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This gene was identified by gene expression studies in patients with acute myeloid leukemia (AML). The gene is conserved among mammals and is not found in lower organisms. Tissues that express this gene develop from the neuroectoderm. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene; however, some of the transcript variants are found only in AML cell lines. [provided by RefSeq, Jul 2008]
BAALC (BAALC Binder Of MAP3K1 And KLF4) is a Protein Coding gene. Diseases associated with BAALC include Acute Leukemia and Leukemia.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IDA | 11707601 |
GO:0005829 | cytosol | IDA | -- |
GO:0014069 | postsynaptic density | IEA | -- |
GO:0016020 | membrane | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||
SP2: | - | ||||||||||||||||
SP3: | - | - | |||||||||||||||
SP4: | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | BAALC 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | BAALC 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | BAALC 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Baalc 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Baalc 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | BAALC 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | BAALC 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | baalc 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | BAALC 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs34542607 | - | p.Ser164Thr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv21700 | CNV | gain | 19812545 |
esv2678140 | CNV | deletion | 23128226 |
nsv1017326 | CNV | gain | 25217958 |
nsv831413 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
acute leukemia |
|
|
leukemia |
|
|
myeloid leukemia |
|
|
childhood acute myeloid leukemia |
|
|
acute promyelocytic leukemia |
|
|