This gene encodes an unspliced long non-coding RNA transcribed from the opposite strand to BACE1. The encoded transcript is thought to form an RNA duplex with BACE1 mRNA thereby regulating its expression and is also thought to promote post-transcriptional feed-forward regulation of BACE1. This may lead to increased levels of beta amyloid and increased senile plaque deposition, ... See more...

Aliases for BACE1-AS Gene

Data sources for BACE1-AS Gene:

RNA type for BACE1-AS Gene

lncRNA

Aliases for BACE1-AS Gene

External Ids for BACE1-AS Gene

Previous HGNC Symbols for BACE1-AS Gene

  • BACE1AS

Previous GeneCards Identifiers for BACE1-AS Gene

  • GC11U901760
  • GC11P117165
  • GC11P117290
  • GC11P117294
  • GC11P117292
  • GC11P117295
  • GC11P117300
  • GC11P117291
  • GC11P117304
  • GC11P117308

Summaries for BACE1-AS Gene

Entrez Gene Summary for BACE1-AS Gene

  • This gene encodes an unspliced long non-coding RNA transcribed from the opposite strand to BACE1. The encoded transcript is thought to form an RNA duplex with BACE1 mRNA thereby regulating its expression and is also thought to promote post-transcriptional feed-forward regulation of BACE1. This may lead to increased levels of beta amyloid and increased senile plaque deposition, and therefore may play a role in the pathophysiology of Alzheimer's disease. [provided by RefSeq, Jan 2015]

GeneCards Summary for BACE1-AS Gene

BACE1-AS (BACE1 Antisense RNA) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with BACE1-AS include Inclusion Body Myositis and Alzheimer Disease.

Additional gene information for BACE1-AS Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BACE1-AS Gene

Genomics for BACE1-AS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BACE1-AS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J117287 Enhancer 0.2 ENCODE 250.7 -0.6 -553 1 BACE1-AS piR-32555 piR-30641 piR-36956 ENSG00000252992 PCSK7 RNF214 ENSG00000254851 BACE1 CEP164
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BACE1-AS on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for BACE1-AS Gene

Latest Assembly
chr11:117,288,453-117,293,571
(GRCh38/hg38)
Size:
5,119 bases
Orientation:
Plus strand

Previous Assembly
chr11:117,162,062-117,162,886
(GRCh37/hg19 by Entrez Gene)
Size:
825 bases
Orientation:
Plus strand

Genomic View for BACE1-AS Gene

Genes around BACE1-AS on UCSC Golden Path with GeneCards custom track
BACE1-AS in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
BACE1-AS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BACE1-AS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BACE1-AS Gene

Proteins for BACE1-AS Gene

Post-translational modifications for BACE1-AS Gene

No Post-translational modifications

No data available for DME Specific Peptides for BACE1-AS Gene

Domains & Families for BACE1-AS Gene

Gene Families for BACE1-AS Gene

genes like me logo Genes that share domains with BACE1-AS: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BACE1-AS Gene

Function for BACE1-AS Gene

Phenotypes From GWAS Catalog for BACE1-AS Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BACE1-AS Gene

Localization for BACE1-AS Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BACE1-AS gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for BACE1-AS Gene

Pathways & Interactions for BACE1-AS Gene

PathCards logo

SuperPathways for BACE1-AS Gene

No Data Available

Gene Ontology (GO) - Biological Process for BACE1-AS Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for BACE1-AS Gene

Drugs & Compounds for BACE1-AS Gene

No Compound Related Data Available

Transcripts for BACE1-AS Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for BACE1-AS Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000077B5A3_9606 lncRNA 520 3

Ensembl: ENST00000614401 (view in UCSC) ,

LncBook: HSALNT0181747,

NONCODE: NONHSAT159735.1,

URS0000776338_9606 lncRNA 774 2

Ensembl: ENST00000618857 (view in UCSC) ,

NONCODE: NONHSAT159736.1,

URS00007E3977_9606 lncRNA 825 1

RefSeq: NR_037803,

URS00009AEE9C_9606 lncRNA 2646 1

NONCODE: NONHSAT159734.1,

URS0001BD1DBB_9606 lncRNA 2646 1

LncBook: HSALNT0181744,

BACE1-AS in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for BACE1-AS Gene

6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for BACE1-AS Gene

No ASD Table

Relevant External Links for BACE1-AS Gene

GeneLoc Exon Structure for
BACE1-AS

Expression for BACE1-AS Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BACE1-AS

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BACE1-AS Gene

Orthologs for BACE1-AS Gene

Evolution for BACE1-AS Gene

ENSEMBL:
Gene Tree for BACE1-AS (if available)
TreeFam:
Gene Tree for BACE1-AS (if available)
Alliance of Genome Resources:
Additional Orthologs for BACE1-AS

No data available for Orthologs for BACE1-AS Gene

Paralogs for BACE1-AS Gene

No data available for Paralogs for BACE1-AS Gene

Variants for BACE1-AS Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for BACE1-AS Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for BACE1-AS Gene

Variant ID Type Subtype PubMed ID
nsv1038815 CNV gain 25217958
nsv509443 CNV insertion 20534489

Additional Variant Information for BACE1-AS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BACE1-AS
Leiden Open Variation Database (LOVD)
BACE1-AS

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for BACE1-AS Gene

Disorders for BACE1-AS Gene

MalaCards: The human disease database

(7) MalaCards diseases for BACE1-AS Gene - From: LNC, COP, and GCD

Disorder Aliases PubMed IDs
inclusion body myositis
  • ibm
alzheimer disease
  • ad
heart disease
  • congenital heart disease
ovarian cancer
  • ovarian cancer, somatic
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for BACE1-AS

genes like me logo Genes that share disorders with BACE1-AS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BACE1-AS Gene

Publications for BACE1-AS Gene

  1. Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis. (PMID: 21785702) Modarresi F … Lopez-Toledano MA (International journal of Alzheimer's disease 2011) 2 3 72
  2. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. (PMID: 18587408) Faghihi MA … Wahlestedt C (Nature medicine 2008) 2 3 72
  3. Increased BACE1-AS long noncoding RNA and β-amyloid levels in heart failure. (PMID: 28158647) Greco S … Martelli F (Cardiovascular research 2017) 3 72
  4. Long non-coding RNA BACE1-AS is a novel target for anisomycin-mediated suppression of ovarian cancer stem cell proliferation and invasion. (PMID: 26783004) Chen Q … Liu T (Oncology reports 2016) 3 72
  5. HuD regulates coding and noncoding RNA to induce APP→Aβ processing. (PMID: 24857657) Kang MJ … Gorospe M (Cell reports 2014) 3 72

Products for BACE1-AS Gene

Sources for BACE1-AS Gene