 17
Aliases for BACE1-AS Gene
External Ids for BACE1-AS Gene
- HGNC: 37125
- Entrez Gene: 100379571
- Ensembl: ENSG00000278768
- OMIM: 614263
Previous HGNC Symbols for BACE1-AS Gene
- BACE1AS
Previous GeneCards Identifiers for BACE1-AS Gene
- GC11U901760
- GC11P117165
- GC11P117290
- GC11P117294
- GC11P117292
- GC11P117295
- GC11P117300
- GC11P117291
Summaries for BACE1-AS Gene
-
This gene encodes an unspliced long non-coding RNA transcribed from the opposite strand to BACE1. The encoded transcript is thought to form an RNA duplex with BACE1 mRNA thereby regulating its expression and is also thought to promote post-transcriptional feed-forward regulation of BACE1. This may lead to increased levels of beta amyloid and increased senile plaque deposition, and therefore may play a role in the pathophysiology of Alzheimer's disease. [provided by RefSeq, Jan 2015]
GeneCards Summary for BACE1-AS Gene
BACE1-AS (BACE1 Antisense RNA) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with BACE1-AS include Inclusion Body Myositis and Heart Disease.
Additional gene information for BACE1-AS Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BACE1-AS Gene
Genomics for BACE1-AS Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BACE1-AS Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11J117287 | Enhancer | 0.2 | ENCODE | 600.7 | -0.6 | -553 | 1 | BACE1-AS piR-32555 piR-30641 piR-36956 ENSG00000252992 PCSK7 RNF214 ENSG00000254851 BACE1 CEP164 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BACE1-AS on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for BACE1-AS Gene
Genomic Locations for BACE1-AS Gene
- chr11:117,288,453-117,293,571
- (GRCh38/hg38)
- Size:
- 5,119 bases
- Orientation:
- Plus strand
- chr11:117,162,062-117,162,859
- (GRCh37/hg19)
- Size:
- 798 bases
- Orientation:
- Plus strand
Genomic View for BACE1-AS Gene
Genes around BACE1-AS on UCSC Golden Path with GeneCards custom track
BACE1-AS in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 11q23.3 by HGNC
- 11q23.3 by Entrez Gene
- 11q23.3 by Ensembl
BACE1-AS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BACE1-AS Gene
Proteins for BACE1-AS Gene
Post-translational modifications for BACE1-AS Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for BACE1-AS
- Origene Custom Protein Services for BACE1-AS
No data available for DME Specific Peptides for BACE1-AS Gene
Domains & Families for BACE1-AS Gene
Gene Families for BACE1-AS Gene
- HGNC:
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BACE1-AS Gene
Function for BACE1-AS Gene
Phenotypes From GWAS Catalog for BACE1-AS Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BACE1-AS - Select products 50% OFF >
- * BACE1-AS CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for BACE1-AS
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for BACE1-AS - Select products 50% OFF >
- * BACE1-AS as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BACE1-AS Gene
Localization for BACE1-AS Gene
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for BACE1-AS Gene
Transcripts for BACE1-AS Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for BACE1-AS Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS000077B5A3_9606 | lncRNA | 520 | 3 |
Ensembl: ENST00000614401 (view in UCSC) , LncBook: HSALNT0181747, NONCODE: NONHSAT159735.1, |
| URS00007E3977_9606 | antisense_RNA | 825 | 2 |
HGNC: 37125, RefSeq: NR_037803, |
| URS0000776338_9606 | lncRNA | 774 | 2 |
Ensembl: ENST00000618857 (view in UCSC) , NONCODE: NONHSAT159736.1, |
| URS00009AEE9C_9606 | lncRNA | 2646 | 1 |
NONCODE: NONHSAT159734.1, |
| URS00001B7C60_9606 | antisense_RNA | 1336 | 1 |
ENA: AB488782.1:1..1344:ncRNA, |
BACE1-AS in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for BACE1-AS Gene
- 6 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000649580 4584 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BACE1-AS - Select products 50% OFF >
- * BACE1-AS CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for BACE1-AS
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for BACE1-AS - Select products 50% OFF >
- * BACE1-AS as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
Relevant External Links for BACE1-AS Gene
- GeneLoc Exon Structure for
- BACE1-AS
Expression for BACE1-AS Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BACE1-AS
No Expression Related Data Available
Primer Products
Gene Expression Assay Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BACE1-AS Gene
Orthologs for BACE1-AS Gene
No data available for Orthologs for BACE1-AS Gene
Paralogs for BACE1-AS Gene
No data available for Paralogs for BACE1-AS Gene
Variants for BACE1-AS Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1038815 | CNV | gain | 25217958 |
| nsv509443 | CNV | insertion | 20534489 |
Additional Variant Information for BACE1-AS Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BACE1-AS
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for BACE1-AS Gene
Disorders for BACE1-AS Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| inclusion body myositis |
|
|
| heart disease |
|
|
| alzheimer disease |
|
|
| ovarian cancer |
|
|
| colorectal cancer |
|
Search BACE1-AS in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BACE1-AS
No data available for UniProtKB/Swiss-Prot and Genatlas for BACE1-AS Gene
Publications for BACE1-AS Gene
- Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis. (PMID: 21785702) Modarresi F … Lopez-Toledano MA (International journal of Alzheimer's disease 2011) 2 3
- Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. (PMID: 18587408) Faghihi MA … Wahlestedt C (Nature medicine 2008) 2 3
- β-Secretase 1 and its Naturally Occurring Anti-Sense RNA are Down-Regulated in Gastric Cancer. (PMID: 30805871) Esfandi F … Taheri M (Pathology oncology research : POR 2019) 3
- Long Non-coding RNA BACE1-AS May Serve as an Alzheimer's Disease Blood-Based Biomarker. (PMID: 31264051) Fotuhi SN … Talebi M (Journal of molecular neuroscience : MN 2019) 3
- Increased BACE1-AS long noncoding RNA and β-amyloid levels in heart failure. (PMID: 28158647) Greco S … Martelli F (Cardiovascular research 2017) 3
ExternalLinks
Products for BACE1-AS Gene
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- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for BACE1-AS
Sources for BACE1-AS Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
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- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
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- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
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- (58) Novus Biologicals
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- (60) Sino Biological
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- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
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- (89) antibodies-online
- (90) CYP
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- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
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- (104) diseasecard
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