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Aliases for B3GNT8 Gene

Aliases for B3GNT8 Gene

  • UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 8 2 3 5
  • UDP-Gal:BetaGal Beta 1,3-Galactosyltransferase Polypeptide 7 2 3
  • Beta-1,3-N-Acetylglucosaminyltransferase 8 3 4
  • Beta-1,3-Gn-T8 3 4
  • Beta3Gn-T8 3 4
  • B3GALT7 3 4
  • BGALT15 3 4
  • BGnT-8 3 4
  • Beta1,3-N-Acetylglucosaminyltransferase 8 3
  • Beta Galactosyltransferase BGALT15 3
  • EC 2.4.1.- 4

External Ids for B3GNT8 Gene

Previous HGNC Symbols for B3GNT8 Gene

  • B3GALT7

Previous GeneCards Identifiers for B3GNT8 Gene

  • GC00U909458
  • GC19M046626
  • GC19M041935
  • GC19M038363

Summaries for B3GNT8 Gene

GeneCards Summary for B3GNT8 Gene

B3GNT8 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 8) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and O-linked glycosylation. Gene Ontology (GO) annotations related to this gene include galactosyltransferase activity and protein N-acetylglucosaminyltransferase activity. An important paralog of this gene is B3GNT2.

UniProtKB/Swiss-Prot for B3GNT8 Gene

  • Beta-1,3-N-acetylglucosaminyltransferase that plays a role in the elongation of specific branch structures of multiantennary N-glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans.

Additional gene information for B3GNT8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GNT8 Gene

Genomics for B3GNT8 Gene

GeneHancer (GH) Regulatory Elements for B3GNT8 Gene

Promoters and enhancers for B3GNT8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I041424 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.8 1844 5 HDGF FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF766 GLIS2 ENSG00000268475 B3GNT8 TMEM91 EXOSC5 DMAC2 ZNF574 SPTBN4 BCKDHA TGFB1 MEGF8
GH19I041217 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.2 +205.8 205783 10.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF302 ZNF416 AXL ENSG00000269652 ZNF574 ZNF526 SNRPA ENSG00000269843 HNRNPUL1 CYP2G1P CCDC97 ENSG00000268366
GH19I041440 Promoter/Enhancer 1.1 EPDnew ENCODE 9.3 -13.9 -13860 3.5 ZNF639 ELF3 KLF1 CLOCK ZC3H11A ELF1 NFIC ZNF366 GLIS1 IKZF1 ERICH4 ENSG00000277136 ZNF526 EXOSC5 ENSG00000269843 SNRPA HNRNPUL1 CCDC97 ZNF574 B3GNT8
GH19I041135 Enhancer 0.6 FANTOM5 Ensembl ENCODE 5 +293.0 292955 1.8 PIR51429 CYP2T3P CYP2F1 ENSG00000205041 B3GNT8 BCKDHA
GH19I041430 Enhancer 1.5 VISTA ENCODE dbSUPER 0.8 -2.9 -2946 2.4 HDAC1 HDGF ATF1 ARNT ZSCAN4 ZNF133 GLI4 RAD21 YY1 TCF12 SNRPA CCDC97 ZNF526 EXOSC5 HNRNPUL1 ENSG00000269843 ITPKC ZNF574 B9D2 TGFB1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around B3GNT8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the B3GNT8 gene promoter:

Genomic Locations for B3GNT8 Gene

Genomic Locations for B3GNT8 Gene
3,498 bases
Minus strand

Genomic View for B3GNT8 Gene

Genes around B3GNT8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
B3GNT8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for B3GNT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B3GNT8 Gene

Proteins for B3GNT8 Gene

  • Protein details for B3GNT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
    Protein Accession:

    Protein attributes for B3GNT8 Gene

    397 amino acids
    Molecular mass:
    43396 Da
    Quaternary structure:
    • Interacts with B3GNT2; this interaction greatly increases B3GNT2 catalytic activity, independently of B3GNT8 enzymatic activity.

neXtProt entry for B3GNT8 Gene

Post-translational modifications for B3GNT8 Gene

  • Glycosylation at Asn57
  • Modification sites at PhosphoSitePlus

Other Protein References for B3GNT8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for B3GNT8 Gene

Domains & Families for B3GNT8 Gene

Gene Families for B3GNT8 Gene

Protein Domains for B3GNT8 Gene

Suggested Antigen Peptide Sequences for B3GNT8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 31 family.
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with B3GNT8: view

Function for B3GNT8 Gene

Molecular function for B3GNT8 Gene

UniProtKB/Swiss-Prot Function:
Beta-1,3-N-acetylglucosaminyltransferase that plays a role in the elongation of specific branch structures of multiantennary N-glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans.
UniProtKB/Swiss-Prot Induction:
Up-regulated in colon cancer.

Enzyme Numbers (IUBMB) for B3GNT8 Gene

Phenotypes From GWAS Catalog for B3GNT8 Gene

Gene Ontology (GO) - Molecular Function for B3GNT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008378 galactosyltransferase activity IEA --
GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity TAS --
GO:0016262 protein N-acetylglucosaminyltransferase activity IDA 15620693
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with B3GNT8: view
genes like me logo Genes that share phenotypes with B3GNT8: view

Animal Model Products

miRNA for B3GNT8 Gene

miRTarBase miRNAs that target B3GNT8

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for B3GNT8 Gene

Localization for B3GNT8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GNT8 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for B3GNT8 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
lysosome 1

Gene Ontology (GO) - Cellular Components for B3GNT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA,IDA 23533145
genes like me logo Genes that share ontologies with B3GNT8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for B3GNT8 Gene

Pathways & Interactions for B3GNT8 Gene

genes like me logo Genes that share pathways with B3GNT8: view

UniProtKB/Swiss-Prot Q7Z7M8-B3GN8_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for B3GNT8 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 21)
Selected Interacting proteins: Q7Z7M8-B3GN8_HUMAN ENSP00000312700 for B3GNT8 Gene via IID STRING

Gene Ontology (GO) - Biological Process for B3GNT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0016266 O-glycan processing TAS --
GO:0030311 poly-N-acetyllactosamine biosynthetic process IDA 15620693
genes like me logo Genes that share ontologies with B3GNT8: view

No data available for SIGNOR curated interactions for B3GNT8 Gene

Drugs & Compounds for B3GNT8 Gene

(1) Additional Compounds for B3GNT8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 2-(Acetylamino)-2-deoxy-4-O-beta-D-galactopyranosyl-D-Glucose
  • 2-(Acetylamino)-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose homopolymer
  • N-Acetyl-4-O-beta-D-galactopyranosyl-D-glucosamine
  • N-Acetyl-lactosamine
  • O-beta-D-Galactopyranosyl-(14)-2-deoxy-2-acetamido-D-glucose
genes like me logo Genes that share compounds with B3GNT8: view

Transcripts for B3GNT8 Gene

mRNA/cDNA for B3GNT8 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for B3GNT8 Gene

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for B3GNT8 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c
SP2: -

Relevant External Links for B3GNT8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for B3GNT8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for B3GNT8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B3GNT8 Gene

This gene is overexpressed in Whole Blood (x20.1) and Esophagus - Mucosa (x7.4).

Protein differential expression in normal tissues from HIPED for B3GNT8 Gene

This gene is overexpressed in Serum (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for B3GNT8 Gene

Protein tissue co-expression partners for B3GNT8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of B3GNT8 Gene:


SOURCE GeneReport for Unigene cluster for B3GNT8 Gene:


mRNA Expression by UniProt/SwissProt for B3GNT8 Gene:

Tissue specificity: Highly expressed in small intestine, pancreas, spleen, bone marrow, lung, throat, and ileum, and weakly in fetal brain, cerebellum, heart, liver, tongue, breast, uteri, and testis. Not detected in colon. Differentially expressed in human tumor cell lines.
genes like me logo Genes that share expression patterns with B3GNT8: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for B3GNT8 Gene

Orthologs for B3GNT8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for B3GNT8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia B3GNT8 33 34
  • 99.5 (n)
(Bos Taurus)
Mammalia B3GNT8 33 34
  • 85.47 (n)
(Canis familiaris)
Mammalia B3GNT8 33
  • 84.05 (n)
(Rattus norvegicus)
Mammalia B3gnt8 33
  • 80.81 (n)
(Mus musculus)
Mammalia B3gnt8 33 16 34
  • 80.38 (n)
(Monodelphis domestica)
Mammalia B3GNT8 34
  • 64 (a)
(Anolis carolinensis)
Reptilia B3GNT8 34
  • 39 (a)
(Danio rerio)
Actinopterygii b3gnt2l 34
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.163 34
  • 21 (a)
Species where no ortholog for B3GNT8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for B3GNT8 Gene

Gene Tree for B3GNT8 (if available)
Gene Tree for B3GNT8 (if available)

Paralogs for B3GNT8 Gene

(6) SIMAP similar genes for B3GNT8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with B3GNT8: view

Variants for B3GNT8 Gene

Sequence variations from dbSNP and Humsavar for B3GNT8 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs10421626 likely-benign, Maple syrup urine disease 41,424,917(-) A/G downstream_transcript_variant
rs528816040 uncertain-significance, Maple syrup urine disease 41,424,942(-) C/T downstream_transcript_variant
rs564517344 uncertain-significance, Maple syrup urine disease 41,424,932(-) G/A downstream_transcript_variant
rs886054463 uncertain-significance, Maple syrup urine disease 41,424,943(-) G/A downstream_transcript_variant
rs886054464 uncertain-significance, Maple syrup urine disease 41,424,973(-) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for B3GNT8 Gene

Variant ID Type Subtype PubMed ID
nsv953578 CNV deletion 24416366

Variation tolerance for B3GNT8 Gene

Residual Variation Intolerance Score: 60.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for B3GNT8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B3GNT8 Gene

Disorders for B3GNT8 Gene

Additional Disease Information for B3GNT8

No disorders were found for B3GNT8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B3GNT8 Gene

Publications for B3GNT8 Gene

  1. A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer. (PMID: 15620693) Ishida H … Narimatsu H (FEBS letters 2005) 3 4 22 58
  2. Cloning and tissue distribution of the human B3GALT7 gene, a member of the beta1,3-Glycosyltransferase family. (PMID: 15486459) Huang C … Yu L (Glycoconjugate journal 2004) 2 3 4 58
  3. Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells. (PMID: 18826941) Seko A … Yamashita K (The Journal of biological chemistry 2008) 3 4 58
  4. Transcription factor c-jun regulates β3Gn-T8 expression in gastric cancer cell line SGC-7901. (PMID: 27459970) Jiang Z … Wu S (Oncology reports 2016) 3 58
  5. β3GnT8 regulates the metastatic potential of colorectal carcinoma cells by altering the glycosylation of CD147. (PMID: 24573103) Ni J … Wu S (Oncology reports 2014) 3 58

Products for B3GNT8 Gene

Sources for B3GNT8 Gene

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