This gene encodes a member of a family of membrane-bound glycoproteins. The encoded protein may synthesize type 1 Lewis antigens, which are elevated in gastrointestinal and pancreatic cancers. Alternatively spliced transcript variants using multiple alternate promoters have been observed for this gene. [provided by RefSeq, Sep 2017] See more...
Aliases for B3GALT5 Gene
Aliases for B3GALT5 Gene
- Beta-1,3-Galactosyltransferase 5 2 3 4 5
- UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,3-Galactosyltransferase 5 3 4
- UDP-Gal:BetaGlcNAc Beta 1,3-Galactosyltransferase, Polypeptide 5 2 3
- Homolog Of C. Elegans Bt Toxin Resistance Gene Bre-5 2 3
- Beta-1,3-GalTase 5 3 4
- Beta-3-Gx-T5 3 4
- Beta3Gal-T5 3 4
- UDP-Gal:Beta-GlcNAc Beta-1,3-Galactosyltransferase 5 4
- UDP-Gal:BetaGlcNAc Beta 1,3-Galactosyltransferase 5 2
External Ids for B3GALT5 Gene
- HGNC: 920
- Entrez Gene: 10317
- Ensembl: ENSG00000183778
- OMIM: 604066
- UniProtKB: Q9Y2C3
Previous GeneCards Identifiers for B3GALT5 Gene
- GC21P037603
- GC21P039950
- GC21P039949
- GC21P039951
- GC21P040928
- GC21P026498
Summaries for B3GALT5 Gene
-
This gene encodes a member of a family of membrane-bound glycoproteins. The encoded protein may synthesize type 1 Lewis antigens, which are elevated in gastrointestinal and pancreatic cancers. Alternatively spliced transcript variants using multiple alternate promoters have been observed for this gene. [provided by RefSeq, Sep 2017]
GeneCards Summary for B3GALT5 Gene
B3GALT5 (Beta-1,3-Galactosyltransferase 5) is a Protein Coding gene. Among its related pathways are Metabolism and Globo Sphingolipid Metabolism. Gene Ontology (GO) annotations related to this gene include galactosyltransferase activity and UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. An important paralog of this gene is B3GALT1.
UniProtKB/Swiss-Prot Summary for B3GALT5 Gene
-
Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor.
Additional gene information for B3GALT5 Gene
- Monarch Initiative
- Search for B3GALT5 at DataMed
- Search for B3GALT5 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for B3GALT5 Gene
Genomics for B3GALT5 Gene
GeneHancer (GH) Regulatory Elements for B3GALT5 Gene
Promoters and enhancers for B3GALT5 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH21J039656 | Promoter/Enhancer | 0.9 | EPDnew Ensembl ENCODE dbSUPER | 756 | +100.8 | 100786 | 1.8 | SCRT2 | B3GALT5 RF00994-605 piR-60331 lnc-IGSF5-3 ENSG00000225330 | |
| GH21J039556 | Enhancer | 0.3 | Ensembl | 750.6 | -0.1 | -141 | 1 | RFX1 BMI1 | B3GALT5 lnc-SH3BGR-3 B3GALT5-AS1 LCA5L piR-42002-010 | |
| GH21J039608 | Promoter | 0.3 | EPDnew | 750.2 | +52.2 | 52182 | 0.1 | piR-43325-061 B3GALT5 B3GALT5-AS1 lnc-SH3BGR-5 | ||
| GH21J039673 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 23.1 | +119.0 | 119006 | 4.1 | SP1 SREBF1 HLF CREB1 POLR2A CTBP1 MNT SCRT2 SCRT1 BCL11A | B3GALT5 B3GALT5-AS1 SH3BGR piR-60331 ENSG00000225330 IGSF5 | |
| GH21J039527 | Enhancer | 1 | Ensembl ENCODE dbSUPER | 24 | -28.3 | -28341 | 2.6 | NR2F6 ZNF217 MNT NFIB SP1 MAFK RXRA REST CTBP1 ZNF316 | B3GALT5 LCA5L SH3BGR LOC729056 lnc-SH3BGR-1 piR-36588-257 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around B3GALT5 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the B3GALT5 gene promoter:
-
- ATF6
- c-Myc
- FOXL1
- Lmo2
- Max1
- p53
- RORalpha1
- RP58
- Sox9
- SRY
Genomic Locations for B3GALT5 Gene
Genomic Locations for B3GALT5 Gene
- chr21:39,556,442-39,673,137
- (GRCh38/hg38)
- Size:
- 116,696 bases
- Orientation:
- Plus strand
- chr21:40,928,369-41,045,064
- (GRCh37/hg19)
- Size:
- 116,696 bases
- Orientation:
- Plus strand
Genomic View for B3GALT5 Gene
Genes around B3GALT5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.2 by HGNC
- 21q22.2 by Entrez Gene
- 21q22.2 by Ensembl
B3GALT5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for B3GALT5 Gene
Proteins for B3GALT5 Gene
-
Protein details for B3GALT5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y2C3-B3GT5_HUMAN
- Recommended name:
- Beta-1,3-galactosyltransferase 5
- Protein Accession:
- Q9Y2C3
- A8KA86
- D3DSI3
- Q2M3L5
- Q53Z19
- Q9NY96
- Q9P1X6
- Q9P1X7
Protein attributes for B3GALT5 Gene
- Size:
- 310 amino acids
- Molecular mass:
- 36189 Da
- Quaternary structure:
- No Data Available
Protein Expression for B3GALT5 Gene
Selected DME Specific Peptides for B3GALT5 Gene
- Q9Y2C3:
-
- TTRFFTG
- YLTELLLKKN
- AIRQTWG
- GALCLYFSM
- VMKTDSD
- IKLEDVFVGLCL
- PPFLVLLVTSSHKQLA
- FCSGTGY
Post-translational modifications for B3GALT5 Gene
Other Protein References for B3GALT5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ B3GALT5 Antibody
- Atlas Antibodies Anti-B3GALT5 Antibody (HPA054684) and Anti-B3GALT5 Antibody (HPA054092)
-
Custom Antibody ServicesOriGene Antibodies for B3GALT5
- Novus Biologicals Antibodies for B3GALT5
-
Abcam antibodies for B3GALT5
- Invitrogen Antibodies for B3GALT5 (AFLGC-B3GALT5)
Protein Products
- Atlas Antibodies PrEST Antigen B3GALT5 (APrEST85728) and PrEST Antigen B3GALT5 (APrEST85729)
-
OriGene Purified Proteins for B3GALT5
- Search Origene for MassSpec and Protein Over-expression Lysates for B3GALT5
- Origene Custom Protein Services for B3GALT5
- Sino Biological Recombinant Proteins for B3GALT5
- Sino Biological Cell Lysates for B3GALT5
- antibodies-online: Show 14 available B3GALT5 Proteins ranked by validation data
- Compare Top B3GALT5 Proteins
-
Quality Products:
-
Abcam proteins for B3GALT5
Assay Products
Domains & Families for B3GALT5 Gene
Gene Families for B3GALT5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for B3GALT5 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for B3GALT5 Gene
- GenScript: Design optimal peptide antigens:
-
- UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5 (B3GT5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y2C3- Family:
-
- Belongs to the glycosyltransferase 31 family.
Function for B3GALT5 Gene
Molecular function for B3GALT5 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor.
- GENATLAS Biochemistry:
- UDP galactose
Enzyme Numbers (IUBMB) for B3GALT5 Gene
Phenotypes From GWAS Catalog for B3GALT5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008376 | acetylgalactosaminyltransferase activity | IBA | 21873635 |
| GO:0008378 | galactosyltransferase activity | IEA | -- |
| GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity | IBA,TAS | 21873635 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
Phenotypes for B3GALT5 Gene
- MGI mutant phenotypes for B3GALT5:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for B3GALT5:
Animal Models for B3GALT5 Gene
- MGI Knock Outs for B3GALT5:
-
- B3galt5 B3galt5<tm1Dgen>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for B3GALT5 - Select products 50% OFF >
- * B3GALT5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * B3GALT5 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for B3GALT5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for B3GALT5
- genomics-online: gRNA clones - Search for available B3GALT5 gRNA products
- Overview of 133 available B3GALT5 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for B3GALT5
miRNA for B3GALT5 Gene
- miRTarBase miRNAs that target B3GALT5
-
- hsa-mir-6780a-5p (MIRT487670)
- hsa-mir-6779-5p (MIRT487671)
- hsa-mir-3689c (MIRT487672)
- hsa-mir-3689b-3p (MIRT487673)
- hsa-mir-3689a-3p (MIRT487674)
- hsa-mir-30b-3p (MIRT487675)
- hsa-mir-1273h-5p (MIRT487676)
- hsa-mir-6799-5p (MIRT487677)
- hsa-mir-6825-5p (MIRT487678)
- hsa-mir-6883-5p (MIRT487679)
- hsa-mir-6785-5p (MIRT487680)
- hsa-mir-4728-5p (MIRT487681)
- hsa-mir-149-3p (MIRT487682)
- hsa-mir-7106-5p (MIRT487683)
- hsa-mir-4261 (MIRT487684)
- hsa-mir-6871-5p (MIRT487685)
- hsa-mir-6783-5p (MIRT487686)
- hsa-mir-6885-3p (MIRT527896)
- hsa-mir-3977 (MIRT527897)
- hsa-mir-1251-3p (MIRT527898)
- hsa-mir-7162-5p (MIRT527899)
- hsa-mir-516b-3p (MIRT527900)
- hsa-mir-516a-3p (MIRT527901)
- hsa-mir-2115-5p (MIRT527902)
- hsa-mir-7152-5p (MIRT527903)
- hsa-mir-3074-5p (MIRT527904)
- hsa-mir-1200 (MIRT527905)
- hsa-mir-378a-5p (MIRT527906)
- hsa-mir-4465 (MIRT527907)
- hsa-mir-26b-5p (MIRT527908)
- hsa-mir-26a-5p (MIRT527909)
- hsa-mir-1297 (MIRT527910)
- hsa-mir-4540 (MIRT527911)
- hsa-mir-6723-5p (MIRT527912)
- hsa-mir-4682 (MIRT527913)
- hsa-mir-544b (MIRT527914)
- hsa-mir-4324 (MIRT527915)
- hsa-mir-5697 (MIRT527916)
- hsa-mir-6790-5p (MIRT610215)
- hsa-mir-4658 (MIRT610216)
- hsa-mir-3941 (MIRT610217)
- hsa-mir-644a (MIRT610218)
- hsa-mir-3659 (MIRT610219)
- hsa-mir-574-5p (MIRT610220)
- hsa-mir-622 (MIRT610221)
- hsa-mir-603 (MIRT610222)
- hsa-mir-362-3p (MIRT615470)
- hsa-mir-329-3p (MIRT615471)
- hsa-mir-8485 (MIRT615472)
- hsa-mir-6818-3p (MIRT624602)
- hsa-mir-6888-3p (MIRT624603)
- hsa-mir-376b-3p (MIRT624604)
- hsa-mir-376a-3p (MIRT624605)
- hsa-mir-593-3p (MIRT624606)
- hsa-mir-6895-3p (MIRT624607)
- hsa-mir-3120-5p (MIRT624608)
- hsa-mir-6739-3p (MIRT624609)
- hsa-mir-4677-5p (MIRT624610)
- hsa-mir-7156-5p (MIRT624611)
- hsa-mir-4273 (MIRT624612)
- hsa-mir-502-5p (MIRT624613)
- hsa-mir-22-5p (MIRT624614)
- hsa-mir-2116-5p (MIRT624615)
- hsa-mir-8064 (MIRT624616)
- hsa-mir-4693-3p (MIRT635299)
- hsa-mir-4712-3p (MIRT635300)
- hsa-mir-2681-5p (MIRT660393)
- hsa-mir-6720-5p (MIRT660394)
- hsa-mir-6512-3p (MIRT660395)
- hsa-mir-5100 (MIRT660396)
- hsa-mir-4777-3p (MIRT660397)
- hsa-mir-6758-3p (MIRT660398)
- hsa-mir-4267 (MIRT660399)
- hsa-mir-10b-3p (MIRT660400)
- hsa-mir-892c-5p (MIRT660401)
- hsa-mir-141-5p (MIRT660402)
- hsa-mir-566 (MIRT662532)
- hsa-mir-6789-3p (MIRT662533)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for B3GALT5
- Browse OriGene Inhibitory RNA Products For B3GALT5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for B3GALT5
- genomics-online: shRNA clones - Search for available B3GALT5 shRNA products
- Overview of 133 available B3GALT5 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for B3GALT5 - Select products 50% OFF >
- * B3GALT5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * B3GALT5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG204357
- MG216786
- MR204357
- MR204357L3
- MR204357L3V
- MR204357L4
- MR204357L4V
- MR216786
- MR216786L3
- MR216786L3V
- MR216786L4
- MR216786L4V
- RC211183
- RC211183L3
- RC211183L3V
- RC211183L4
- RC211183L4V
- RC213317
- RC213317L3
- RC213317L3V
- RC213317L4
- RC213317L4V
- RC214669
- RC214669L3
- RC214669L3V
- RC214669L4
- RC214669L4V
- RC214721
- RC214721L3
- RC214721L3V
- RC214721L4
- RC214721L4V
- RC215430
- RC215430L3
- RC215430L3V
- RC215430L4
- RC215430L4V
- RC237364
- RG211183
- RG213317
- RG214669
- RG214721
- RG215430
- RR206042
- RR206042L3
- RR206042L3V
- RR206042L4
- RR206042L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for B3GALT5
- Addgene plasmids for B3GALT5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for B3GALT5
Cell Line Products
-
Horizon Cell Lines for B3GALT5
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for B3GALT5 Gene
Localization for B3GALT5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for B3GALT5 Gene
- Golgi apparatus membrane; Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 4 |
| extracellular | 3 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IBA | 21873635 |
| GO:0005794 | Golgi apparatus | IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for B3GALT5 Gene
Pathways & Interactions for B3GALT5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Globo Sphingolipid Metabolism | ||
| 2 | Glycosphingolipid biosynthesis - lacto and neolacto series | ||
| 3 | Metabolism | ||
Pathways by source for B3GALT5 Gene
1 BioSystems pathway for B3GALT5 Gene
3 KEGG pathways for B3GALT5 Gene
UniProtKB/Swiss-Prot Q9Y2C3-B3GT5_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for B3GALT5 Gene
GPS-Prot Interaction Network for B3GALT5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006486 | protein glycosylation | IBA,TAS | 21873635 |
| GO:0006487 | protein N-linked glycosylation | IBA | 21873635 |
| GO:0009312 | oligosaccharide biosynthetic process | IBA | 21873635 |
| GO:0009617 | response to bacterium | IEA | -- |
No data available for SIGNOR curated interactions for B3GALT5 Gene
Drugs & Compounds for B3GALT5 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Phytosphingosine | Experimental | Pharma | 0 | |||
| Sphingosine | Experimental | Pharma | 0 | |||
| sphinganine | Pharma | 0 | ||||
| Sphingosine-1-phosphate | Pharma | Full agonist, Agonist | endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 3-Dehydrosphinganine |
|
16105-69-4 |
|
|||
| 3-O-Sulfogalactosylceramide (d18:1/12:0) |
|
852100-88-0 |
|
|||
| 3-O-Sulfogalactosylceramide (d18:1/14:0) |
|
|
||||
| 3-O-Sulfogalactosylceramide (d18:1/16:0) |
|
862509-48-6 |
|
|||
| 3-O-Sulfogalactosylceramide (d18:1/18:0) |
|
244215-65-4 |
|
Drug Products
- Atlas Antibodies PrEST Antigen B3GALT5 (APrEST85728) and PrEST Antigen B3GALT5 (APrEST85729)
Transcripts for B3GALT5 Gene
mRNA/cDNA for B3GALT5 Gene
- (9) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (14) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000380620 13170 bps (ENST00000380620.8)
- ENST00000475838 658 bps (ENST00000475838.1)
- ENST00000380618 2763 bps (ENST00000380618.5)
- ENST00000398714 2341 bps (ENST00000398714.3)
- ENST00000615480 2617 bps (ENST00000615480.4)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for B3GALT5 - Select products 50% OFF >
- * B3GALT5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * B3GALT5 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for B3GALT5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for B3GALT5
- genomics-online: gRNA clones - Search for available B3GALT5 gRNA products
- Overview of 133 available B3GALT5 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for B3GALT5
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for B3GALT5
- Browse OriGene Inhibitory RNA Products For B3GALT5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for B3GALT5
- genomics-online: shRNA clones - Search for available B3GALT5 shRNA products
- Overview of 133 available B3GALT5 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for B3GALT5 - Select products 50% OFF >
- * B3GALT5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * B3GALT5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG204357
- MG216786
- MR204357
- MR204357L3
- MR204357L3V
- MR204357L4
- MR204357L4V
- MR216786
- MR216786L3
- MR216786L3V
- MR216786L4
- MR216786L4V
- RC211183
- RC211183L3
- RC211183L3V
- RC211183L4
- RC211183L4V
- RC213317
- RC213317L3
- RC213317L3V
- RC213317L4
- RC213317L4V
- RC214669
- RC214669L3
- RC214669L3V
- RC214669L4
- RC214669L4V
- RC214721
- RC214721L3
- RC214721L3V
- RC214721L4
- RC214721L4V
- RC215430
- RC215430L3
- RC215430L3V
- RC215430L4
- RC215430L4V
- RC237364
- RG211183
- RG213317
- RG214669
- RG214721
- RG215430
- RR206042
- RR206042L3
- RR206042L3V
- RR206042L4
- RR206042L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for B3GALT5
- Addgene plasmids for B3GALT5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for B3GALT5
Expression for B3GALT5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
- Granulosa Cells Primary Follicle
- Oviduct
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Cerebral Cortex
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Intestine (Gastrointestinal Tract)
-
Colon (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for B3GALT5 Gene
This gene is overexpressed in Colon - Transverse (x15.7) and Small Intestine - Terminal Ileum (x10.1).
This gene is overexpressed in Heart (47.9) and Colon (21.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for B3GALT5 Gene
NURSA nuclear receptor signaling pathways regulating expression of B3GALT5 Gene:
B3GALT5SOURCE GeneReport for Unigene cluster for B3GALT5 Gene:
Hs.733638mRNA Expression by UniProt/SwissProt for B3GALT5 Gene:
Q9Y2C3-B3GT5_HUMAN
Tissue specificity:
Expressed in stomach, jejunum, colon, pancreas, small intestine, testis and gastrointestinal and pancreatic cancer cell lines. Hardly detected in lung, liver, adrenal gland and peripheral blood leukocytes.
Evidence on tissue expression from TISSUES for B3GALT5 Gene
- Intestine(4.4)
Primer Products
-
OriGene qPCR primer pairs for B3GALT5
-
OriGene qPCR primer pairs and template standards for B3GALT5
- genomics-online: primer clones - Search for available B3GALT5 Primer products
- Overview of 133 available B3GALT5 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for B3GALT5 Gene
Orthologs for B3GALT5 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | B3GALT5 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | B3GALT5 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | B3GALT5 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | B3galt5 32 |
|
||
| mouse (Mus musculus) |
Mammalia | B3galt5 17 33 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | B3GALT5 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | B3GALT5 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | B3GALT5 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100495133 32 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.16252 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | CR759791.2 33 |
|
ManyToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG8673 32 |
|
||
| CG8668 34 |
|
|
|||
| brn 34 |
|
|
|||
| rice (Oryza sativa) |
Liliopsida | Os02g0577300 32 |
|
- Species where no ortholog for B3GALT5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for B3GALT5 Gene
- ENSEMBL:
- Gene Tree for B3GALT5 (if available)
- TreeFam:
- Gene Tree for B3GALT5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for B3GALT5: view image
Paralogs for B3GALT5 Gene
Paralogs for B3GALT5 Gene
(9) SIMAP similar genes for B3GALT5 Gene using alignment to 1 proteins:
- B3GT5_HUMAN
Variants for B3GALT5 Gene
| SNP ID | Clin | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000052312 | -- | 39,637,787(+) | T/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000112770 | -- | 39,636,533(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000126124 | -- | 39,656,088(+) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000174079 | -- | 39,618,157(+) | AAAAAAAA/AAAAAAA | genic_upstream_transcript_variant, intron_variant | |
| rs1000294625 | -- | 39,653,332(+) | A/G | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv27418 | CNV | gain | 19812545 |
| esv3568195 | CNV | loss | 25503493 |
| esv3647020 | CNV | gain | 21293372 |
| esv3647022 | CNV | loss | 21293372 |
| esv3647023 | CNV | loss | 21293372 |
| nsv1061454 | CNV | gain | 25217958 |
| nsv587484 | CNV | loss | 21841781 |
| nsv587485 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.04;
21.32% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for B3GALT5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- B3GALT5
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B3GALT5 Gene
Disorders for B3GALT5 Gene
Additional Disease Information for B3GALT5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for B3GALT5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B3GALT5 Gene
Publications for B3GALT5 Gene
- Cloning, expression, and characterization of a novel UDP-galactose:beta-N-acetylglucosamine beta1,3-galactosyltransferase (beta3Gal-T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom. (PMID: 10212226) Isshiki S … Narimatsu H (The Journal of biological chemistry 1999) 2 3 4 23 56
- Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept. (PMID: 19567891) Hamshere ML … Craddock N (The British journal of psychiatry : the journal of mental science 2009) 3 43 56
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
- An endogenous retroviral long terminal repeat is the dominant promoter for human beta1,3-galactosyltransferase 5 in the colon. (PMID: 14534330) Dunn CA … Mager DL (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 56
- Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins. (PMID: 12855703) Isshiki S … Narimatsu H (The Journal of biological chemistry 2003) 3 23 56
ExternalLinks
Products for B3GALT5 Gene
- Custom Antibody ServicesOriGene Antibodies for B3GALT5
- Browse OriGene ELISA Kits
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- MG204357
- MG216786
- MR204357
- MR204357L3
- MR204357L3V
- MR204357L4
- MR204357L4V
- MR216786
- MR216786L3
- MR216786L3V
- MR216786L4
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- RC211183
- RC211183L3
- RC211183L3V
- RC211183L4
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- RC213317
- RC213317L3
- RC213317L3V
- RC213317L4
- RC213317L4V
- RC214669
- RC214669L3
- RC214669L3V
- RC214669L4
- RC214669L4V
- RC214721
- RC214721L3
- RC214721L3V
- RC214721L4
- RC214721L4V
- RC215430
- RC215430L3
- RC215430L3V
- RC215430L4
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- RC237364
- RG211183
- RG213317
- RG214669
- RG214721
- RG215430
- RR206042
- RR206042L3
- RR206042L3V
- RR206042L4
- RR206042L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- High-throughput Antibody Production Service
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- Novus Biologicals proteins and lysates for B3GALT5
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for B3GALT5
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- Browse Primary Antibodies
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for B3GALT5 (AFLGC-B3GALT5)
- Addgene plasmids for B3GALT5
- antibodies-online: Show 9 available B3GALT5 Antibodies ranked by validation data
- Compare Top B3GALT5 Antibodies
- antibodies-online: Show 12 available B3GALT5 Elisa Kits ranked by validation data
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- antibodies-online: Show 14 available B3GALT5 Proteins ranked by validation data
- Compare Top B3GALT5 Proteins
- Quality Products:
- Horizon Cell Lines for B3GALT5
- genomics-online: cdna clones - Search for available B3GALT5 CDNA products
- Overview of 133 available B3GALT5 gene related products
- orf clones - Search for available B3GALT5 ORF products
- Overview of 133 available B3GALT5 gene related products
- genomics-online: gRNA clones - Search for available B3GALT5 gRNA products
- Overview of 133 available B3GALT5 gene related products
- genomics-online: primer clones - Search for available B3GALT5 Primer products
- Overview of 133 available B3GALT5 gene related products
- genomics-online: shRNA clones - Search for available B3GALT5 shRNA products
- Overview of 133 available B3GALT5 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for B3GALT5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for B3GALT5
- Search GeneCopoeia for miRNA 3'UTR Target clone products for B3GALT5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for B3GALT5
Sources for B3GALT5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource