The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins ... See more...

Aliases for ARL1 Gene

Aliases for ARL1 Gene

  • ADP Ribosylation Factor Like GTPase 1 2 3 5
  • ADP-Ribosylation Factor-Like Protein 1 3 4
  • ADP-Ribosylation Factor-Like 1 2 3
  • ARFL1 3

External Ids for ARL1 Gene

Previous GeneCards Identifiers for ARL1 Gene

  • GC12M100928
  • GC12M101772
  • GC12M101719
  • GC12M100291
  • GC12M100289
  • GC12M101786
  • GC12M098846

Summaries for ARL1 Gene

Entrez Gene Summary for ARL1 Gene

  • The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for ARL1 Gene

ARL1 (ADP Ribosylation Factor Like GTPase 1) is a Protein Coding gene. Diseases associated with ARL1 include Cholera and Dyggve-Melchior-Clausen Disease. Among its related pathways are Vesicle-mediated transport and Golgi-to-ER retrograde transport. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is ARF5.

UniProtKB/Swiss-Prot Summary for ARL1 Gene

  • GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex (PubMed:9624189, PubMed:21239483, PubMed:27436755, PubMed:22679020, PubMed:27373159). Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells (PubMed:22981988).

Gene Wiki entry for ARL1 Gene

Additional gene information for ARL1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARL1 Gene

Genomics for ARL1 Gene

GeneHancer (GH) Regulatory Elements for ARL1 Gene

Promoters and enhancers for ARL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J101406 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 517.9 +0.0 19 3.2 HNRNPK ZBTB40 ZNF217 EP300 SIN3A NRF1 TCF12 POLR2G NCOR1 GTF2E2 ARL1 ENSG00000257543 lnc-SLC5A8-4 lnc-UTP20-4 ENSG00000257222 UTP20 NUP37 ENSG00000258230
GH12J101279 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 19.3 +127.3 127319 2.6 ZNF217 SIN3A NRF1 MYC TCF12 POLR2G USF1 GTF2E2 PHF8 ZNF639 UTP20 ARL1 NUP37 piR-33270-009
GH12J101695 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11 -290.9 -290868 6.9 ZNF217 CTCF NRF1 POLR2G GTF2E2 PHF8 PHB2 ZFX ZNF10 ZIC2 CHPT1 NONHSAG012080.2 ENSG00000257222 UTP20 ARL1 NUP37 GNPTAB ENSG00000274560 RF00019-021 RNY1P16
GH12J101298 Enhancer 0.5 Ensembl 13.7 +109.4 109419 2 FOS ZNF316 MAFK HLF RFX5 NFE2L2 piR-33270-009 ARL1 UTP20 FJ601684-084
GH12J101300 Enhancer 0.2 Ensembl 12 +107.7 107719 0.2 ARL1 piR-33270-009 UTP20 FJ601684-084
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARL1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARL1

Top Transcription factor binding sites by QIAGEN in the ARL1 gene promoter:
  • Brachyury
  • C/EBPbeta
  • Cart-1
  • Egr-2
  • FOXF2
  • p53
  • Pbx1a
  • POU2F1
  • RORalpha2

Genomic Locations for ARL1 Gene

Genomic Locations for ARL1 Gene
chr12:101,393,116-101,407,820
(GRCh38/hg38)
Size:
14,705 bases
Orientation:
Minus strand
chr12:101,786,898-101,801,598
(GRCh37/hg19)
Size:
14,701 bases
Orientation:
Minus strand

Genomic View for ARL1 Gene

Genes around ARL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL1 Gene

Proteins for ARL1 Gene

  • Protein details for ARL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40616-ARL1_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 1
    Protein Accession:
    P40616
    Secondary Accessions:
    • B4DWW1
    • P80417
    • Q53XB1

    Protein attributes for ARL1 Gene

    Size:
    181 amino acids
    Molecular mass:
    20418 Da
    Quaternary structure:
    • The GTP-bound form interacts with GOLGA1 (By similarity). The GTP-bound form interacts with GOLGA4 and RGPD8. The GTP-bound form directly interacts with ARFIP2 (PubMed:11303027, PubMed:21239483, PubMed:22679020). Binds to SCOC, preferentially in its GTP-bound form. May interact with UNC119 (PubMed:11303027, PubMed:14580338). Interacts with ARFIP1; this interaction directs ARFIP1 to the trans-Golgi membranes (PubMed:21239483, PubMed:22981988). Interacts with ARFGEF1 (via N-terminus) (PubMed:27436755, PubMed:27373159).

    Three dimensional structures from OCA and Proteopedia for ARL1 Gene

    Alternative splice isoforms for ARL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARL1 Gene

Post-translational modifications for ARL1 Gene

  • Ubiquitination at Lys62 and Lys157
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARL1 Gene

Domains & Families for ARL1 Gene

Gene Families for ARL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARL1 Gene

Blocks:
  • ADP-ribosylation factor
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARL1 Gene

GenScript: Design optimal peptide antigens:
  • ADP-ribosylation factor-like protein 1 (ARL1_HUMAN)
  • cDNA FLJ51704, highly similar to ADP-ribosylation factor-like protein 1 (B4DWW1_HUMAN)
  • cDNA FLJ50309, highly similar to ADP-ribosylation factor-like protein 1 (B4DZG7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P40616

UniProtKB/Swiss-Prot:

ARL1_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL1: view

Function for ARL1 Gene

Molecular function for ARL1 Gene

UniProtKB/Swiss-Prot Function:
GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex (PubMed:9624189, PubMed:21239483, PubMed:27436755, PubMed:22679020, PubMed:27373159). Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells (PubMed:22981988).
GENATLAS Biochemistry:
ADP-ribosylation factor-like 1,low molecular weight GTP binding protein,widely expressed,except in brain,Ras superfamily member

Phenotypes From GWAS Catalog for ARL1 Gene

Gene Ontology (GO) - Molecular Function for ARL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IDA 8798635
GO:0005525 GTP binding IDA,IEA 9624189
GO:0008047 enzyme activator activity IDA 9624189
GO:0019904 protein domain specific binding IPI 14580338
genes like me logo Genes that share ontologies with ARL1: view
genes like me logo Genes that share phenotypes with ARL1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ARL1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARL1

Clone Products

  • Addgene plasmids for ARL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL1 Gene

Localization for ARL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL1 Gene

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane. Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL1 gene
Compartment Confidence
golgi apparatus 5
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS,IBA --
GO:0005794 Golgi apparatus IDA,IBA 19224922
GO:0005802 trans-Golgi network IDA,ISS --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ARL1: view

Pathways & Interactions for ARL1 Gene

genes like me logo Genes that share pathways with ARL1: view

Gene Ontology (GO) - Biological Process for ARL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0007030 Golgi organization ISS --
GO:0009404 toxin metabolic process IDA 9624189
GO:0016192 vesicle-mediated transport IBA 21873635
GO:0031584 activation of phospholipase D activity IDA 9624189
genes like me logo Genes that share ontologies with ARL1: view

No data available for SIGNOR curated interactions for ARL1 Gene

Drugs & Compounds for ARL1 Gene

(1) Drugs for ARL1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma Target 0

(1) Additional Compounds for ARL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARL1: view

Transcripts for ARL1 Gene

mRNA/cDNA for ARL1 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARL1

Clone Products

  • Addgene plasmids for ARL1

Alternative Splicing Database (ASD) splice patterns (SP) for ARL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: -
SP4: - - - -
SP5: - - - - - -
SP6: -

Relevant External Links for ARL1 Gene

GeneLoc Exon Structure for
ARL1

Expression for ARL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARL1 Gene

This gene is overexpressed in Nasal epithelium (9.6) and Salivary gland (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARL1 Gene



Protein tissue co-expression partners for ARL1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARL1

SOURCE GeneReport for Unigene cluster for ARL1 Gene:

Hs.372616

mRNA Expression by UniProt/SwissProt for ARL1 Gene:

P40616-ARL1_HUMAN
Tissue specificity: Detected in heart, liver, lung and liver (at protein level). Detected in fetal heart, lung, liver and kidney. Detected in adult heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for ARL1 Gene

  • Nervous system(4.8)
  • Heart(4.3)
  • Eye(4.1)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with ARL1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL1 Gene

Orthologs for ARL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL1 31 30
  • 99.82 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARL1 31
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARL1 31 30
  • 95.4 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ARL1 31 30
  • 95.03 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Arl1 17 31 30
  • 91.9 (n)
rat
(Rattus norvegicus)
Mammalia Arl1 30
  • 91.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 44 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ARL1 31 30
  • 82.44 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARL1 31
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arl1 30
  • 82.04 (n)
Str.4004 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.24080 30
zebrafish
(Danio rerio)
Actinopterygii arl1 31 30
  • 79.44 (n)
OneToOne
Dr.28553 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13814 30
fruit fly
(Drosophila melanogaster)
Insecta Arf72A 31 32 30
  • 66.07 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011730 30
  • 64.27 (n)
worm
(Caenorhabditis elegans)
Secernentea arl-1 31 32 30
  • 64.07 (n)
OneToOne
arl-6 32
  • 51 (a)
arl-5 32
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARL1 33 31 30
  • 62.48 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24773g 30
  • 60.64 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR221W 30
  • 57.68 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARF3 30
  • 62.63 (n)
rice
(Oryza sativa)
Liliopsida Os08g0248900 30
  • 61.85 (n)
corn
(Zea mays)
Liliopsida Zm.8989 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.887 31
  • 77 (a)
OneToOne
Cin.15548 30
bread mold
(Neurospora crassa)
Ascomycetes NCU08989 30
  • 59.3 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15548 30
Species where no ortholog for ARL1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL1 Gene

ENSEMBL:
Gene Tree for ARL1 (if available)
TreeFam:
Gene Tree for ARL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARL1: view image

Paralogs for ARL1 Gene

(30) SIMAP similar genes for ARL1 Gene using alignment to 7 proteins:

  • ARL1_HUMAN
  • B4DWW1_HUMAN
  • B4DZG7_HUMAN
  • F8VP63_HUMAN
  • F8VP99_HUMAN
  • F8VYN9_HUMAN
  • F8W1Z8_HUMAN
genes like me logo Genes that share paralogs with ARL1: view

Variants for ARL1 Gene

Additional dbSNP identifiers (rs#s) for ARL1 Gene

Variation tolerance for ARL1 Gene

Residual Variation Intolerance Score: 48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for ARL1 Gene

Disorders for ARL1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cholera
  • cholera - vibrio cholerae
dyggve-melchior-clausen disease
  • dmc
- elite association - COSMIC cancer census association via MalaCards
Search ARL1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ARL1

genes like me logo Genes that share disorders with ARL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARL1 Gene

Publications for ARL1 Gene

  1. ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. (PMID: 11303027) Van Valkenburgh H … Kahn RA (The Journal of biological chemistry 2001) 3 4 23 54
  2. Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1). (PMID: 9624189) Hong JX … Vaughan M (The Journal of biological chemistry 1998) 3 4 23 54
  3. Different ARF domains are required for the activation of cholera toxin and phospholipase D. (PMID: 7814376) Zhang GF … Vaughan M (The Journal of biological chemistry 1995) 3 4 23 54
  4. Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi. (PMID: 27373159) Galindo A … Munro S (Cell reports 2016) 3 4 54
  5. Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase. (PMID: 22679020) Nakamura K … Wakatsuki S (The Journal of biological chemistry 2012) 3 4 54

Products for ARL1 Gene

Sources for ARL1 Gene