Aliases for B3GNT2 Gene
Aliases for B3GNT2 Gene
- UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 2 2 3 4 5
- UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 1 2 3
- Beta3Gn-T1 3 4
- Beta3Gn-T2 3 4
- B3GNT1 3 4
- BGnT-2 3 4
- UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,3-Galactosyltransferase 7 4
- N-Acetyllactosaminide Beta-1,3-N-Acetylglucosaminyltransferase 2 3
- UDP-Gal:Beta-GlcNAc Beta-1,3-Galactosyltransferase 7 4
- Beta-1,3-N-Acetylglucosaminyltransferase BGnT-1 3
- Beta-1,3-N-Acetylglucosaminyltransferase BGnT-2 3
- Beta-1,3-N-Acetylglucosaminyltransferase 1 4
- Beta-1,3-N-Acetylglucosaminyltransferase 2 4
- Beta-1,3-Galactosyltransferase 7 4
- Beta-1,3-GalTase 7 4
- Beta-1,3-Gn-T1 4
- Beta-1,3-Gn-T2 4
External Ids for B3GNT2 Gene
- HGNC: 15629
- Entrez Gene: 10678
- Ensembl: ENSG00000170340
- OMIM: 605581
- UniProtKB: Q9NY97
Previous HGNC Symbols for B3GNT2 Gene
- B3GNT1
Previous GeneCards Identifiers for B3GNT2 Gene
- GC02P062276
- GC02P062423
Summaries for B3GNT2 Gene
-
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2016]
GeneCards Summary for B3GNT2 Gene
B3GNT2 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 2) is a Protein Coding gene. Diseases associated with B3GNT2 include Kidney Fibrosarcoma and Walker-Warburg Syndrome. Among its related pathways are O-linked glycosylation and Metabolism. Gene Ontology (GO) annotations related to this gene include galactosyltransferase activity and N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity. An important paralog of this gene is B3GNT9.
UniProtKB/Swiss-Prot for B3GNT2 Gene
-
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase.
Additional gene information for B3GNT2 Gene
- Monarch Initiative
- Search for B3GNT2 at DataMed
- Search for B3GNT2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GNT2 Gene
Genomics for B3GNT2 Gene
GeneHancer (GH) Regulatory Elements for B3GNT2 Gene
Promoters and enhancers for B3GNT2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02J062194 | Promoter/Enhancer | 2.5 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 654.7 | +1.6 | 1574 | 7.1 | HDGF FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 | B3GNT2 XPO1 USP34 LOC105377633 GC02P062192 MIR5192 GC02M062151 | |
| GH02J062214 | Promoter/Enhancer | 1.5 | EPDnew Ensembl ENCODE | 662.7 | +22.1 | 22140 | 6.7 | HDAC1 DNMT3B GATA2 EGR1 ZFP91 RCOR1 FOS CEBPB ZNF592 NR2F2 | B3GNT2 MIR5192 RN7SL51P GC02M062151 | |
| GH02J062000 | Promoter | 0.7 | EPDnew | 650.1 | -195.3 | -195259 | 0.1 | CTCF SCRT2 | GC02P062000 B3GNT2 GC02P062003 COMMD1 | |
| GH02J062135 | Promoter | 0.5 | EPDnew | 661.4 | -60.2 | -60174 | 0.1 | B3GNT2 ENSG00000229839 RPSAP26 GC02P062003 COMMD1 | ||
| GH02J062302 | Enhancer | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 29.6 | +110.4 | 110375 | 8 | HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 IRF4 ZNF766 FOS JUNB | B3GNT2 GC02M062151 LOC105374761 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around B3GNT2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for B3GNT2 Gene
Genomic Locations for B3GNT2 Gene
- chr2:62,196,113-62,224,731
- (GRCh38/hg38)
- Size:
- 28,619 bases
- Orientation:
- Plus strand
- chr2:62,423,248-62,451,866
- (GRCh37/hg19)
Genomic View for B3GNT2 Gene
Genes around B3GNT2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p15 by Entrez Gene
- 2p15 by HGNC
- 2p15 by Ensembl
B3GNT2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for B3GNT2 Gene
Proteins for B3GNT2 Gene
-
Protein details for B3GNT2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NY97-B3GN2_HUMAN
- Recommended name:
- N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
- Protein Accession:
- Q9NY97
- Q54AC1
- Q9NQQ9
- Q9NQR0
- Q9NUT9
Protein attributes for B3GNT2 Gene
- Size:
- 397 amino acids
- Molecular mass:
- 46022 Da
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Interacts with B3GNT8; this interaction greatly increases B3GNT2 catalytic activity, independently of B3GNT8 enzymatic activity.
- SequenceCaution:
-
- Sequence=BAA92031.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for B3GNT2 Gene
Post-translational modifications for B3GNT2 Gene
Other Protein References for B3GNT2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for B3GNT2 ("Beta-1,3-N-Acetylglucosaminyltransferase 2/B3GNT2")
- Novus Biologicals Antibodies for B3GNT2
- Invitrogen Antibodies for B3GNT2
- GeneTex B3GNT2 Antibody for B3GNT2
-
Boster Bio Antibodies for B3GNT2
-
Santa Cruz Biotechnology (SCBT) Antibodies for B3GNT2
Protein Products
- R&D Systems Proteins and Enzymes for B3GNT2 ("Beta-1,3-N-Acetylglucosaminyltransferase 2/B3GNT2")
-
OriGene Purified Proteins for B3GNT2
- Search Origene for MassSpec and Protein Over-expression Lysates for B3GNT2
- Origene Custom Protein Services for B3GNT2
- Sino Biological Cell Lysates for B3GNT2
- Sino Biological Recombinant Proteins for B3GNT2
- ProSpec Recombinant Proteins for B3GNT2
- Search GeneTex for Proteins for B3GNT2
Assay Products
- antibodies-online: Search results for 1 available B3GNT2 Elisa Kits ranked by validation data
- Compare Top B3GNT2 Elisa Kits
-
Recommended
No data available for DME Specific Peptides for B3GNT2 Gene
Domains & Families for B3GNT2 Gene
Gene Families for B3GNT2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted membrane proteins
Protein Domains for B3GNT2 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for B3GNT2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NY97- Family:
-
- Belongs to the glycosyltransferase 31 family.
Function for B3GNT2 Gene
Molecular function for B3GNT2 Gene
- UniProtKB/Swiss-Prot Function:
- Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase.
- UniProtKB/Swiss-Prot CatalyticActivity:
- UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R.
Enzyme Numbers (IUBMB) for B3GNT2 Gene
Phenotypes From GWAS Catalog for B3GNT2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008375 | acetylglucosaminyltransferase activity | IBA | -- |
| GO:0008376 | acetylgalactosaminyltransferase activity | IBA | -- |
| GO:0008378 | galactosyltransferase activity | IEA | -- |
| GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity | TAS | -- |
| GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity | TAS,IEA | -- |
Phenotypes for B3GNT2 Gene
- MGI mutant phenotypes for B3GNT2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for B3GNT2:
Animal Models for B3GNT2 Gene
- MGI Knock Outs for B3GNT2:
-
- B3gnt2 B3gnt2<tm1Dgen>
Animal Model Products
-
Taconic Biosciences Mouse Models for B3GNT2
- Cyagen custom Knockout/knockin (KOKI) mouse models for B3GNT2
-
CRISPR Products
-
OriGene CRISPR knockouts for B3GNT2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for B3GNT2
- genomics-online: gRNA clones - Search results for available B3GNT2 gene related products
- Applied Biological Materials CRISPR for B3GNT2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for B3GNT2
- GenScript: Design CRISPR guide RNA sequences for B3GNT2
miRNA for B3GNT2 Gene
- miRTarBase miRNAs that target B3GNT2
-
- hsa-mir-124-3p (MIRT022296)
- hsa-mir-1-3p (MIRT023499)
- hsa-mir-15a-5p (MIRT089105)
- hsa-mir-16-5p (MIRT089106)
- hsa-mir-95-5p (MIRT089107)
- hsa-mir-103a-3p (MIRT089108)
- hsa-mir-107 (MIRT089109)
- hsa-mir-15b-5p (MIRT089110)
- hsa-mir-195-5p (MIRT089111)
- hsa-mir-424-5p (MIRT089112)
- hsa-mir-497-5p (MIRT089113)
- hsa-mir-568 (MIRT089114)
- hsa-mir-643 (MIRT089115)
- hsa-mir-3607-5p (MIRT089116)
- hsa-mir-5583-3p (MIRT089117)
- hsa-mir-6792-5p (MIRT089118)
- hsa-mir-6838-5p (MIRT089119)
- hsa-mir-10a-3p (MIRT303046)
- hsa-mir-590-3p (MIRT303047)
- hsa-mir-888-5p (MIRT303048)
- hsa-mir-875-3p (MIRT303049)
- hsa-mir-1299 (MIRT303051)
- hsa-mir-6128 (MIRT303052)
- hsa-mir-2467-5p (MIRT481089)
- hsa-mir-4756-3p (MIRT481090)
- hsa-mir-3919 (MIRT481091)
- hsa-mir-4699-3p (MIRT481092)
- hsa-mir-6856-5p (MIRT481093)
- hsa-mir-6758-5p (MIRT481094)
- hsa-mir-24-3p (MIRT481095)
- hsa-mir-1248 (MIRT559273)
- hsa-mir-5706 (MIRT559274)
- hsa-mir-4782-5p (MIRT559275)
- hsa-mir-516b-5p (MIRT559276)
- hsa-mir-183-5p (MIRT559277)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for B3GNT2
- Browse OriGene Inhibitory RNA Products For B3GNT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for B3GNT2
- genomics-online: shRNA clones - Search results for available B3GNT2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for B3GNT2
- VectorBuilder custom plasmid, inducible vectors for B3GNT2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for B3GNT2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for B3GNT2
- genomics-online: cdna clones - Search results for available B3GNT2 gene related products
- orf clones - Search results for available B3GNT2 gene related products
- Applied Biological Materials Clones for B3GNT2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for B3GNT2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for B3GNT2 Gene
Localization for B3GNT2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for B3GNT2 Gene
- Golgi apparatus membrane; Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| golgi apparatus | 5 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005783 | endoplasmic reticulum | IBA | -- |
| GO:0005794 | Golgi apparatus | IEA,IBA | -- |
| GO:0016020 | membrane | IEA,IBA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for B3GNT2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Keratan sulfate/keratin metabolism | ||
| 2 | Metabolism |
.37
|
|
| 3 | Glycosaminoglycan metabolism | ||
| 4 | Metabolism of proteins | ||
| 5 | O-linked glycosylation | ||
Pathways by source for B3GNT2 Gene
9 Reactome pathways for B3GNT2 Gene
3 KEGG pathways for B3GNT2 Gene
UniProtKB/Swiss-Prot Q9NY97-B3GN2_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for B3GNT2 Gene
GPS-Prot Interaction Network for B3GNT2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006486 | protein glycosylation | IEA,IBA | -- |
| GO:0006493 | protein O-linked glycosylation | IBA | -- |
| GO:0007411 | axon guidance | IEA | -- |
| GO:0007608 | sensory perception of smell | IEA | -- |
| GO:0016266 | O-glycan processing | TAS | -- |
No data available for SIGNOR curated interactions for B3GNT2 Gene
Transcripts for B3GNT2 Gene
mRNA/cDNA for B3GNT2 Gene
- (124) Selected AceView cDNA sequences:
- (8) Additional mRNA sequences :
- (4) REFSEQ mRNAs :
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000301998 2763 bps (uc002sbs.4)
- ENST00000405767 2436 bps (uc061jpq.1)
Unigene Clusters for B3GNT2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for B3GNT2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for B3GNT2
- genomics-online: gRNA clones - Search results for available B3GNT2 gene related products
- Applied Biological Materials CRISPR for B3GNT2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for B3GNT2
- GenScript: Design CRISPR guide RNA sequences for B3GNT2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for B3GNT2
- Browse OriGene Inhibitory RNA Products For B3GNT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for B3GNT2
- genomics-online: shRNA clones - Search results for available B3GNT2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for B3GNT2
- VectorBuilder custom plasmid, inducible vectors for B3GNT2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for B3GNT2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for B3GNT2
- genomics-online: cdna clones - Search results for available B3GNT2 gene related products
- orf clones - Search results for available B3GNT2 gene related products
- Applied Biological Materials Clones for B3GNT2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for B3GNT2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Mature Rod Bipolar Cells Inner Nuclear Layer
-
Neurons
- Mature Rod Bipolar Cells Inner Nuclear Layer
- Brain (Nervous System)
- Neural Tube (Nervous System)
This gene is overexpressed in Serum (47.4) and Plasma (15.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for B3GNT2 Gene
NURSA nuclear receptor signaling pathways regulating expression of B3GNT2 Gene:
B3GNT2SOURCE GeneReport for Unigene cluster for B3GNT2 Gene:
Hs.173203mRNA Expression by UniProt/SwissProt for B3GNT2 Gene:
Q9NY97-B3GN2_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for B3GNT2 Gene
- Nervous system(4.1)
- Bone marrow(4)
Primer Products
-
OriGene qPCR primer pairs and template standards for B3GNT2
-
OriGene qPCR primer pairs for B3GNT2
- genomics-online: primer clones - Search results for available B3GNT2 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for B3GNT2 Gene
Orthologs for B3GNT2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | B3GNT2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | B3GNT2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | B3GNT2 34 33 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | B3gnt2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | B3gnt2 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | B3GNT2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | B3GNT2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | B3GNT2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | B3GNT2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | b3gnt2 33 |
|
||
| Str.7170 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | b3gnt2b 34 33 |
|
OneToMany | |
| b3gnt2a 34 |
|
OneToMany | |||
| B3GNT2 (2 of 4) 34 |
|
OneToMany | |||
| B3GNT2 (3 of 4) 34 |
|
OneToMany | |||
| wufa55h04 33 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.163 34 |
|
OneToMany |
- Species where no ortholog for B3GNT2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for B3GNT2 Gene
- ENSEMBL:
- Gene Tree for B3GNT2 (if available)
- TreeFam:
- Gene Tree for B3GNT2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for B3GNT2: view image
Paralogs for B3GNT2 Gene
Paralogs for B3GNT2 Gene
(8) SIMAP similar genes for B3GNT2 Gene using alignment to 1 proteins:
- B3GN2_HUMAN
Pseudogenes.org Pseudogenes for B3GNT2 Gene
Variants for B3GNT2 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000026275 | -- | 62,214,248(+) | G/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000065201 | -- | 62,213,040(+) | G/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000087316 | -- | 62,220,543(+) | A/G | intron_variant | |
| rs1000103210 | -- | 62,221,937(+) | T/C | intron_variant | |
| rs1000148909 | -- | 62,209,182(+) | A/G | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1000005 | CNV | gain | 25217958 |
| nsv1143939 | CNV | deletion | 24896259 |
| nsv582123 | CNV | gain | 21841781 |
| nsv7313 | OTHER | inversion | 18451855 |
Residual Variation Intolerance Score:
36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.83;
17.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for B3GNT2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- B3GNT2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B3GNT2 Gene
Disorders for B3GNT2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| kidney fibrosarcoma |
|
|
| walker-warburg syndrome |
|
|
Search B3GNT2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for B3GNT2
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for B3GNT2 Gene
Publications for B3GNT2 Gene
- Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family. (PMID: 11042166) Shiraishi N … Sasaki K (The Journal of biological chemistry 2001) 2 3 4 22 58
- A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases. (PMID: 9892646) Zhou D … Hennet T (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3 4 22 58
- B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of α-dystroglycan. (PMID: 25279697) Praissman JL … Wells L (eLife 2014) 3 4 58
- Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PMID: 22446963) Okada Y … Yamamoto K (Nature genetics 2012) 3 44 58
- Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. (PMID: 20062062) Australo-Anglo-American Spondyloarthritis Consortium (TASC) … Brown MA (Nature genetics 2010) 3 44 58
Products for B3GNT2 Gene
- R&D Systems Antibodies for B3GNT2 ("Beta-1,3-N-Acetylglucosaminyltransferase 2/B3GNT2")
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- antibodies-online: Search results for 32 available B3GNT2 Antibodies ranked by validation data
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